Published in Am J Pathol on August 01, 2006
Validation of suitable house keeping genes for hypoxia-cultured human chondrocytes. BMC Mol Biol (2009) 1.30
Action mechanisms of du-huo-ji-sheng-tang on cartilage degradation in a rabbit model of osteoarthritis. Evid Based Complement Alternat Med (2011) 1.14
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer (2014) 1.01
Biochemical and proteomic characterization of alkaptonuric chondrocytes. J Cell Physiol (2012) 0.99
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Exp Cell Res (2009) 0.99
Rare cell proteomic reactor applied to stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics study of human embryonic stem cell differentiation. Mol Cell Proteomics (2010) 0.98
Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther (2008) 0.97
Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes. Arthritis Res Ther (2010) 0.95
Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis. Pflugers Arch (2007) 0.93
Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes. J Biol Chem (2012) 0.92
Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma. Histochem Cell Biol (2009) 0.89
Extracellular matrix genes as hypoxia-inducible targets. Cell Tissue Res (2009) 0.87
Posttranslational modifications of collagens as targets of hypoxia and Hif-1alpha in endochondral bone development. Ann N Y Acad Sci (2010) 0.78
Amplified and selective assay of collagens by enzymatic and fluorescent reactions. Sci Rep (2014) 0.78
Col2-Cre and tamoxifen-inducible Col2-CreER target different cell populations in the knee joint. Osteoarthritis Cartilage (2015) 0.78
Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer (2013) 0.76
Fibrochondrogenic potential of synoviocytes from osteoarthritic and normal joints cultured as tensioned bioscaffolds for meniscal tissue engineering in dogs. PeerJ (2014) 0.76
O-GlcNAcylation: a bridge between glucose and cell differentiation. J Cell Mol Med (2016) 0.75
Expression of hypoxia-inducible factor-1α in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis. Exp Ther Med (2016) 0.75
Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage. Int J Rheumatol (2016) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol (1992) 11.03
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am (1971) 9.93
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
The etiology of chondromalacia patellae. J Bone Joint Surg Br (1961) 8.60
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell (2001) 4.75
Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev (2001) 4.45
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell (2003) 3.66
YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst (2003) 2.91
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature (1994) 2.49
Structure and biology of cartilage and bone matrix noncollagenous macromolecules. FASEB J (1989) 2.24
Oxygen tension in synovial fluids. Arthritis Rheum (1971) 2.14
Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy. Arthritis Rheum (1992) 2.10
HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci (2003) 1.93
Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum (2001) 1.83
Measurement of pH and ionic composition of pericellular sites. Philos Trans R Soc Lond B Biol Sci (1975) 1.74
Evidence for altered synthesis of type II collagen in patients with osteoarthritis. J Clin Invest (1998) 1.66
The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum (2001) 1.64
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (2004) 1.58
Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. J Biol Chem (2000) 1.56
2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. Clin Cancer Res (2004) 1.50
Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage. J Clin Invest (1993) 1.49
Mechanism of action of 2-methoxyestradiol: new developments. Drug Resist Updat (2003) 1.42
Proteoglycans: their structure, interactions and molecular organization in cartilage. Biochem Soc Trans (1981) 1.41
Characterization of the human prolyl 4-hydroxylase tetramer and its multifunctional protein disulfide-isomerase subunit synthesized in a baculovirus expression system. Proc Natl Acad Sci U S A (1992) 1.40
Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints. Ann Rheum Dis (2001) 1.38
Oxygen tension regulates the expression of a group of procollagen hydroxylases. Eur J Biochem (2003) 1.38
Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage (2002) 1.35
Collagen synthesis in normal and osteoarthritic human cartilage. J Clin Invest (1977) 1.35
Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. J Biol Chem (1997) 1.34
Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum (2002) 1.32
Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. Am J Pathol (2001) 1.30
Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol (2004) 1.18
Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme. J Biol Chem (2003) 1.16
Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage (2004) 1.14
Cartilage collagens. What is their function, and are they involved in articular disease? Arthritis Rheum (1989) 1.14
Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop (2004) 1.13
The regulation of MMPs and TIMPs in cartilage turnover. Ann N Y Acad Sci (1999) 1.13
Structure and function of cartilage collagens. Microsc Res Tech (1994) 1.12
Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering. J Biomech (2001) 1.07
