Published in Clin Sci (Lond) on September 01, 2000
Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension (2011) 1.60
Genetic polymorphisms of adrenergic receptors. Clin Auton Res (2001) 1.45
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest (2007) 1.44
Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta 1-adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium. Br J Pharmacol (2003) 1.13
Pharmacogenetics of beta-blockers. Pharmacotherapy (2007) 1.13
Beta-adrenoceptor polymorphisms. Naunyn Schmiedebergs Arch Pharmacol (2003) 1.09
Beta-adrenoceptor blocker treatment and the cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failure. Naunyn Schmiedebergs Arch Pharmacol (2007) 1.01
Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.97
Markedly reduced effects of (-)-isoprenaline but not of (-)-CGP12177 and unchanged affinity of beta-blockers at Gly389-beta1-adrenoceptors compared to Arg389-beta1-adrenoceptors. Br J Pharmacol (2004) 0.96
Dissecting complex traits: recent advances in hypertension genomics. Genome Med (2009) 0.93
The functional significance of genetic variation within the beta-adrenoceptor. Br J Clin Pharmacol (2005) 0.93
Hypertension pharmacogenomics: in search of personalized treatment approaches. Nat Rev Nephrol (2015) 0.85
Polymorphisms of genes CYP2D6, ADRB1 and GNAS1 in pharmacokinetics and systemic effects of ophthalmic timolol. A pilot study. Eur J Clin Pharmacol (2005) 0.81
Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor. PLoS One (2013) 0.78
Functional effects of β₁-adrenoceptor polymorphisms on the hemodynamic response to dobutamine with and without β-blocker administration. Clin Res Cardiol (2010) 0.78
The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart. Clin Res Cardiol (2011) 0.76
Receptor gene polymorphisms: lessons on functional relevance from the beta 1-adrenoceptor. Br J Pharmacol (2003) 0.75
Pharmacogenetics of cardiovascular drug therapy. Clin Cases Miner Bone Metab (2009) 0.75
Pharmacogenomics of hypertension: a realizable goal? Clin Sci (Lond) (2000) 0.75
A case for pharmacogenomics in management of cardiac arrhythmias. Indian Pacing Electrophysiol J (2012) 0.75
Personalized medicine and treatment approaches in hypertension: current perspectives. Integr Blood Press Control (2016) 0.75
Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004-BHS IV. J Hum Hypertens (2004) 8.32
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol (2000) 5.55
Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science (2000) 3.95
Optimisation of antihypertensive treatment by crossover rotation of four major classes. Lancet (1999) 3.69
Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med (1983) 3.52
Hypokalemia from beta2-receptor stimulation by circulating epinephrine. N Engl J Med (1983) 3.27
Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes. J Immunol (1999) 3.06
Lead poisoning among refugee children resettled in Massachusetts, 1995 to 1999. Pediatrics (2001) 2.58
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest (1999) 2.58
Novel double-isotope technique for enzymatic assay of catecholamines, permitting high precision, sensitivity and plasma sample capacity. Clin Sci (Lond) (1981) 2.52
Childhood lead poisoning in Massachusetts communities: its association with sociodemographic and housing characteristics. Am J Public Health (1995) 2.39
Grommets and glue ear: a five-year follow up of a controlled trial. J R Soc Med (1978) 2.31
A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK. Circulation (1999) 2.29
Circulating catecholamines in exercise and hyperventilation induced asthma. Thorax (1981) 2.22
Influence of age on general practitioners' definition and treatment of hypertension. BMJ (1995) 2.16
Gaucher disease. Clinical, laboratory, radiologic, and genetic features of 53 patients. Medicine (Baltimore) (1992) 1.96
Angiotensin-converting enzyme and the cough reflex. Lancet (1987) 1.94
Cytosine arabinoside in the treatment of acute myeloblastic leukaemia. Lancet (1971) 1.94
A calcium antagonist, nifedipine, modifies exercise-induced asthma. Thorax (1981) 1.90
