Published in J Biol Chem on January 14, 2002
A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry (2013) 2.93
Arsenic exposure and toxicology: a historical perspective. Toxicol Sci (2011) 2.63
The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ Health Perspect (2002) 2.48
Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr (2006) 2.41
Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proc Natl Acad Sci U S A (2006) 2.37
Pathway of human AS3MT arsenic methylation. Chem Res Toxicol (2014) 2.25
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp Biol Med (Maywood) (2007) 2.18
Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ Health Perspect (2005) 1.97
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Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico. Environ Health (2011) 1.73
Biotransformation of arsenic by a Yellowstone thermoacidophilic eukaryotic alga. Proc Natl Acad Sci U S A (2009) 1.70
Folic acid supplementation lowers blood arsenic. Am J Clin Nutr (2007) 1.70
Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. Environ Health Perspect (2007) 1.69
Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase. Toxicol Sci (2008) 1.66
Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect (2010) 1.53
Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. Toxicol Appl Pharmacol (2005) 1.52
Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). J Anal At Spectrom (2008) 1.49
Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Environ Health Perspect (2005) 1.49
Possible positive selection for an arsenic-protective haplotype in humans. Environ Health Perspect (2012) 1.49
Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an improved gene knockout system. J Bacteriol (2004) 1.43
Arsenic biomethylation by photosynthetic organisms. Trends Plant Sci (2012) 1.41
From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood (2011) 1.41
Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions. Toxicol Appl Pharmacol (2009) 1.38
Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1. Biochem J (2004) 1.30
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shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Chem Res Toxicol (2006) 1.17
Arsenic exposure and the induction of human cancers. J Toxicol (2011) 1.16
Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology (2006) 1.08
Methylarsonous acid transport by aquaglyceroporins. Environ Health Perspect (2006) 1.08
Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione. Toxicol Appl Pharmacol (2012) 1.07
A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. Nat Med (2016) 1.06
Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity. Environ Health Perspect (2010) 1.03
Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water. Environ Health Perspect (2008) 1.03
Folic Acid and Creatine as Therapeutic Approaches to Lower Blood Arsenic: A Randomized Controlled Trial. Environ Health Perspect (2015) 1.02
Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT. PLoS One (2013) 1.01
Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Int J Mol Sci (2011) 1.00
Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues. Metallomics (2011) 0.99
Arsenic transport by zebrafish aquaglyceroporins. BMC Mol Biol (2009) 0.96
Nutritional manipulation of one-carbon metabolism: effects on arsenic methylation and toxicity. J Toxicol (2012) 0.95
A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett (2012) 0.94
Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol (2014) 0.93
Effects of selenium on the structure and function of recombinant human S-adenosyl-L-methionine dependent arsenic (+3 oxidation state) methyltransferase in E. coli. J Biol Inorg Chem (2009) 0.92
The epigenetic effects of a high prenatal folate intake in male mouse fetuses exposed in utero to arsenic. Toxicol Appl Pharmacol (2012) 0.91
Mathematical model insights into arsenic detoxification. Theor Biol Med Model (2011) 0.89
Arsenic (+ 3 oxidation state) methyltransferase and the methylation of arsenicals in the invertebrate chordate Ciona intestinalis. Toxicol Sci (2009) 0.88
Altered arsenic disposition in experimental nonalcoholic fatty liver disease. Drug Metab Dispos (2012) 0.88
Pentavalent methylated arsenicals are substrates of human AQP9. Biometals (2009) 0.87
Interspecies differences in metabolism of arsenic by cultured primary hepatocytes. Toxicol Appl Pharmacol (2010) 0.87
Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood. Chem Res Toxicol (2012) 0.86
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci (2015) 0.84
Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Mol Biol Int (2011) 0.84
Interaction of plasma glutathione redox and folate deficiency on arsenic methylation capacity in Bangladeshi adults. Free Radic Biol Med (2014) 0.83
Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes. J Mol Cell Cardiol (2008) 0.83
Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes. Inorg Chem (2013) 0.82
Influence of cobalamin on arsenic metabolism in Bangladesh. Environ Health Perspect (2009) 0.82
Genomic evidence reveals the extreme diversity and wide distribution of the arsenic-related genes in Burkholderiales. PLoS One (2014) 0.82
Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan. J Biomed Sci (2011) 0.82
Comparative oxidation state specific analysis of arsenic species by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry and hydride generation-cryotrapping-atomic absorption spectrometry. J Anal At Spectrom (2013) 0.81
