Published in Mol Cell on January 01, 2002
Control of intracellular heme levels: heme transporters and heme oxygenases. Biochim Biophys Acta (2011) 1.48
Bradyrhizobium japonicum senses iron through the status of haem to regulate iron homeostasis and metabolism. Mol Microbiol (2006) 1.45
Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol (2007) 1.43
The Iron control element, acting in positive and negative control of iron-regulated Bradyrhizobium japonicum genes, is a target for the Irr protein. J Bacteriol (2006) 1.27
A novel heme-regulatory motif mediates heme-dependent degradation of the circadian factor period 2. Mol Cell Biol (2008) 1.07
Control of bacterial iron homeostasis by manganese. Proc Natl Acad Sci U S A (2010) 1.07
The Rhizobium leguminosarum regulator IrrA affects the transcription of a wide range of genes in response to Fe availability. Mol Genet Genomics (2006) 1.06
Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. PLoS Biol (2005) 1.05
Antiparallel and interlinked control of cellular iron levels by the Irr and RirA regulators of Agrobacterium tumefaciens. J Bacteriol (2011) 1.03
KatG is the primary detoxifier of hydrogen peroxide produced by aerobic metabolism in Bradyrhizobium japonicum. J Bacteriol (2004) 1.02
A model for tetrapyrrole synthesis as the primary mechanism for plastid-to-nucleus signaling during chloroplast biogenesis. Front Plant Sci (2013) 1.02
The Bradyrhizobium japonicum Irr protein is a transcriptional repressor with high-affinity DNA-binding activity. J Bacteriol (2008) 1.02
Positive control of ferric siderophore receptor gene expression by the Irr protein in Bradyrhizobium japonicum. J Bacteriol (2008) 1.01
The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. J Biol Chem (2013) 1.00
Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria. Biometals (2008) 0.99
Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum. J Biol Chem (2010) 0.98
Controlling the delicate balance of tetrapyrrole biosynthesis. Philos Trans R Soc Lond B Biol Sci (2013) 0.98
Transcriptional regulation of the heme binding protein gene family of Bartonella quintana is accomplished by a novel promoter element and iron response regulator. Infect Immun (2007) 0.97
Agrobacterium tumefaciens fur has important physiological roles in iron and manganese homeostasis, the oxidative stress response, and full virulence. Appl Environ Microbiol (2007) 0.97
Discovery of intracellular heme-binding protein HrtR, which controls heme efflux by the conserved HrtB-HrtA transporter in Lactococcus lactis. J Biol Chem (2011) 0.96
A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases. Biochem J (2006) 0.95
Bacterial outer membrane channel for divalent metal ion acquisition. Proc Natl Acad Sci U S A (2011) 0.95
Identification of an iron-regulated, hemin-binding outer membrane protein in Sinorhizobium meliloti. Appl Environ Microbiol (2002) 0.95
Function, regulation, and transcriptional organization of the hemin utilization locus of Bartonella quintana. Infect Immun (2008) 0.93
Transcriptional control of the Bradyrhizobium japonicum irr gene requires repression by fur and Antirepression by Irr. J Biol Chem (2010) 0.93
The Bradyrhizobium japonicum Fur protein is an iron-responsive regulator in vivo. Mol Genet Genomics (2006) 0.89
The iron-responsive regulator irr is required for wild-type expression of the gene encoding the heme transporter BhuA in Brucella abortus 2308. J Bacteriol (2011) 0.87
Role of the Irr protein in the regulation of iron metabolism in Rhodobacter sphaeroides. PLoS One (2012) 0.87
Manganese is required for oxidative metabolism in unstressed Bradyrhizobium japonicum cells. Mol Microbiol (2012) 0.86
Differential control of Bradyrhizobium japonicum iron stimulon genes through variable affinity of the iron response regulator (Irr) for target gene promoters and selective loss of activator function. Mol Microbiol (2014) 0.85
A bacterial iron exporter for maintenance of iron homeostasis. J Biol Chem (2014) 0.85
Tetrapyrrole biosynthesis in Rhodobacter capsulatus is transcriptionally regulated by the heme-binding regulatory protein, HbrL. J Bacteriol (2006) 0.83
Iron-dependent cytochrome c1 expression is mediated by the status of heme in Bradyrhizobium japonicum. J Bacteriol (2005) 0.81
Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death. PLoS One (2014) 0.80
Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response. Redox Biol (2015) 0.80
Synthetic Lethality of the bfr and mbfA Genes Reveals a Functional Relationship between Iron Storage and Iron Export in Managing Stress Responses in Bradyrhizobium japonicum. PLoS One (2016) 0.79
