Published in Arthritis Rheum on December 01, 2001
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61
Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix. Osteoarthritis Cartilage (2009) 2.65
Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum (2012) 1.91
Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther (2007) 1.85
Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. Eur Cell Mater (2011) 1.84
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis (2008) 1.82
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis. Arthritis Rheum (2005) 1.65
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Res Ther (2006) 1.51
A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis. Arthritis Res Ther (2010) 1.35
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30
Analysis of meniscal degeneration and meniscal gene expression. BMC Musculoskelet Disord (2010) 1.17
Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop (2004) 1.13
Analysing the role of endogenous matrix molecules in the development of osteoarthritis. Int J Exp Pathol (2009) 1.13
Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow. Arthritis Res Ther (2006) 1.11
Developmental mechanisms in articular cartilage degradation in osteoarthritis. Arthritis (2010) 1.10
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Res Ther (2005) 1.10
Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading. Arthritis Res Ther (2004) 1.09
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol (2006) 1.07
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. BMC Musculoskelet Disord (2011) 1.06
Expression stability of commonly used reference genes in canine articular connective tissues. BMC Vet Res (2007) 1.05
Matrix metalloproteinase-3 in articular cartilage is upregulated by joint immobilization and suppressed by passive joint motion. Matrix Biol (2010) 1.02
New findings in osteoarthritis pathogenesis: therapeutic implications. Ther Adv Chronic Dis (2013) 1.00
A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials (2011) 0.99
Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. Growth Factors (2009) 0.93
Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis. Rheumatol Int (2005) 0.93
Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome. J Biomol Tech (2005) 0.93
Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One (2010) 0.91
Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis. Ann Rheum Dis (2004) 0.91
Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther (2011) 0.90
Does protein kinase R mediate TNF-alpha- and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism? Arthritis Res Ther (2003) 0.88
Sequential alterations in catabolic and anabolic gene expression parallel pathological changes during progression of monoiodoacetate-induced arthritis. PLoS One (2011) 0.88
The increased expression of matrix metalloproteinases associated with elastin degradation and fibrosis of the ligamentum flavum in patients with lumbar spinal stenosis. Clin Orthop Surg (2009) 0.87
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes. Arthritis Res Ther (2009) 0.86
Signaling pathways in cartilage repair. Int J Mol Sci (2014) 0.86
Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis. PLoS One (2012) 0.86
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. Osteoarthritis Cartilage (2014) 0.85
Identification and initial characterization of 6,000 expressed sequenced tags (ESTs) from rat normal-growing cartilage and swarm rat chondrosarcoma cDNA libraries. Iowa Orthop J (2002) 0.84
Matrix metalloproteinase-3 inhibitor retards treadmill running-induced cartilage degradation in rats. Arthritis Res Ther (2011) 0.84
Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement Altern Med (2011) 0.84
Fibronectin III 13-14 domains induce joint damage via Toll-like receptor 4 activation and synergize with interleukin-1 and tumour necrosis factor. J Innate Immun (2011) 0.83
Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR. Orthop J Sports Med (2016) 0.82
Tenascin-C fragments are endogenous inducers of cartilage matrix degradation. Rheumatol Int (2011) 0.82
Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage (2009) 0.82
Collagen metabolism of human osteoarthritic articular cartilage as modulated by bovine collagen hydrolysates. PLoS One (2013) 0.81
Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms). Rheumatol Int (2008) 0.81
Pigment epithelium derived factor--the product of the EPC-1 gene--is expressed by articular chondrocytes and up regulated in osteoarthritis. Ann Rheum Dis (2006) 0.81
Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface. Cartilage (2013) 0.80
Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments. Tissue Eng Part A (2013) 0.80
Mild degenerative changes of hip cartilage in elderly patients: an available sample representative of early osteoarthritis. Int J Clin Exp Pathol (2014) 0.80
