Published in Hum Gene Ther on January 20, 2002
Treatment of human disease by adeno-associated viral gene transfer. Hum Genet (2006) 1.84
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A (2004) 1.64
Cloning and characterization of a bovine adeno-associated virus. J Virol (2004) 1.46
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome. Ann Rheum Dis (2005) 1.20
Effect of soluble ICAM-1 on a Sjögren's syndrome-like phenotype in NOD mice is disease stage dependent. PLoS One (2011) 0.82
Use of localised gene transfer to develop new treatment strategies for the salivary component of Sjögren's syndrome. Ann Rheum Dis (2003) 0.82
Convenient and reproducible in vivo gene transfer to mouse parotid glands. Oral Dis (2011) 0.81
Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands. Oral Dis (2010) 0.77
Advances in salivary gland gene therapy - oral and systemic implications. Expert Opin Biol Ther (2015) 0.76
Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect. Int J Mol Sci (2017) 0.75
RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A (2005) 4.79
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med (2004) 4.63
Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther (2002) 3.92
Inhibitory effects of B cells on antitumor immunity. Cancer Res (2006) 2.57
Identification of PDGFR as a receptor for AAV-5 transduction. Nat Med (2003) 2.43
Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer. Arch Otolaryngol Head Neck Surg (2003) 2.36
The family Parvoviridae. Arch Virol (2013) 2.12
Risk factors for positive minor salivary gland biopsy findings in Sjögren's syndrome and dry mouth patients. Arthritis Rheum (2002) 2.10
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J Virol (2006) 1.97
Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys (2010) 1.84
A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther (2009) 1.80
Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science (2010) 1.75
Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol Cell (2002) 1.74
Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist (2010) 1.71
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome. Arthritis Rheum (2009) 1.67
Immune globulins and thrombotic adverse events as recorded in a large administrative database in 2008 through 2010. Transfusion (2012) 1.66
Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A (2004) 1.64
Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity. J Virol (2007) 1.60
AAV transcytosis through barrier epithelia and endothelium. Mol Ther (2005) 1.60
Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography. Hum Gene Ther (2002) 1.60
Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors. J Neurosci (2005) 1.56
Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet (2003) 1.56
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Hum Gene Ther (2010) 1.51
Structure of adeno-associated virus serotype 5. J Virol (2004) 1.50
Structure of adeno-associated virus type 4. J Virol (2005) 1.47
Cloning and characterization of a bovine adeno-associated virus. J Virol (2004) 1.46
The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol Cell (2004) 1.46
Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis. FEMS Immunol Med Microbiol (2004) 1.46
Immune globulins and same-day thrombotic events as recorded in a large health care database during 2008 to 2012. Transfusion (2014) 1.45
Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A (2012) 1.38
Cloning of an avian adeno-associated virus (AAAV) and generation of recombinant AAAV particles. J Virol (2003) 1.37
Development of a novel vaccinia-neutralization assay based on reporter-gene expression. J Infect Dis (2003) 1.37
Etanercept in Sjögren's syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial. Arthritis Rheum (2004) 1.36
Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res (2007) 1.34
Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol (2002) 1.30
Gene transfer to salivary glands. Int Rev Cytol (2002) 1.28
Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. Hum Gene Ther (2003) 1.28
Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. J Biol Chem (2002) 1.27
Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res (2005) 1.27
Xerostomia and the geriatric patient. J Am Geriatr Soc (2002) 1.26
Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Hum Gene Ther (2009) 1.24
Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders. J Endocrinol (2005) 1.23
MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling. Infect Immun (2005) 1.22
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med (2010) 1.22
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20
Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther (2007) 1.18
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.17
Gangliosides are essential for bovine adeno-associated virus entry. J Virol (2006) 1.17
Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. Hum Gene Ther (2006) 1.17
Endogenous osteonectin/SPARC/BM-40 expression inhibits MDA-MB-231 breast cancer cell metastasis. Cancer Res (2005) 1.16
Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys (2005) 1.16
The parvovirus capsid odyssey: from the cell surface to the nucleus. Trends Microbiol (2008) 1.15
Development of a gene transfer-based treatment for radiation-induced salivary hypofunction. Oral Oncol (2009) 1.15
Identification and characterization of novel adeno-associated virus isolates in ATCC virus stocks. J Virol (2006) 1.13
Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands. Mol Ther (2005) 1.13
Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer. Arthritis Res Ther (2010) 1.13
Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer. Hum Gene Ther (2008) 1.12
Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. Hum Gene Ther (2003) 1.12
Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent. J Immunol (2003) 1.12
Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9. J Immunol (2005) 1.11
Characterization of antibodies to capsular polysaccharide antigens of Haemophilus influenzae type b and Streptococcus pneumoniae in human immune globulin intravenous preparations. Clin Diagn Lab Immunol (2004) 1.11
Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear. Proc Natl Acad Sci U S A (2008) 1.11
The stable nitroxide tempol facilitates salivary gland protection during head and neck irradiation in a mouse model. Clin Cancer Res (2004) 1.10
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol Ther (2008) 1.10
Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates. Hum Gene Ther (2007) 1.10
Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland. J Gene Med (2010) 1.09
Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function. Lab Invest (2010) 1.08
PKA/PrKX activity is a modulator of AAV/adenovirus interaction. EMBO J (2003) 1.08
Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clin Cancer Res (2009) 1.07
Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. J Virol (2006) 1.07
Developing a convenient large animal model for gene transfer to salivary glands in vivo. J Gene Med (2004) 1.07
Baculovirus: an insect-derived vector for diverse gene transfer applications. Mol Ther (2013) 1.07
IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer. Lab Invest (2010) 1.07
Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clin Cancer Res (2011) 1.07
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Mol Ther (2011) 1.05
A novel bovine virus efficiently transduces inner ear neuroepithelial cells. Mol Ther (2005) 1.05
Gene therapy: some history, applications, problems, and prospects. Toxicol Pathol (2008) 1.04
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors. Hum Gene Ther (2011) 1.04
Serum-free production and column purification of adeno-associated virus type 5. J Virol Methods (2003) 1.03
Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system. J Gene Med (2007) 1.03