The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells. J Biol Chem (1998) 1.06
Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis. Arthritis Res Ther (2005) 1.05
Osteoarthritis in the human knee: a dynamic process of cartilage matrix degradation, synthesis and reorganization. Agents Actions Suppl (1993) 1.03
Presence and distribution of collagen II, collagen I, fibronectin, and tenascin in rabbit normal and osteoarthritic cartilage. J Rheumatol (1999) 0.99
Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage. Ann Rheum Dis (2000) 0.98
Matrix metalloproteinase pattern in celiac duodenal mucosa. Lab Invest (2005) 0.97
Hepatocyte growth factor in human osteoarthritic cartilage. Osteoarthritis Cartilage (1999) 0.91
Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis. Ann Rheum Dis (2004) 0.91
Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque. Circulation (2003) 0.90
Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several human tissues. J Histochem Cytochem (2001) 0.90
Increased content of type-VI collagen epitopes in human osteoarthritic cartilage: quantitation by inhibition ELISA. J Orthop Res (1998) 0.88
[Intra-articular oxygen partial pressure measurements under functional conditions]. Z Orthop Ihre Grenzgeb (1996) 0.87
Tonic activation of hypoxia-inducible factor 1alpha in avascular articular cartilage and implications for metabolic homeostasis. Arthritis Rheum (2005) 0.86
[Metabolic activation of chondrocytes in human osteoarthritis. Expression of type II collagen]. Z Orthop Ihre Grenzgeb (1999) 0.80
Increased prolylhydroxylase activity in chondrocytes but not synovial cells from adjuvant arthritic rat knees. Coll Relat Res (1986) 0.76
Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum (2006) 4.16
HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest (2005) 3.77
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med (2005) 3.43
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev Cell (2002) 3.23
Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science (2007) 2.70
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet (2004) 2.67
Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am (2003) 2.24
Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst (2003) 2.19
Association between crystals and cartilage degeneration in the ankle. J Rheumatol (2008) 2.15
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum (2002) 1.97
HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci (2003) 1.93
Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat (2011) 1.87
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. Am J Sports Med (2010) 1.81
MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU. Toxicol Lett (2009) 1.60
Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum (2003) 1.59
Chondromodulin 1 stabilizes the chondrocyte phenotype and inhibits endochondral ossification of porcine cartilage repair tissue. Arthritis Rheum (2011) 1.57
NEK1 mutations cause short-rib polydactyly syndrome type majewski. Am J Hum Genet (2011) 1.56
Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. J Biol Chem (2002) 1.56
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort. Genes Chromosomes Cancer (2010) 1.50
Transforming growth factor beta 1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res (2003) 1.48
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat Res (2005) 1.45
Application of two-dimensional gel-based mass spectrometry to functionally dissect resistance to targeted cancer therapy. Proteomics Clin Appl (2013) 1.39
Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum (2008) 1.33
Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol (2007) 1.28
Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One (2010) 1.27
HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells (2014) 1.23
Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum (2005) 1.23
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutat Res (2007) 1.22
Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity. Arthritis Rheum (2007) 1.20
Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. Cancer Res (2008) 1.19
Polycyclic aromatic hydrocarbons in foods: human exposure through the diet in Catalonia, Spain. J Food Prot (2003) 1.15
2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol (2008) 1.14
Hypoxia and HIF-1alpha in osteoarthritis. Int Orthop (2004) 1.13
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Lett (2005) 1.13
Inter- and intraobserver assessment of periacetabular osteodensitometry after cemented and uncemented total hip arthroplasty using computed tomography. Arch Orthop Trauma Surg (2005) 1.11
Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol (2003) 1.10
Neurodevelopmental deficits in Pierson (microcoria-congenital nephrosis) syndrome. Am J Med Genet A (2007) 1.09
Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma. Ann Diagn Pathol (2006) 1.07
Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Cell Microbiol (2003) 1.07
Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum (2007) 1.04
Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells. J Gene Med (2006) 1.04
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU. Mutat Res (2009) 1.03
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J Endocrinol (2008) 1.03
