Published in Oncogene on January 20, 2005
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76
Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo. Proc Natl Acad Sci U S A (2007) 1.97
Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells--implications for pregnancy-induced protection against breast cancer. Stem Cells (2008) 1.96
The protective role of pregnancy in breast cancer. Breast Cancer Res (2005) 1.95
Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev (2009) 1.95
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92
Complexities of TGF-β targeted cancer therapy. Int J Biol Sci (2012) 1.84
The mammary microenvironment alters the differentiation repertoire of neural stem cells. Proc Natl Acad Sci U S A (2008) 1.77
Murine mammary epithelial stem cells: discovery, function, and current status. Cold Spring Harb Perspect Biol (2011) 1.63
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell (2007) 1.53
Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands. Breast Cancer Res (2006) 1.46
Reprogramming human cancer cells in the mouse mammary gland. Cancer Res (2010) 1.32
Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res (2009) 1.29
Re-evaluation of mammary stem cell biology based on in vivo transplantation. Breast Cancer Res (2008) 1.28
The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells. Oncogene (2010) 1.22
Targeting TGF-β signaling in cancer. Expert Opin Ther Targets (2013) 1.16
Of microenvironments and mammary stem cells. Stem Cell Rev (2007) 1.14
The origin of breast tumor heterogeneity. Oncogene (2015) 1.09
Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel) (2010) 1.06
STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinol (2013) 1.04
Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene (2010) 1.03
The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium. Carcinogenesis (2007) 0.98
Functional characterization of stem cell activity in the mouse mammary gland. Stem Cell Rev (2011) 0.98
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res (2007) 0.98
New insights into lineage restriction of mammary gland epithelium using parity-identified mammary epithelial cells. Breast Cancer Res (2014) 0.96
Wnt5a as an effector of TGFβ in mammary development and cancer. J Mammary Gland Biol Neoplasia (2011) 0.96
Two faces of TGF-beta1 in breast cancer. Mediators Inflamm (2014) 0.92
Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. Breast Cancer Res (2010) 0.92
The mouse mammary microenvironment redirects mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate. Stem Cells Dev (2011) 0.91
p63 is a prosurvival factor in the adult mammary gland during post-lactational involution, affecting PI-MECs and ErbB2 tumorigenesis. Cell Death Differ (2014) 0.91
Reprogramming non-mammary and cancer cells in the developing mouse mammary gland. Semin Cell Dev Biol (2012) 0.90
Cyclins and cell cycle control in cancer and disease. Genes Cancer (2012) 0.90
Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epithelium. Breast Cancer Res (2013) 0.90
Breast cancer, stem cells and prospects for therapy. Breast Cancer Res (2006) 0.90
Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating. Breast Cancer Res (2006) 0.89
Reprogramming cell fates in the mammary microenvironment. Cell Cycle (2009) 0.89
Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor. Oncogene (2011) 0.89
Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia (2015) 0.88
Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R. Oncogenesis (2013) 0.87
VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol (2010) 0.87
Embryonic stem cells are redirected to non-tumorigenic epithelial cell fate by interaction with the mammary microenvironment. PLoS One (2013) 0.87
RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Dis Model Mech (2014) 0.87
The unmasking of novel unipotent stem cells in the mammary gland. EMBO J (2011) 0.86
Stem cells and the mammary microenvironment. Breast Dis (2008) 0.84
The mammary cellular hierarchy and breast cancer. Cell Mol Life Sci (2014) 0.84
Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res (2013) 0.83
Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors. PLoS One (2012) 0.81
The mammary stem cell hierarchy: a looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer (2015) 0.81
Pregnancy protection of breast cancer: new insights reveal unanswered questions. Breast Cancer Res (2013) 0.81
The complexities of TGF-β action during mammary and squamous cell carcinogenesis. Curr Pharm Biotechnol (2011) 0.81
Faith, heresy and the cancer stem cell hypothesis. Future Oncol (2008) 0.79
Regulation of mammary epithelial cell homeostasis by lncRNAs. Int J Biochem Cell Biol (2014) 0.79
ERrrr…Where are the Progenitors? Hormone Receptors and Mammary Cell Heterogeneity. J Mammary Gland Biol Neoplasia (2015) 0.79
Molecular pathways involved in pregnancy-induced prevention against breast cancer. Front Endocrinol (Lausanne) (2014) 0.78
The dynamics of murine mammary stem/progenitor cells. Front Biol (Beijing) (2014) 0.78
Redirection of Human Cancer Cells upon the Interaction with the Regenerating Mouse Mammary Gland Microenvironment. Cells (2013) 0.78
Co-expression of LASS2 and TGF-β1 predicts poor prognosis in hepatocellular carcinoma. Sci Rep (2016) 0.78
