Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex.

PubWeight™: 2.47‹?› | Rank: Top 2%

🔗 View Article (PMID 11856535)

Published in Neuron on February 14, 2002

Authors

Martine Hamann1, David J Rossi, David Attwell

Author Affiliations

1: Department of Physiology, University College London, Gower Street, WC1E 6BT, London, United Kingdom.

Articles citing this

(truncated to the top 100)

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2003) 4.33

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21

Extrasynaptic GABA(A) receptors: their function in the CNS and implications for disease. Neuron (2012) 2.40

Extrasynaptic GABAA receptors: form, pharmacology, and function. J Neurosci (2009) 2.39

Different transmitter transients underlie presynaptic cell type specificity of GABAA,slow and GABAA,fast. Proc Natl Acad Sci U S A (2007) 1.88

Multiple modes of GABAergic inhibition of rat cerebellar granule cells. J Physiol (2003) 1.88

Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration. Neuron (2009) 1.79

Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus. J Physiol (2006) 1.74

Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why? Prog Biophys Mol Biol (2005) 1.74

Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron (2007) 1.57

Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices. J Physiol (2005) 1.50

Aspects of the homeostaic plasticity of GABAA receptor-mediated inhibition. J Physiol (2004) 1.42

Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors. Mol Pharmacol (2004) 1.31

Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover. J Neurosci (2011) 1.31

GABAA receptor kinetics in the cerebellar nuclei: evidence for detection of transmitter from distant release sites. Biophys J (2004) 1.23

Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. J Neurosci (2006) 1.22

Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS One (2007) 1.22

High-affinity, slowly desensitizing GABAA receptors mediate tonic inhibition in hippocampal dentate granule cells. Mol Pharmacol (2005) 1.21

Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem (2010) 1.19

Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. Eur J Neurosci (2009) 1.18

Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. J Neurophysiol (2009) 1.18

Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? Neuroscience (2006) 1.15

The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses. J Physiol (2003) 1.14

Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability. Psychopharmacology (Berl) (2013) 1.14

Neurosteroid regulation of central nervous system development. Pharmacol Ther (2007) 1.12

Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats. J Physiol (2005) 1.10

Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism. J Neurosci (2011) 1.10

Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies. Alcohol (2007) 1.10

Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters. J Physiol (2009) 1.09

Puberty, steroids and GABA(A) receptor plasticity. Psychoneuroendocrinology (2009) 1.06

Are extrasynaptic GABAA receptors important targets for sedative/hypnotic drugs? J Neurosci (2012) 1.06

Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. J Physiol (2007) 1.04

The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex. J Neurosci (2011) 1.02

Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol (2003) 1.02

Raising cytosolic Cl- in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J (2012) 1.00

Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons. J Physiol (2010) 1.00

Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current. PLoS One (2011) 0.98

Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals. Neurobiol Dis (2010) 0.97

γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting. J Biol Chem (2012) 0.96

Temporal regulation of nuclear factor one occupancy by calcineurin/NFAT governs a voltage-sensitive developmental switch in late maturing neurons. J Neurosci (2013) 0.95

Presynaptic GABAA receptors facilitate GABAergic transmission to dopaminergic neurons in the ventral tegmental area of young rats. J Physiol (2007) 0.93

Balanced excitatory and inhibitory synaptic currents promote efficient coding and metabolic efficiency. PLoS Comput Biol (2013) 0.93

Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures. J Physiol (2006) 0.93

Repetitive firing of rat cerebellar parallel fibres after a single stimulation. J Physiol (2003) 0.92

Acting locally but sensing globally: impact of GABAergic synaptic plasticity on phasic and tonic inhibition in the thalamus. J Physiol (2008) 0.92

Relationship between tonic inhibitory currents and phasic inhibitory activity in the spinal cord lamina II region of adult mice. Mol Pain (2006) 0.92

NMDA receptors with incomplete Mg²⁺ block enable low-frequency transmission through the cerebellar cortex. J Neurosci (2012) 0.91

The cerebellar Golgi cell and spatiotemporal organization of granular layer activity. Front Neural Circuits (2013) 0.90

Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity. Front Syst Neurosci (2014) 0.89

In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. J Physiol (2007) 0.89

Wakefulness Is Governed by GABA and Histamine Cotransmission. Neuron (2015) 0.89

GABA as a rising gliotransmitter. Front Neural Circuits (2014) 0.89

Bestrophin1 Channels are Insensitive to Ethanol and Do not Mediate Tonic GABAergic Currents in Cerebellar Granule Cells. Front Neurosci (2012) 0.88

Menthol enhances phasic and tonic GABAA receptor-mediated currents in midbrain periaqueductal grey neurons. Br J Pharmacol (2014) 0.88

Methods for recording and measuring tonic GABAA receptor-mediated inhibition. Front Neural Circuits (2013) 0.88

