Published in Org Lett on October 02, 2003
Antitumor peptides from marine organisms. Mar Drugs (2011) 0.99
Marine Indole Alkaloids. Mar Drugs (2015) 0.82
Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs. Bioorg Med Chem Lett (2010) 0.78
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges. Mar Drugs (2014) 0.77
The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates. Front Pharmacol (2016) 0.76
Potent cytotoxic peptides from the Australian marine sponge Pipestela candelabra. Mar Drugs (2014) 0.76
Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Nat Prod Rep (2004) 2.82
4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents. Bioorg Med Chem (2006) 2.47
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem (2011) 2.24
Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol (2010) 2.05
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nat Chem Biol (2007) 1.83
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. J Med Chem (2005) 1.80
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci (2010) 1.54
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity. Biochemistry (2002) 1.45
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell (2013) 1.44
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol Pharmacol (2006) 1.42
Tedanolide C: a potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp. J Org Chem (2006) 1.35
Marine natural product libraries for high-throughput screening and rapid drug discovery. J Nat Prod (2008) 1.34
New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. J Med Chem (2006) 1.28
The anti-neoplastic and novel topoisomerase II-mediated cytotoxicity of neoamphimedine, a marine pyridoacridine. Biochem Pharmacol (2003) 1.28
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. Cancer Res (2005) 1.28
3D models of epithelial-mesenchymal transition in breast cancer metastasis: high-throughput screening assay development, validation, and pilot screen. J Biomol Screen (2011) 1.24
EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1. Cell Cycle (2008) 1.23
Fractionated marine invertebrate extract libraries for drug discovery. Molecules (2008) 1.23
Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges. Mar Drugs (2010) 1.22
Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously. Mol Pharmacol (2004) 1.22
A central strategy for converting natural products into fluorescent probes. Chembiochem (2006) 1.21
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin. Mol Pharmacol (2003) 1.20
(-)-Doliculide, a new macrocyclic depsipeptide enhancer of actin assembly. J Biol Chem (2002) 1.20
Interactions of halichondrin B and eribulin with tubulin. J Chem Inf Model (2011) 1.19
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod (2002) 1.19
Halogenated cyclic peptides isolated from the sponge Corticium sp. J Nat Prod (2007) 1.18
Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. J Med Chem (2015) 1.14
One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization. J Med Chem (2002) 1.14
New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies. J Med Chem (2009) 1.14
Arylthioindoles, potent inhibitors of tubulin polymerization. J Med Chem (2004) 1.13
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J Med Chem (2005) 1.10
MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol (2011) 1.09
Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance. J Immunol (2011) 1.09
Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones. Eur J Med Chem (2004) 1.07
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chem Biol (2005) 1.07
Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae. Chem Biol (2005) 1.06
Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues. J Med Chem (2010) 1.06
Comparative metabolomics of breast cancer. Pac Symp Biocomput (2007) 1.06
Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa. J Nat Prod (2011) 1.06
Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei. J Org Chem (2002) 1.06
Functional specialization in proline biosynthesis of melanoma. PLoS One (2012) 1.06
Aurantosides G, H, and I: three new tetramic acid glycosides from a Papua New Guinea Theonella swinhoei. J Nat Prod (2005) 1.05
Up-regulation of CYP26A1 in adenomatous polyposis coli-deficient vertebrates via a WNT-dependent mechanism: implications for intestinal cell differentiation and colon tumor development. Cancer Res (2006) 1.04
Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. J Med Chem (2007) 1.04
Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. Bioorg Med Chem (2005) 1.04
Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mol Pharmacol (2007) 1.04
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization. J Med Chem (2007) 1.04
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J Med Chem (2012) 1.03
Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp. J Nat Prod (2008) 1.03
Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry (2005) 1.03
Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity. J Med Chem (2008) 1.02
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. Mol Cancer Ther (2008) 1.02
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. J Med Chem (2010) 1.02
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata. J Nat Prod (2002) 1.02
Brominated polyacetylenes from the Philippines sponge Diplastrella sp. J Nat Prod (2003) 1.01
CB694, a novel antimitotic with antitumor activities. Int J Cancer (2006) 1.00
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem (2008) 0.99
Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. J Med Chem (2010) 0.99
Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. J Med Chem (2002) 0.99
Theopapuamide, a cyclic depsipeptide from a Papua New Guinea lithistid sponge Theonella swinhoei. J Nat Prod (2006) 0.98
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. J Med Chem (2011) 0.98
The tumor suppressor adenomatous polyposis coli and caudal related homeodomain protein regulate expression of retinol dehydrogenase L. J Biol Chem (2004) 0.98
Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina. J Org Chem (2004) 0.98
Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity. J Med Chem (2011) 0.97
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine. J Org Chem (2004) 0.97
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. Eur J Biochem (2003) 0.97
Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity. J Org Chem (2010) 0.96
Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity. J Med Chem (2004) 0.96
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. J Nat Prod (2013) 0.95
Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem (2005) 0.95
Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. Chem Biol (2012) 0.95
Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation. J Biol Chem (2014) 0.95
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem (2002) 0.94
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. J Med Chem (2011) 0.94
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine. J Med Chem (2004) 0.94
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids. J Med Chem (2013) 0.94