Published in Eur J Pharmacol on January 25, 2002
Kappa opioid antagonists: past successes and future prospects. AAPS J (2005) 1.41
The role of central mu opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther (2004) 1.33
Neural processing of itch. Neuroscience (2013) 1.32
Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron (2014) 1.28
TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J (2013) 1.22
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther (2003) 1.05
Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism. Mol Pharmacol (2015) 1.01
Nalfurafine prevents 5'-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5'-guanidinonaltrindole-elicited scratching behavior in mice. Neuroscience (2009) 0.97
Effects of butorphanol on morphine-induced itch and analgesia in primates. Anesthesiology (2007) 0.94
Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther (2008) 0.94
Neuraxial opioid-induced pruritus: An update. J Anaesthesiol Clin Pharmacol (2013) 0.93
Therapy of pruritus. Expert Opin Pharmacother (2010) 0.93
Pruritus: management algorithms and experimental therapies. Semin Cutan Med Surg (2011) 0.90
Sex differences in kappa opioid pharmacology. Life Sci (2010) 0.90
Anatomy and neurophysiology of pruritus. Semin Cutan Med Surg (2011) 0.89
A novel method for analyzing extremely biased agonism at G protein-coupled receptors. Mol Pharmacol (2015) 0.87
Anthocyanins from bilberry (Vaccinium myrtillus L.) alleviate pruritus in a mouse model of chronic allergic contact dermatitis. Pharmacognosy Res (2011) 0.85
Nalfurafine hydrochloride to treat pruritus: a review. Clin Cosmet Investig Dermatol (2015) 0.83
Targeted treatment of pruritus: a look into the future. Br J Dermatol (2011) 0.83
Intravenous butorphanol administration reduces intrathecal morphine-induced pruritus after cesarean delivery: a randomized, double-blind, placebo-controlled study. J Anesth (2012) 0.82
Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology (2015) 0.80
Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.80
Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice. Neurosci Lett (2014) 0.80
Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors. Eur J Pharmacol (2015) 0.80
Nalfurafine, the kappa opioid agonist, inhibits icilin-induced wet-dog shakes in rats and antagonizes glutamate release in the dorsal striatum. Neuropharmacology (2006) 0.78
Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice. Br J Pharmacol (2015) 0.77
Kappa Opioid Receptor Agonist and Brain Ischemia. Transl Perioper Pain Med (2014) 0.77
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal (2016) 0.76
Neuraxial opioid-induced itch and its pharmacological antagonism. Handb Exp Pharmacol (2015) 0.75
Targeting the Opioid Pathway for Uremic Pruritus: A Systematic Review and Meta-analysis. Can J Kidney Health Dis (2016) 0.75
Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling. Genesis (2015) 0.75
Phoenixin: A candidate pruritogen in the mouse. Neuroscience (2015) 0.75
The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem (2001) 2.16
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther (2007) 1.97
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res (2007) 1.90
A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency. Eur J Endocrinol (2007) 1.65
Imaging exocytosis of single insulin secretory granules with evanescent wave microscopy: distinct behavior of granule motion in biphasic insulin release. J Biol Chem (2001) 1.61
Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients. J Clin Endocrinol Metab (2004) 1.55
Cytochrome P450 oxidoreductase gene mutations and Antley-Bixler syndrome with abnormal genitalia and/or impaired steroidogenesis: molecular and clinical studies in 10 patients. J Clin Endocrinol Metab (2004) 1.51
Two patients with acute rotavirus encephalitis associated with cerebellar signs and symptoms. Eur J Pediatr (2010) 1.50
Chlorpheniramine exerts anxiolytic-like effects and activates prefrontal 5-HT systems in mice. Psychopharmacology (Berl) (2009) 1.44
A successfully treated case of blunt traumatic right coronary ostium rupture. Ann Thorac Surg (2003) 1.43
Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents. J Pharmacol Sci (2004) 1.42
Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers. Cancer Res (2006) 1.32
Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Cancer Res (2006) 1.30
Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome. J Clin Endocrinol Metab (2004) 1.24
Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab (2005) 1.17
Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress. Metabolism (2004) 1.16
Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol (2003) 1.11
Retroperitoneoscopic nephrectomy of a horseshoe kidney with renal-cell carcinoma. J Endourol (2003) 1.11
Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor. Nat Commun (2012) 1.10
Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy. Biochem J (2002) 1.09
A novel approach and protocol for discovering extremely low-abundance proteins in serum. Proteomics (2006) 1.08
Esophagectomy: is it necessary after chemoradiotherapy for a locally advanced T4 esophageal cancer? Prospective nonrandomized trial comparing chemoradiotherapy with surgery versus without surgery. World J Surg (2005) 1.07
Compound heterozygous mutations in the cholesterol side-chain cleavage enzyme gene (CYP11A) cause congenital adrenal insufficiency in humans. J Clin Endocrinol Metab (2002) 1.06
Optimal lymphadenectomy for squamous cell carcinoma in the thoracic esophagus: comparing the short- and long-term outcome among the four types of lymphadenectomy. World J Surg (2003) 1.03
Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray. Clin Cancer Res (2007) 1.01
The comparison of the effects of short-term growth hormone treatment in patients with achondroplasia and with hypochondroplasia. Endocr J (2003) 1.01
Design, synthesis, and AMPA receptor antagonistic activity of a novel 6-nitro-3-oxoquinoxaline-2-carboxylic acid with a substituted phenyl group at the 7 position. Bioorg Med Chem (2005) 1.00
Phase I clinical study of anti-apoptosis protein survivin-derived peptide vaccination for patients with advanced or recurrent urothelial cancer. Cancer Immunol Immunother (2009) 1.00
JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. Am J Physiol Endocrinol Metab (2008) 1.00
Design of the Nationwide Nursery School Survey on Child Health Throughout the Great East Japan Earthquake. J Epidemiol (2015) 0.99
Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats. Psychopharmacology (Berl) (2005) 0.99
Effects of combined training with breathing resistance and sustained physical exertion to improve endurance capacity and respiratory muscle function in healthy young adults. J Phys Ther Sci (2013) 0.99
Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats. Am J Respir Cell Mol Biol (2005) 0.98
Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence. Ann N Y Acad Sci (2004) 0.98
Prognostic impact of primary tumor resection and lymph node dissection in stage IV colorectal cancer with unresectable metastasis: a propensity score analysis in a multicenter retrospective study. Ann Surg Oncol (2014) 0.98
Validation of a new method for automated determination of bone age in Japanese children. Horm Res Paediatr (2010) 0.96
Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method. Endocr J (2012) 0.96
New reference growth charts for Japanese girls with Turner syndrome. Pediatr Int (2009) 0.94
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions. Behav Brain Res (2011) 0.94
Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor. Cancer Sci (2013) 0.93
Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem (2005) 0.93
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy. Mol Brain (2011) 0.93
Prospective non-randomized trial comparing esophagectomy-followed-by-chemoradiotherapy versus chemoradiotherapy-followed-by-esophagectomy for T4 esophageal cancers. J Surg Oncol (2005) 0.93
Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma. Clin Cancer Res (2008) 0.92
Chemoradiation provides a physiological selective pressure that increases the expansion of aberrant TP53 tumor variants in residual rectal cancerous regions. Oncotarget (2014) 0.92
Adjuvant chemotherapy after radical resection of squamous cell carcinoma in the thoracic esophagus: who benefits? A retrospective study. Dig Surg (2003) 0.92
Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. Mol Pharmacol (2013) 0.91
Prognostic impact of the expression of ALDH1 and SOX2 in urothelial cancer of the upper urinary tract. Mod Pathol (2012) 0.91
Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray. Dis Colon Rectum (2009) 0.91
Pathophysiology underlying irritable bowel syndrome--from the viewpoint of dysfunction of autonomic nervous system activity. J Smooth Muscle Res (2009) 0.91
PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein. Biochem Biophys Res Commun (2004) 0.91
Paclitaxel, ifosfamide, and nedaplatin as second-line treatment for patients with metastatic urothelial carcinoma: a phase II study of the SUOC group. Cancer Sci (2011) 0.90
к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep (2013) 0.90
Laparoscopic surgery for ulcerative colitis: a review of the literature. Surg Today (2014) 0.90
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Jpn J Pharmacol (2002) 0.90
Evaluation of valproate effects on acylcarnitine in epileptic children by LC-MS/MS. Brain Dev (2010) 0.90
Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test. Neuropsychopharmacology (2004) 0.90
Laparoscopic resection of a gastrointestinal stromal tumor of the lower rectum in a patient with coronary artery disease following long-term neoadjuvant imatinib treatment and anticoagulation therapy. World J Surg Oncol (2014) 0.90
The preoperative platelet to lymphocyte ratio is a prognostic marker in patients with stage II colorectal cancer. Int J Colorectal Dis (2015) 0.90
Three-field dissection for squamous cell carcinoma in the thoracic esophagus. Ann Thorac Cardiovasc Surg (2002) 0.89
Determination of specific activities and kinetic constants of biotinidase and lipoamidase in LEW rat and Lactobacillus casei (Shirota). J Chromatogr B Analyt Technol Biomed Life Sci (2006) 0.89
Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells. Eur J Pharmacol (2003) 0.89
Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys. Life Sci (2004) 0.89
T1 squamous cell carcinoma of the esophagus: long-term outcomes and prognostic factors after esophagectomy. Ann Surg Oncol (2014) 0.89
Hearing loss in Turner syndrome. J Pediatr (2006) 0.88
Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. Clin Colorectal Cancer (2011) 0.88
Microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum: relationship to clinicopathological features. J Clin Pathol (2007) 0.88
Statural growth in 31 Japanese patients with SHOX haploinsufficiency: support for a disadvantageous effect of gonadal estrogens. Endocr J (2004) 0.88
Determination of biotin (vitamin H) by the high-performance affinity chromatography with a trypsin-treated avidin-bound column. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.88
Lysophosphatidylcholine activates extracellular signal-regulated kinases 1/2 through reactive oxygen species in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2002) 0.88
Relationships between erectile dysfunction, depression, and anxiety in Japanese subjects. J Sex Med (2005) 0.88
Silencing of secreted frizzled-related protein genes in MSI colorectal carcinogenesis. Hepatogastroenterology (2008) 0.88
Effects of a newly synthesized kappa-opioid receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats. Psychopharmacology (Berl) (2002) 0.87
Antitumor activity of type III interferon alone or in combination with type I interferon against human non-small cell lung cancer. Cancer Sci (2011) 0.87
Modulation of kappa-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats. Neurosci Lett (2002) 0.87
Antitussive effect of WIN 55212-2, a cannabinoid receptor agonist. Eur J Pharmacol (2003) 0.86
Benefit of primary tumor resection in stage IV colorectal cancer with unresectable metastasis: a multicenter retrospective study using a propensity score analysis. Int J Colorectal Dis (2015) 0.86
Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma. Virchows Arch (2012) 0.86
[Effect of TRK-820, a selective kappa opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis]. Nihon Shinkei Seishin Yakurigaku Zasshi (2008) 0.86
Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2. Bioorg Med Chem Lett (2006) 0.86
Antidepressant-like effect of leptin in streptozotocin-induced diabetic mice. Pharmacol Biochem Behav (2006) 0.86
Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes. Eur J Cancer (2010) 0.86
Effects of remote muscle contraction on transcranial magnetic stimulation-induced motor evoked potentials and silent periods in humans. Clin Neurophysiol (2007) 0.85
Modulations of interlimb and intralimb cutaneous reflexes during simultaneous arm and leg cycling in humans. Clin Neurophysiol (2006) 0.85
Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. J Biochem (2004) 0.85
Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2. J Atheroscler Thromb (2003) 0.85
Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome. Am J Med Genet A (2004) 0.85