Published in J Biol Chem on February 08, 2002
Lack of heme synthesis in a free-living eukaryote. Proc Natl Acad Sci U S A (2005) 1.95
Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug. Exp Parasitol (2009) 1.26
Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro. Antimicrob Agents Chemother (2005) 1.17
Intracellular trafficking of porphyrins. ACS Chem Biol (2006) 1.13
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. PLoS One (2009) 1.05
Development of Vaccines against Visceral Leishmaniasis. J Trop Med (2011) 1.03
Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway. Exp Parasitol (2007) 1.02
Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts. PLoS One (2011) 1.00
Genome-wide analysis reveals novel genes essential for heme homeostasis in Caenorhabditis elegans. PLoS Genet (2010) 0.99
Intracellular targeting specificity of novel phthalocyanines assessed in a host-parasite model for developing potential photodynamic medicine. PLoS One (2011) 0.98
Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth. Proc Natl Acad Sci U S A (2008) 0.95
Molecular determinants and regulation of Leishmania virulence. Kinetoplastid Biol Dis (2002) 0.95
Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani. EMBO J (2003) 0.94
Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. Enzyme Res (2011) 0.93
Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis. Eur J Immunol (2009) 0.90
Combinational sensitization of Leishmania with uroporphyrin and aluminum phthalocyanine synergistically enhances their photodynamic inactivation in vitro and in vivo. Photochem Photobiol (2012) 0.86
Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS. PLoS One (2011) 0.84
Delta-aminolevulinate-induced host-parasite porphyric disparity for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: a potential novel platform for vaccine delivery. Eukaryot Cell (2012) 0.82
Functional Characterization of Monomeric GTPase Rab1 in the Secretory Pathway of Leishmania. J Biol Chem (2015) 0.81
Identification of specific inhibitors for a trypanosomatid RNA editing reaction. RNA (2010) 0.81
Cellular growth and mitochondrial ultrastructure of leishmania (Viannia) braziliensis promastigotes are affected by the iron chelator 2,2-dipyridyl. PLoS Negl Trop Dis (2013) 0.79
Aminophthalocyanine-Mediated Photodynamic Inactivation of Leishmania tropica. Antimicrob Agents Chemother (2016) 0.78
In vitro and in vivo studies of the utility of dimethyl and diethyl carbaporphyrin ketals in treatment of cutaneous leishmaniasis. Antimicrob Agents Chemother (2011) 0.78
Leishmania major possesses a unique HemG-type protoporphyrinogen IX oxidase. Biosci Rep (2014) 0.76
New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasit Vectors (2016) 0.75
Vaccination for Disease Prevention and Control: the Necessity of Renewed Emphasis and New Approaches. J Immunol Immunotech (2014) 0.75
Host-bacterial mutualism in the human intestine. Science (2005) 26.39
Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell (2006) 18.83
SolexaQA: At-a-glance quality assessment of Illumina second-generation sequencing data. BMC Bioinformatics (2010) 9.47
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci U S A (2010) 6.10
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell (2011) 4.08
Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05
Identification of a human heme exporter that is essential for erythropoiesis. Cell (2004) 2.66
Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J Neurosci (2002) 2.35
Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination. Nat Methods (2005) 2.09
When neurogenesis encounters aging and disease. Trends Neurosci (2010) 1.73
Diversification of the gut symbiont Lactobacillus reuteri as a result of host-driven evolution. ISME J (2009) 1.73
Enhanced survival of the LINCL mouse following CLN2 gene transfer using the rh.10 rhesus macaque-derived adeno-associated virus vector. Mol Ther (2006) 1.71
Targeted retrograde gene delivery for neuronal protection. Mol Ther (2002) 1.59
Acute psychosocial stress reduces cell survival in adult hippocampal neurogenesis without altering proliferation. J Neurosci (2007) 1.58
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58
Gut microbiome composition is linked to whole grain-induced immunological improvements. ISME J (2012) 1.54
Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide? Antioxid Redox Signal (2004) 1.32
Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications for parasite virulence. J Biol Chem (2002) 1.21