Functional differences between growth plate apoptotic bodies and matrix vesicles. J Bone Miner Res (2003) 1.02
Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. FASEB J (2003) 1.02
Population doublings and percentage of S100-positive cells as predictors of in vitro chondrogenicity of expanded human articular chondrocytes. J Cell Physiol (2010) 1.02
Computational toxicology in drug development. Drug Discov Today (2008) 1.01
Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum (2013) 1.00
IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine (2004) 1.00
Tobacco smoke: unraveling a controversial subject. Exp Toxicol Pathol (2008) 1.00
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. Am J Sports Med (2011) 0.99
Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. Arthritis Res Ther (2008) 0.97
Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes. J Orthop Res (2003) 0.96
Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity. Arthritis Rheum (2005) 0.96
Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes. Rheumatol Int (2006) 0.95
Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta. Arthritis Rheum (2004) 0.94
SOX gene expression in human osteoarthritic cartilage. Pathobiology (2008) 0.93
Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop. Mutat Res (2008) 0.92
Helicobacter pylori determination in non-municipal drinking water and epidemiological findings. Isotopes Environ Health Stud (2004) 0.92
FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer (2008) 0.92
Periacetabular bone changes after uncemented total hip arthroplasty evaluated by quantitative computed tomography. Acta Orthop (2006) 0.92
Osteomyelitis of the ulna caused by Porphyromonas gingivalis. J Clin Microbiol (2006) 0.92
Towards the creation of an international toxicology information centre. Toxicology (2005) 0.91
Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton. Mod Pathol (2005) 0.91
Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage. J Bone Miner Res (2002) 0.91
Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery? Pediatr Hematol Oncol (2010) 0.90
Regulation of chondrocyte gene expression by osteogenic protein-1. Arthritis Res Ther (2011) 0.90
Ultrasound-guided spinal fracture repositioning, ligamentotaxis, and remodeling after thoracolumbar burst fractures. Spine (Phila Pa 1976) (2006) 0.90
Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma. Histochem Cell Biol (2009) 0.89
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling. Arthritis Rheum (2005) 0.88
Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling. Arthritis Rheum (2006) 0.88
The role of HIF-1alpha in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis. Arthritis Res Ther (2006) 0.87
HIFs as central regulators of gastric cancer pathogenesis. Cancer Biol Ther (2010) 0.86
Impact of microvessel density on lymph node metastasis and survival after curative resection of pancreatic cancer. Surg Today (2011) 0.86
Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes. Front Biosci (2004) 0.85
TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomed Pharmacother (2005) 0.85
Thrombospondin-1 prevents excessive ossification in cartilage repair tissue induced by osteogenic protein-1. Tissue Eng Part A (2011) 0.85
ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta. J Rheumatol (2004) 0.85
Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients. Toxicol Lett (2009) 0.85
ADAM15 exerts an antiapoptotic effect on osteoarthritic chondrocytes via up-regulation of the X-linked inhibitor of apoptosis. Arthritis Rheum (2010) 0.84
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage. Arthritis Res Ther (2005) 0.84
Combined arthroscopic and radiation synovectomy of the knee joint in rheumatoid arthritis: 14-year follow-up. Arthroscopy (2010) 0.83
Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate. Toxicol Lett (2009) 0.83
Mesenchymal stem cells and carcinoma-associated fibroblasts sensitize breast cancer cells in 3D cultures to kinase inhibitors. Int J Oncol (2011) 0.83
Polychlorinated naphthalenes in foods: estimated dietary intake by the population of Catalonia, Spain. Environ Sci Technol (2003) 0.83
Analysis of glomerular VEGF mRNA and protein expression in murine mesangioproliferative glomerulonephritis. Virchows Arch (2006) 0.83
Modes of periacetabular load transfer to cortical and cancellous bone after cemented versus uncemented total hip arthroplasty: a prospective study using computed tomography-assisted osteodensitometry. J Orthop Res (2009) 0.83
Combination of hypoxia and RNA-interference targeting VEGF induces apoptosis in hepatoma cells via autocrine mechanisms. Curr Pharm Biotechnol (2012) 0.82
Functional and morphologic characterization of eosinophils in the lower intestinal mucosa of patients with food allergy. Am J Gastroenterol (2003) 0.82
Physical responses of different small-sided game formats in elite youth soccer players. J Strength Cond Res (2012) 0.82
E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells. J Mol Histol (2007) 0.82
Monitoring recovery from iron deficiency using total hemoglobin mass. Med Sci Sports Exerc (2015) 0.82
EBV-associated post-transplantation B-cell lymphoproliferative disorder following allogenic stem cell transplantation for acute lymphoblastic leukaemia: tumor regression after reduction of immunosuppression--a case report. Diagn Pathol (2010) 0.82