Published in Proc Natl Acad Sci U S A on February 27, 2007
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65
Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nat Biotechnol (2012) 1.90
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79
Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep (2013) 1.55
Research resource: the pdx1 cistrome of pancreatic islets. Mol Endocrinol (2012) 1.17
Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. J Biol Chem (2010) 1.08
Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion. Nat Med (2015) 1.07
Rfx6 maintains the functional identity of adult pancreatic β cells. Cell Rep (2014) 1.05
CRFR1 is expressed on pancreatic beta cells, promotes beta cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc Natl Acad Sci U S A (2009) 1.04
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. Elife (2014) 1.04
Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis. Proc Natl Acad Sci U S A (2010) 0.98
Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior. Alcohol (2012) 0.94
Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One (2012) 0.91
Concise review: pluripotent stem cell-based regenerative applications for failing β-cell function. Stem Cells Transl Med (2014) 0.88
Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets. Endocrinology (2010) 0.88
Structure of Class B GPCRs: new horizons for drug discovery. Br J Pharmacol (2014) 0.86
Type 2 corticotropin-releasing factor receptor in the ventromedial nucleus of hypothalamus is critical in regulating feeding and lipid metabolism in white adipose tissue. Endocrinology (2011) 0.86
Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia (2011) 0.86
Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells. J Endocrinol (2008) 0.85
Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart. Proc Natl Acad Sci U S A (2013) 0.85
Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity. Front Mol Neurosci (2012) 0.83
Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3. Rev Diabet Stud (2014) 0.80
Vascular effects of urocortins 2 and 3 in healthy volunteers. J Am Heart Assoc (2013) 0.80
Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus. Front Endocrinol (Lausanne) (2013) 0.80
Increased alcohol consumption in urocortin 3 knockout mice is unaffected by chronic inflammatory pain. Alcohol Alcohol (2014) 0.79
Urocortins and CRF type 2 receptor isoforms expression in the rat stomach are regulated by endotoxin: role in the modulation of delayed gastric emptying. Am J Physiol Gastrointest Liver Physiol (2012) 0.79
Advances and challenges in the differentiation of pluripotent stem cells into pancreatic β cells. World J Stem Cells (2015) 0.78
Corticotropin-releasing factor receptor 2 mediates sex-specific cellular stress responses. Mol Med (2013) 0.78
CRFR1 activation protects against cytokine-induced β-cell death. J Mol Endocrinol (2014) 0.77
Corticotropin-releasing factor family peptide signaling in feline bladder urothelial cells. J Endocrinol (2014) 0.76
Regulation of gonadotropins by corticotropin-releasing factor and urocortin. Front Endocrinol (Lausanne) (2013) 0.76
Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res (2015) 0.76
Recent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem Cells. Int J Mol Sci (2016) 0.76
D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells. Mol Cell Endocrinol (2014) 0.76
All mixed up: defining roles for β-cell subtypes in mature islets. Genes Dev (2017) 0.75
One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance. JCI Insight (2016) 0.75
Urocortin 3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle. J Endocrinol (2014) 0.75
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms. Int J Obes (Lond) (2014) 0.75
Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells into β-Cells in Vivo. Diabetes (2017) 0.75
Anatomical Organization of Urocortin 3-Synthesizing Neurons and Immunoreactive Terminals in the Central Nervous System of Non-Human Primates [Sapajus spp.]. Front Neuroanat (2017) 0.75
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
The biology of incretin hormones. Cell Metab (2006) 8.92
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A (2001) 3.23
Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci (1995) 3.04
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev (2001) 2.92
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab (2005) 2.71
Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab (2003) 2.51
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med (2001) 2.33
Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol (1986) 2.01
Caloric restriction in primates and relevance to humans. Ann N Y Acad Sci (2001) 1.76
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology (1995) 1.73
Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem (2000) 1.65
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem (2002) 1.53
Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion. Endocrinology (2003) 1.46
Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold. Endocrinology (2003) 1.34
Age-related insulin resistance: is it an obligatory finding? The lesson from healthy centenarians. Diabetes Metab Res Rev (2001) 1.30
Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors. Endocrinology (2003) 1.19
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Proc Natl Acad Sci U S A (2006) 1.08
Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Endocrinology (2004) 1.02
Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis. Proc Natl Acad Sci U S A (2006) 0.98
High fat diet-induced insulin resistance. Lessons and implications from animal studies. Ann N Y Acad Sci (1993) 0.96
Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells. Diabetes (1999) 0.91
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78
Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron (2005) 2.46
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci (2005) 2.21
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron (2008) 1.97
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci (2007) 1.76
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology (2003) 1.76
Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci (2003) 1.75
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol Cell (2003) 1.72
Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A (2002) 1.72
Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice. J Neurosci (2013) 1.71
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res (2004) 1.67
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol (2007) 1.64
Surface plasmonic effects of metallic nanoparticles on the performance of polymer bulk heterojunction solar cells. ACS Nano (2011) 1.63
Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion. Endocrinology (2003) 1.46
Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. J Neurosci (2002) 1.42
The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci (2006) 1.40