Mutant p53 Amplifies Epidermal Growth Factor Receptor Family Signaling to Promote Mammary Tumorigenesis. Mol Cancer Res (2015) 0.77
A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors. Stem Cell Reports (2015) 0.77
Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium. PLoS One (2014) 0.76
The more things change... the more things change: developmental plasticity of tumor-initiating mammary epithelial cells. Breast Cancer Res (2010) 0.76
Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo. Sci Rep (2017) 0.75
Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for "reprogramming" neural stem cells. Aging (Albany NY) (2016) 0.75
Microvesicle-mediated Wnt/β-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. J Biol Chem (2016) 0.75
Hormone Signaling Requirements for the Conversion of Non-Mammary Mouse Cells to Mammary Cell Fate(s) in Vivo. J Mammary Gland Biol Neoplasia (2015) 0.75
Stem cells, hormones, and mammary cancer. Adv Exp Med Biol (2008) 0.75
Potential Mechanisms underlying the Protective Effect of Pregnancy against Breast Cancer: A Focus on the IGF Pathway. Front Oncol (2016) 0.75
Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2. PLoS One (2015) 0.75
Who do they think they are? Wnt-responsive cells reveal their family trees. Breast Cancer Res (2012) 0.75
Mammary stem cells: expansion and animal productivity. J Anim Sci Biotechnol (2014) 0.75
An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal. Development (2002) 3.16
Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development (2002) 2.42
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33
Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo. Proc Natl Acad Sci U S A (2007) 1.97
Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Dev Biol (2006) 1.90
Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proc Natl Acad Sci U S A (2007) 1.82
Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development (2003) 1.79
BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol (2012) 1.77
The mammary microenvironment alters the differentiation repertoire of neural stem cells. Proc Natl Acad Sci U S A (2008) 1.77
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci U S A (2004) 1.67
Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice. Oncogene (2004) 1.65
Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment. Cancer Res (2008) 1.64
Murine mammary epithelial stem cells: discovery, function, and current status. Cold Spring Harb Perspect Biol (2011) 1.63
Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation. J Cell Physiol (2007) 1.55
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling. Proc Natl Acad Sci U S A (2010) 1.50
Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem (2002) 1.48
Estrogen receptor-alpha and progesterone receptor are expressed in label-retaining mammary epithelial cells that divide asymmetrically and retain their template DNA strands. Breast Cancer Res (2006) 1.46
Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med (2010) 1.44
Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation. Oncogene (2003) 1.37
Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis (2004) 1.34
Reprogramming human cancer cells in the mouse mammary gland. Cancer Res (2010) 1.32
Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death. J Biol Chem (2002) 1.27
Pregnancy and stem cell behavior. J Mammary Gland Biol Neoplasia (2005) 1.24
Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium. Mol Endocrinol (2002) 1.22
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol (2013) 1.21
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. J Clin Invest (2011) 1.17
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells. Mol Endocrinol (2007) 1.15
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest (2011) 1.10
Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways. Mol Endocrinol (2007) 1.09
Differential effects of hydroxyurea and INC424 on mutant allele burden and myeloproliferative phenotype in a JAK2-V617F polycythemia vera mouse model. Blood (2012) 1.07
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions. Proc Natl Acad Sci U S A (2010) 1.07
Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol Endocrinol (2002) 1.07
Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy. J Hematol Oncol (2012) 1.06
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol (2010) 1.05
Loss of Jak2 impairs endothelial function by attenuating Raf-1/MEK1/Sp-1 signaling along with altered eNOS activities. Am J Pathol (2013) 1.04
Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS One (2013) 1.03
Common integration sites for MMTV in viral induced mouse mammary tumors. J Mammary Gland Biol Neoplasia (2008) 1.02
HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development (2003) 1.02
Jak2 is necessary for neuroendocrine control of female reproduction. J Neurosci (2011) 0.99
A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences. J Virol (2005) 0.99
Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. Cancer Res (2004) 0.98
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells. Cell Signal (2012) 0.98
Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS. Cell Cycle (2004) 0.98
