Published in J Med Chem on January 17, 2002
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front Mol Neurosci (2011) 1.47
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica. J Nat Prod (2006) 1.20
Marine invertebrate natural products for anti-inflammatory and chronic diseases. Evid Based Complement Alternat Med (2013) 1.15
Marine bioactives: pharmacological properties and potential applications against inflammatory diseases. Mar Drugs (2012) 1.00
Mechanism targeted discovery of antitumor marine natural products. Curr Med Chem (2004) 0.95
Kinase inhibitors from marine sponges. Mar Drugs (2011) 0.85
Marine bioactives and potential application in sports. Mar Drugs (2014) 0.82
Prevalence and Mechanisms of Dynamic Chemical Defenses in Tropical Sponges. PLoS One (2015) 0.78
Stimulators of translation identified during a small molecule screening campaign. Anal Biochem (2014) 0.76
Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep (2004) 2.82
Losses disguised as wins in modern multi-line video slot machines. Addiction (2010) 1.56
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci (2010) 1.54
Tedanolide C: a potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp. J Org Chem (2006) 1.35
Marine natural product libraries for high-throughput screening and rapid drug discovery. J Nat Prod (2008) 1.34
The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem Pharmacol (2003) 1.28
3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen. J Biomol Screen (2011) 1.24
Fractionated marine invertebrate extract libraries for drug discovery. Molecules (2008) 1.23
Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges. Mar Drugs (2010) 1.22
Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor. Clin Cancer Res (2011) 1.21
A central strategy for converting natural products into fluorescent probes. Chembiochem (2006) 1.21
Halogenated cyclic peptides isolated from the sponge Corticium sp. J Nat Prod (2007) 1.18
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens. Antimicrob Agents Chemother (2006) 1.14
Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance. J Immunol (2011) 1.09
Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae. Chem Biol (2005) 1.06
Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J Nat Prod (2011) 1.06
Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei. J Org Chem (2002) 1.06
Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei. J Nat Prod (2005) 1.05
Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res (2006) 1.04
Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg Med Chem (2005) 1.04
Increasing readiness to decide and strengthening behavioral intentions: evaluating the impact of a web-based patient decision aid for breast cancer treatment options (BresDex: www.bresdex.com). Patient Educ Couns (2012) 1.04
Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. J Nat Prod (2008) 1.03
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata. J Nat Prod (2002) 1.02
Brominated polyacetylenes from the Philippines sponge Diplastrella sp. J Nat Prod (2003) 1.01
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem (2008) 0.99
Choices in cancer treatment: a qualitative study of the older women's (>70 years) perspective. Psychooncology (2008) 0.99
Theopapuamide, a cyclic depsipeptide from a Papua New Guinea lithistid sponge Theonella swinhoei. J Nat Prod (2006) 0.98
The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J Biol Chem (2004) 0.98
Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina. J Org Chem (2004) 0.98
Liphagal, a Selective inhibitor of PI3 kinase alpha isolated from the sponge akacoralliphaga: structure elucidation and biomimetic synthesis. Org Lett (2006) 0.98
Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria. Antimicrob Agents Chemother (2004) 0.96
Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity. J Med Chem (2004) 0.96
Acremonidins, new polyketide-derived antibiotics produced by Acremonium sp., LL-Cyan 416. J Antibiot (Tokyo) (2003) 0.94
Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid. Planta Med (2009) 0.93
Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp. Z Naturforsch C (2002) 0.92
The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells. Anticancer Drugs (2009) 0.92
Araiosamines A-D: tris-bromoindole cyclic guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. J Org Chem (2011) 0.91
Research achievement award--D. John Faulkner. J Nat Prod (2004) 0.91
Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10. Biochem Pharmacol (2002) 0.91
Heptyl prodigiosin, a bacterial metabolite, is antimalarial in vivo and non-mutagenic in vitro. J Nat Toxins (2002) 0.91
Investigating beta-hydroxyenduracididine formation in the biosynthesis of the mannopeptimycins. Chem Biol (2005) 0.90
Novel alpha-pyrones produced by a marine Pseudomonas sp. F92S91: taxonomy and biological activities. J Antibiot (Tokyo) (2003) 0.90
Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors. Bioorg Med Chem Lett (2011) 0.89
New destruxins from the marine-derived fungus Beauveria felina. J Antibiot (Tokyo) (2006) 0.89
Brocaenols A-C: novel polyketides from a marine derived Penicillium brocae. J Org Chem (2003) 0.89
Production of fungal antibiotics using polymeric solid supports in solid-state and liquid fermentation. J Ind Microbiol Biotechnol (2006) 0.89
Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp. J Org Chem (2009) 0.88
Naamidine A intensifies the phosphotransferase activity of extracellular signal-regulated kinases causing A-431 cells to arrest in G1. Mol Cancer Ther (2003) 0.88
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors. Bioorg Med Chem Lett (2009) 0.88
Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis. Planta Med (2010) 0.88
Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis. J Nat Prod (2008) 0.88
Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate. FEMS Microbiol Lett (2007) 0.88
Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proc Natl Acad Sci U S A (2006) 0.87
Production of novel rapamycin analogs by precursor-directed biosynthesis. Appl Environ Microbiol (2005) 0.87
Thiazoline peptides and a tris-phenethyl urea from Didemnum molle with anti-HIV activity. J Nat Prod (2012) 0.86
A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp. Org Lett (2003) 0.86
Penicillium dravuni, a new marine-derived species from an alga in Fiji. Mycologia (2006) 0.85
The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells. Anticancer Drugs (2005) 0.85
Single-molecule inhibition of human kinesin by adociasulfate-13 and -14 from the sponge Cladocroce aculeata. Proc Natl Acad Sci U S A (2013) 0.85
The total synthesis of neoamphimedine. J Org Chem (2007) 0.85
Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species. Mar Drugs (2009) 0.83
Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. J Nat Prod (2009) 0.83
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies. Bioorg Med Chem Lett (2009) 0.83