Published in Nature on January 24, 2002
Biologists urged to address risk of data aiding bioweapon design. Nature (2001) 1.67
Delivering death in the mail. Nature (2002) 1.11
The end of innocence? Nature (2001) 0.97
Dynamically driven protein allostery. Nat Struct Mol Biol (2006) 4.53
Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism. Science (2006) 4.36
Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching. Science (2006) 3.76
Accurate FRET measurements within single diffusing biomolecules using alternating-laser excitation. Biophys J (2005) 3.22
Structural organization of bacterial RNA polymerase holoenzyme and the RNA polymerase-promoter open complex. Cell (2002) 3.21
Catabolite activator protein: DNA binding and transcription activation. Curr Opin Struct Biol (2004) 2.91
Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell (2005) 2.88
Structural basis of transcription activation: the CAP-alpha CTD-DNA complex. Science (2002) 2.67
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein. Proc Natl Acad Sci U S A (2009) 2.39
Structural basis of transcription initiation. Science (2012) 2.23
An open letter to Elias Zerhouni. Science (2005) 2.19
The RNA polymerase "switch region" is a target for inhibitors. Cell (2008) 1.96
Retention of transcription initiation factor sigma70 in transcription elongation: single-molecule analysis. Mol Cell (2005) 1.96
Direct observation of abortive initiation and promoter escape within single immobilized transcription complexes. Biophys J (2005) 1.90
Promoter unwinding and promoter clearance by RNA polymerase: detection by single-molecule DNA nanomanipulation. Proc Natl Acad Sci U S A (2004) 1.81
Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. Mol Cell (2004) 1.80
The sigma 70 subunit of RNA polymerase mediates a promoter-proximal pause at the lac promoter. Nat Struct Mol Biol (2004) 1.77
Opening and closing of the bacterial RNA polymerase clamp. Science (2012) 1.73
Thermodynamic and kinetic modeling of transcriptional pausing. Proc Natl Acad Sci U S A (2006) 1.61
Direct detection of abortive RNA transcripts in vivo. Science (2009) 1.53
Structure of antibacterial peptide microcin J25: a 21-residue lariat protoknot. J Am Chem Soc (2003) 1.51
The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA. Nature (2016) 1.50
Single-molecule DNA nanomanipulation: improved resolution through use of shorter DNA fragments. Nat Methods (2005) 1.47
Response of RNA polymerase to ppGpp: requirement for the omega subunit and relief of this requirement by DksA. Genes Dev (2005) 1.45
The initiation factor TFE and the elongation factor Spt4/5 compete for the RNAP clamp during transcription initiation and elongation. Mol Cell (2011) 1.40
The interaction between sigma70 and the beta-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation. Proc Natl Acad Sci U S A (2005) 1.38
Determinants of the C-terminal domain of the Escherichia coli RNA polymerase alpha subunit important for transcription at class I cyclic AMP receptor protein-dependent promoters. J Bacteriol (2002) 1.33
Functional interaction between RNA polymerase alpha subunit C-terminal domain and sigma70 in UP-element- and activator-dependent transcription. Mol Cell (2003) 1.31
Structures of RNA polymerase-antibiotic complexes. Curr Opin Struct Biol (2009) 1.28
Three-dimensional EM structure of an intact activator-dependent transcription initiation complex. Proc Natl Acad Sci U S A (2009) 1.26
New target for inhibition of bacterial RNA polymerase: 'switch region'. Curr Opin Microbiol (2011) 1.26
Transcription factor B contacts promoter DNA near the transcription start site of the archaeal transcription initiation complex. J Biol Chem (2003) 1.17
Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis. Infect Immun (2005) 1.17
Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center. Proc Natl Acad Sci U S A (2008) 1.16
Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro. J Interferon Cytokine Res (2006) 1.14
Role of glutathione in macrophage control of mycobacteria. Infect Immun (2003) 1.14
The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection. J Mol Biol (2012) 1.12
Molecular beacons for multiplex detection of four bacterial bioterrorism agents. Clin Chem (2004) 1.10
Preventing pandemics: The fight over flu. Nature (2012) 1.10
Systematic structure-activity analysis of microcin J25. J Biol Chem (2008) 1.10
Fluorescence resonance energy transfer (FRET) in analysis of transcription-complex structure and function. Methods Enzymol (2003) 1.09
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife (2014) 1.09
Indirect readout of DNA sequence at the primary-kink site in the CAP-DNA complex: recognition of pyrimidine-purine and purine-purine steps. J Mol Biol (2006) 1.07
Natural killer cells, glutathione, cytokines, and innate immunity against Mycobacterium tuberculosis. J Interferon Cytokine Res (2008) 1.06
Arginine homeostasis in J774.1 macrophages in the context of Mycobacterium bovis BCG infection. J Bacteriol (2006) 1.05
Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J Bacteriol (2006) 1.05
Human beta-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells. Antimicrob Agents Chemother (2006) 1.03
Glutathione levels and immune responses in tuberculosis patients. Microb Pathog (2007) 1.03
Distance-restrained docking of rifampicin and rifamycin SV to RNA polymerase using systematic FRET measurements: developing benchmarks of model quality and reliability. Biophys J (2004) 1.03
Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing. Microb Pathog (2008) 1.01
Requirement for two copies of RNA polymerase alpha subunit C-terminal domain for synergistic transcription activation at complex bacterial promoters. Genes Dev (2002) 0.96
Upstream promoter sequences and alphaCTD mediate stable DNA wrapping within the RNA polymerase-promoter open complex. EMBO Rep (2007) 0.92
The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J Mol Biol (2011) 0.89
Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects. AIDS Res Ther (2006) 0.89
Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy. Methods Enzymol (2010) 0.86
Frequency, spectrum, and nonzero fitness costs of resistance to myxopyronin in Staphylococcus aureus. Antimicrob Agents Chemother (2012) 0.82
Modulation of J774.1 macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG. Infect Immun (2003) 0.81
Static and kinetic site-specific protein-DNA photocrosslinking: analysis of bacterial transcription initiation complexes. Methods Mol Biol (2009) 0.79
Nitric oxide regulation of L-arginine uptake in murine and human macrophages. Tuberculosis (Edinb) (2003) 0.79
Nonradioactive, ultrasensitive site-specific protein-protein photocrosslinking: interactions of alpha-helix 2 of TATA-binding protein with general transcription factor TFIIA and transcriptional repressor NC2. Nucleic Acids Res (2008) 0.78
Engaging actively with issues in the responsible conduct of science: lessons from international efforts are relevant for undergraduate education in the United States. CBE Life Sci Educ (2013) 0.78
Effects by anthrax toxins on hematopoiesis: a key role for cytokines as mediators. Cytokine (2011) 0.77
Synthesis and evaluation of novel analogues of ripostatins. Chemistry (2014) 0.76
Non-canonical effects of anthrax toxins on haematopoiesis: implications for vaccine development. J Cell Mol Med (2008) 0.76
Site-specific incorporation of probes into RNA polymerase by unnatural-amino-acid mutagenesis and Staudinger-Bertozzi ligation. Methods Mol Biol (2015) 0.75
Site-specific protein-DNA photo-cross-linking: analysis of structural organization of protein-DNA and multiprotein-DNA complexes. CSH Protoc (2006) 0.75
The Challenge of Global Catastrophic Biological Risks. Health Secur (2017) 0.75