Postdepolarization potentiation of GABAA receptors: a novel mechanism regulating tonic conductance in hippocampal neurons. J Neurosci (2010) 0.88

Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations. J Neurosci (2014) 0.87

Looking for GABA in all the wrong places: the relevance of extrasynaptic GABA(A) receptors to epilepsy. Epilepsy Curr (2005) 0.87

Neurosteroid influences on sensitivity to ethanol. Front Endocrinol (Lausanne) (2012) 0.87

Structure, function, and plasticity of GABA transporters. Front Cell Neurosci (2014) 0.86

Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING. J Biol Chem (2015) 0.86

Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity. Nat Neurosci (2013) 0.86

Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. Neurochem Int (2009) 0.86

Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats. Neuropharmacology (2013) 0.85

Function and modulation of delta-containing GABA(A) receptors. Psychoneuroendocrinology (2009) 0.85

Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition. Proc Natl Acad Sci U S A (2015) 0.85

Pre- and postsynaptic modulation of monosynaptic reflex by GABAA receptors on turtle spinal cord. J Physiol (2010) 0.85

Role of central neurotransmission and chemoreception on airway control. Respir Physiol Neurobiol (2010) 0.83

Upregulation of high-affinity GABA(A) receptors in cultured rat dorsal root ganglion neurons. Neuroscience (2012) 0.83

The contribution of δ subunit-containing GABAA receptors to phasic and tonic conductance changes in cerebellum, thalamus and neocortex. Front Neural Circuits (2013) 0.83

Neuronal network analyses: premises, promises and uncertainties. Philos Trans R Soc Lond B Biol Sci (2010) 0.83

A TRP among the astrocytes. J Physiol (2012) 0.83

Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. Front Cell Neurosci (2014) 0.82

Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome. Brain Res (2012) 0.82

Nuclear factor I and cerebellar granule neuron development: an intrinsic-extrinsic interplay. Cerebellum (2012) 0.82

Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci (2013) 0.82

The population firing rate in the presence of GABAergic tonic inhibition in single neurons and application to general anaesthesia. Cogn Neurodyn (2011) 0.82

Neurosteroids and GABA-A Receptor Function. Front Endocrinol (Lausanne) (2011) 0.82

Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness. Sleep (2013) 0.81

Pathophysiological power of improper tonic GABA(A) conductances in mature and immature models. Front Neural Circuits (2013) 0.81

Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells. PLoS One (2013) 0.80

Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype. Front Neural Circuits (2013) 0.80

Cerebellar Golgi cells in the rat receive convergent peripheral inputs via a lateral reticular nucleus relay. Eur J Neurosci (2010) 0.80

Golgi cell-mediated activation of postsynaptic GABA(B) receptors induces disinhibition of the Golgi cell-granule cell synapse in rat cerebellum. PLoS One (2012) 0.80

Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia. J Comput Neurosci (2014) 0.79

GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation. Eur J Neurosci (2014) 0.79

Homeostatic competition between phasic and tonic inhibition. J Biol Chem (2013) 0.79

Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential. Channels (Austin) (2011) 0.79

GABAA alpha6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. J Biol Chem (2007) 0.79

Normalization of input patterns in an associative network. J Neurophysiol (2013) 0.78

Single granule cells excite Golgi cells and evoke feedback inhibition in the cochlear nucleus. J Neurosci (2015) 0.78

Active Dendrites and Differential Distribution of Calcium Channels Enable Functional Compartmentalization of Golgi Cells. J Neurosci (2015) 0.78

Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy. Mol Biol Cell (2011) 0.77

Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions. Psychopharmacology (Berl) (2014) 0.77

Fast detection of extrasynaptic GABA with a whole-cell sniffer. Front Cell Neurosci (2014) 0.76

Delta-subunit-containing GABAA-receptors mediate tonic inhibition in paracapsular cells of the mouse amygdala. Front Neural Circuits (2014) 0.76

Mechanisms for motor timing in the cerebellar cortex. Curr Opin Behav Sci (2016) 0.76

Modulation of the input-output function by GABAA receptor-mediated currents in rat oculomotor nucleus motoneurons. J Physiol (2014) 0.76

GABAA , NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus. Eur J Neurosci (2013) 0.76

Activation and integration of bilateral GABA-mediated synaptic inputs in neonatal rat sympathetic preganglionic neurones in vitro. J Physiol (2003) 0.76

Articles by these authors

Bidirectional control of CNS capillary diameter by pericytes. Nature (2006) 5.27

Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature (2005) 3.25

Do astrocytes really exocytose neurotransmitters? Nat Rev Neurosci (2010) 3.17

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter. Nat Neurosci (2008) 2.97

Synaptic energy use and supply. Neuron (2012) 2.40

Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron (2013) 2.33

Multiple modes of GABAergic inhibition of rat cerebellar granule cells. J Physiol (2003) 1.88

