Published in Biochim Biophys Acta on January 14, 2011
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans. Biochim Biophys Acta (2012) 1.46
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest (2012) 1.36
HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. PLoS Pathog (2012) 1.13
Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Gastroenterology (2014) 1.01
The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages. J Biol Chem (2014) 1.01
Heme levels are increased in human failing hearts. J Am Coll Cardiol (2013) 0.98
Iron metabolism in the pathogenesis of iron-induced kidney injury. Nat Rev Nephrol (2013) 0.98
Iron absorption in Drosophila melanogaster. Nutrients (2013) 0.95
Erythroid heme biosynthesis and its disorders. Cold Spring Harb Perspect Med (2013) 0.95
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases. Front Pharmacol (2012) 0.94
Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis. PLoS One (2012) 0.92
The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica (2015) 0.92
Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation. Haematologica (2015) 0.92
ATP-binding cassette B10 regulates early steps of heme synthesis. Circ Res (2013) 0.87
Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway. Oxid Med Cell Longev (2013) 0.87
Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. PLoS One (2013) 0.86
Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med (2013) 0.86
Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods. Cell Mol Life Sci (2012) 0.84
Hemin uptake and release by neurons and glia. Free Radic Res (2013) 0.84
Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Invest Ophthalmol Vis Sci (2011) 0.83
The crimson conundrum: heme toxicity and tolerance in GAS. Front Cell Infect Microbiol (2014) 0.83
Mitochondrial heme: an exit strategy at last. J Clin Invest (2012) 0.83
Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement. Int J Mol Sci (2015) 0.82
Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury. J Am Heart Assoc (2015) 0.81
Heme exporter FLVCR is required for T cell development and peripheral survival. J Immunol (2015) 0.81
ATP Binding Cassette Transporter Mediates Both Heme and Pesticide Detoxification in Tick Midgut Cells. PLoS One (2015) 0.80
Disrupting the bimolecular binding of the haem-binding protein 5 (AtHBP5) to haem oxygenase 1 (HY1) leads to oxidative stress in Arabidopsis. J Exp Bot (2012) 0.80
Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding. Nucleic Acids Res (2014) 0.79
Acquisition of exogenous haem is essential for tick reproduction. Elife (2016) 0.79
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. Oncotarget (2016) 0.78
Quantification of labile heme in live malaria parasites using a genetically encoded biosensor. Proc Natl Acad Sci U S A (2017) 0.78
Carbon monoxide induced erythroid differentiation of K562 cells mimics the central macrophage milieu in erythroblastic islands. PLoS One (2012) 0.77
Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. J Biol Chem (2014) 0.77
The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders. Pharmaceuticals (Basel) (2013) 0.76
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom. PLoS One (2014) 0.75
A heme-binding domain controls regulation of ATP-dependent potassium channels. Proc Natl Acad Sci U S A (2016) 0.75
Nondestructive Methods for Monitoring Cell Removal During Rat Liver Decellularization. Tissue Eng Part C Methods (2016) 0.75
Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells. Acta Pharmacol Sin (2015) 0.75
Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics (2015) 0.75
The ins and outs of erythroid heme transport. Haematologica (2015) 0.75
TLR Stimulation Dynamically Regulates Heme and Iron Export Gene Expression in Macrophages. J Immunol Res (2016) 0.75
Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption. PLoS One (2017) 0.75
TAT-mediated transduction of bacterial redox proteins generates a cytoprotective effect on neuronal cells. PLoS One (2017) 0.75
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (2004) 19.19
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med (2001) 11.94
Bilirubin is an antioxidant of possible physiological importance. Science (1987) 11.26
Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol (1990) 11.00
Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science (1997) 8.16
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Disorders of iron metabolism. N Engl J Med (1999) 7.49
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46
Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science (2001) 6.81
The 20 years of PROSITE. Nucleic Acids Res (2007) 6.06
The human ATP-binding cassette (ABC) transporter superfamily. Genome Res (2001) 5.47
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab (2005) 5.32
Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol (2002) 4.94
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell (2006) 4.84
Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A (1997) 4.74
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest (1999) 4.66
Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A (1997) 4.63
ABC transporters: the power to change. Nat Rev Mol Cell Biol (2009) 4.48
Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference. Br J Haematol (2008) 4.41
Biliverdin reductase: a major physiologic cytoprotectant. Proc Natl Acad Sci U S A (2002) 4.38
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J (1999) 4.05
Regulators of iron balance in humans. Blood (1994) 3.67
Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science (2004) 3.28
Chloroplast to nucleus communication triggered by accumulation of Mg-protoporphyrinIX. Nature (2003) 3.27
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A (2009) 3.13
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem (2004) 3.10
Identification of an intestinal heme transporter. Cell (2005) 3.05