Genetics in osteoarthritis. Curr Genomics (2008) 0.80
Molecular characterization of spontaneous and growth-factor-augmented chondrogenesis in periosteum-bone tissue transferred into a joint. Histochem Cell Biol (2005) 0.79
Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats. Histochem Cell Biol (2015) 0.79
The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells. Biomaterials (2013) 0.79
The roles of catabolic factors in the development of osteoarthritis. Tissue Eng Part B Rev (2013) 0.79
Up-regulation of multiple proteins and biological processes during maxillary expansion in rats. BMC Musculoskelet Disord (2008) 0.77
[Typing, grading and staging of osteoarthritis: histopathological assessment of joint degeneration]. Z Rheumatol (2008) 0.77
Evaluating Osteoarthritic Chondrocytes through a Novel 3-Dimensional In Vitro System for Cartilage Tissue Engineering and Regeneration. Cartilage (2012) 0.77
A Three-Dimensional Chondrocyte-Macrophage Coculture System to Probe Inflammation in Experimental Osteoarthritis. Tissue Eng Part A (2016) 0.75
Correlation between Gene Expression and Osteoarthritis Progression in Human. Int J Mol Sci (2016) 0.75
Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed (2015) 0.75
Osteoarthritis in the Knee Joints of Göttingen Minipigs after Resection of the Anterior Cruciate Ligament? Missing Correlation of MRI, Gene and Protein Expression with Histological Scoring. PLoS One (2016) 0.75
The effects of interleukin-1β in modulating osteoclast-conditioned medium's influence on gelatinases in chondrocytes through mitogen-activated protein kinases. Int J Oral Sci (2015) 0.75
Age dependent changes in cartilage matrix, subchondral bone mass, and estradiol levels in blood serum, in naturally occurring osteoarthritis in Guinea pigs. Int J Mol Sci (2014) 0.75
Swarm rat chondrosarcoma cells as an in vivo model: lung colonization and effects of tissue environment on tumor growth. Iowa Orthop J (2012) 0.75
Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway. Exp Ther Med (2015) 0.75
Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment. Matrix Biol (2016) 0.75
Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci (2002) 1.64
DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthritis Cartilage (2012) 1.59
Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999. Clin Otolaryngol Allied Sci (2001) 1.53
Normalization strategies for mRNA expression data in cartilage research. Osteoarthritis Cartilage (2008) 1.52
Molecular phenotyping of human chondrocyte cell lines T/C-28a2, T/C-28a4, and C-28/I2. Arthritis Rheum (2003) 1.35
Osteoarthritis: pathobiology-targets and ways for therapeutic intervention. Adv Drug Deliv Rev (2006) 1.34
Tinnitus impairs cognitive efficiency. Int J Audiol (2004) 1.16
Tinnitus and suicide. Clin Otolaryngol Allied Sci (1994) 1.05
Effective isolation of high-quality total RNA from human adult articular cartilage. Anal Biochem (2000) 0.93
YKL-39 (chitinase 3-like protein 2), but not YKL-40 (chitinase 3-like protein 1), is up regulated in osteoarthritic chondrocytes. Ann Rheum Dis (2003) 0.92
The black-pearl gene of Drosophila defines a novel conserved protein family and is required for larval growth and survival. Gene (2001) 0.91
Up-regulation of MDC15 (metargidin) messenger RNA in human osteoarthritic cartilage. Arthritis Rheum (1999) 0.85
Tinnitus masking and depression. Audiology (1998) 0.83
Phenotypic characterization of chondrosarcoma-derived cell lines. Cancer Lett (2004) 0.80
Support group membership and perceptions of control over health in HIV+ men. J Clin Psychol (1997) 0.80
Children's experience of tinnitus: a preliminary survey of children presenting to a psychology department. Br J Audiol (2000) 0.80
A comparison of methods used in the UK and Ireland for the extraction and detection of semen on swabs and cloth samples. Sci Justice (2007) 0.78
Turning tapes into text: issues surrounding the transcription of interviews. Contemp Nurse (2001) 0.78
Scoping the context of programs and services for maintaining wellness of older people in rural areas of Indonesia. Int Nurs Rev (2014) 0.75
The psychological assessment of cochlear implant patients. Br J Audiol (1986) 0.75
Goal planning in audiological rehabilitation. Br J Audiol (1987) 0.75
Belongingness in the workplace: a study of Malaysian nurses' experiences. Int Nurs Rev (2013) 0.75
[cDNA-microarrays in cartilage research - functional genomics of osteoarthritis]. Z Orthop Ihre Grenzgeb (2004) 0.75
Saudi Arabian nurses' experiences of studying Masters degrees in Australia. Int Nurs Rev (2011) 0.75
Application of parameter optimization to molecular comparison problems. Pac Symp Biocomput (1999) 0.75
[Painful tumour at the knee joint: case report and review of the literature]. Handchir Mikrochir Plast Chir (2006) 0.75
Listening styles of undergraduate health students. Educ Health (Abingdon) (2010) 0.75