Published in Nucleic Acids Res on December 15, 2001
Laboratory-directed protein evolution. Microbiol Mol Biol Rev (2005) 1.69
Phage TP901-1 site-specific integrase functions in human cells. J Bacteriol (2002) 1.57
Gene therapy for severe combined immunodeficiency: are we there yet? J Clin Invest (2007) 1.42
Chimeric recombinases with designed DNA sequence recognition. Proc Natl Acad Sci U S A (2003) 1.35
A diversity of serine phage integrases mediate site-specific recombination in mammalian cells. Mol Genet Genomics (2006) 1.26
Recombinase technology: applications and possibilities. Plant Cell Rep (2010) 1.25
Mutational derivatives of PhiC31 integrase with increased efficiency and specificity. Mol Ther (2008) 1.23
Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration. Proc Natl Acad Sci U S A (2005) 1.22
Viral vectors: from virology to transgene expression. Br J Pharmacol (2009) 1.19
Directed evolution of recombinase specificity by split gene reassembly. Nucleic Acids Res (2010) 1.19
Evolution of variants of yeast site-specific recombinase Flp that utilize native genomic sequences as recombination target sites. Nucleic Acids Res (2006) 1.13
Current advances in retroviral gene therapy. Curr Gene Ther (2011) 1.13
Phage integrases for the construction and manipulation of transgenic mammals. Reprod Biol Endocrinol (2003) 1.12
A look to future directions in gene therapy research for monogenic diseases. PLoS Genet (2006) 1.11
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells. Nucleic Acids Res (2013) 1.04
Utilizing natural diversity to evolve protein function: applications towards thermostability. Curr Opin Chem Biol (2011) 0.99
Regulated gene insertion by steroid-induced PhiC31 integrase. Nucleic Acids Res (2008) 0.99
Attachment site recognition and regulation of directionality by the serine integrases. Nucleic Acids Res (2013) 0.97
DAXX interacts with phage PhiC31 integrase and inhibits recombination. Nucleic Acids Res (2006) 0.95
Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells. Mol Ther (2010) 0.94
Expanding the scope of site-specific recombinases for genetic and metabolic engineering. Biotechnol Bioeng (2013) 0.92
Zinc-finger recombinase activities in vitro. Nucleic Acids Res (2011) 0.84
Selection of bacteriophage lambda integrases with altered recombination specificity by in vitro compartmentalization. Nucleic Acids Res (2009) 0.83
Site-specific recombination for genetic engineering in plants. Plant Cell Rep (2003) 0.83
Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign. J Am Chem Soc (2014) 0.81
Mutants of Cre recombinase with improved accuracy. Nat Commun (2013) 0.81
Mutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombination. PLoS One (2010) 0.80
Recombinase mediated cassette exchange into genomic targets using an adenovirus vector. Nucleic Acids Res (2010) 0.80
A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells. Nucleic Acids Res (2016) 0.79
Improved site-specific recombinase-based method to produce selectable marker- and vector-backbone-free transgenic cells. Sci Rep (2014) 0.78
Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity. Gene Ther (2014) 0.77
Cross-talk between diverse serine integrases. J Mol Biol (2013) 0.77
Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage. PLoS One (2014) 0.76
Screening of potential pseudo att sites of Streptomyces phage ΦC31 integrase in the human genome. Acta Pharmacol Sin (2013) 0.76
Serine integrase chimeras with activity in E. coli and HeLa cells. Biol Open (2014) 0.75
Real time quantitative PCR. Genome Res (1996) 35.79
A novel method for real time quantitative RT-PCR. Genome Res (1996) 15.83
Rapid evolution of a protein in vitro by DNA shuffling. Nature (1994) 9.67
DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution. Proc Natl Acad Sci U S A (1994) 5.69
A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A (2000) 5.13
Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08
In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family. Proc Natl Acad Sci U S A (1998) 5.04
DNA shuffling of a family of genes from diverse species accelerates directed evolution. Nature (1998) 4.21
Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol (1998) 4.14
Promoters of Escherichia coli: a hierarchy of in vivo strength indicates alternate structures. EMBO J (1986) 3.89
Catalysis by site-specific recombinases. Trends Genet (1992) 3.86
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol (2001) 3.39
Mammalian genomes contain active recombinase recognition sites. Gene (2000) 3.08
Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents. Nat Biotechnol (1996) 3.07
Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site. Cell (1995) 2.92
Analysis of the integration function of the streptomycete bacteriophage phi C31. J Mol Biol (1991) 2.82
Structural analysis of the actinophage phi C31 attachment site. Nucleic Acids Res (1991) 1.68
Identifying determinants of recombination specificity: construction and characterization of mutant bacteriophage integrases. J Mol Biol (1995) 1.54
Protein evolution by molecular breeding. Curr Opin Chem Biol (1999) 1.44
Molecular genetic analysis of transposase-end DNA sequence recognition: cooperativity of three adjacent base-pairs in specific interaction with a mutant Tn5 transposase. J Mol Biol (1998) 1.32
Identifying determinants of recombination specificity: construction and characterization of chimeric bacteriophage integrases. J Mol Biol (1995) 1.31
Cre mutants with altered DNA binding properties. J Biol Chem (1998) 1.28
New cloning vectors with temperature-sensitive replication. Plasmid (1999) 1.21
The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Mol Microbiol (1995) 1.04
Site-specific recombination in mammalian cells catalyzed by gammadelta resolvase mutants: implications for the topology of episomal DNA. FEBS Lett (2000) 0.93
Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude. J Mol Biol (1998) 0.87
Altering the DNA-binding specificity of Mu transposase in vitro. Nucleic Acids Res (1998) 0.84
Construction of lacIts and lacIqts expression plasmids and evaluation of the thermosensitive lac repressor. Gene (1995) 0.82
Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cell Biol (1987) 11.36
Transposable elements. Cell (1980) 10.84
On the formation of spontaneous deletions: the importance of short sequence homologies in the generation of large deletions. Cell (1982) 9.72
High mutation frequency in DNA transfected into mammalian cells. Proc Natl Acad Sci U S A (1983) 6.05
DNA sequence for a low-level promoter of the lac repressor gene and an 'up' promoter mutation. Nature (1978) 5.31
A phage integrase directs efficient site-specific integration in human cells. Proc Natl Acad Sci U S A (2000) 5.13
DNA sequence at the integration sites of the insertion element IS1. Cell (1978) 4.27
Transfected DNA is mutated in monkey, mouse, and human cells. Mol Cell Biol (1984) 3.63
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol (2001) 3.39
Isolation of human sequences that replicate autonomously in human cells. Mol Cell Biol (1989) 3.16
Mammalian genomes contain active recombinase recognition sites. Gene (2000) 3.08
Sequence analysis of Tn9 insertions in the lacZ gene. J Mol Biol (1980) 2.85
Use of simian virus 40 replication to amplify Epstein-Barr virus shuttle vectors in human cells. J Virol (1988) 2.43
Specificity of mutations induced in transfected DNA by mammalian cells. EMBO J (1984) 2.27
Replication initiates at multiple locations on an autonomously replicating plasmid in human cells. Mol Cell Biol (1991) 2.13
Simian virus 40 replication in adenovirus-transformed human cells antagonizes gene expression. Nature (1985) 1.98
Autonomous DNA replication in human cells is affected by the size and the source of the DNA. Mol Cell Biol (1991) 1.96
The lacI shuttle: rapid analysis of the mutagenic specificity of ultraviolet light in human cells. Proc Natl Acad Sci U S A (1985) 1.82
Genetic and sequence analysis of frameshift mutations induced by ICR-191. J Mol Biol (1981) 1.82
The transposon Tn9 generates a 9 bp repeated sequence during integration. Cell (1978) 1.73
Phage R4 integrase mediates site-specific integration in human cells. Gene (2001) 1.71
Autonomous replication in human cells of multimers of specific human and bacterial DNA sequences. Mol Cell Biol (1993) 1.54
