Published in Nat Genet on January 22, 2002
High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol (2005) 3.10
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 2.09
Genetic fate of recombinant adeno-associated virus vector genomes in muscle. J Virol (2003) 2.07
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01
Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J Virol (2005) 1.85
Frequent endonuclease cleavage at off-target locations in vivo. Mol Ther (2010) 1.52
Recombinant adeno-associated virus transduction and integration. Mol Ther (2008) 1.44
Host cell DNA repair pathways in adeno-associated viral genome processing. J Virol (2006) 1.43
Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol (2006) 1.36
Novel adeno-associated virus vector vaccine restricts replication of simian immunodeficiency virus in macaques. J Virol (2005) 1.36
Numt-mediated double-strand break repair mitigates deletions during primate genome evolution. PLoS Genet (2008) 1.25
Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes. J Virol (2005) 1.21
Adeno-associated virus vector integration. Curr Opin Mol Ther (2009) 1.20
Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity. Mol Ther (2012) 1.19
Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog (2010) 1.12
A look to future directions in gene therapy research for monogenic diseases. PLoS Genet (2006) 1.11
Adeno-associated virus: a key to the human genome? Future Virol (2010) 1.03
Complete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria. Gene Ther (2006) 1.02
Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice. J Virol (2003) 0.99
Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver. Mol Ther (2012) 0.98
Packaging of human chromosome 19-specific adeno-associated virus (AAV) integration sites in AAV virions during AAV wild-type and recombinant AAV vector production. J Virol (2003) 0.98
Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors. Proc Natl Acad Sci U S A (2005) 0.97
Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease. Int J Hypertens (2010) 0.95
Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes. J Virol (2010) 0.95
Transfection of cells using flow-through electroporation based on constant voltage. Nat Protoc (2011) 0.92
De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications. Chromosome Res (2015) 0.88
Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy. NeuroRx (2005) 0.87
Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases. Sci Rep (2014) 0.85
Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing. Nucleic Acid Ther (2015) 0.79
Local gene delivery system by bubble liposomes and ultrasound exposure into joint synovium. J Drug Deliv (2011) 0.78
Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson's Disease. Front Aging Neurosci (2016) 0.77
Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide. Nucleic Acids Res (2015) 0.76
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21
Systemic delivery of genes to striated muscles using adeno-associated viral vectors. Nat Med (2004) 5.59
Transplanted bone marrow regenerates liver by cell fusion. Nature (2003) 5.06
Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res (2010) 4.14
Clinical importance of the cytochromes P450. Lancet (2002) 3.77
AAV vector integration sites in mouse hepatocellular carcinoma. Science (2007) 3.73
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci U S A (2004) 2.89
Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat Biotechnol (2002) 2.73
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell (2002) 2.68
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome. Nat Genet (2013) 2.59
Foamy virus vector integration sites in normal human cells. Proc Natl Acad Sci U S A (2006) 2.52
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab (2007) 2.51
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res (2002) 2.45
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell (2012) 2.38
Adeno-associated virus vectors integrate at chromosome breakage sites. Nat Genet (2004) 2.27
A mouse macrophage lipidome. J Biol Chem (2010) 2.14
25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A (2009) 2.14
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J Biol Chem (2003) 2.11
Purification of nucleic acids by extraction with phenol:chloroform. CSH Protoc (2006) 2.04
Gene targeting in vivo by adeno-associated virus vectors. Nat Biotechnol (2006) 2.03
Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions. J Biol Chem (2004) 2.02
Engineering of human pluripotent stem cells by AAV-mediated gene targeting. Mol Ther (2010) 1.99
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem (2003) 1.89
Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J Virol (2005) 1.85
Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev (2003) 1.84
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest (2002) 1.84
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci U S A (2006) 1.77
Gene targeting in stem cells from individuals with osteogenesis imperfecta. Science (2004) 1.75
Improved foamy virus vectors with minimal viral sequences. Mol Ther (2002) 1.71
AAV-mediated gene targeting methods for human cells. Nat Protoc (2011) 1.70
Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility. J Clin Invest (2006) 1.66
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry. Methods Enzymol (2007) 1.63
Human osteoblast-like cells express predominantly steroid 5alpha-reductase type 1. J Clin Endocrinol Metab (2002) 1.62
Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. Nat Med (2007) 1.58
Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology (2013) 1.57