The LysR-type transcription factor HbrL is a global regulator of iron homeostasis and porphyrin synthesis in Rhodobacter capsulatus. Mol Microbiol (2013) 0.78
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product. Microbiol Mol Biol Rev (2017) 0.77
Magnesium-dependent processes are targets of bacterial manganese toxicity. Mol Microbiol (2014) 0.77
Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator. Sci Rep (2016) 0.76
A Mur regulator protein in the extremophilic bacterium Deinococcus radiodurans. PLoS One (2014) 0.75
Metal homeostasis and resistance in bacteria. Nat Rev Microbiol (2017) 0.75
Metabolic modeling of common Escherichia coli strains in human gut microbiome. Biomed Res Int (2014) 0.75
Metal-specific control of gene expression mediated by Bradyrhizobium japonicum Mur and Escherichia coli Fur is determined by the cellular context. Mol Microbiol (2016) 0.75
Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia. Front Cell Infect Microbiol (2017) 0.75
A whole genome view of prokaryotic haem biosynthesis. Microbiology (2002) 1.92
Bradyrhizobium japonicum senses iron through the status of haem to regulate iron homeostasis and metabolism. Mol Microbiol (2006) 1.45
Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein. J Biol Chem (2004) 1.29
Oxidative stress promotes degradation of the Irr protein to regulate haem biosynthesis in Bradyrhizobium japonicum. Mol Microbiol (2006) 1.29
The hmuQ and hmuD genes from Bradyrhizobium japonicum encode heme-degrading enzymes. J Bacteriol (2006) 1.21
A novel DNA-binding site for the ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum. J Biol Chem (2003) 1.19
Fur is involved in manganese-dependent regulation of mntA (sitA) expression in Sinorhizobium meliloti. Appl Environ Microbiol (2004) 1.12
Identification of a soybean protein that interacts with GAGA element dinucleotide repeat DNA. Plant Physiol (2002) 1.12
The mntH gene encodes the major Mn(2+) transporter in Bradyrhizobium japonicum and is regulated by manganese via the Fur protein. Mol Microbiol (2009) 1.10
The ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum is an iron-responsive transcriptional repressor in vitro. J Biol Chem (2004) 1.07
Control of bacterial iron homeostasis by manganese. Proc Natl Acad Sci U S A (2010) 1.07
KatG is the primary detoxifier of hydrogen peroxide produced by aerobic metabolism in Bradyrhizobium japonicum. J Bacteriol (2004) 1.02
The Bradyrhizobium japonicum Irr protein is a transcriptional repressor with high-affinity DNA-binding activity. J Bacteriol (2008) 1.02
Positive control of ferric siderophore receptor gene expression by the Irr protein in Bradyrhizobium japonicum. J Bacteriol (2008) 1.01
Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria. Biometals (2008) 0.99
Bacterial outer membrane channel for divalent metal ion acquisition. Proc Natl Acad Sci U S A (2011) 0.95
Transcriptional control of the Bradyrhizobium japonicum irr gene requires repression by fur and Antirepression by Irr. J Biol Chem (2010) 0.93
Control of DegP-dependent degradation of c-type cytochromes by heme and the cytochrome c maturation system in Escherichia coli. J Bacteriol (2007) 0.87
Manganese is required for oxidative metabolism in unstressed Bradyrhizobium japonicum cells. Mol Microbiol (2012) 0.86
Unusual heme binding in the bacterial iron response regulator protein: spectral characterization of heme binding to the heme regulatory motif. Biochemistry (2011) 0.85
Differential control of Bradyrhizobium japonicum iron stimulon genes through variable affinity of the iron response regulator (Irr) for target gene promoters and selective loss of activator function. Mol Microbiol (2014) 0.85
The Bradyrhizobium japonicum frcB gene encodes a diheme ferric reductase. J Bacteriol (2011) 0.85
HmuP is a coactivator of Irr-dependent expression of heme utilization genes in Bradyrhizobium japonicum. J Bacteriol (2012) 0.83
A new small regulatory protein, HmuP, modulates haemin acquisition in Sinorhizobium meliloti. Microbiology (2010) 0.83
Iron-dependent cytochrome c1 expression is mediated by the status of heme in Bradyrhizobium japonicum. J Bacteriol (2005) 0.81
Legume biology: sequence to seeds. Plant Physiol (2007) 0.80
ShmR is essential for utilization of heme as a nutritional iron source in Sinorhizobium meliloti. Appl Environ Microbiol (2008) 0.79
Magnesium-dependent processes are targets of bacterial manganese toxicity. Mol Microbiol (2014) 0.77
Legume focus: model species sequenced, mutagenesis approaches extended, and debut of a new model. Plant Physiol (2009) 0.75