Published in Oncogene on February 07, 2002
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. BMC Dev Biol (2006) 2.50
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol (2010) 2.38
Agglomerative epigenetic aberrations are a common event in human breast cancer. Cancer Res (2008) 2.22
Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem (2005) 1.84
Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res (2012) 1.78
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation. Genome Res (2010) 1.77
An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet (2008) 1.49
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol (2005) 1.45
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis. Adv Genet (2010) 1.44
Senescent cells harbour features of the cancer epigenome. Nat Cell Biol (2013) 1.34
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32
DNA methylation patterns in lung carcinomas. Semin Cancer Biol (2009) 1.25
High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis. J Mol Diagn (2009) 1.21
DNA methylation as a marker for the past and future. J Gastroenterol (2006) 1.20
TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res (2014) 1.19
Rapid analysis of CpG methylation patterns using RNase T1 cleavage and MALDI-TOF. Nucleic Acids Res (2004) 1.10
The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res (2011) 1.09
Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription. BMC Genomics (2011) 1.08
Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res (2006) 1.01
Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia. Gut Liver (2007) 0.94
Novel method for high throughput DNA methylation marker evaluation using PNA-probe library hybridization and MALDI-TOF detection. Nucleic Acids Res (2006) 0.94
Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island. Nucleic Acids Res (2012) 0.93
Epigenetics in prostate cancer. Prostate Cancer (2011) 0.92
Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis. DNA Res (2009) 0.91
Silencing of mouse Aprt is a gradual process in differentiated cells. Mol Cell Biol (2003) 0.91
Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha. J Biol Chem (2009) 0.88
Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding. PLoS One (2012) 0.86
Validation of DAB2IP methylation and its relative significance in predicting outcome in renal cell carcinoma. Oncotarget (2016) 0.85
Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin Exp Med (2009) 0.84
Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins. Am J Pathol (2006) 0.83
Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia. Leuk Res (2013) 0.83
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol (2016) 0.82
DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation. Cell Death Differ (2014) 0.80
Cytostatic drug treatment causes seeding of gene promoter methylation. Eur J Cancer (2007) 0.80
Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus. Hum Genet (2007) 0.76
Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer. Oncogene (2016) 0.75
Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation. Mutat Res (2010) 0.75
Comprehensive evaluation of genome-wide 5-hydroxymethylcytosine profiling approaches in human DNA. Epigenetics Chromatin (2017) 0.75
The degree of methylation burden is determined by the exposure period to carcinogenic factors. Cancer Sci (2016) 0.75
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet (2006) 4.86
Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology (2008) 3.89
miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. EMBO J (2011) 3.55
DNA methylation: bisulphite modification and analysis. Nat Protoc (2006) 3.44
Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements. Nucleic Acids Res (2007) 2.80
The information-seeking behaviour of doctors: a review of the evidence. Health Info Libr J (2007) 2.74
Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. Int J Cancer (2011) 2.49
Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity. Nat Cell Biol (2010) 2.38
Identification and resolution of artifacts in bisulfite sequencing. Methods (2002) 2.27
Regional activation of the cancer genome by long-range epigenetic remodeling. Cancer Cell (2012) 1.91
Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res (2004) 1.89
Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA. Genome Res (2012) 1.78
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation. Genome Res (2010) 1.77
Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias. Epigenetics (2011) 1.76
DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol Oncol (2008) 1.69
Epigenetics in prostate cancer: biologic and clinical relevance. Eur Urol (2011) 1.49
Repitools: an R package for the analysis of enrichment-based epigenomic data. Bioinformatics (2010) 1.45
Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancer. Genome Res (2011) 1.39
Protocol matters: which methylome are you actually studying? Epigenomics (2010) 1.37
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. J Thorac Oncol (2011) 1.33
