Published in J Physiol on December 21, 2006
Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. J Neurosci (2008) 2.14
Extracellular glutamate concentration in hippocampal slice. J Neurosci (2007) 2.13
Developmental switch in the contribution of presynaptic and postsynaptic NMDA receptors to long-term depression. J Neurosci (2007) 1.81
Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine. J Neurosci (2009) 1.72
Synapse-specific expression of functional presynaptic NMDA receptors in rat somatosensory cortex. J Neurosci (2008) 1.61
Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. Eur J Neurosci (2010) 1.51
Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity. Neuroscientist (2008) 1.51
Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci (2013) 1.44
Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. J Neurosci (2008) 1.30
NMDA receptor activation strengthens weak electrical coupling in mammalian brain. Neuron (2014) 1.30
Inhibition of NMDARs in the Nucleus Reticularis of the Thalamus Produces Delta Frequency Bursting. Front Neural Circuits (2009) 1.28
Glial regulation of neuronal function: from synapse to systems physiology. J Neuroendocrinol (2012) 1.11
State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signalling in neurosecretory neurons. J Physiol (2011) 1.08
Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes. Front Pharmacol (2012) 1.06
Regulation of synaptic transmission by ambient extracellular glutamate. Neuroscientist (2007) 1.05
Physiological fluctuations in brain temperature as a factor affecting electrochemical evaluations of extracellular glutamate and glucose in behavioral experiments. ACS Chem Neurosci (2013) 1.02
The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine. J Physiol (2009) 0.98
A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity. BMC Neurosci (2008) 0.96
Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons. J Neurophysiol (2012) 0.95
Recent insights into the mode of action of memantine and ketamine. Curr Opin Pharmacol (2014) 0.94
Organization, control and function of extrasynaptic NMDA receptors. Philos Trans R Soc Lond B Biol Sci (2014) 0.93
Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons. J Neurosci (2013) 0.93
GABA release by hippocampal astrocytes. Front Comput Neurosci (2012) 0.93
α7 Nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model. PLoS One (2013) 0.91
Activation of the tonic GABAC receptor current in retinal bipolar cell terminals by nonvesicular GABA release. J Neurophysiol (2009) 0.91
Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity. Front Syst Neurosci (2014) 0.89
Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. Am J Physiol Regul Integr Comp Physiol (2012) 0.89
Endogenous activation of presynaptic NMDA receptors enhances glutamate release from the primary afferents in the spinal dorsal horn in a rat model of neuropathic pain. J Physiol (2013) 0.89
Pharmacological stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat. Psychopharmacology (Berl) (2008) 0.89
The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology (Berl) (2010) 0.89
Backpropagating action potentials enable detection of extrasynaptic glutamate by NMDA receptors. Cell Rep (2012) 0.88
Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla. J Neurophysiol (2013) 0.86
Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine. Neurochem Int (2009) 0.86
Extrasynaptic targeting of NMDA receptors following D1 dopamine receptor activation and cocaine self-administration. J Neurosci (2013) 0.85
P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. J Neurochem (2014) 0.84
Is neuronal communication with NG2 cells synaptic or extrasynaptic? J Anat (2011) 0.84
Extrasynaptic NMDA Receptor in Excitotoxicity: Function Revisited. Neuroscientist (2014) 0.84
Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses. J Neurophysiol (2010) 0.83
Distribution of extracellular glutamate in the neuropil of hippocampus. PLoS One (2011) 0.82
Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinase. Sci Rep (2013) 0.82
Bidirectional neuro-glial signaling modalities in the hypothalamus: role in neurohumoral regulation. Auton Neurosci (2013) 0.81
Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol (2009) 0.81
The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease. Aging Dis (2015) 0.80
Pharmacological analysis of the activation and receptor properties of the tonic GABA(C)R current in retinal bipolar cell terminals. PLoS One (2011) 0.79
Molecular diffusion model of neurotransmitter homeostasis around synapses supporting gradients. Neural Comput (2011) 0.79
Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin. Philos Trans R Soc Lond B Biol Sci (2015) 0.79
Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors. Neuroscience (2009) 0.78
Frequency-dependent facilitation of synaptic throughput via postsynaptic NMDA receptors in the nucleus of the solitary tract. J Physiol (2014) 0.78
Inverse relationship between seizure expression and extrasynaptic NMDAR function following chronic NMDAR inhibition. Epilepsia (2010) 0.78
Out of the cleft: the source and target of extra-synaptic glutamate in the CA1 region of the hippocampus. J Physiol (2007) 0.77
Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil. Biophys J (2015) 0.77
Astrocytic Actions on Extrasynaptic Neuronal Currents. Front Cell Neurosci (2015) 0.77
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition. J Neurophysiol (2012) 0.77
Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex. J Neurosci (2016) 0.77
Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression. Mol Neurodegener (2016) 0.76
Abeta(1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptors. Neural Plast (2014) 0.76
Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology (2013) 0.76
Facilitated glutamate release at Schaffer collateral to CA1 synapses has access to an exclusive population of NMDA receptors. Brain Res (2015) 0.75
Molecular lock regulates binding of glycine to a primitive NMDA receptor. Proc Natl Acad Sci U S A (2016) 0.75
Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in mouse substantia nigra dopaminergic neurons. Eur J Neurosci (2015) 0.75
Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments. Cell Rep (2017) 0.75
Dendritic Release of Neurotransmitters. Compr Physiol (2016) 0.75
Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells. Korean J Physiol Pharmacol (2016) 0.75
Different pools of glutamate receptors mediate sensitivity to ambient glutamate in the cochlear nucleus. J Neurophysiol (2015) 0.75
Memantine and ketamine differentially alter NMDA receptor desensitization. J Neurosci (2017) 0.75
Turning down the volume: Astrocyte volume change in the generation and termination of epileptic seizures. Neurobiol Dis (2017) 0.75
