Published in Proc Natl Acad Sci U S A on March 13, 2006
Control of sleep and wakefulness. Physiol Rev (2012) 3.06
The histamine H3 receptor: an attractive target for the treatment of cognitive disorders. Br J Pharmacol (2008) 1.49
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci (2011) 1.23
Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep (2009) 1.16
Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol (2008) 1.16
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A (2006) 1.15
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proc Natl Acad Sci U S A (2008) 1.15
Sleep neurobiology from a clinical perspective. Sleep (2011) 1.14
Histamine in the regulation of wakefulness. Sleep Med Rev (2010) 1.05
Effect of environmental temperature on sleep, locomotor activity, core body temperature and immune responses of C57BL/6J mice. Brain Behav Immun (2007) 1.05
The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. PLoS One (2012) 0.96
Repeated sleep restriction in adolescent rats altered sleep patterns and impaired spatial learning/memory ability. Sleep (2012) 0.93
Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice. Br J Pharmacol (2012) 0.88
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev (2015) 0.88
Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states. Acta Physiol (Oxf) (2009) 0.87
Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia? Sleep (2009) 0.85
Sites of action of sleep and wake drugs: insights from model organisms. Curr Opin Neurobiol (2013) 0.85
Interactions of the histamine and hypocretin systems in CNS disorders. Nat Rev Neurol (2015) 0.84
Histamine from brain resident MAST cells promotes wakefulness and modulates behavioral states. PLoS One (2013) 0.84
Hypothalamic neuronal histamine mediates the thyrotropin-releasing hormone-induced suppression of food intake. J Neurochem (2007) 0.83
Mammalian sleep genetics. Neurogenetics (2012) 0.80
Histaminergic system in brain disorders: lessons from the translational approach and future perspectives. Ann Gen Psychiatry (2014) 0.79
H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval. Psychopharmacology (Berl) (2008) 0.78
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain. Psychopharmacology (Berl) (2014) 0.78
Histamine-HisCl1 receptor axis regulates wake-promoting signals in Drosophila melanogaster. PLoS One (2013) 0.78
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency. PLoS One (2015) 0.78
Continuous exposure to a novel stressor based on water aversion induces abnormal circadian locomotor rhythms and sleep-wake cycles in mice. PLoS One (2013) 0.77
The wake-promoting transmitter histamine preferentially enhances α-4 subunit-containing GABAA receptors. Neuropharmacology (2011) 0.77
Acid reflux directly causes sleep disturbances in rat with chronic esophagitis. PLoS One (2014) 0.77
Induction of prolonged, continuous slow-wave sleep by blocking cerebral H₁ histamine receptors in rats. Br J Pharmacol (2012) 0.77
Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep. eNeuro (2017) 0.75
Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice. Acta Pharmacol Sin (2015) 0.75
Essential roles of GABA transporter-1 in controlling rapid eye movement sleep and in increased slow wave activity after sleep deprivation. PLoS One (2013) 0.75
Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GABAergic transmission onto the neurons at both pre- and postsynaptic sites. Acta Pharmacol Sin (2016) 0.75
General anesthetic actions on GABAA receptors in vivo are reduced in phospholipase C-related catalytically inactive protein knockout mice. J Anesth (2017) 0.75
Hypothalamic tuberomammillary nucleus neurons: electrophysiological diversity and essential role in arousal stability. J Neurosci (2017) 0.75
Hypothalamic regulation of sleep and circadian rhythms. Nature (2005) 8.23
The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci (2002) 3.52
Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science (1997) 3.40
The role of histamine and the tuberomamillary nucleus in the nervous system. Nat Rev Neurosci (2003) 2.71
Behavioral state instability in orexin knock-out mice. J Neurosci (2004) 2.56
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci (2005) 2.34
Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat. J Neurosci (1998) 2.21
Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A (2001) 2.20
Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep-wake control. J Neurosci (2002) 2.10
Identification of sleep-promoting neurons in vitro. Nature (2000) 1.90
High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature (2000) 1.60
Sleep and sleep regulation in normal and prion protein-deficient mice. J Neurosci (1997) 1.53
Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor. J Sleep Res (2003) 1.44
Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors. Proc Natl Acad Sci U S A (1996) 1.43
Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther (1998) 1.38
Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors. Naunyn Schmiedebergs Arch Pharmacol (1989) 1.37
Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates. Brain Res (1990) 1.29
The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. Trends Pharmacol Sci (2004) 1.27
Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors. J Neural Transm Gen Sect (1993) 1.16
Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat. J Neurosci (1996) 1.16
Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A (2001) 1.14
Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats. Behav Brain Res (2003) 1.11
Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors. Neuroscience (1998) 1.10
Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats. Br J Pharmacol (1996) 1.06
An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J Neurochem (2005) 1.04
A detailed mapping of histamine H1-receptors in guinea-pig central nervous system established by autoradiography with [125I]iodobolpyramine. Neuroscience (1988) 1.03
Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat. Brain Res (1990) 1.02
Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res (2004) 1.02
Genes for prostaglandin d synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of nrem sleep. Arch Ital Biol (2004) 1.01
Histamine H3A receptor-mediated inhibition of noradrenaline release in the mouse brain cortex. Naunyn Schmiedebergs Arch Pharmacol (1992) 0.97
Hypothalamo-preoptic histaminergic projections in sleep-wake control in the cat. Eur J Neurosci (1994) 0.97
Involvement of presynaptic H3 receptors in the inhibitory effect of histamine on serotonin release in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol (1990) 0.92
Wakefulness-inducing effects of histamine in the basal forebrain of freely moving rats. Behav Brain Res (2004) 0.92
Prostaglandin E2 activates the histaminergic system via the EP4 receptor to induce wakefulness in rats. J Neurosci (2003) 0.92
Histaminergic systems and sleep. Studies in man with H1 and H2 antagonists. Neuropharmacology (1985) 0.92
Endogenous histamine in the medial septum-diagonal band complex increases the release of acetylcholine from the hippocampus: a dual-probe microdialysis study in the freely moving rat. Eur J Neurosci (2002) 0.88
Effects of alpha-fluoromethylhistidine on sleep-waking parameters in rats. Physiol Behav (1985) 0.84
Activation of sensory nerves participates in stress-induced histamine release from mast cells in rats. Neurosci Lett (1999) 0.82
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood (2005) 6.16
Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci (2005) 2.34
A toxic monomeric conformer of the polyglutamine protein. Nat Struct Mol Biol (2007) 2.33
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci (2007) 2.05
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest (2010) 1.83
Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A (2005) 1.77
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. J Neurosci (2008) 1.72
Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. Chem Rev (2011) 1.67
A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet. Liver Int (2011) 1.65
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. Immunity (2011) 1.65
Development and evaluation of a practical ELISA for human urinary lipocalin-type prostaglandin D synthase. Clin Chem (2002) 1.65
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci (2011) 1.57
Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol (2006) 1.54
Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol (2003) 1.52
Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. Hypertension (2013) 1.48
Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes. Cancer Res (2002) 1.46
Pronounced eosinophilic lung inflammation and Th2 cytokine release in human lipocalin-type prostaglandin D synthase transgenic mice. J Immunol (2002) 1.46
Endogenous prostaglandin D2 synthesis reduces an increase in plasminogen activator inhibitor-1 following interleukin stimulation in bovine endothelial cells. J Hypertens (2002) 1.43
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. J Exp Med (2002) 1.41
Lipocalin-type prostaglandin D synthase is associated with coronary vasospasm and vasomotor reactivity in response to acetylcholine. Circ J (2011) 1.40
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36
Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci (2011) 1.35
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science (2002) 1.33
Neural circuitry of stress-induced insomnia in rats. J Neurosci (2008) 1.32
Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J Neurosci (2006) 1.32
PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism. Cancer Res (2004) 1.31
Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). J Pharmacol Exp Ther (2008) 1.29
Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein. Lab Invest (2008) 1.28
Hematopoietic prostaglandin D synthase. Prostaglandins Leukot Essent Fatty Acids (2003) 1.27
Accelerated glucose intolerance, nephropathy, and atherosclerosis in prostaglandin D2 synthase knock-out mice. J Biol Chem (2005) 1.26
Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep (2007) 1.26
Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med (2008) 1.25
Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol (2006) 1.25
Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes (2004) 1.25
Generation of a synthetic lymphoid tissue-like organoid in mice. Nat Biotechnol (2004) 1.23
Sleep regulation in adenosine A2A receptor-deficient mice. Neurology (2003) 1.22
The role of adenosine in the regulation of sleep. Curr Top Med Chem (2011) 1.22
The H1 histamine receptor regulates allergic lung responses. J Clin Invest (2006) 1.21
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity. PLoS One (2011) 1.21
Chitinases A, B, and C1 of Serratia marcescens 2170 produced by recombinant Escherichia coli: enzymatic properties and synergism on chitin degradation. Biosci Biotechnol Biochem (2002) 1.19
Low nitrogen fertilization adapts rice root microbiome to low nutrient environment by changing biogeochemical functions. Microbes Environ (2014) 1.17
Immune regulation by histamine. Curr Opin Immunol (2002) 1.16
Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A (2006) 1.15
Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep. Proc Natl Acad Sci U S A (2008) 1.15
Prostaglandin D2 protects neonatal mouse brain from hypoxic ischemic injury. J Neurosci (2007) 1.14
The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development (2009) 1.13
Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J Clin Invest (2009) 1.12
Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem (2006) 1.12
Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice. J Neurosci (2010) 1.12
High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.11
Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid. Proc Natl Acad Sci U S A (2007) 1.11
Prostaglandin D2 and sleep/wake regulation. Sleep Med Rev (2011) 1.10
Abnormal sleep/wake dynamics in orexin knockout mice. Sleep (2010) 1.10
Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proc Natl Acad Sci U S A (2008) 1.09
Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neurosci (2013) 1.09
Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. Arch Biochem Biophys (2002) 1.08
The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model. J Infect Dis (2002) 1.08
Expression and diagnostic evaluation of the human tumor-associated antigen RCAS1 in pancreatic cancer. Pancreas (2003) 1.08
22-Oxacalcitriol prevents progressive glomerulosclerosis without adversely affecting calcium and phosphorus metabolism in subtotally nephrectomized rats. Nephrol Dial Transplant (2002) 1.08
Lipocalin-type prostaglandin d synthase in essential hypertension. Hypertension (2002) 1.07
Improvement in the quality of hematopoietic prostaglandin D synthase crystals in a microgravity environment. J Synchrotron Radiat (2010) 1.07
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nat Immunol (2013) 1.06
Colored floral organs influence pollinator behavior and pollen transfer in Commelina communis (Commelinaceae). Am J Bot (2007) 1.06
Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1. J Biol Chem (2001) 1.06
Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood (2004) 1.06
How do the basal ganglia regulate sleep-wake behavior? Trends Neurosci (2012) 1.05
Implication of allelic polymorphism of osteopontin in the development of lupus nephritis in MRL/lpr mice. Eur J Immunol (2005) 1.05
Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion. Eur J Immunol (2003) 1.05
Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. Nat Commun (2013) 1.05
An adenosine A receptor agonist induces sleep by increasing GABA release in the tuberomammillary nucleus to inhibit histaminergic systems in rats. J Neurochem (2005) 1.04
Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res (2007) 1.04
Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase. J Biol Chem (2010) 1.04
Generation and characterization of severe combined immunodeficiency rats. Cell Rep (2012) 1.04
Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7. J Biochem (2008) 1.03
Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci U S A (2013) 1.03
A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium. Arthritis Rheum (2013) 1.03
Extracellular histamine level in the frontal cortex is positively correlated with the amount of wakefulness in rats. Neurosci Res (2004) 1.02
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res (2011) 1.01
Increased expression and cellular localization of lipocalin-type prostaglandin D synthase in Helicobacter pylori-induced gastritis. J Pathol (2009) 1.01
Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol (2010) 1.01
Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity. J Immunol (2010) 1.01
Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. Antimicrob Agents Chemother (2005) 1.01
Induction and function of lipocalin prostaglandin D synthase in host immunity. J Immunol (2007) 1.01
Prostaglandin D2 in sleep-wake regulation: recent progress and perspectives. Neuroscientist (2002) 0.99