Replication control of autonomously replicating human sequences. Nucleic Acids Res (1991) 1.36
Determination of DNA sequence changes induced by ethyl methanesulfonate in human cells, using a shuttle vector system. Mol Cell Biol (1986) 1.36
Replication of centromere II of Schizosaccharomyces pombe. Mol Cell Biol (1995) 1.35
Genetic analysis of transpositions in the lac region of Escherichia coli. J Mol Biol (1980) 1.29
Autonomous replication in Drosophila melanogaster tissue culture cells. Chromosoma (1995) 1.29
Specific initiation at an origin of replication from Schizosaccharomyces pombe. Mol Cell Biol (1994) 1.28
Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells. J Mol Biol (1989) 1.27
Deletion of plasmid sequences during Saccharomyces cerevisiae transformation. J Bacteriol (1984) 1.25
Analysis of the autonomous replication behavior in human cells of the dihydrofolate reductase putative chromosomal origin of replication. Nucleic Acids Res (1992) 1.24
Transcription inhibits the replication of autonomously replicating plasmids in human cells. Mol Cell Biol (1994) 1.20
Physical mapping of origins of replication in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell (1994) 1.17
Further correlations of the lacI genetic map with the DNA sequence. J Mol Biol (1981) 1.15
Amplification of a bovine papillomavirus-simian virus 40 chimera. J Virol (1985) 1.12
Long-term gene expression from autonomously replicating vectors in mammalian cells. Gene Ther (1996) 1.04
Molecular consequences of deletion formation mediated by the transposon Tn9. Nature (1980) 1.03
Recombinant shuttle vectors for the study of mutation in mammalian cells. Mutagenesis (1988) 1.03
Epstein-Barr virus-based vectors that replicate in rodent cells. Gene (1993) 1.01
Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice. Mol Ther (2001) 1.00
Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli. Cold Spring Harb Symp Quant Biol (1983) 0.89
The DNA sequence change resulting from the IQ1 mutation, which greatly increases promoter strength. Mol Gen Genet (1981) 0.88
Lean mass predicts asthma better than fat mass among females. Eur Respir J (2010) 0.88
Elevated levels of recombinational DNA repair in human somatic cells expressing the Saccharomyces cerevisiae RAD52 gene. Mutat Res (1996) 0.87
Long-term phenotypic correction in factor IX knockout mice by using ΦC31 integrase-mediated gene therapy. Gene Ther (2011) 0.87
Effect of nuclear localization and hydrodynamic delivery-induced cell division on phiC31 integrase activity. Gene Ther (2009) 0.86
Effects of homology length and donor vector arrangement on the efficiency of double-strand break-mediated recombination in human cells. Somat Cell Mol Genet (1999) 0.86
Polymorphisms in the base excision repair pathway and graft-versus-host disease. Leukemia (2010) 0.84
Epstein-Barr virus vectors for gene expression and transfer. Curr Opin Biotechnol (1998) 0.83
The replication behavior of Saccharomyces cerevisiae DNA in human cells. Chromosoma (1993) 0.82
DNA sequence alteration resulting from a mutation impairing promoter function in the lac repressor gene. Mol Gen Genet (1980) 0.82
Genetic studies of the lac repressor. VIII. DNA sequence change resulting from an intragenic duplication. J Mol Biol (1978) 0.81
Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts. Biomarkers (2013) 0.80
Reduced Ca2+ uptake by mitochondria in pyruvate dehydrogenase-deficient human diploid fibroblasts. Am J Physiol (1998) 0.78
Telomeric sequences from human herpesvirus 6 do not mediate nuclear retention of episomal DNA in human cells. Arch Virol (1998) 0.78
An extrachromosomal tetracycline-regulatable system for mammalian cells. Nucleic Acids Res (2000) 0.78
Epstein-Barr virus plasmid model system for analyzing recombination in human cells. Plasmid (1999) 0.78
Genetic and sequencing studies of the specificity of transposition into the lac region of E. coli. Cold Spring Harb Symp Quant Biol (1981) 0.78
Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide. Indian J Pharmacol (2009) 0.75
Improved EBV shuttle vectors. Mutat Res (1989) 0.75