Selective segregation of DNA strands persists in long-label-retaining mammary cells during pregnancy. Breast Cancer Res (2008) 0.98
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res (2007) 0.98
Functional characterization of stem cell activity in the mouse mammary gland. Stem Cell Rev (2011) 0.98
Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development. Oncogene (2005) 0.96
Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy. Cancer Res (2009) 0.95
IRF4 is a suppressor of c-Myc induced B cell leukemia. PLoS One (2011) 0.95
Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development. Endocrinology (2006) 0.95
Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging. Genesis (2009) 0.95
Human breast cancer cells are redirected to mammary epithelial cells upon interaction with the regenerating mammary gland microenvironment in-vivo. PLoS One (2012) 0.94
Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin. Mech Dev (2004) 0.94
Effects of age and parity on mammary gland lesions and progenitor cells in the FVB/N-RC mice. PLoS One (2012) 0.94
Hepatocyte-specific deletion of Janus kinase 2 (JAK2) protects against diet-induced steatohepatitis and glucose intolerance. J Biol Chem (2012) 0.94
Amphiregulin mediates self-renewal in an immortal mammary epithelial cell line with stem cell characteristics. Exp Cell Res (2009) 0.93
Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies. Cancer Res (2014) 0.93
Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells. Genesis (2005) 0.93
Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression. Cancer Res (2011) 0.92
Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer. Cancer Res (2013) 0.92
Immortalized, pre-malignant epithelial cell populations contain long-lived, label-retaining cells that asymmetrically divide and retain their template DNA. Breast Cancer Res (2010) 0.92
Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J Biol Chem (2004) 0.92
Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget (2011) 0.92
The mouse mammary microenvironment redirects mesoderm-derived bone marrow cells to a mammary epithelial progenitor cell fate. Stem Cells Dev (2011) 0.91
Roles of transforming growth factor-alpha in mammary development and disease. Growth Factors (2007) 0.90
Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells. Stem Cells (2014) 0.90
Reprogramming non-mammary and cancer cells in the developing mouse mammary gland. Semin Cell Dev Biol (2012) 0.90
Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Oncotarget (2012) 0.89
Temporally and spatially controlled expression of transgenes in embryonic and adult tissues. Transgenic Res (2009) 0.89
Reprogramming cell fates in the mammary microenvironment. Cell Cycle (2009) 0.89
Stem cell marker prominin-1 regulates branching morphogenesis, but not regenerative capacity, in the mammary gland. Dev Dyn (2011) 0.89
D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells. Mol Cell Endocrinol (2013) 0.89
Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species. Cardiovasc Res (2011) 0.87
Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol (2008) 0.87
Selective deletion of Jak2 in adult mouse hematopoietic cells leads to lethal anemia and thrombocytopenia. Haematologica (2014) 0.87
Embryonic stem cells are redirected to non-tumorigenic epithelial cell fate by interaction with the mammary microenvironment. PLoS One (2013) 0.87
Contributions of mouse biology to breast cancer research. Comp Med (2002) 0.86
A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death. PLoS One (2012) 0.86
Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Mol Endocrinol (2013) 0.85
The mammary gland microenvironment directs progenitor cell fate in vivo. Int J Cell Biol (2011) 0.85
Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary. Biol Reprod (2002) 0.85
G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. J Biol Chem (2013) 0.85
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol (2014) 0.84
A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis. Neoplasia (2008) 0.84
Stem cells and the mammary microenvironment. Breast Dis (2008) 0.84
Vascular smooth muscle Jak2 deletion prevents angiotensin II-mediated neointima formation following injury in mice. J Mol Cell Cardiol (2011) 0.82
Stem cells and tissue homeostasis in mammary glands. J Mammary Gland Biol Neoplasia (2005) 0.80
Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax. Genesis (2011) 0.80
ESCRT proteins: Double-edged regulators of cellular signaling. Bioarchitecture (2011) 0.80
Generation of conditional knockout mice. Methods Mol Biol (2014) 0.79
Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. Mol Endocrinol (2011) 0.79
TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium. Int J Cancer (2007) 0.79
The mouse as a model for mammary tumorigenesis: history and current aspects. J Mammary Gland Biol Neoplasia (2008) 0.79
Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland. PLoS One (2012) 0.78
Role of epithelial stem/progenitor cells in mammary cancer. Gene Expr (2011) 0.78
Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J Cell Sci (2013) 0.78
Late developing mammary tumors and hyperplasia induced by a low-oncogenic variant of mouse mammary tumor virus (MMTV) express genes identical to those induced by canonical MMTV. Mol Cancer (2013) 0.77