Updated energy budgets for neural computation in the neocortex and cerebellum. J Cereb Blood Flow Metab (2012) 1.81

The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70

Regulation of oligodendrocyte development and myelination by glucose and lactate. J Neurosci (2011) 1.67

The energetics of CNS white matter. J Neurosci (2012) 1.63

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease. Front Neuroenergetics (2010) 1.59

Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices. J Physiol (2005) 1.50

Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing. J Neurosci (2012) 1.47

A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. J Neurosci (2005) 1.37

Endocannabinoid signaling depends on the spatial pattern of synapse activation. Nat Neurosci (2005) 1.30

The physiology of developmental changes in BOLD functional imaging signals. Dev Cogn Neurosci (2011) 1.26

Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse. J Neurosci (2012) 1.24

Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol (2002) 1.24

Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences. Prog Biophys Mol Biol (2005) 1.24

The role of glial glutamate transporters in maintaining the independent operation of juvenile mouse cerebellar parallel fibre synapses. J Physiol (2003) 1.14

Testing NMDA receptor block as a therapeutic strategy for reducing ischaemic damage to CNS white matter. Glia (2008) 1.10

Control of intracellular chloride concentration and GABA response polarity in rat retinal ON bipolar cells. J Physiol (2002) 1.08

Short- and long-term depression of rat cerebellar parallel fibre synaptic transmission mediated by synaptic crosstalk. J Physiol (2006) 1.07

Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum. J Physiol (2010) 1.07

Role of glial amino acid transporters in synaptic transmission and brain energetics. Glia (2004) 1.06

The ionic stoichiometry of the GLAST glutamate transporter in salamander retinal glia. J Physiol (2006) 1.06

Sequential release of GABA by exocytosis and reversed uptake leads to neuronal swelling in simulated ischemia of hippocampal slices. J Neurosci (2004) 1.06

The energy use associated with neural computation in the cerebellum. J Cereb Blood Flow Metab (2009) 1.04

Assessing the physiological concentration and targets of nitric oxide in brain tissue. J Physiol (2008) 1.03

Combining patch-clamping of cells in brain slices with immunocytochemical labeling to define cell type and developmental stage. Nat Protoc (2006) 1.00

Another BOLD role for astrocytes: coupling blood flow to neural activity. Nat Neurosci (2006) 0.99

The electrical response of cerebellar Purkinje neurons to simulated ischaemia. Brain (2005) 0.98

Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence. Proc Natl Acad Sci U S A (2011) 0.97

Neurotransmitter depletion by bafilomycin is promoted by vesicle turnover. Neurosci Lett (2006) 0.97

The effect of simulated ischaemia on spontaneous GABA release in area CA1 of the juvenile rat hippocampus. J Physiol (2004) 0.97

The node of Ranvier in CNS pathology. Acta Neuropathol (2014) 0.97

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain (2009) 0.94

Electrical signalling properties of oligodendrocyte precursor cells. Neuron Glia Biol (2009) 0.93

A role for glutamate transporters in the regulation of insulin secretion. PLoS One (2011) 0.92

Active release of glycine or D-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse. Eur J Neurosci (2003) 0.90

Neurobiology: feeding the brain. Nature (2004) 0.90

Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur J Neurosci (2002) 0.89

Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. Pflugers Arch (2004) 0.89

The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Mol Cell Neurosci (2002) 0.89

The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells. Brain (2010) 0.89

The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes. J Physiol (2010) 0.88

Neurosteroid influences on sensitivity to ethanol. Front Endocrinol (Lausanne) (2012) 0.87

Opposite actions of alcohol on tonic GABA(A) receptor currents mediated by nNOS and PKC activity. Nat Neurosci (2013) 0.86

The cortical energy needed for conscious perception. Neuroimage (2008) 0.84

Why do oligodendrocyte lineage cells express glutamate receptors? F1000 Biol Rep (2010) 0.82

Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. Eur J Neurosci (2008) 0.82

Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices. Neuropharmacology (2009) 0.81

Release of L-aspartate by reversal of glutamate transporters. Neuropharmacology (2005) 0.81

Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons. Ann Neurol (2014) 0.80

Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype. Front Neural Circuits (2013) 0.80

Simulated ischaemia induces Ca2+-independent glutamatergic vesicle release through actin filament depolymerization in area CA1 of the hippocampus. J Physiol (2010) 0.80

An astrocyte TRP switch for inhibition. Nat Neurosci (2011) 0.78

Is myelin a mitochondrion? J Cereb Blood Flow Metab (2012) 0.78

Neuroscience: Brain power. Nature (2008) 0.77

Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal. Psychopharmacology (Berl) (2014) 0.77

Transports of delight. Neuron (2006) 0.75

Corrigendum: Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nat Neurosci (2017) 0.75