Published in Acta Crystallogr D Biol Crystallogr on February 21, 2002
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17
Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta (2010) 4.99
The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity (2006) 3.51
The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis. Nat Cell Biol (2006) 2.23
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. J Biol Chem (2003) 2.14
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol (2006) 2.12
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. Cell (2006) 2.10
Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PLoS Pathog (2008) 2.09
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol (2009) 2.06
Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol (2006) 2.00
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol (2004) 1.99
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem (2002) 1.92
Structural and functional insights into the B30.2/SPRY domain. EMBO J (2006) 1.82
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Nat Immunol (2003) 1.73
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature (2002) 1.71
Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase. Mol Microbiol (2006) 1.70
Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins. J Biol Chem (2006) 1.69
Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line. Gynecol Oncol (2005) 1.69
Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol (2003) 1.67
Crystal structure of a clip-domain serine protease and functional roles of the clip domains. EMBO J (2005) 1.58
Structural studies of a bacterial condensin complex reveal ATP-dependent disruption of intersubunit interactions. Cell (2009) 1.58
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. J Biol Chem (2001) 1.56
Structural basis for protein recognition by B30.2/SPRY domains. Mol Cell (2006) 1.54
Apoptotic signaling pathways: caspases and stress-activated protein kinases. J Biochem Mol Biol (2002) 1.54
Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proc Natl Acad Sci U S A (2012) 1.53
An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One (2007) 1.53
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability. Aging Cell (2012) 1.49
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell Res (2010) 1.48
Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Proc Natl Acad Sci U S A (2007) 1.44
The TRAPP complex: insights into its architecture and function. Traffic (2008) 1.40
NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation. Mol Cell Biol (2004) 1.37
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol (2002) 1.35
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons. J Biol Chem (2004) 1.31
Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae. J Cell Biol (2010) 1.31
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood (2008) 1.30
Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis. J Immunol (2006) 1.30
UVRAG: a new player in autophagy and tumor cell growth. Autophagy (2007) 1.29
Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. Proc Natl Acad Sci U S A (2010) 1.28
Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA. EMBO J (2009) 1.26
Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb. Mol Cell Biol (2009) 1.25
Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda. J Biol Chem (2002) 1.23
o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells. Cell Signal (2007) 1.23
Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1). J Biol Chem (2003) 1.22
Compromised MAPK signaling in human diseases: an update. Arch Toxicol (2015) 1.22
Structure of malonamidase E2 reveals a novel Ser-cisSer-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature. EMBO J (2002) 1.20
DeSUMOylating isopeptidase: a second class of SUMO protease. EMBO Rep (2012) 1.18
An asymmetric SMC-kleisin bridge in prokaryotic condensin. Nat Struct Mol Biol (2013) 1.17
Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism. J Biol Chem (2003) 1.15
Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cells. Antioxid Redox Signal (2010) 1.15
Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase. J Cell Sci (2010) 1.15
Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis. Blood (2008) 1.15
PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal (2006) 1.11
Sensitization of epidermal growth factor-induced signaling by bradykinin is mediated by c-Src. Implications for a role of lipid microdomains. J Biol Chem (2003) 1.11
Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP. Nat Struct Mol Biol (2004) 1.11
Phospholipase signalling networks in cancer. Nat Rev Cancer (2012) 1.10
5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity. Nucleic Acids Res (2011) 1.09
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway. Proc Natl Acad Sci U S A (2005) 1.08
Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches. Mol Cell Biol (2008) 1.07
Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells. J Biol Chem (2008) 1.06
Cyclomaltodextrinase, neopullulanase, and maltogenic amylase are nearly indistinguishable from each other. J Biol Chem (2002) 1.06
MST1 limits the kinase activity of aurora B to promote stable kinetochore-microtubule attachment. Curr Biol (2010) 1.06
Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis. Mol Ther (2013) 1.06
An insight into the mechanistic role of Beclin 1 and its inhibition by prosurvival Bcl-2 family proteins. Autophagy (2008) 1.06
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A (2009) 1.06
The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. J Biol Chem (2005) 1.05
Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP-activated protein kinase. J Cell Physiol (2012) 1.05
Electrospinning of chitin nanofibers: degradation behavior and cellular response to normal human keratinocytes and fibroblasts. Biomaterials (2006) 1.04
Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. J Biol Chem (2009) 1.04
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Mol Biol Cell (2002) 1.02
Two-promoter vector is highly efficient for overproduction of protein complexes. Protein Sci (2004) 1.02
Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J (2005) 1.02
Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1. EMBO J (2007) 1.01
CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia (2014) 1.01
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem (2002) 1.01
VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PLoS Pathog (2012) 1.00
Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. J Virol (2013) 0.99
Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J Cell Sci (2004) 0.99
Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol (2010) 0.99
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. J Cell Biol (2003) 0.99
Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu. J Biol Chem (2004) 0.99
Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis. Proteomics (2010) 0.98
Novel candidate targets of Wnt/beta-catenin signaling in hepatoma cells. Life Sci (2006) 0.98
Filamin B serves as a molecular scaffold for type I interferon-induced c-Jun NH2-terminal kinase signaling pathway. Mol Biol Cell (2008) 0.98
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway. Mol Cell (2004) 0.98
Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochim Biophys Acta (2004) 0.98
RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. J Biol Chem (2002) 0.98
Differential activation of formyl peptide receptor signaling by peptide ligands. Mol Pharmacol (2003) 0.98
Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin. J Biol Chem (2004) 0.98
Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion. J Biol Chem (2012) 0.97
Phospholipase D2 directly interacts with aldolase via Its PH domain. Biochemistry (2002) 0.97
Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr (2011) 0.97
The roles of phospholipase D in EGFR signaling. Biochim Biophys Acta (2009) 0.97
G2 arrest and apoptosis by 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS), a novel cytotoxic compound. Biochem Pharmacol (2005) 0.97
MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc Natl Acad Sci U S A (2013) 0.97
AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C. J Biol Chem (2004) 0.96
p57KIP2 modulates stress-activated signaling by inhibiting c-Jun NH2-terminal kinase/stress-activated protein Kinase. J Biol Chem (2003) 0.96