Methylation sequencing from limiting DNA: embryonic, fixed, and microdissected cells. Methods (2002) 1.30
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation. PLoS Genet (2006) 1.26
Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer. Cancer Res (2007) 1.23
Conversion-specific detection of DNA methylation using real-time polymerase chain reaction (ConLight-MSP) to avoid false positives. Methods (2002) 1.23
MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS One (2011) 1.23
Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning. Hum Mol Genet (2009) 1.20
Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer. Gynecol Oncol (2011) 1.17
ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer. PLoS Biol (2012) 1.16
Impact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twins. PLoS One (2011) 1.16
Low O6-methylguanine-DNA methyltransferase (MGMT) expression and response to temozolomide in aggressive pituitary tumours. Clin Endocrinol (Oxf) (2008) 1.15
Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Res (2007) 1.15
Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflamm Bowel Dis (2011) 1.14
Copy-number-aware differential analysis of quantitative DNA sequencing data. Genome Res (2012) 1.12
Discovery pipeline for epigenetically deregulated miRNAs in cancer: integration of primary miRNA transcription. BMC Genomics (2011) 1.08
Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice. BMC Physiol (2008) 1.07
Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events. BMC Cancer (2012) 1.05
Breast cancer epigenetics: normal human mammary epithelial cells as a model system. J Mol Med (Berl) (2008) 1.03
Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers. Cancer Lett (2011) 1.02
DNA methylation changes in leukaemia. Semin Cancer Biol (2002) 1.02
Lineage specific methylation of the Elf5 promoter in mammary epithelial cells. Stem Cells (2011) 0.97
Epigenetic deregulation across chromosome 2q14.2 differentiates normal from prostate cancer and provides a regional panel of novel DNA methylation cancer biomarkers. Cancer Epidemiol Biomarkers Prev (2010) 0.97
Identifying information needs of people with multiple sclerosis. Nurs Times (2004) 0.95
Headloop suppression PCR and its application to selective amplification of methylated DNA sequences. Nucleic Acids Res (2005) 0.95
NGSANE: a lightweight production informatics framework for high-throughput data analysis. Bioinformatics (2014) 0.93
BayMeth: improved DNA methylation quantification for affinity capture sequencing data using a flexible Bayesian approach. Genome Biol (2014) 0.93
Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Oncogene (2005) 0.91
Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma. BMC Genomics (2014) 0.91
Epigenetic architecture and miRNA: reciprocal regulators. Epigenomics (2010) 0.91
Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts. Oncogene (2004) 0.90
A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer. Biomaterials (2013) 0.89
BCL-2 hypermethylation is a potential biomarker of sensitivity to antimitotic chemotherapy in endocrine-resistant breast cancer. Mol Cancer Ther (2013) 0.88
Clinical librarianship in the UK: temporary trend or permanent profession? Part I: a review of the role of the clinical librarian. Health Info Libr J (2004) 0.86
DNA methylation analysis in mammalian cells. Methods (2002) 0.85
Exploring and exploiting the aberrant DNA methylation profile of endocrine-resistant breast cancer. Epigenomics (2013) 0.84
Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis. Breast Cancer Res (2012) 0.84
Epigenetic markers of ovarian cancer. Adv Exp Med Biol (2008) 0.82
Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells. Epigenetics (2011) 0.81
ZNF300P1 encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer. Mol Cancer (2014) 0.79
Chromatin remodeler mutations in human cancers: epigenetic implications. Epigenomics (2014) 0.79
Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells. Cancer Res (2006) 0.79
Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways. Breast Cancer Res (2014) 0.79
Improved detection of gastrointestinal pathogens using generalised sample processing and amplification panels. Pathology (2014) 0.78
Bisulphite differential denaturation PCR for analysis of DNA methylation. Epigenetics (2006) 0.76
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association. Twin Res Hum Genet (2013) 0.75
Incidence of low free T4 values in premature infants as determined by direct equilibrium dialysis. J Perinatol (2004) 0.75
Hormonal and Metabolic Responses to a Single Bout of Resistance Exercise in Prader-Willi Syndrome . Horm Res Paediatr (2017) 0.75
Cytokine Responses to Acute Intermittent Aerobic Exercise in Children With Prader-Willi Syndrome and Nonsyndromic Obesity. Pediatr Exerc Sci (2015) 0.75
Integrating the CEREC technology at UT College of Dentistry. J Tenn Dent Assoc (2012) 0.75
Opportunities for change: the future roles of the health library and information professional. Health Info Libr J (2006) 0.75