Essential roles of Her2/erbB2 in cardiac development and function. Recent Prog Horm Res (2004) 1.39
Cripto forms a complex with activin and type II activin receptors and can block activin signaling. Proc Natl Acad Sci U S A (2003) 1.35
Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold. Endocrinology (2003) 1.34
Differential actions of peripheral corticotropin-releasing factor (CRF), urocortin II, and urocortin III on gastric emptying and colonic transit in mice: role of CRF receptor subtypes 1 and 2. J Pharmacol Exp Ther (2002) 1.33
Type 1 corticotropin-releasing factor receptor expression reported in BAC transgenic mice: implications for reconciling ligand-receptor mismatch in the central corticotropin-releasing factor system. J Comp Neurol (2008) 1.32
ErbB2 is required for ductal morphogenesis of the mammary gland. Proc Natl Acad Sci U S A (2004) 1.29
A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors. Mol Cell (2004) 1.26
Inhibin is an antagonist of bone morphogenetic protein signaling. J Biol Chem (2002) 1.24
The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure. Proc Natl Acad Sci U S A (2004) 1.22
A disorganized innervation of the inner ear persists in the absence of ErbB2. Brain Res (2006) 1.21
Corticotropin-releasing factor (CRF) sensitization of ethanol withdrawal-induced anxiety-like behavior is brain site specific and mediated by CRF-1 receptors: relation to stress-induced sensitization. J Pharmacol Exp Ther (2009) 1.20
Mice deficient for both corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 have an impaired stress response and display sexually dichotomous anxiety-like behavior. J Neurosci (2002) 1.19
Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci (2007) 1.17
Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids. Mol Endocrinol (2004) 1.16
Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling. Mol Cell Biol (2006) 1.15
Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet (2002) 1.13
Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron (2003) 1.12
Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats. Hepatology (2003) 1.10
Growth factors and myometrium: biological effects in uterine fibroid and possible clinical implications. Hum Reprod Update (2011) 1.10
Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats. Am J Physiol Gastrointest Liver Physiol (2002) 1.09
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. Proc Natl Acad Sci U S A (2006) 1.08
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell (2012) 1.06
Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. Brain Res (2002) 1.06
Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain. J Comp Neurol (2013) 1.05
An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors. J Biol Chem (2004) 1.04
Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci U S A (2002) 1.03
Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Endocrinology (2004) 1.02
Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A (2012) 1.02
Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids. Endocrinology (2006) 1.02
The bound leading the bound: target-derived receptors act as guidance cues. Neuron (2002) 1.01
Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J Med Chem (2007) 1.01
The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology (2008) 1.00
Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides. Endocrinology (2003) 1.00
Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. J Neurosci (2006) 0.99
Corticotropin-releasing factor receptor 1-deficient mice do not develop postoperative gastric ileus. Gastroenterology (2003) 0.99
erbB2 is required for G protein-coupled receptor signaling in the heart. Proc Natl Acad Sci U S A (2006) 0.95
Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A (2010) 0.95
IGF-I (CA) repeat polymorphisms and risk of cancer: a meta-analysis. J Hum Genet (2008) 0.93
Injection of Urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axis. Am J Physiol Endocrinol Metab (2009) 0.93
Detection of immunoglobulin M antibodies specific for Toxoplasma gondii with increased selectivity for recently acquired infections. J Clin Microbiol (2004) 0.92
Inhibin-A antagonizes TGFbeta2 signaling by down-regulating cell surface expression of the TGFbeta coreceptor betaglycan. Mol Endocrinol (2010) 0.91
Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. Autophagy (2013) 0.91
Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis. FEBS Lett (2012) 0.91
Modulation of activin and BMP signaling. Mol Cell Endocrinol (2004) 0.90
Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis. Endocrinology (2003) 0.90
Fasting activates neuropeptide Y neurons in the arcuate nucleus and the paraventricular nucleus in the rhesus macaque. Brain Res Mol Brain Res (2003) 0.89
A novel corticotropin-releasing factor receptor splice variant exhibits dominant negative activity: a putative link to stress-induced heart disease. FASEB J (2009) 0.89
Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse. Nat Neurosci (2011) 0.89
Activin A/bone morphogenetic protein (BMP) chimeras exhibit BMP-like activity and antagonize activin and myostatin. J Biol Chem (2007) 0.88
Roles of activin family in pancreatic development and homeostasis. Mol Cell Endocrinol (2012) 0.88
Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals. Mol Endocrinol (2011) 0.88
Urocortins in human reproduction. Peptides (2004) 0.87
Presence, actions, and regulation of myostatin in rat uterus and myometrial cells. Endocrinology (2008) 0.87
Actively controlled self-assembly of colloidal crystals in microfluidic networks by electrocapillary forces. J Am Chem Soc (2004) 0.87
Expression of CRF1 and CRF2 receptors in human cancers. J Clin Endocrinol Metab (2003) 0.86
Type 2 corticotropin-releasing factor receptor in the ventromedial nucleus of hypothalamus is critical in regulating feeding and lipid metabolism in white adipose tissue. Endocrinology (2011) 0.86
Polymer-based cell-free expression of ligand-binding family B G-protein coupled receptors without detergents. Protein Sci (2011) 0.86
Activin-A in myometrium: characterization of the actions on myometrial cells. Endocrinology (2008) 0.86
Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes. Mol Endocrinol (2009) 0.85
Exploring the formation of focal adhesions on patterned surfaces using super-resolution imaging. Small (2011) 0.85
MrpacC regulates sporulation, insect cuticle penetration and immune evasion in Metarhizium robertsii. Environ Microbiol (2014) 0.84
Glucocorticoids regulate the expression of the mouse urocortin II gene: a putative connection between the corticotropin-releasing factor receptor pathways. Mol Endocrinol (2003) 0.84
p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A (2009) 0.83
The role of corticotropin-releasing factor receptors in stress and anxiety. Integr Comp Biol (2002) 0.83
Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. Am J Obstet Gynecol (2006) 0.83