Published in Endocrinology on March 01, 2002
NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80
Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci U S A (2002) 11.11
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res (2005) 11.02
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24
Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther (2008) 8.83
The knockout mouse project. Nat Genet (2004) 7.80
Production and purification of lentiviral vectors. Nat Protoc (2006) 6.01
Oncogenic mutations of ALK kinase in neuroblastoma. Nature (2008) 5.80
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature (2009) 5.37
Gene therapy: therapeutic gene causing lymphoma. Nature (2006) 4.89
Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell (2007) 4.87
A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA. Proc Natl Acad Sci U S A (2003) 4.17
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science (2012) 4.14
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A (2009) 3.58
Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos. Proc Natl Acad Sci U S A (2002) 3.53
Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A (2011) 3.45
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab (2009) 3.10
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest (2010) 3.10
Development of a novel mouse glioma model using lentiviral vectors. Nat Med (2009) 3.08
Efficient transgenic rat production by a lentiviral vector. Am J Physiol Heart Circ Physiol (2007) 3.07
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A (2005) 2.95
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Med (2006) 2.78
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci (2005) 2.75
Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells. Proc Natl Acad Sci U S A (2003) 2.71
Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. J Neurosci (2007) 2.68
Biology of AAV serotype vectors in liver-directed gene transfer to nonhuman primates. Mol Ther (2005) 2.48
Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer (2012) 2.48
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol (2010) 2.32
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature (2005) 2.29
Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci (2003) 2.28
Total correction of hemophilia A mice with canine FVIII using an AAV 8 serotype. Blood (2003) 2.21
Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron (2003) 2.17
Sustained correction of disease in naive and AAV2-pretreated hemophilia B dogs: AAV2/8-mediated, liver-directed gene therapy. Blood (2005) 2.12
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity (2007) 2.11
CtIP links DNA double-strand break sensing to resection. Mol Cell (2009) 2.11
Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. J Biol Chem (2002) 2.08
Streptococcus suis sequence type 7 outbreak, Sichuan, China. Emerg Infect Dis (2006) 2.07
Experimental demonstration of topological surface states protected by time-reversal symmetry. Phys Rev Lett (2009) 1.99
CRE recombinase-inducible RNA interference mediated by lentiviral vectors. Proc Natl Acad Sci U S A (2004) 1.95
Inflammation-associated cancer: NF-kappaB is the lynchpin. Trends Immunol (2005) 1.94
Transmission of MDR and XDR tuberculosis in Shanghai, China. PLoS One (2009) 1.93
Targeting SphK1 as a new strategy against cancer. Curr Drug Targets (2008) 1.91
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. J Neurosci (2003) 1.88
Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nat Cell Biol (2012) 1.87
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression. Hepatology (2015) 1.81
15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. Am J Respir Crit Care Med (2009) 1.81
High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival. Breast Cancer Res Treat (2013) 1.78
Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta (2009) 1.76
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology (2003) 1.76
Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity. Nat Cell Biol (2005) 1.75
Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration. BMC Biol (2009) 1.74
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell (2003) 1.72
Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A (2002) 1.72
Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice. J Neurosci (2013) 1.71
Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses. Hum Gene Ther (2009) 1.71
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
A model for harmonizing flow cytometry in clinical trials. Nat Immunol (2010) 1.70
Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A (2007) 1.69
Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma. Proc Natl Acad Sci U S A (2011) 1.68
Gene therapy with viral vectors. Annu Rev Pharmacol Toxicol (2002) 1.66
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell (2012) 1.65
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol (2007) 1.64
Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. J Clin Invest (2002) 1.63
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell (2006) 1.62
In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification. J Bone Joint Surg Am (2003) 1.59
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron (2008) 1.59
Band structure engineering in (Bi(1-x)Sb(x))(2)Te(3) ternary topological insulators. Nat Commun (2011) 1.58
Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia. Blood (2012) 1.58
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci (2007) 1.58
Adeno-associated virus antibody profiles in newborns, children, and adolescents. Clin Vaccine Immunol (2011) 1.57
Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Mol Ther (2002) 1.57
Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines. Proc Natl Acad Sci U S A (2012) 1.57
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Proc Natl Acad Sci U S A (2007) 1.57
Synthetic clonal reproduction through seeds. Science (2011) 1.56
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med (2011) 1.54
Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A (2007) 1.50
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49
Design and cloning of lentiviral vectors expressing small interfering RNAs. Nat Protoc (2006) 1.48
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A (2014) 1.47
Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion. Endocrinology (2003) 1.46
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science (2004) 1.46
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci U S A (2009) 1.45
Vignettes: Diverse library staff offering diverse bioinformatics services. J Med Libr Assoc (2006) 1.44
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Proc Natl Acad Sci U S A (2005) 1.41
Editorial expression of concern: Experimental evidence of massive-scale emotional contagion through social networks. Proc Natl Acad Sci U S A (2014) 1.41
Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell (2008) 1.41
Host immune responses to chronic adenovirus infections in human and nonhuman primates. J Virol (2008) 1.41
Reciprocity between phase shifts and amplitude changes in the mammalian circadian clock. Proc Natl Acad Sci U S A (2007) 1.41
IKK biology. Immunol Rev (2012) 1.40
Retracted Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network. J Ovarian Res (2014) 1.40
Retracted Gene-gene interaction network analysis of ovarian cancer using TCGA data. J Ovarian Res (2013) 1.40