Anatomy and neurophysiology of pruritus.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3694590)

Published in Semin Cutan Med Surg on June 01, 2011

Authors

Akihiko Ikoma1, Ferda Cevikbas, Cordula Kempkes, Martin Steinhoff

Author Affiliations

1: Department of Dermatology and Surgery, University of California, San Francisco, San Francisco, CA, USA. IkomaA@derm.ucsf.edu

Articles cited by this

Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci (2005) 6.06

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature (2007) 4.83

Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (1997) 4.03

Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci (2001) 3.66

Specific C-receptors for itch in human skin. J Neurosci (1997) 3.51

Cellular basis of itch sensation. Science (2009) 3.38

The neurobiology of itch. Nat Rev Neurosci (2006) 3.25

Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci (2003) 2.94

Separate peripheral pathways for pruritus in man. J Neurophysiol (2008) 2.64

The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci (2007) 2.63

Phenotype and function of somatic primary afferent nociceptive neurones with C-, Adelta- or Aalpha/beta-fibres. Exp Physiol (2002) 2.40

Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens. J Neurophysiol (2003) 2.39

Central mechanisms of pathological pain. Nat Med (2010) 2.37

Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev (2006) 2.30

Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch. J Neurosci (2007) 2.10

Mechanism of action of antipruritic drugs. Br Med J (Clin Res Ed) (1983) 1.68

The multiple pathways for itch and their interactions with pain. Trends Neurosci (2010) 1.61

Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol (1994) 1.59

Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli. J Neurophysiol (2004) 1.57

Activation of superficial dorsal horn neurons in the mouse by a PAR-2 agonist and 5-HT: potential role in itch. J Neurosci (2009) 1.48

Discharge patterns of human C-fibers induced by itching and burning stimuli. J Neurophysiol (1991) 1.42

Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat. J Neurophysiol (2004) 1.39

Excitation of mouse superficial dorsal horn neurons by histamine and/or PAR-2 agonist: potential role in itch. J Neurophysiol (2009) 1.38

Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior. J Neurophysiol (2002) 1.36

Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol (2005) 1.34

Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch. Neurology (2004) 1.34

Histamine, histamine receptors and their role in immune pathology. Clin Exp Allergy (2009) 1.33

Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant (2009) 1.31

Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. Pain (2006) 1.29

Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy. Ann Oncol (2007) 1.28

Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol (2002) 1.26

Electrically evoked itch in humans. Pain (2005) 1.25

Imaging of central itch modulation in the human brain using positron emission tomography. Pain (2003) 1.24

Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One (2010) 1.24

An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli. Pain (2000) 1.22

The types of neuron in spinal dorsal horn which possess neurokinin-1 receptors. Neuroscience (1995) 1.19

Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis. J Comp Neurol (1995) 1.19

Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc Natl Acad Sci U S A (1994) 1.19

Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport (2008) 1.19

Mucunain, the active pruritogenic proteinase of cowhage. Science (1955) 1.18

Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies. Pain (2001) 1.16

Histamine release during morphine and fentanyl anesthesia. Anesthesiology (1982) 1.14

Itch evoked by electrical stimulation of the skin. J Invest Dermatol (1982) 1.10

Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol (1994) 1.10

Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. Arch Dermatol (2003) 1.09

Increased intraepithelial innervation in women with vulvar vestibulitis syndrome. Gynecol Obstet Invest (1998) 1.09

Itching after epidural and spinal opiates. Pain (1988) 1.05

The correlation between the distribution of the NK1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons. J Neurosci (1994) 1.03

Cerebral representation of the relief of itch by scratching. J Neurophysiol (2009) 1.02

Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study. Virchows Arch (1998) 1.01

Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol (1995) 1.00

Rostral spread of epidural morphine. Anesthesiology (1982) 0.99

The pruritus of cholestasis. J Hepatol (2005) 0.98

Randomised crossover trial of naltrexone in uraemic pruritus. Lancet (1996) 0.94

Effects of butorphanol on morphine-induced itch and analgesia in primates. Anesthesiology (2007) 0.94

Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions. J Invest Dermatol (2000) 0.94

