Published in Mol Cell Biol on February 01, 2002
The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol (2003) 1.52
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Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain. Mol Cell Biol (2007) 1.29
Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication. Mol Cell Biol (2003) 1.21
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The Drosophila sterile-20 kinase slik controls cell proliferation and apoptosis during imaginal disc development. PLoS Biol (2003) 1.00
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Cytokine-induced activation of mixed lineage kinase 3 requires TRAF2 and TRAF6. Cell Signal (2009) 0.99
Deltex regulates T-cell activation by targeted degradation of active MEKK1. Mol Cell Biol (2005) 0.98
Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1. J Biol Chem (2010) 0.92
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol (2006) 0.91
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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev (2001) 13.15
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A mammalian scaffold complex that selectively mediates MAP kinase activation. Science (1998) 4.78
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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron (1999) 4.51
Defective T cell differentiation in the absence of Jnk1. Science (1998) 4.40
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Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. Genes Dev (1998) 3.33
The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol (1999) 3.18
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (1998) 2.93
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature (1996) 2.79
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TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem (2000) 2.53
Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. J Biol Chem (1998) 2.42
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J (1997) 2.38
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci U S A (2000) 2.12
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science (1998) 2.10
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell (1998) 2.07
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J (1996) 1.92
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A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Curr Biol (1999) 1.51
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Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J Biol Chem (1995) 1.42
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J (1996) 1.39
Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center. J Biol Chem (1994) 1.31
Signaling by the germinal center kinase family of protein kinases. J Biol Chem (1999) 1.30
MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem (1997) 1.28
MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem (2000) 1.25
Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem J (1997) 1.21
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Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase C. J Biol Chem (1997) 1.06
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nat Cell Biol (2004) 2.27
Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function. J Biol Chem (2004) 1.62
Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci U S A (2006) 1.35
Involvement of 14-3-3 signaling protein binding in the functional regulation of the transcriptional activator REPRESSION OF SHOOT GROWTH by gibberellins. Plant Cell (2004) 1.31
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A tobacco calcium-dependent protein kinase, CDPK1, regulates the transcription factor REPRESSION OF SHOOT GROWTH in response to gibberellins. Plant Cell (2008) 1.15
Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J (2003) 1.11
Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. EMBO J (2002) 1.11
Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol (2002) 1.09
Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Mol Cell Biol (2006) 1.04
Reactive oxygen species are involved in gibberellin/abscisic acid signaling in barley aleurone cells. Plant Physiol (2012) 1.02
Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. Mol Cell Biol (2004) 0.99
Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. J Biol Chem (2007) 0.99
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Mol Biol Cell (2010) 0.99
Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation. J Biol Chem (2010) 0.98
A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation. Cell Cycle (2004) 0.97
Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. Am J Physiol Cell Physiol (2003) 0.95
Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling. Mol Cell Biol (2006) 0.93
Biochemical examination of the potential eukaryotic-type protein kinase genes in the complete genome of the unicellular Cyanobacterium synechocystis sp. PCC 6803. DNA Res (2002) 0.92
Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. Am J Physiol Cell Physiol (2011) 0.89
Phosphatidylinositol 3'-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products. J Biol Chem (2003) 0.88
Biochemical and functional characterization of a eukaryotic-type protein kinase, SpkB, in the cyanobacterium, Synechocystis sp. PCC 6803. Curr Microbiol (2003) 0.88
Retracted GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. Proc Natl Acad Sci U S A (2009) 0.87
Regulation of soybean seed germination through ethylene production in response to reactive oxygen species. Ann Bot (2012) 0.86
Hydrogen peroxide scavenging regulates germination ability during wheat (Triticum aestivum L.) seed maturation. Plant Signal Behav (2008) 0.84
Hydrogen peroxide spraying alleviates drought stress in soybean plants. J Plant Physiol (2011) 0.82
Three-beam spectral-domain optical coherence tomography for retinal imaging. J Biomed Opt (2012) 0.81
CDPK1, a calcium-dependent protein kinase, regulates transcriptional activator RSG in response to gibberellins. Plant Signal Behav (2009) 0.78
Activation of SAPK/JNKs in vitro. Methods Mol Biol (2010) 0.78
Retraction for Zhong et al. GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38. Proc Natl Acad Sci U S A (2012) 0.77
Assimilate translocation and expression of sucrose transporter, OsSUT1, contribute to high-performance ripening under heat stress in the heat-tolerant rice cultivar Genkitsukushi. J Plant Physiol (2013) 0.75
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Deficiency of transcriptional regulator p8 induces autophagy and causes impaired cardiac function. Autophagy (2010) 0.75
[Preparation of a manual treatment of pressure ulcers which draws attention to moisture of the affected part]. Gan To Kagaku Ryoho (2003) 0.75
The ethylene signal mediates induction of GmATG8i in soybean plants under starvation stress. Biosci Biotechnol Biochem (2011) 0.75