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells. Blood (1997) 2.93
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci U S A (1999) 2.84
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A (2002) 2.79
The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci U S A (1974) 2.77
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci U S A (2002) 2.74
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci U S A (2005) 2.67
Identification of a human heme exporter that is essential for erythropoiesis. Cell (2004) 2.66
Cyclic changes in metabolic state during the life of a yeast cell. Proc Natl Acad Sci U S A (2007) 2.65
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. Free Radic Biol Med (2000) 2.61
Cell biology of heme. Am J Med Sci (1999) 2.51
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet (2009) 2.37
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 2.36
Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells. J Cell Biol (1994) 2.33
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Identification of a mammalian mitochondrial porphyrin transporter. Nature (2006) 2.28
Heme is involved in microRNA processing. Nat Struct Mol Biol (2006) 2.27
Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem Sci (1995) 2.25
Biosynthesis of heme in mammals. Biochim Biophys Acta (2006) 2.25
Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits. Blood (2006) 2.22
The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett (1997) 2.21
The eIF-2alpha kinases and the control of protein synthesis. FASEB J (1996) 2.19
Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem (1997) 2.16
Reactive oxygen species modulate Anopheles gambiae immunity against bacteria and Plasmodium. J Biol Chem (2007) 2.09
Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem (2007) 2.08
Role of ABCG2/BCRP in biology and medicine. Annu Rev Pharmacol Toxicol (2006) 2.06
Heme binds to a short sequence that serves a regulatory function in diverse proteins. EMBO J (1995) 1.98
Identification of the receptor scavenging hemopexin-heme complexes. Blood (2005) 1.97
Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci U S A (2009) 1.96
Differentiation and erythropoietin receptor gene expression in human erythroid progenitor cells. Blood (1992) 1.96
Lack of heme synthesis in a free-living eukaryote. Proc Natl Acad Sci U S A (2005) 1.95
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol (1999) 1.93
The meso-reactivity of porphyrins and related compounds. VI. Oxidative cleavage of the haem system. The four isomeric biliverdins of the IX series. J Chem Soc Perkin 1 (1973) 1.92
Function of transferrin. Nature (1968) 1.87
Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Annu Rev Cell Biol (1989) 1.83
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood (1968) 1.81
Regulation by heme of mitochondrial protein transport through a conserved amino acid motif. Science (1993) 1.79
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases. Cell Res (2006) 1.79
The association rate constant for heme binding to globin is independent of protein structure. Biochemistry (1996) 1.77
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis. EMBO J (2004) 1.75
The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation. Antioxid Redox Signal (2006) 1.75
ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J (2000) 1.72
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry (2010) 1.72
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. Am J Hum Genet (2010) 1.72
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Iron regulation and erythropoiesis. Curr Opin Hematol (2008) 1.70
PDZ domains: folding and binding. Biochemistry (2007) 1.68
Iron uptake and metabolism in the new millennium. Trends Cell Biol (2006) 1.66
Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci U S A (1999) 1.64
Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood (2000) 1.64
The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc Natl Acad Sci U S A (2005) 1.64
Modern diagnosis and management of the porphyrias. Br J Haematol (2006) 1.63
Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron (1995) 1.63
Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Am J Physiol Gastrointest Liver Physiol (2005) 1.63
Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie (1998) 1.62
Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking. Curr Opin Cell Biol (2007) 1.61
A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells. J Biol Chem (2001) 1.59
Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J (2004) 1.54
Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood (2000) 1.54
Interaction between the bacterial iron response regulator and ferrochelatase mediates genetic control of heme biosynthesis. Mol Cell (2002) 1.53
The biochemistry of heme biosynthesis. Arch Biochem Biophys (2008) 1.53
Heme scavenging and the other facets of hemopexin. Antioxid Redox Signal (2010) 1.52
Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin. Eur J Biochem (1974) 1.52
Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution. Blood (2010) 1.51
Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC Struct Biol (2003) 1.50
The role of transporters in cellular heme and porphyrin homeostasis. Pharmacol Ther (2007) 1.50
Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48
A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily. J Virol (1999) 1.48
Studies of bilirubin kinetics in normal adults. J Clin Invest (1969) 1.47
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica (2010) 1.47
A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (2008) 2.36
Improved transduction of human sheep repopulating cells by retrovirus vectors pseudotyped with feline leukemia virus type C or RD114 envelopes. Blood (2005) 0.91
Heme and FLVCR-related transporter families SLC48 and SLC49. Mol Aspects Med (2013) 0.86