Aprepitant as an antipruritic agent? N Engl J Med (2009) 0.91

Gastrin-releasing peptide: different forms, different functions. Biofactors (2009) 0.91

Antipruritic treatment with systemic μ-opioid receptor antagonists: a review. J Am Acad Dermatol (2010) 0.89

c-fos expression in superficial dorsal horn of cervical spinal cord associated with spontaneous scratching in rats with dry skin. Neurosci Lett (2003) 0.89

Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS Neurosci Ther (2010) 0.86

Pain as a complication of use of opiate antagonists for symptom control in cholestasis. Gastroenterology (2003) 0.86

Epidural-morphine-induced pruritus: propofol versus naloxone. Anesth Analg (1994) 0.82

Histamine receptors in human skin: indirect evidence. Br J Dermatol (1982) 0.82

Itch--mediators and mechanisms. J Dermatol Sci (2002) 0.81

How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom. Vascul Pharmacol (2006) 0.80

Efficacy of intrathecal morphine with epidural ropivacaine infusion for postcesarean analgesia. J Clin Anesth (2010) 0.80

Histamine as the chemical mediator for cutaneous pain. J Invest Dermatol (1977) 0.79

Unusual urticarias. J Dermatol (2001) 0.76

Articles by these authors

The neurobiology of itch. Nat Rev Neurosci (2006) 3.25

IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol (2006) 2.39

Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev (2006) 2.30

Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest (2007) 2.09

Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol (2006) 2.08

Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest (2006) 1.90

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal (2011) 1.75

Evaluation of protease-activated receptor 2 in murine models of arthritis. Arthritis Rheum (2007) 1.70

"Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J Invest Dermatol (2008) 1.64

Tumor immune escape by the loss of homeostatic chemokine expression. Proc Natl Acad Sci U S A (2007) 1.58

Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol (2004) 1.52

Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol (2011) 1.51

Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. Cancer Res (2006) 1.42

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J Biol Chem (2009) 1.27

The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest (2013) 1.27

Clinical, cellular, and molecular aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc (2011) 1.27

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A (2013) 1.26

Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases. J Invest Dermatol (2007) 1.25

Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J (2003) 1.22

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proc Natl Acad Sci U S A (2007) 1.21

Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol (2002) 1.21

Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. J Biol Chem (2007) 1.21

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol (2007) 1.20

Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharmacol (2003) 1.17

Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol (2005) 1.16

Retracted A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest (2004) 1.15

Efficacy and safety of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double-blind, and vehicle-controlled pivotal studies. J Drugs Dermatol (2013) 1.14

Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol (2002) 1.12

Neurophysiology of pruritus: cutaneous elicitation of itch. Arch Dermatol (2003) 1.12

Ubiquitin-dependent down-regulation of the neurokinin-1 receptor. J Biol Chem (2006) 1.12

Neurovascular and neuroimmune aspects in the pathophysiology of rosacea. J Investig Dermatol Symp Proc (2011) 1.10

Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. J Immunol (2002) 1.10

Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. Arch Dermatol (2003) 1.09

PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun (2011) 1.09

Proteinase-activated receptor-2 in the skin: receptor expression, activation and function during health and disease. Drug News Perspect (2008) 1.08

Recycling and resensitization of the neurokinin 1 receptor. Influence of agonist concentration and Rab GTPases. J Biol Chem (2004) 1.07

Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection. Am J Pathol (2006) 1.07

Proteinase-activated receptors: novel signals for peripheral nerves. Trends Neurosci (2003) 1.06

Successful treatment of generalized eruptive histiocytoma with PUVA. J Dtsch Dermatol Ges (2007) 1.05

IL-33: a novel danger signal system in atopic dermatitis. J Invest Dermatol (2012) 1.05

Mouse model of touch-evoked itch (alloknesis). J Invest Dermatol (2012) 1.04

Neurophysiology of pruritus: interaction of itch and pain. Arch Dermatol (2003) 1.03

Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea. J Invest Dermatol (2011) 1.02

Endothelin-converting enzyme-1 degrades internalized somatostatin-14. Endocrinology (2008) 1.01

Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol (2010) 0.98

Pruritus in elderly patients--eruptions of senescence. Semin Cutan Med Surg (2011) 0.98

Neuroimmune interactions in allergic skin diseases. Curr Opin Allergy Clin Immunol (2007) 0.97

Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies. J Drugs Dermatol (2014) 0.96

Agonists of proteinase-activated receptor-2 affect transendothelial migration and apoptosis of human neutrophils. Exp Dermatol (2007) 0.95

Functional characterization and expression analysis of the proteinase-activated receptor-2 in human cutaneous mast cells. J Invest Dermatol (2006) 0.94

Microfluidic reveals generation of platelet-strings on tumor-activated endothelium. Thromb Haemost (2007) 0.92

Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer. J Invest Dermatol (2009) 0.90

Role of protease-activated receptors in human skin fibrosis and scleroderma. Exp Dermatol (2011) 0.90

Pruritus: management algorithms and experimental therapies. Semin Cutan Med Surg (2011) 0.90

Proteinase-activated receptor-1 is an anti-inflammatory signal for colitis mediated by a type 2 immune response. Inflamm Bowel Dis (2005) 0.89

Management of itch in atopic dermatitis. Semin Cutan Med Surg (2011) 0.89

Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection. J Immunol (2008) 0.89

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones. J Physiol (2011) 0.88

Intermedin: a skin peptide that is downregulated in atopic dermatitis. J Invest Dermatol (2006) 0.88

Proteinase-activated receptor-2 (PAR2): a tumor suppressor in skin carcinogenesis. J Invest Dermatol (2007) 0.88

Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice. Am J Physiol Gastrointest Liver Physiol (2013) 0.87

Rosacea: The cytokine and chemokine network. J Investig Dermatol Symp Proc (2011) 0.87

Improvement in facial erythema within 30 minutes of initial application of brimonidine tartrate in patients with rosacea. J Drugs Dermatol (2014) 0.87

Role of spinal neurotransmitter receptors in itch: new insights into therapies and drug development. CNS Neurosci Ther (2010) 0.86

Pruritus and renal failure. Semin Cutan Med Surg (2011) 0.86

Psychoneuroimmunology of psychological stress and atopic dermatitis: pathophysiologic and therapeutic updates. Acta Derm Venereol (2012) 0.86

Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials. J Drugs Dermatol (2014) 0.86

PAR-2 inhibition reverses experimental pulmonary hypertension. Circ Res (2012) 0.85

Innovative management of pruritus. Dermatol Clin (2010) 0.85

Localization of mu-opioid receptor 1A on sensory nerve fibers in human skin. Regul Pept (2002) 0.84

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine. Am J Pathol (2011) 0.84

Thrombin receptor: An endogenous inhibitor of inflammatory pain, activating opioid pathways. Pain (2009) 0.84

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus. J Clin Invest (2014) 0.84

Agonist-induced endocytosis of rat somatostatin receptor 1. Endocrinology (2006) 0.83

Calcineurin inhibitors for the treatment of atopic dermatitis. Expert Opin Pharmacother (2008) 0.83

Histamine and antihistamines in atopic dermatitis. Adv Exp Med Biol (2010) 0.83

Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo. Exp Dermatol (2006) 0.83

Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis. Inflamm Res (2010) 0.82

Serum kallikrein-8 correlates with skin activity, but not psoriatic arthritis, in patients with psoriatic disease. Clin Chem Lab Med (2013) 0.82

Rosacea and small intestinal bacterial overgrowth: prevalence and response to rifaximin. J Am Acad Dermatol (2013) 0.82

Preliminary evidence for a role of mast cells in epidermal growth factor receptor inhibitor-induced pruritus. J Am Acad Dermatol (2010) 0.81

Pituitary adenylate cyclase activating polypeptide: an important vascular regulator in human skin in vivo. Am J Pathol (2010) 0.81

New tools for assessing the individual risk of metastasis in renal cell carcinoma. Clin Exp Metastasis (2012) 0.81

Role of proteinase-activated receptor-2 in anti-bacterial and immunomodulatory effects of interferon-γ on human neutrophils and monocytes. Immunology (2011) 0.81