Expression of AS3MT alters transcriptional profiles in human urothelial cells exposed to arsenite. Hum Exp Toxicol (2009) 0.81
Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+3 oxidation state) methyltransferase-knockout mice. J Environ Sci (China) (2016) 0.80
Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS One (2014) 0.80
Residues in human arsenic (+3 oxidation state) methyltransferase forming potential hydrogen bond network around S-adenosylmethionine. PLoS One (2013) 0.79
Identification of the third binding site of arsenic in human arsenic (III) methyltransferase. PLoS One (2013) 0.78
The organoarsenical biocycle and the primordial antibiotic methylarsenite. Metallomics (2016) 0.78
Renal function is associated with indicators of arsenic methylation capacity in Bangladeshi adults. Environ Res (2015) 0.77
A transgenic Drosophila model for arsenic methylation suggests a metabolic rationale for differential dose-dependent toxicity endpoints. Toxicol Sci (2011) 0.77
Methylated trivalent arsenic-glutathione complexes are more stable than their arsenite analog. Bioinorg Chem Appl (2008) 0.77
Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer. J Can Res Updates (2012) 0.76
High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. Anal Biochem (2015) 0.76
Positive selection of AS3MT to arsenic water in Andean populations. Mutat Res (2015) 0.76
Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity. Cancer Epidemiol Biomarkers Prev (2015) 0.75
Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis. Reprod Toxicol (2016) 0.75
AS3MT-mediated tolerance to arsenic evolved by multiple independent horizontal gene transfers from bacteria to eukaryotes. PLoS One (2017) 0.75
Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). Chem Res Toxicol (2015) 0.75
From schizophrenia risk locus to schizophrenia genes. Nat Med (2016) 0.75
Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase from Aspergillus fumigatus. Mol Microbiol (2017) 0.75
Purification of arsenic (+3 oxidation state) methyltransferase from rat liver cytosol. Curr Protoc Toxicol (2009) 0.75
In vitro assays of inorganic arsenic methylation. Curr Protoc Toxicol (2009) 0.75
Recurrent horizontal transfer of arsenite methyltransferase genes facilitated adaptation of life to arsenic. Sci Rep (2017) 0.75
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res (2006) 6.77
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81
Arsenic exposure and toxicology: a historical perspective. Toxicol Sci (2011) 2.63
The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environ Health Perspect (2002) 2.48
Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr (2007) 2.28
Health effects and risk assessment of arsenic. J Nutr (2003) 2.21
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp Biol Med (Maywood) (2007) 2.18
Elucidating the pathway for arsenic methylation. Toxicol Appl Pharmacol (2004) 2.09
Evaluation of the association between arsenic and diabetes: a National Toxicology Program workshop review. Environ Health Perspect (2012) 2.05
High-throughput identification of catalytic redox-active cysteine residues. Science (2007) 1.92
A superfamily of voltage-gated sodium channels in bacteria. J Biol Chem (2003) 1.84
Molecular mechanisms of the diabetogenic effects of arsenic: inhibition of insulin signaling by arsenite and methylarsonous acid. Environ Health Perspect (2007) 1.77
Metabolism of arsenic in human liver: the role of membrane transporters. Arch Toxicol (2009) 1.74
The burden of obesity on infectious disease. Exp Biol Med (Maywood) (2010) 1.67
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther (2005) 1.66
Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes. Toxicol Appl Pharmacol (2004) 1.63
Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicol Appl Pharmacol (2005) 1.59
Diet-induced obesity impairs the T cell memory response to influenza virus infection. J Immunol (2010) 1.58
Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL. Pediatr Blood Cancer (2013) 1.54
Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase. Toxicol Appl Pharmacol (2005) 1.52
Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. J Biol Chem (2003) 1.52
Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase. Chem Res Toxicol (2004) 1.50
Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). J Anal At Spectrom (2008) 1.49
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. Proc Natl Acad Sci U S A (2009) 1.47
Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicol Appl Pharmacol (2004) 1.44
The impact of obesity on the immune response to infection. Proc Nutr Soc (2012) 1.41
Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chem Res Toxicol (2009) 1.41
Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radic Biol Med (2008) 1.39
Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus. Immunology (2008) 1.38
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol (2014) 1.28
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate. J Virol (2012) 1.28
Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. Chem Res Toxicol (2004) 1.27
Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol (2010) 1.27
Diesel exhaust enhances influenza virus infections in respiratory epithelial cells. Toxicol Sci (2005) 1.27
Differential microRNA expression in childhood B-cell precursor acute lymphoblastic leukemia. Pediatr Hematol Oncol (2009) 1.25
Differential activation of AP-1 in human bladder epithelial cells by inorganic and methylated arsenicals. FASEB J (2002) 1.22
Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicol Appl Pharmacol (2005) 1.20
Transforming growth factor-β1 induced epithelial-mesenchymal transition in hepatic fibrosis. Hepatogastroenterology (2012) 1.20
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus. Obesity (Silver Spring) (2013) 1.17
shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Chem Res Toxicol (2006) 1.17
The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils. PLoS One (2006) 1.15
Oxidation State Specific Generation of Arsines from Methylated Arsenicals Based on L- Cysteine Treatment in Buffered Media for Speciation Analysis by Hydride Generation - Automated Cryotrapping - Gas Chromatography-Atomic Absorption Spectrometry with the Multiatomizer. Spectrochim Acta Part B At Spectrosc (2008) 1.11
Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity. Cancer Res (2005) 1.10
Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice. Toxicol Appl Pharmacol (2010) 1.10
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol (2012) 1.09
Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration. Toxicol Appl Pharmacol (2005) 1.09
PAR-1 contributes to the innate immune response during viral infection. J Clin Invest (2013) 1.09
Methylarsonous acid transport by aquaglyceroporins. Environ Health Perspect (2006) 1.08
Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chem Res Toxicol (2003) 1.08
Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology (2006) 1.08
Preabsorptive metabolism of sodium arsenate by anaerobic microbiota of mouse cecum forms a variety of methylated and thiolated arsenicals. Chem Res Toxicol (2011) 1.08
Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione. Toxicol Appl Pharmacol (2012) 1.07
Ischemic volvulus of the transverse colon: A case report and review of literature. Cases J (2008) 1.06
Plasticity of influenza haemagglutinin fusion peptides and their interaction with lipid bilayers. Biophys J (2004) 1.06
Bacterial communities in the sediments of Dianchi Lake, a partitioned eutrophic waterbody in China. PLoS One (2012) 1.05
Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer. J Med Chem (2011) 1.05
Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr (2010) 1.04
Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation. Chem Res Toxicol (2013) 1.04
Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water. Environ Health Perspect (2008) 1.03
Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J Ethnopharmacol (2011) 1.02
Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate. Toxicol Appl Pharmacol (2003) 1.00
Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Cancer Res (2003) 0.99
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion. Mol Cancer Ther (2007) 0.98
Exploring the in vitro formation of trimethylarsine sulfide from dimethylthioarsinic acid in anaerobic microflora of mouse cecum using HPLC-ICP-MS and HPLC-ESI-MS. Toxicol Appl Pharmacol (2008) 0.98
Fish oil-fed mice have impaired resistance to influenza infection. J Nutr (2009) 0.96
Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environ Mol Mutagen (2003) 0.95
Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. Toxicol Sci (2011) 0.95
Arsenic and Environmental Health: State of the Science and Future Research Opportunities. Environ Health Perspect (2015) 0.94
Diet-induced obese mice exhibit altered heterologous immunity during a secondary 2009 pandemic H1N1 infection. J Immunol (2013) 0.94
An aged host promotes the evolution of avirulent coxsackievirus into a virulent strain. Proc Natl Acad Sci U S A (2006) 0.91
Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Chem Res Toxicol (2014) 0.90
Glutathione-S-transferase pi inhibits As2O3-induced apoptosis in lymphoma cells: involvement of hydrogen peroxide catabolism. Blood (2004) 0.88
Detection of multiple cytokines by protein arrays from cell lysate and tissue lysate. Clin Chem Lab Med (2003) 0.88
Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice. Chin Med J (Engl) (2006) 0.88
Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection. Exp Biol Med (Maywood) (2007) 0.87
Total arsenic concentrations in toenails quantified by two techniques provide a useful biomarker of chronic arsenic exposure in drinking water. Environ Res (2005) 0.87
Vitamin C deficiency increases the lung pathology of influenza virus-infected gulo-/- mice. J Nutr (2006) 0.87
Synthesis and bioactivity of pyrazole acyl thiourea derivatives. Molecules (2012) 0.87
Interspecies differences in metabolism of arsenic by cultured primary hepatocytes. Toxicol Appl Pharmacol (2010) 0.87
Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci (2014) 0.87
Environmental arsenic as a disruptor of insulin signaling. Met Ions Biol Med (2008) 0.86
In vitro biotransformation of an arsenosugar by mouse anaerobic cecal microflora and cecal tissue as examined using IC-ICP-MS and LC-ESI-MS/MS. Analyst (2006) 0.86
Impact of life stage and duration of exposure on arsenic-induced proliferative lesions and neoplasia in C3H mice. Toxicology (2009) 0.86
Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. Cell Res (2013) 0.86
Severe systemic toxicity and urinary bladder cytotoxicity and regenerative hyperplasia induced by arsenite in arsenic (+3 oxidation state) methyltransferase knockout mice. A preliminary report. Toxicol Appl Pharmacol (2010) 0.86
Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration. Toxicol Appl Pharmacol (2007) 0.85
Alterations in physical state of silver nanoparticles exposed to synthetic human stomach fluid. Sci Total Environ (2012) 0.85