Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMID 15930162)

Published in J Endocrinol on June 01, 2005

Authors

Antonis Voutetakis1, Ioannis Bossis, Marc R Kok, Weitian Zhang, Jianghua Wang, Ana P Cotrim, Changyu Zheng, John A Chiorini, Lynnette K Nieman, Bruce J Baum

Author Affiliations

1: Gene Therapy and Therapeutics Branch, NIDCR, NIH, DHHS, Bethesda, Maryland 20892, USA.

Articles citing this

Treatment of human disease by adeno-associated viral gene transfer. Hum Genet (2006) 1.84

Intravital two-photon microscopy for studying the uptake and trafficking of fluorescently conjugated molecules in live rodents. Traffic (2008) 1.36

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer. Hum Gene Ther (2008) 1.12

Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol Ther (2008) 1.10

Differential sorting of human parathyroid hormone after transduction of mouse and rat salivary glands. Hum Gene Ther (2008) 1.04

Gene delivery in salivary glands: from the bench to the clinic. Biochim Biophys Acta (2011) 0.98

Salivary epithelial cells: an unassuming target site for gene therapeutics. Int J Biochem Cell Biol (2010) 0.93

Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors. J Gene Med (2009) 0.91

Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands. Hum Gene Ther (2008) 0.89

α-Galactosidase A expressed in the salivary glands partially corrects organ biochemical deficits in the fabry mouse through endocrine trafficking. Hum Gene Ther (2011) 0.88

Mouse salivary glands and human beta-defensin-2 as a study model for antimicrobial gene therapy: technical considerations. Int J Antimicrob Agents (2006) 0.85

Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands. Biochem Biophys Res Commun (2008) 0.84

Convenient and reproducible in vivo gene transfer to mouse parotid glands. Oral Dis (2011) 0.81

Isoproterenol increases sorting of parotid gland cargo proteins to the basolateral pathway. Am J Physiol Cell Physiol (2007) 0.81

Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation. J Physiol (2015) 0.81

Functional salivary gland regeneration as the next generation of organ replacement regenerative therapy. Odontology (2015) 0.79

Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation. Oral Dis (2008) 0.79

A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands. Hum Gene Ther Methods (2012) 0.79

Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. Toxicol Sci (2011) 0.78

An AAV2/5 vector enhances safety of gene transfer to the mouse salivary gland. J Dent Res (2012) 0.78

Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PLoS One (2012) 0.78

In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands. J Gene Med (2009) 0.75

Neutralizing antibodies against adeno-associated viruses in Sjögren's patients: implications for gene therapy. Gene Ther (2017) 0.75

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Cushing's syndrome. Lancet (2006) 5.19

Cushing's syndrome due to ectopic corticotropin secretion: twenty years' experience at the National Institutes of Health. J Clin Endocrinol Metab (2005) 3.32

Salivary proteomic and genomic biomarkers for primary Sjögren's syndrome. Arthritis Rheum (2007) 2.90

A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Nat Genet (2006) 2.86

Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res (2008) 2.81

The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J Proteome Res (2008) 2.53

Identification of PDGFR as a receptor for AAV-5 transduction. Nat Med (2003) 2.43

A protective and broadly cross-neutralizing epitope of human papillomavirus L2. J Virol (2007) 2.36

Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer. Arch Otolaryngol Head Neck Surg (2003) 2.36

Pilot clinical trial of dehydroepiandrosterone (DHEA) versus placebo for Sjögren's syndrome. Arthritis Rheum (2004) 2.15

The family Parvoviridae. Arch Virol (2013) 2.12

Risk factors for positive minor salivary gland biopsy findings in Sjögren's syndrome and dry mouth patients. Arthritis Rheum (2002) 2.10

Diagnostic accuracy of laparoscopy, magnetic resonance imaging, and histopathologic examination for the detection of endometriosis. Fertil Steril (2003) 2.00

Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J Virol (2006) 1.97

CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial. Obstet Gynecol (2008) 1.95

Recurrent chimeric RNAs enriched in human prostate cancer identified by deep sequencing. Proc Natl Acad Sci U S A (2011) 1.94

Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers. Int J Radiat Oncol Biol Phys (2010) 1.84

Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission. J Clin Endocrinol Metab (2005) 1.83

The hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment. Endocr Rev (2005) 1.77

Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science (2010) 1.75

Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population. Cancer Res (2006) 1.72

Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist (2010) 1.71

Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome. Arthritis Rheum (2009) 1.67

Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids. Genes Chromosomes Cancer (2004) 1.65

Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc Natl Acad Sci U S A (2004) 1.64

Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease. J Neurosurg (2009) 1.61

Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity. J Virol (2007) 1.60

AAV transcytosis through barrier epithelia and endothelium. Mol Ther (2005) 1.60

Scalable purification of adeno-associated virus type 2, 4, or 5 using ion-exchange chromatography. Hum Gene Ther (2002) 1.60

miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1. J Am Soc Nephrol (2013) 1.57

Functional correction of CNS phenotypes in a lysosomal storage disease model using adeno-associated virus type 4 vectors. J Neurosci (2005) 1.56

Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet (2003) 1.56

Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Hum Gene Ther (2010) 1.51

The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer. Cancer Res (2004) 1.51

Structure of adeno-associated virus serotype 5. J Virol (2004) 1.50

Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency. Hum Mol Genet (2006) 1.47

Structure of adeno-associated virus type 4. J Virol (2005) 1.47

Cloning and characterization of a bovine adeno-associated virus. J Virol (2004) 1.46

Spoiled gradient recalled acquisition in the steady state technique is superior to conventional postcontrast spin echo technique for magnetic resonance imaging detection of adrenocorticotropin-secreting pituitary tumors. J Clin Endocrinol Metab (2003) 1.44

mTOR kinase and the regulatory subunit of protein kinase A (PRKAR1A) spatially and functionally interact during autophagosome maturation. Autophagy (2007) 1.43

Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases. Ann N Y Acad Sci (2002) 1.42

Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors. Cancer Res (2008) 1.39

In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. Hum Mutat (2008) 1.39

Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids. Clin Chem (2008) 1.38

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proc Natl Acad Sci U S A (2012) 1.38

Cloning of an avian adeno-associated virus (AAAV) and generation of recombinant AAAV particles. J Virol (2003) 1.37

PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex. J Clin Endocrinol Metab (2006) 1.36

The role of [(18)F]fluorodeoxyglucose positron emission tomography and [(111)In]-diethylenetriaminepentaacetate-D-Phe-pentetreotide scintigraphy in the localization of ectopic adrenocorticotropin-secreting tumors causing Cushing's syndrome. J Clin Endocrinol Metab (2004) 1.36

Etanercept in Sjögren's syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial. Arthritis Rheum (2004) 1.36

Large deletions of the PRKAR1A gene in Carney complex. Clin Cancer Res (2008) 1.36

Differential radiation protection of salivary glands versus tumor by Tempol with accompanying tissue assessment of Tempol by magnetic resonance imaging. Clin Cancer Res (2007) 1.34

Aging: central role for autophagy and the lysosomal degradative system. Ageing Res Rev (2009) 1.31

Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev (2012) 1.30

Salivary glands: novel target sites for gene therapeutics. Trends Mol Med (2004) 1.30

Gene transfer to salivary glands. Int Rev Cytol (2002) 1.28

Local adeno-associated virus-mediated interleukin 10 gene transfer has disease-modifying effects in a murine model of Sjögren's syndrome. Hum Gene Ther (2003) 1.28

Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5. J Biol Chem (2002) 1.27

Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. Clin Cancer Res (2005) 1.27

E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res (2005) 1.26

Vaccination of healthy volunteers with human papillomavirus type 16 L2E7E6 fusion protein induces serum antibody that neutralizes across papillomavirus species. Cancer Res (2006) 1.26

Xerostomia and the geriatric patient. J Am Geriatr Soc (2002) 1.26

Cushing's syndrome during pregnancy: personal experience and review of the literature. J Clin Endocrinol Metab (2005) 1.24

Utility of various functional and anatomic imaging modalities for detection of ectopic adrenocorticotropin-secreting tumors. J Clin Endocrinol Metab (2010) 1.24

Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med (2010) 1.22

Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20

Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation. Int J Biochem Cell Biol (2010) 1.18

Prevention of irradiation-induced salivary hypofunction by microvessel protection in mouse salivary glands. Mol Ther (2007) 1.18

Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. Hum Gene Ther (2006) 1.17

Gangliosides are essential for bovine adeno-associated virus entry. J Virol (2006) 1.17

Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 1.17

A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort) vs. conventional hydrocortisone (Cortef) in the treatment of congenital adrenal hyperplasia. Clin Endocrinol (Oxf) (2009) 1.17

Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys (2005) 1.16

The parvovirus capsid odyssey: from the cell surface to the nucleus. Trends Microbiol (2008) 1.15

RNAprotect saliva: An optimal room- temperature stabilization reagent for the salivary transcriptome. Clin Chem (2006) 1.15

Development of a gene transfer-based treatment for radiation-induced salivary hypofunction. Oral Oncol (2009) 1.15

Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death. Int J Cancer (2008) 1.15

Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis Rheum (2009) 1.14

Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer. Arthritis Res Ther (2010) 1.13

Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands. Mol Ther (2005) 1.13

Development of the selective progesterone receptor modulator CDB-2914 for clinical indications. Steroids (2003) 1.13