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44
Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci (2005) 9.25
Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (1987) 8.89
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci (2002) 7.57
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science (2004) 5.76
Integration of quanta in cerebellar granule cells during sensory processing. Nature (2004) 4.48
Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron (2004) 4.35
Tonically active GABA A receptors: modulating gain and maintaining the tone. Trends Neurosci (2004) 4.28
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A (2000) 3.71
The origin and neuronal function of in vivo nonsynaptic glutamate. J Neurosci (2002) 3.40
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. J Exp Biol (1997) 3.35
Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci (1996) 3.13
Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J Neurosci (1990) 2.95
DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters. Mol Pharmacol (1998) 2.93
Cooperation between independent hippocampal synapses is controlled by glutamate uptake. Nat Neurosci (2002) 2.80
Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons. Science (1989) 2.79
Impact of spontaneous synaptic activity on the resting properties of cat neocortical pyramidal neurons In vivo. J Neurophysiol (1998) 2.72
Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res (1979) 2.62
Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron (2002) 2.47
Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J Neurosci (2004) 2.32
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation. J Neurosci (2005) 2.19
Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes. J Neurosci (2005) 2.16
Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci (2006) 2.16
Clearance of glutamate inside the synapse and beyond. Curr Opin Neurobiol (1999) 1.88
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc Natl Acad Sci U S A (1999) 1.82
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett (2002) 1.79
NR2B-containing receptors mediate cross talk among hippocampal synapses. J Neurosci (2004) 1.78
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. J Physiol (2004) 1.70
Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy. Magn Reson Med (2003) 1.57
Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain. J Neurochem (2006) 1.56
Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices. J Physiol (2005) 1.50
Neuroenergetics and the kinetic design of excitatory synapses. Nat Rev Neurosci (2005) 1.50
Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Br J Pharmacol (2004) 1.45
Metabolic compartmentation of glutamate and glutamine: morphological evidence obtained by quantitative immunocytochemistry in rat cerebellum. Neuroscience (1992) 1.36
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures. J Neurochem (1995) 1.29
Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences. Prog Biophys Mol Biol (2005) 1.24
Developmental expression of glutamate transporters and glutamate dehydrogenase in astrocytes of the postnatal rat hippocampus. Hippocampus (2004) 1.21
Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J Biol Chem (2005) 1.21
Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. J Neurophysiol (2003) 1.20
Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity. J Neurosci (2002) 1.14
Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation: evidence for a unique role of the NR2D subunit. Brain Res Mol Brain Res (2002) 1.12
D-Serine differently modulates NMDA receptor function in rat CA1 hippocampal pyramidal cells and interneurons. J Physiol (2003) 1.08
Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett (1990) 1.03
Differential properties of two stably expressed brain-specific glycine transporters. J Neurochem (1998) 1.02
Intracerebral dialysis and the blood-brain barrier. J Neurochem (1995) 0.95
Advances in the enzymology of glutamine synthesis. Adv Enzymol Relat Areas Mol Biol (1998) 0.86
Spontaneous openings of NMDA receptor channels in cultured rat hippocampal neurons. Eur J Neurosci (1997) 0.81
Homomeric GluR1 excitatory amino acid receptors expressed in Xenopus oocytes. Mol Pharmacol (1990) 0.81
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci (2003) 8.23
Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J Neurosci (2004) 2.32
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. Proc Natl Acad Sci U S A (2003) 2.31
Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc Natl Acad Sci U S A (2003) 2.21
Two types of nicotinic receptors mediate an excitation of neocortical layer I interneurons. J Neurophysiol (2002) 1.38
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. J Neurosci (2008) 1.35
Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. J Neurosci (2012) 1.26
Holographic photolysis for multiple cell stimulation in mouse hippocampal slices. PLoS One (2010) 1.11
GABA, a forgotten gliotransmitter. Prog Neurobiol (2008) 1.07
Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor. J Neurochem (2009) 0.99
Two populations of layer v pyramidal cells of the mouse neocortex: development and sensitivity to anesthetics. J Neurophysiol (2005) 0.98
Paradoxical effects of minocycline in the developing mouse somatosensory cortex. Glia (2013) 0.97
Oligodendrocyte precursor cells are accurate sensors of local K+ in mature gray matter. J Neurosci (2013) 0.96
Predominant functional expression of Kv1.3 by activated microglia of the hippocampus after Status epilepticus. PLoS One (2009) 0.94
Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. Glia (2009) 0.94
Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells. J Neurosci (2010) 0.94
GABA release by hippocampal astrocytes. Front Comput Neurosci (2012) 0.93
Involvement of P2X4 receptors in hippocampal microglial activation after status epilepticus. Glia (2013) 0.91
Central role of GABA in neuron-glia interactions. Neuroscientist (2011) 0.89
Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory "Barrel" cortex. Glia (2013) 0.87
Distinct local circuits between neocortical pyramidal cells and fast-spiking interneurons in young adult rats. J Neurophysiol (2003) 0.86
Is neuronal communication with NG2 cells synaptic or extrasynaptic? J Anat (2011) 0.84
Role of the vesicular transporter VGLUT3 in retrograde release of glutamate by cerebellar Purkinje cells. J Neurophysiol (2010) 0.78
Purinergic signaling in the cerebellum: Bergmann glial cells express functional ionotropic P2X7 receptors. Glia (2011) 0.77
PEGylated Red-Emitting Calcium Probe with Improved Sensing Properties for Neuroscience. ACS Sens (2017) 0.75