1
|
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland.
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Development
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2002
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2.42
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2
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Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression.
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Oncogene
|
2005
|
2.37
|
3
|
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
|
Hepatology
|
2011
|
2.33
|
4
|
Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells.
|
Dev Biol
|
2006
|
1.90
|
5
|
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice.
|
Proc Natl Acad Sci U S A
|
2007
|
1.82
|
6
|
Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.
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Development
|
2003
|
1.79
|
7
|
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.
|
Nat Chem Biol
|
2012
|
1.77
|
8
|
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
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Proc Natl Acad Sci U S A
|
2004
|
1.67
|
9
|
Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice.
|
Oncogene
|
2004
|
1.65
|
10
|
Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment.
|
Cancer Res
|
2008
|
1.64
|
11
|
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
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Proc Natl Acad Sci U S A
|
2010
|
1.50
|
12
|
Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility.
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J Biol Chem
|
2002
|
1.48
|
13
|
Erythropoietin protects against diabetes through direct effects on pancreatic beta cells.
|
J Exp Med
|
2010
|
1.44
|
14
|
Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.
|
Oncogene
|
2003
|
1.37
|
15
|
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice.
|
Genesis
|
2004
|
1.34
|
16
|
Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death.
|
J Biol Chem
|
2002
|
1.27
|
17
|
Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium.
|
Mol Endocrinol
|
2002
|
1.22
|
18
|
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
|
Nat Immunol
|
2013
|
1.21
|
19
|
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.
|
J Clin Invest
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2011
|
1.17
|
20
|
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
|
Mol Endocrinol
|
2007
|
1.15
|
21
|
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
|
J Clin Invest
|
2011
|
1.10
|
22
|
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
|
Mol Endocrinol
|
2007
|
1.09
|
23
|
Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model.
|
Blood
|
2012
|
1.07
|
24
|
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.
|
Proc Natl Acad Sci U S A
|
2010
|
1.07
|
25
|
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy.
|
J Hematol Oncol
|
2012
|
1.06
|
26
|
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.
|
Mol Cell Biol
|
2010
|
1.05
|
27
|
Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities.
|
Am J Pathol
|
2013
|
1.04
|
28
|
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans.
|
PLoS One
|
2013
|
1.03
|
29
|
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland.
|
Development
|
2003
|
1.02
|
30
|
Jak2 is necessary for neuroendocrine control of female reproduction.
|
J Neurosci
|
2011
|
0.99
|
31
|
Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
|
Cancer Res
|
2004
|
0.98
|
32
|
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.
|
Cell Signal
|
2012
|
0.98
|
33
|
Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.
|
Cell Cycle
|
2004
|
0.98
|
34
|
Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.
|
Oncogene
|
2005
|
0.96
|
35
|
Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development.
|
Endocrinology
|
2006
|
0.95
|
36
|
Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.
|
Genesis
|
2009
|
0.95
|
37
|
IRF4 is a suppressor of c-Myc induced B cell leukemia.
|
PLoS One
|
2011
|
0.95
|
38
|
Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy.
|
Cancer Res
|
2009
|
0.95
|
39
|
Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance.
|
J Biol Chem
|
2012
|
0.94
|
40
|
Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies.
|
Cancer Res
|
2014
|
0.93
|
41
|
Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
|
Genesis
|
2005
|
0.93
|
42
|
Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.
|
Cancer Res
|
2011
|
0.92
|
43
|
Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.
|
J Biol Chem
|
2004
|
0.92
|
44
|
Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias.
|
Oncotarget
|
2011
|
0.92
|
45
|
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.
|
Cancer Res
|
2013
|
0.92
|
46
|
Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells.
|
Stem Cells
|
2014
|
0.90
|
47
|
Temporally and spatially controlled expression of transgenes in embryonic and adult tissues.
|
Transgenic Res
|
2009
|
0.89
|
48
|
D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells.
|
Mol Cell Endocrinol
|
2013
|
0.89
|
49
|
Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia.
|
Haematologica
|
2014
|
0.87
|
50
|
Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species.
|
Cardiovasc Res
|
2011
|
0.87
|
51
|
A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.
|
PLoS One
|
2012
|
0.86
|
52
|
Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH.
|
Mol Endocrinol
|
2013
|
0.85
|
53
|
G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.
|
J Biol Chem
|
2013
|
0.85
|
54
|
Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary.
|
Biol Reprod
|
2002
|
0.85
|
55
|
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.
|
Mol Cell Biol
|
2014
|
0.84
|
56
|
A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis.
|
Neoplasia
|
2008
|
0.84
|
57
|
Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice.
|
J Mol Cell Cardiol
|
2011
|
0.82
|
58
|
ESCRT proteins: Double-edged regulators of cellular signaling.
|
Bioarchitecture
|
2011
|
0.80
|
59
|
Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax.
|
Genesis
|
2011
|
0.80
|
60
|
Generation of conditional knockout mice.
|
Methods Mol Biol
|
2014
|
0.79
|
61
|
Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH.
|
Mol Endocrinol
|
2011
|
0.79
|
62
|
Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland.
|
PLoS One
|
2012
|
0.78
|
63
|
Mouse models of breast cancer.
|
Methods Mol Biol
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2015
|
0.75
|