Cloning, expression, and purification of a novel recombinant antigen from Leishmania donovani. Protein Expr Purif (2005) 1.19
Transmembrane molecules for phylogenetic analyses of pathogenic protists: Leishmania-specific informative sites in hydrophilic loops of trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase. Eukaryot Cell (2006) 1.19
D1 dopamine receptor stimulation increases GluR1 surface expression in nucleus accumbens neurons. J Neurochem (2002) 1.18
Photodynamic sensitization of Leishmania amazonensis in both extracellular and intracellular stages with aluminum phthalocyanine chloride for photolysis in vitro. Antimicrob Agents Chemother (2005) 1.17
Human mesenchymal stem cell grafts enhance normal and impaired wound healing by recruiting existing endogenous tissue stem/progenitor cells. Stem Cells Transl Med (2012) 1.14
Dextramers: new generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells. J Immunol Methods (2006) 1.13
Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63. Infect Immun (2003) 1.13
Survival advantage of neonatal CNS gene transfer for late infantile neuronal ceroid lipofuscinosis. Exp Neurol (2008) 1.13
Sand fly specificity of saliva-mediated protective immunity in Leishmania amazonensis-BALB/c mouse model. Microbes Infect (2005) 1.11
Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice. Genome Biol (2014) 1.10
A microplate assay for Leishmania amazonensis promastigotes expressing multimeric green fluorescent protein. Parasitol Res (2002) 1.10
Neurogenesis and brain injury: managing a renewable resource for repair. J Clin Invest (2003) 1.08
Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes. Infect Immun (2010) 1.07
Laser microdissection separation of pure spermatozoa from epithelial cells for short tandem repeat analysis. J Forensic Sci (2006) 1.07
Real-time in vivo green fluorescent protein imaging of a murine leishmaniasis model as a new tool for Leishmania vaccine and drug discovery. Clin Vaccine Immunol (2008) 1.07
Aberrant iron accumulation and oxidized status of erythroid-specific delta-aminolevulinate synthase (ALAS2)-deficient definitive erythroblasts. Blood (2002) 1.06
Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells. Aging Cell (2011) 1.04
Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway. Exp Parasitol (2007) 1.02
Acute exposure to predator odor elicits a robust increase in corticosterone and a decrease in activity without altering proliferation in the adult rat hippocampus. Exp Neurol (2006) 1.01
Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. J Biol Chem (2003) 0.98
Location of T-cell epitopes in nonstructural proteins 9 and 10 of type-II porcine reproductive and respiratory syndrome virus. Virus Res (2012) 0.96
Neural stem cells as therapeutic agents for age-related brain repair. Aging Cell (2004) 0.95
Detection and characterization of variant Salmonella genomic island 1s from Salmonella Derby isolates. Jpn J Infect Dis (2006) 0.95
Impaired therapeutic capacity of autologous stem cells in a model of type 2 diabetes. Stem Cells Transl Med (2012) 0.94
Late-onset X-linked sideroblastic anemia following hemodialysis. Blood (2003) 0.94
Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Mol Biochem Parasitol (2007) 0.93
The colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhances adaptive immune responses to a bacterial antigen. PLoS One (2012) 0.93
Cytoprotective effects of heme oxygenase in acute renal failure. Contrib Nephrol (2005) 0.93
Comparison of conventional and polymerase chain reaction diagnostic techniques for leishmaniasis in the endemic region of Adana, Turkey. Int J Dermatol (2006) 0.92
Intensity-modulated radiation therapy using static ports of tomotherapy (TomoDirect): comparison with the TomoHelical mode. Radiat Oncol (2013) 0.90
Photodynamic vaccination of hamsters with inducible suicidal mutants of Leishmania amazonensis elicits immunity against visceral leishmaniasis. Eur J Immunol (2009) 0.90
delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations. Mol Genet Metab (2005) 0.89
Cytoarchitecture of fibroblast growth factor receptor 2 (FGFR-2) immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain. J Comp Neurol (2006) 0.89
Diagnostic value of rK39 dipstick in zoonotic visceral leishmaniasis in Turkey. J Parasitol (2004) 0.89
Cell-specific expression of neuropeptide Y Y1 receptor immunoreactivity in the rat basolateral amygdala. J Comp Neurol (2009) 0.88
Down-regulation of gp63 level in Leishmania amazonensis promastigotes reduces their infectivity in BALB/c mice. Microbes Infect (2006) 0.88
