Published in Arch Biochem Biophys on January 15, 2002
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci U S A (2003) 2.80
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. Chem Rev (2011) 1.67
Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol (2006) 1.63
Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J (2004) 1.42
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. J Exp Med (2002) 1.41
mPGES-1 as a target for cancer suppression: A comprehensive invited review "Phospholipase A2 and lipid mediators". Biochimie (2010) 1.07
Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proc Natl Acad Sci U S A (2003) 1.07
The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. Br J Pharmacol (2010) 0.96
FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils. Am J Pathol (2011) 0.87
Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophys J (2014) 0.87
Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. J Biol Chem (2009) 0.85
Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics. Proc Natl Acad Sci U S A (2003) 0.84
Melatonin modulates microsomal PGE synthase 1 and NF-E2-related factor-2-regulated antioxidant enzyme expression in LPS-induced murine peritoneal macrophages. Br J Pharmacol (2014) 0.80
Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages. J Phys Chem B (2016) 0.77
Microsomal prostaglandin e synthase-1 in rheumatic diseases. Front Pharmacol (2011) 0.76
Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). Biochemistry (2012) 0.76
PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity. Proc Natl Acad Sci U S A (2003) 2.89
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci (2005) 2.34
A toxic monomeric conformer of the polyglutamine protein. Nat Struct Mol Biol (2007) 2.33
Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci (2008) 1.72
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. Chem Rev (2011) 1.67
A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet. Liver Int (2011) 1.65
Development and evaluation of a practical ELISA for human urinary lipocalin-type prostaglandin D synthase. Clin Chem (2002) 1.65
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity (2011) 1.65
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci (2011) 1.57
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol (2006) 1.54
Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol (2003) 1.52
Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. Hypertension (2013) 1.48
Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol (2002) 1.46
Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity. Proc Natl Acad Sci U S A (2006) 1.43
Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. J Hypertens (2002) 1.43
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. J Exp Med (2002) 1.41
Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. Circ J (2011) 1.40
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci (2011) 1.35
Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins Other Lipid Mediat (2002) 1.32
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J Neurosci (2006) 1.32
Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). J Pharmacol Exp Ther (2008) 1.29
Hematopoietic prostaglandin D synthase. Prostaglandins Leukot Essent Fatty Acids (2003) 1.27
Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice. J Biol Chem (2005) 1.26
Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol (2006) 1.25
Sleep regulation in adenosine A2A receptor-deficient mice. Neurology (2003) 1.22
Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A (2006) 1.22
The role of adenosine in the regulation of sleep. Curr Top Med Chem (2011) 1.22
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A (2006) 1.15
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proc Natl Acad Sci U S A (2008) 1.15
Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. J Neurosci (2007) 1.14
The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development (2009) 1.13
Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J Clin Invest (2009) 1.12
Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem (2006) 1.12
Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci (2010) 1.12
High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.11
Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci U S A (2007) 1.11
Prostaglandin D2 and sleep/wake regulation. Sleep Med Rev (2011) 1.10
Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proc Natl Acad Sci U S A (2008) 1.09
Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment. J Synchrotron Radiat (2010) 1.07
Lipocalin-type prostaglandin d synthase in essential hypertension. Hypertension (2002) 1.07
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol (2013) 1.06
How do the basal ganglia regulate sleep-wake behavior? Trends Neurosci (2012) 1.05
Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion. Eur J Immunol (2003) 1.05
An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J Neurochem (2005) 1.04
Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res (2007) 1.04
Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase. J Biol Chem (2010) 1.04
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci U S A (2013) 1.03
Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. J Biochem (2008) 1.03
Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res (2004) 1.02
Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. J Pathol (2009) 1.01
Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. Antimicrob Agents Chemother (2005) 1.01
Induction and function of lipocalin prostaglandin D synthase in host immunity. J Immunol (2007) 1.01
Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. Neuroscientist (2002) 0.99
Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A (2011) 0.98
The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. PLoS One (2012) 0.96
Role of the basal ganglia in the control of sleep and wakefulness. Curr Opin Neurobiol (2013) 0.96
Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. Biochem Biophys Res Commun (2008) 0.95
A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c. J Biol Chem (2007) 0.95
Lipocalin-type prostaglandin D synthase is a powerful biomarker for severity of stable coronary artery disease. Atherosclerosis (2008) 0.95
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions. PLoS One (2009) 0.95
A novel role of prostaglandin E2 in neuropathic pain: blockade of microglial migration in the spinal cord. Glia (2011) 0.95
Perineuronal oligodendrocytes protect against neuronal apoptosis through the production of lipocalin-type prostaglandin D synthase in a genetic demyelinating model. J Neurosci (2002) 0.94
Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin. Am J Pathol (2009) 0.94
Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells. J Biol Chem (2002) 0.93
De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, beta-trace, in the kidneys. FEBS J (2009) 0.93
Anti-inflammatory therapy by ibudilast, a phosphodiesterase inhibitor, in demyelination of twitcher, a genetic demyelination model. J Neuroinflammation (2005) 0.92
Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. J Neurosci (2003) 0.92
Increased expression of lipocalin-type-prostaglandin D synthase in ulcerative colitis and exacerbating role in murine colitis. Am J Physiol Gastrointest Liver Physiol (2010) 0.92
EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals. Am J Physiol Gastrointest Liver Physiol (2011) 0.91
Localization of various secretory phospholipase A2 enzymes in male reproductive organs. Biochim Biophys Acta (2004) 0.91
Regulation of prostaglandin endoperoxide synthase-2 and IL-6 expression in mouse bone marrow-derived mast cells by exogenous but not endogenous prostanoids. J Immunol (2002) 0.91
Urinary excretions of lipocalin-type prostaglandin D synthase predict renal injury in type-2 diabetes: a cross-sectional and prospective multicentre study. Nephrol Dial Transplant (2008) 0.91
Characterization of the unfolding process of lipocalin-type prostaglandin D synthase. J Biol Chem (2002) 0.90