Published in Proc Natl Acad Sci U S A on January 15, 2002
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med (2011) 2.07
Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (2011) 1.54
Pooling breast cancer datasets has a synergetic effect on classification performance and improves signature stability. BMC Genomics (2008) 1.45
A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Mol Biosyst (2008) 1.19
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis. Cancer Cell (2009) 1.14
Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2. Biochem J (2003) 1.13
Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. PLoS One (2009) 1.08
Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells. Mol Biol Cell (2006) 1.07
Deficiency of the tensin2 gene in the ICGN mouse: an animal model for congenital nephrotic syndrome. Mamm Genome (2006) 1.04
Structure of the PTB domain of tensin1 and a model for its recruitment to fibrillar adhesions. Protein Sci (2007) 0.96
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. J Cell Biochem (2010) 0.96
Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. Hum Genet (2006) 0.91
Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions. Dev Biol (2006) 0.84
C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Mol Cell Biol (2013) 0.83
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochim Biophys Acta (2011) 0.81
Identification of candidate driver genes in common focal chromosomal aberrations of microsatellite stable colorectal cancer. PLoS One (2013) 0.80
Tensin1 positively regulates RhoA activity through its interaction with DLC1. Biochim Biophys Acta (2015) 0.80
Tensin2-deficient mice on FVB/N background develop severe glomerular disease. J Vet Med Sci (2016) 0.79
Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes. Biochemistry (2012) 0.78
Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. Oncotarget (2016) 0.77
Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer (2016) 0.77
Multiple sclerosis-linked and interferon-beta-regulated gene expression in plasmacytoid dendritic cells. J Neuroimmunol (2012) 0.76
Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J Biol Chem (2012) 0.76
Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia. Genome Med (2016) 0.75
Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration. Biol Open (2016) 0.75
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (1997) 29.34
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet (1997) 15.38
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (1995) 6.45
The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains. FASEB J (2000) 6.26
Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev (1995) 4.89
Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts. Nat Cell Biol (2000) 3.99
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci (1999) 3.93
Negative regulation of fibroblast motility by Ena/VASP proteins. Cell (2000) 3.89
Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev (1995) 3.80
Vinculin knockout results in heart and brain defects during embryonic development. Development (1998) 3.44
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol (2000) 3.13
Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene (1995) 2.22
Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. J Biol Chem (1993) 2.05
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res (1999) 1.82
Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem (2000) 1.61
Overexpression of vinculin suppresses cell motility in BALB/c 3T3 cells. Cell Motil Cytoskeleton (1992) 1.57
Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol (1994) 1.40
GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain. FEBS Lett (1997) 1.32
Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest (1999) 1.31
Molecular dissection of zyxin function reveals its involvement in cell motility. J Cell Biol (1999) 1.27
Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene (1995) 1.23
Progressive kidney degeneration in mice lacking tensin. J Cell Biol (1997) 1.20
Molecular cloning, expression, and mapping of the high affinity actin-capping domain of chicken cardiac tensin. J Cell Biol (1995) 1.17
Molecular characterization of human tensin. Biochem J (2000) 1.04
Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. J Biol Chem (1994) 1.00
Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery (1996) 0.99
Tensin: a potential link between the cytoskeleton and signal transduction. Bioessays (1994) 0.95
Primary structure of the neuronal clathrin-associated protein auxilin and its expression in bacteria. Eur J Biochem (1995) 0.85
A role of tensin in skeletal-muscle regeneration. Biochem J (2001) 0.81
A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol (2007) 2.85
Balloon guide catheter improves revascularization and clinical outcomes with the Solitaire device: analysis of the North American Solitaire Acute Stroke Registry. Stroke (2013) 2.46
The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol (2006) 2.10
Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol (2007) 1.64
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes Cancer (2010) 1.63
Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin. Cancer Res (2009) 1.18
Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer. Cancer Res (2006) 1.16
Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2. Biochem J (2003) 1.13
Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res (2004) 1.10
Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function. Cancer Res (2008) 1.09
The N-terminal half of talin2 is sufficient for mouse development and survival. Biochem Biophys Res Commun (2005) 1.03
Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog (2009) 0.95
Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Dev Biol (2005) 0.95
Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton. Exp Cell Res (2002) 0.95
DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res (2010) 0.95
Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions. J Biol Chem (2007) 0.95
Cleavage of cten by caspase-3 during apoptosis. Oncogene (2005) 0.94
Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. Mol Carcinog (2013) 0.93
Microsnare-assisted mechanical removal of intraprocedural distal middle cerebral arterial thromboembolism. AJNR Am J Neuroradiol (2003) 0.91
North American SOLITAIRE Stent-Retriever Acute Stroke Registry: choice of anesthesia and outcomes. Stroke (2014) 0.90
Cell tracing dyes significantly change single cell mechanics. J Phys Chem B (2009) 0.89
Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene (2013) 0.84
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells. Mol Cancer Res (2011) 0.84
CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. Cancer Res (2013) 0.79
Do all patients with left costal margin injuries require radiographic evaluation for intraabdominal injury? Ann Emerg Med (2005) 0.78
Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes. Biochemistry (2012) 0.78
Sedation of children undergoing MRI--a risky business! S Afr Med J (2004) 0.75
Endovascular management of intracranial aneurysms--current status in South Africa. S Afr Med J (2003) 0.75
Characterization of a first thoracic rib ligament: anatomy and possible clinical relevance. Spine (Phila Pa 1976) (2010) 0.75
Evaluation of Internet Information About Rotator Cuff Repair. Am J Orthop (Belle Mead NJ) (2016) 0.75