Intracoronary injections of salbutamol demonstrate the presence of functional beta 2-adrenoceptors in the human heart. Circ Res (1989) 1.82
Reciprocal chromosome painting among human, aardvark, and elephant (superorder Afrotheria) reveals the likely eutherian ancestral karyotype. Proc Natl Acad Sci U S A (2003) 1.79
Benign sickle-cell anaemia. Lancet (1972) 1.79
Modeling Uhthoff's phenomenon in MS patients with internuclear ophthalmoparesis. Neurology (2008) 1.78
Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol (1983) 1.77
Painful diabetic neuropathy. A morphometric study. Arch Neurol (1976) 1.77
A 5-hydroxytryptamine receptor in human atrium. Br J Pharmacol (1990) 1.76
Circulating catecholamines in acute asthma. Br Med J (Clin Res Ed) (1985) 1.73
Similarities and differences between augmentation index and pulse wave velocity in the assessment of arterial stiffness. QJM (1999) 1.71
Multifocal demyelinating neuropathy with persistent conduction block. Neurology (1982) 1.69
2-Chlorodeoxyadenosine treatment of low-grade lymphomas. J Clin Oncol (1992) 1.65
Selective arterial embolization. A new method for control of acute gastrointestinal bleeding. Radiology (1972) 1.62
Model-based drug development: a rational approach to efficiently accelerate drug development. Clin Pharmacol Ther (2013) 1.57
Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium. Circ Res (1990) 1.57
Autoradiographical localization of binding sites for porcine [125I]endothelin-1 in humans, pigs, and rats: functional relevance in humans. J Cardiovasc Pharmacol (1989) 1.57
A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics. J Allergy Clin Immunol (1982) 1.56
The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. Structure (2001) 1.54
A new opportunity for training in clinical pharmacology. Br J Clin Pharmacol (1996) 1.52
Selective suprasensitivity to calcitonin-gene-related peptide in the hands in Raynaud's phenomenon. Lancet (1989) 1.50
Enzyme replacement therapy for Gaucher disease. Blood (1991) 1.48
Clinical value of ACE genotyping in diagnosis of sarcoidosis. Lancet (1997) 1.46
Measurement of plasma histamine in asthma. Clin Allergy (1983) 1.46
Linkage of Gordon's syndrome to the long arm of chromosome 17 in a region recently linked to familial essential hypertension. J Hum Hypertens (1998) 1.45
Role of venous sampling in locating a phaeochromocytoma. Br Med J (Clin Res Ed) (1983) 1.45
Catamenial mononeuropathy and radiculopathy: a treatable neuropathic disorder. J Neurosurg (1998) 1.45
Diabetic neuropathy. Ann Neurol (1984) 1.44
mRNA quantification by real time TaqMan polymerase chain reaction: validation and comparison with RNase protection. Anal Biochem (1999) 1.44
Increased sensitivity and accuracy of phaeochromocytoma diagnosis achieved by use of plasma-adrenaline estimations and a pentolinium-suppression test. Lancet (1981) 1.42
A hybrid modular polyketide synthase obtained by domain swapping. Chem Biol (1996) 1.42
Palatal myoclonus affected by neck position. J Laryngol Otol (1995) 1.41
Mortality in the CHAOS trial. Lancet (1999) 1.41
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science (1995) 1.41
A comparison of parametric and non-parametric approaches to target-controlled infusion of propofol. Anaesth Intensive Care (2010) 1.39
Re: Improving ENT trainees' training opportunity in percutaneous tracheostomy: how we do it. Clin Otolaryngol (2011) 1.39
Endonasal phototherapy for the treatment of allergic rhinitis/hayfever. Clin Otolaryngol (2011) 1.39
Serum hepatitis in a haemophiliac. Br Med J (1969) 1.38
Lessons in the diagnosis and management of Conn's syndrome. Clin Med (2007) 1.38
Males of social insects can prevent queens from multiple mating. Proc Biol Sci (2001) 1.35
Hazards of 'deleading' homes of children with lead poisoning. Am J Dis Child (1987) 1.34
Blunted sympathoadrenal response to exercise in asthmatic subjects. Br J Dis Chest (1982) 1.31
A controlled study of cromolyn sodium sponsored by the Drug Committee of the American Academy of Allergy. J Allergy Clin Immunol (1972) 1.28
A 5-HT4-like receptor in human right atrium. Naunyn Schmiedebergs Arch Pharmacol (1991) 1.27
Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Br J Pharmacol (1986) 1.27
Experimental allergic neuritis induced by sensitization with galactocerebroside. Science (1979) 1.26
Adrenaline and hypertension. Clin Exp Hypertens A (1984) 1.26
In vivo demyelination induced by intraneural injection of anti-galactocerebroside serum: a morphologic study. Am J Pathol (1979) 1.25
Antiserum-mediated demyelination in vivo: a sequential study using intraneural injection of experimental allergic neuritis serum. Lab Invest (1978) 1.25
Monoclonal immunoassays for major dust mite (Dermatophagoides) allergens, Der p I and Der f I, and quantitative analysis of the allergen content of mite and house dust extracts. J Allergy Clin Immunol (1987) 1.25
Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. J Cell Sci (1999) 1.24
Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates. J Exp Med (2000) 1.23
N-acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals. J Appl Physiol (1985) (2004) 1.23
A comparison of the effects of adrenaline and noradrenaline on human heart: the role of beta 1- and beta 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force. Eur Heart J (1989) 1.23
Transfer of demyelination by intraneural injection of experimental allergic neuritis serum. Nature (1978) 1.23
Functioning middle mediastinal paraganglioma (phaeochromocytoma) associated with intercarotid paragangliomas. Lancet (1986) 1.22
Venous plasma histamine in exercise- and hyperventilation-induced asthma in man. Clin Sci (Lond) (1981) 1.21
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity. FEBS Lett (2001) 1.21
Circadian rhythms of epinephrine and norepinephrine in man. J Clin Endocrinol Metab (1985) 1.21
Home abatement and blood lead changes in children with class III lead poisoning. Clin Pediatr (Phila) (1994) 1.20
A specific radioenzymatic assay for dihydroxyphenylalanine (DOPA). Plasma dopa may be the precursor of urine free dopamine. Br J Clin Pharmacol (1981) 1.19
Rapid changes in plasma potassium during a game of squash. Clin Sci (Lond) (1988) 1.18
Exercise-induced release of histamine and neutrophil chemotactic factor in atopic asthmatics. J Allergy Clin Immunol (1982) 1.18
Pulmonary embolism: prospective comparison of spiral CT with ventilation-perfusion scintigraphy. Radiology (1997) 1.17
N-acetylcysteine infusion alters blood redox status but not time to fatigue during intense exercise in humans. J Appl Physiol (1985) (2002) 1.17
A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals. Anal Biochem (1980) 1.16
Distal neuropathy in experimental diabetes mellitus. Ann Neurol (1980) 1.15
Human calcitonin gene related peptide: a potent endogenous vasodilator in man. Clin Sci (Lond) (1986) 1.15
Endothelin-1 mRNA is widely expressed in porcine and human tissues. J Clin Invest (1990) 1.13
Cross-species chromosome painting in the golden mole and elephant-shrew: support for the mammalian clades Afrotheria and Afroinsectiphillia but not Afroinsectivora. Proc Biol Sci (2004) 1.13
Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta 1-adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium. Br J Pharmacol (2003) 1.13
Residential deleading: effects on the blood lead levels of lead-poisoned children. Pediatrics (1991) 1.12
The methylerythritol phosphate pathway and its significance as a novel drug target. Curr Pharm Biotechnol (2003) 1.11
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1. J Exp Med (2000) 1.11
Synthetic studies of nucleic acids on polymer supports. I. Oligodeoxyribonucleotide synthesis on an insoluble polymer support. J Chem Soc Perkin 1 (1967) 1.10
The effects of nifedipine and hydralazine induced hypotension on sympathetic activity. Eur J Clin Pharmacol (1982) 1.10
Hypokalemia from beta 2-receptor stimulation by circulating epinephrine. Am J Cardiol (1985) 1.10
The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJM (2007) 1.09
Noise exposure and hearing loss among student employees working in university entertainment venues. Ann Occup Hyg (2002) 1.08
Equivalent-circuit model for the thickness-shear mode resonator with a viscoelastic film near film resonance. Anal Chem (2000) 1.07