The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury. Crit Care Med (2005) 0.87
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway. FEBS J (2008) 0.87
Protective role of heme oxygenase-1 in renal ischemia. Antioxid Redox Signal (2004) 0.87
A protective role of interleukin 11 on hepatic injury in acute endotoxemia. Shock (2004) 0.86
Multiple mechanisms for hereditary sideroblastic anemia. Cell Mol Biol (Noisy-le-grand) (2002) 0.86
Modification of pax6 and olig2 expression in adult hippocampal neurogenesis selectively induces stem cell fate and alters both neuronal and glial populations. Stem Cells (2012) 0.85
Fundamental role of heme oxygenase in the protection against ischemic acute renal failure. Jpn J Pharmacol (2002) 0.85
Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis. Crit Care Med (2003) 0.85
Even neural stem cells get the blues: evidence for a molecular link between modulation of adult neurogenesis and depression. Gene Expr (2008) 0.84
Insights into neurogenesis and aging: potential therapy for degenerative disease? Future Neurol (2010) 0.84
CYP2E1 overexpression up-regulates both non-specific delta-aminolevulinate synthase and heme oxygenase-1 in the human hepatoma cell line HLE/2E1. Int J Mol Med (2003) 0.84
Consistence of miniexon polymerase chain reaction-restriction fragment length polymorphism and single-copy gene sequence analyses in discriminating Leishmania genotypes. Diagn Microbiol Infect Dis (2006) 0.83
Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex. J Neurosci (2006) 0.83
Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J (2011) 0.83
Arg452 substitution of the erythroid-specific 5-aminolaevulinate synthase, a hot spot mutation in X-linked sideroblastic anaemia, does not itself affect enzyme activity. Eur J Haematol (2006) 0.82
Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease. Nephron Clin Pract (2014) 0.82
Comparison of Salmonella enterica serovar Abortusequi isolates of equine origin by pulsed-field gel electrophoresis and fluorescent amplified-fragment length polymorphism fingerprinting. Vet Microbiol (2003) 0.82
Highly liver-specific heme oxygenase-1 induction by interleukin-11 prevents carbon tetrachloride-induced hepatotoxicity. Int J Mol Med (2006) 0.82
Delta-aminolevulinate-induced host-parasite porphyric disparity for selective photolysis of transgenic Leishmania in the phagolysosomes of mononuclear phagocytes: a potential novel platform for vaccine delivery. Eukaryot Cell (2012) 0.82
Oxidative stress is involved in hydroxyurea-induced erythroid differentiation. Br J Haematol (2003) 0.82
Differential gene expression profiling between wild-type and ALAS2-null erythroblasts: identification of novel heme-regulated genes. Biochem Biophys Res Commun (2005) 0.82
The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies. Parasitology (2013) 0.81
Down-regulation of gp63 in Leishmania amazonensis reduces its early development in Lutzomyia longipalpis. Microbes Infect (2004) 0.81
Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient. Br J Haematol (2006) 0.80
Flow cytometric screening for anti-leishmanials in a human macrophage cell line. Exp Parasitol (2010) 0.78
Porphyrias in Japan: compilation of all cases reported through 2002. Int J Hematol (2004) 0.78
A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol. J Antimicrob Chemother (2013) 0.77
A neurogenic theory of depression gains momentum. Mol Interv (2003) 0.77
First isolation of Actinobacillus genomospecies 2 in Japan. J Vet Med Sci (2015) 0.75
Images: keep a distinction between beauty and truth. Nature (2005) 0.75
Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders. J Comp Neurol (2014) 0.75
Micro- and Macroevolutionary Trade-Offs in Plant-Feeding Insects. Am Nat (2016) 0.75
[Heme biosynthesis and iron metabolism]. Seikagaku (2003) 0.75
[Contribution of Japanese researchers to progress in the field of hematology in the last 100 years: Porphyria/congenital heme synthetase deficiency]. Nihon Naika Gakkai Zasshi (2002) 0.75
Retraction. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity (2009) 0.75
Corrigendum: The Mouse Intestinal Bacterial Collection (miBC) provides host-specific insight into cultured diversity and functional potential of the gut microbiota. Nat Microbiol (2016) 0.75
Changes in the Gut Microbiota After Early Administration of Oral Synbiotics to Young Infants in India. J Pediatr Gastroenterol Nutr (2017) 0.75
The expression system of biologically active canine interleukin-8 in Leishmania promastigotes. Parasitol Int (2002) 0.75