Published in J Biol Chem on December 31, 2001
Ena/VASP is required for endothelial barrier function in vivo. J Cell Biol (2007) 1.53
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell (2008) 1.40
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. Traffic (2009) 1.31
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell (2002) 1.28
An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I. Mol Biol Cell (2012) 1.18
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12
Arf6 plays an early role in platelet activation by collagen and convulxin. Blood (2005) 1.12
The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic (2010) 1.04
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell (2004) 1.03
Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin. J Virol (2010) 1.02
Overexpression of ASAP1 is associated with poor prognosis in epithelial ovarian cancer. Int J Clin Exp Pathol (2013) 0.80
The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling. J Biol Chem (2013) 0.80
Microvesicle removal of anticancer drugs contributes to drug resistance in human pancreatic cancer cells. Oncotarget (2016) 0.79
ACAP-A/B are ArfGAP homologs in dictyostelium involved in sporulation but not in chemotaxis. PLoS One (2010) 0.79
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6. BMC Cell Biol (2009) 0.77
AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions. Sci Rep (2014) 0.76
eIF5B increases ASAP1 expression to promote HCC proliferation and invasion. Oncotarget (2016) 0.75
Arf proteins in cancer cell migration. Small GTPases (2016) 0.75
Syndecan-2 can promote clearance of T-cell receptor/CD3 from the cell surface. Immunology (2012) 0.75
GB virus type C E2 protein inhibits human immunodeficiency virus type 1 Gag assembly by downregulating human ADP-ribosylation factor 1. Oncotarget (2015) 0.75
The biology of uveal melanoma. Cancer Metastasis Rev (2017) 0.75
The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Mol Biol Cell (2016) 0.75
Focus on cutaneous and uveal melanoma specificities. Genes Dev (2017) 0.75
Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking. J Cell Biol (2017) 0.75
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 14.62
Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov (2009) 10.59
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60
A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature (2008) 6.04
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A (2005) 3.72
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell (2003) 3.33
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov (2013) 2.52
Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle (2006) 2.39
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res (2004) 2.32
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A (2006) 2.23
Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR. Am J Surg Pathol (2006) 2.23
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A (2011) 2.14
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol (2006) 2.08
Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research. Mol Cell Proteomics (2004) 2.00
Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science (2003) 1.89
Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell (2002) 1.86
Enhanced analysis of metastatic prostate cancer using stable isotopes and high mass accuracy instrumentation. J Proteome Res (2006) 1.82
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest (2011) 1.74
Gene therapy of prostate cancer with the soluble vascular endothelial growth factor receptor Flk1. Cancer Biol Ther (2002) 1.67
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol (2005) 1.59
Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression. J Biol Chem (2004) 1.58
Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol (2009) 1.47
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature. Bioconjug Chem (2007) 1.46
Identification of a transcriptional profile associated with in vitro invasion in non-small cell lung cancer cell lines. Cancer Biol Ther (2004) 1.42
Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A (2004) 1.42
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell (2005) 1.37
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol (2008) 1.35
The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev (2012) 1.32
The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet (2008) 1.30
Cancer biomarkers: knowing the present and predicting the future. Future Oncol (2005) 1.29
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res (2013) 1.24
Rescue of paclitaxel sensitivity by repression of Prohibitin1 in drug-resistant cancer cells. Proc Natl Acad Sci U S A (2010) 1.23
Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology (2011) 1.22
Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov (2012) 1.22
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A (2007) 1.20
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology (2008) 1.20
Functional genetics and experimental models of human cancer. Trends Mol Med (2004) 1.17
Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A (2007) 1.17
K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One (2012) 1.16
PI3 kinases in cancer: from oncogene artifact to leading cancer target. Sci STKE (2006) 1.15
The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2004) 1.14
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem (2006) 1.13
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer. Proc Natl Acad Sci U S A (2012) 1.12
Endostatin inhibits the growth of endometriotic lesions but does not affect fertility. Fertil Steril (2005) 1.08
A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One (2008) 1.08
Cystatin B as a tissue and urinary biomarker of bladder cancer recurrence and disease progression. Clin Cancer Res (2009) 1.04
Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res (2007) 1.03
Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. Mol Biol Cell (2003) 1.03
A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. J Cell Sci (2003) 1.02
Short synthetic endostatin peptides inhibit endothelial migration in vitro and endometriosis in a mouse model. Fertil Steril (2006) 1.01
The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol (2007) 1.01
A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A (2010) 1.01
Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Mol Cancer Res (2011) 1.00
Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. J Cell Sci (2006) 0.99
Bub1: escapades in a cellular world. Cell Cycle (2007) 0.99
Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer. BMC Cancer (2014) 0.98
Assessing enzyme activities using stable isotope labeling and mass spectrometry. Mol Cell Proteomics (2007) 0.98
A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell (2007) 0.95
siRNA off-target effects can be reduced at concentrations that match their individual potency. PLoS One (2011) 0.95
Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. J Clin Invest (2014) 0.94
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A (2014) 0.93
Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Mol Biol Cell (2009) 0.93
Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potential. Clin Exp Metastasis (2012) 0.93
Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. FASEB J (2010) 0.92
Regulation of epithelial plasticity by miR-424 and miR-200 in a new prostate cancer metastasis model. Sci Rep (2013) 0.91
Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo. ACS Nano (2010) 0.90
Insulin-like growth factors promote vasculogenesis in embryonic stem cells. PLoS One (2012) 0.89
Type XXIII collagen, a new transmembrane collagen identified in metastatic tumor cells. J Biol Chem (2003) 0.89
Collagen XXIII expression is associated with prostate cancer recurrence and distant metastases. Clin Cancer Res (2007) 0.89
Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol (2010) 0.89
Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells. Exp Cell Res (2004) 0.88
Biomaterials for mRNA delivery. Biomater Sci (2015) 0.87
Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. J Mol Biol (2005) 0.87
Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol (2011) 0.87
Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol (2005) 0.87
Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer. Cancer Epidemiol Biomarkers Prev (2010) 0.86
The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci U S A (2008) 0.86
Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem (2005) 0.86
Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer. J Proteome Res (2010) 0.85
2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. J Mol Biol (2002) 0.85
Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction. Curr Biol (2011) 0.84
Cytoskeleton dynamics powers nematode sperm motility. Adv Protein Chem (2005) 0.84
Proteomics in tumor progression and metastasis. Ann N Y Acad Sci (2005) 0.84
14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer. Clin Cancer Res (2009) 0.82
Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol (2011) 0.81
The Contribution of Angiogenesis to the Process of Metastasis. Cancer J (2015) 0.80
miRNA Alterations Modify Kinase Activation In The IGF-1 Pathway And Correlate With Colorectal Cancer Stage And Progression In Patients. J Cancer (2011) 0.80
Differential regulation of human thymosin beta 15 isoforms by transforming growth factor beta 1. Genes Chromosomes Cancer (2009) 0.79
Dietary plant phenolic improves survival of bacterial infection in Manduca sexta caterpillars. Entomol Exp Appl (2013) 0.79
Thymosin beta-NB is the human isoform of rat thymosin beta15. Ann N Y Acad Sci (2007) 0.79
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A (2003) 0.78
Knockdown of antizyme inhibitor decreases prostate tumor growth in vivo. Amino Acids (2011) 0.78
Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motil Cytoskeleton (2007) 0.77