Frequent endonuclease cleavage at off-target locations in vivo. Mol Ther (2010) 1.52
Human gene targeting by adeno-associated virus vectors is enhanced by DNA double-strand breaks. Mol Cell Biol (2003) 1.51
A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. J Lipid Res (2012) 1.48
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J Comp Neurol (2008) 1.47
Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res (2010) 1.46
Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration. J Lipid Res (2003) 1.45
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity (2012) 1.44
Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors. J Virol (2004) 1.44
Gene targeting with viral vectors. Mol Ther (2005) 1.42
Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family. J Biol Chem (2004) 1.38
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol (2008) 1.35
Trisomy correction in Down syndrome induced pluripotent stem cells. Cell Stem Cell (2012) 1.35
Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors. Proc Natl Acad Sci U S A (2002) 1.32
Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta. Mol Ther (2007) 1.31
Induction of hepatocellular carcinoma by in vivo gene targeting. Proc Natl Acad Sci U S A (2012) 1.31
Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes. Hum Mol Genet (2011) 1.23
Expression of the androgen receptor and 5 alpha-reductase type 2 in the developing human fetal penis and urethra. Cell Tissue Res (2001) 1.21
Adeno-associated virus vector integration. Curr Opin Mol Ther (2009) 1.20
HLA engineering of human pluripotent stem cells. Mol Ther (2013) 1.19
Globin phenotype of erythroid cells derived from human induced pluripotent stem cells. Blood (2010) 1.19
Foamy-virus-mediated gene transfer to canine repopulating cells. Blood (2006) 1.18
A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses. Mol Ther (2008) 1.15
CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. J Biol Chem (2009) 1.13
Gene transfer with foamy virus vectors. Methods Enzymol (2002) 1.13
Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors. Mol Ther (2008) 1.12
Calcium-phosphate-mediated Transfection of Eukaryotic Cells with Plasmid DNAs. CSH Protoc (2006) 1.11
Normal collagen and bone production by gene-targeted human osteogenesis imperfecta iPSCs. Mol Ther (2011) 1.07
Transduction of long-term and mobilized peripheral blood-derived NOD/SCID repopulating cells by foamy virus vectors. Hum Gene Ther (2004) 1.06
Transduction of human embryonic stem cells by foamy virus vectors. Mol Ther (2007) 1.02
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan. Proc Natl Acad Sci U S A (2009) 1.02
Cell fusion: an alternative to stem cell plasticity and its therapeutic implications. Curr Opin Genet Dev (2003) 1.00
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc Natl Acad Sci U S A (2008) 1.00
Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice. J Virol (2003) 0.99
Gene targeting by adeno-associated virus vectors is cell-cycle dependent. Hum Gene Ther (2005) 0.98
Isolation of High-molecular-weight DNA from Mammalian Cells Using Proteinase K and Phenol. CSH Protoc (2006) 0.98
Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiol Genomics (2004) 0.98
Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function. Proc Natl Acad Sci U S A (2007) 0.97
Separation of RNA According to Size: Electrophoresis of Glyoxylated RNA through Agarose Gels. CSH Protoc (2006) 0.93
Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol (2010) 0.91
Foamy and lentiviral vectors transduce canine long-term repopulating cells at similar efficiency. Hum Gene Ther (2009) 0.91
Development of human gene reporter cell lines using rAAV mediated homologous recombination. Biol Proced Online (2007) 0.89
Isolation of DNA fragments from polyacrylamide gels by the crush and soak method. CSH Protoc (2006) 0.89
Agarose gel electrophoresis. CSH Protoc (2006) 0.88
Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. J Clin Endocrinol Metab (2003) 0.88
Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency. J Clin Endocrinol Metab (2012) 0.88
Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. J Lipid Res (2013) 0.87
Foamy virus vectors expressing anti-HIV transgenes efficiently block HIV-1 replication. Mol Ther (2007) 0.86
AAV loves an active genome. Nat Genet (2003) 0.86
Differential diagnosis in patients with suspected bile acid synthesis defects. World J Gastroenterol (2012) 0.86
Familial hyperestrogenism in both sexes: clinical, hormonal, and molecular studies of two siblings. J Clin Endocrinol Metab (2003) 0.86
SRD5A3: A surprising role in glycosylation. Cell (2010) 0.86
The inoue method for preparation and transformation of competent e. Coli: "ultra-competent" cells. CSH Protoc (2006) 0.86
The effects of polymorphisms on human gene targeting. Nucleic Acids Res (2013) 0.85
Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency. Mol Ther (2013) 0.85
Preparation and Transformation of Competent E. coli Using Calcium Chloride. CSH Protoc (2006) 0.85
Rapid Amplification of 5' cDNA Ends (5'-RACE). CSH Protoc (2006) 0.84
25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem (2013) 0.84
Nonintegrating foamy virus vectors. J Virol (2010) 0.84
Isolation of BAC DNA from Small-scale Cultures. CSH Protoc (2006) 0.84
SDS-Polyacrylamide Gel Electrophoresis of Proteins. CSH Protoc (2006) 0.84
Tracking of specific integrant clones in dogs treated with foamy virus vectors. Hum Gene Ther (2010) 0.84
Fragmentation of DNA by sonication. CSH Protoc (2006) 0.83
Recovery of DNA from Agarose Gels: Electrophoresis onto DEAE-cellulose Membranes. CSH Protoc (2006) 0.83
Alkaline agarose gel electrophoresis. CSH Protoc (2006) 0.83