Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees.

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🔗 View Article (PMID 11869080)

Published in Osteoarthritis Cartilage on March 01, 2002

Authors

S Wakitani1, K Imoto, T Yamamoto, M Saito, N Murata, M Yoneda

Author Affiliations

1: Department of Orthopaedic Surgery, Sinshu University School of Medicine, Japan. wakitani@hsp.md.shinshu-u.ac.jp

Associated clinical trials:

Autologous Mesenchymal Stem Cells vs. Chondrocytes for the Repair of Chondral Knee Defects (ASCROD) | NCT01399749

Injections of FloGraft Therapy, Autologous Stem Cells, or Platelet Rich Plasma for the Treatment of Degenerative Joint Pain | NCT01978639

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The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell (1984) 12.54

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06

A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol (2001) 8.45

A high-density rice genetic linkage map with 2275 markers using a single F2 population. Genetics (1998) 6.82

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature (1986) 6.67

Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol (2010) 5.96

Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14

Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06

Calcium channel characteristics conferred on the sodium channel by single mutations. Nature (1992) 4.90

Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophys J (1996) 4.58

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ (2000) 4.34

Molecular distinction between fetal and adult forms of muscle acetylcholine receptor. Nature (1986) 4.30

Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology (2004) 4.24

Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell (1984) 4.21

Enhancement of chilling tolerance of a cyanobacterium by genetic manipulation of fatty acid desaturation. Nature (1990) 4.11

Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature (1992) 3.96

Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93

Predictive factors of response to intravenous ciclosporin in severe ulcerative colitis: the development of a novel prediction formula. Aliment Pharmacol Ther (2012) 3.91

Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (1991) 3.86

The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell (1983) 3.82

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci U S A (1985) 3.80

The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75

The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity. Science (1986) 3.74

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells (1999) 3.69

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66

Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell (2001) 3.49

Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature (1990) 3.42

BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med (2001) 3.40

Identification of toxin A-negative, toxin B-positive Clostridium difficile by PCR. J Clin Microbiol (1998) 3.34

Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci U S A (1990) 3.31

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell (1997) 3.30

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Lett (1991) 3.29

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Hum Mol Genet (1999) 3.24

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci U S A (1986) 3.19

Control of excitation transfer in photosynthesis. I. Light-induced change of chlorophyll a fluorescence in Porphyridium cruentum. Biochim Biophys Acta (1969) 3.17

Isolation from corynebacterium diphtheriae C7(beta) of bacterial mutants that produce toxin in medium with excess iron. Infect Immun (1977) 3.12

A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol (1986) 3.09

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07

Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (1984) 3.06

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01

Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology (2008) 2.85

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem (1996) 2.85

Purification and properties of the dnaJ replication protein of Escherichia coli. J Biol Chem (1985) 2.84

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci U S A (1992) 2.82

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene (1997) 2.80

Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science (1986) 2.76

CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem (1991) 2.75

Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem (1999) 2.74

Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell (1989) 2.73

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70

Enteropathogenic Escherichia coli associated with diarrhea in children and adults. Jpn J Med Sci Biol (1967) 2.62

Mitochondrial genotype associated with longevity. Lancet (1998) 2.58

Correlation of the highest-energy cosmic rays with nearby extragalactic objects. Science (2007) 2.57

Control of excitation transfer in photosynthesis. II. Magnesium ion-dependent distribution of excitation energy between two pigment systems in spinach chloroplasts. Biochim Biophys Acta (1969) 2.52

Focal adhesion kinase: at the crossroads of signal transduction. J Cell Sci (1997) 2.51

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity (1995) 2.50

Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans. J Biol Chem (1984) 2.48

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem (2001) 2.46

Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA. Proc Natl Acad Sci U S A (1980) 2.45

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44

Expression of functional acetylcholine receptor from cloned cDNAs. Nature (1984) 2.41

Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis. Nature (1985) 2.40

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J (2001) 2.37

Low-temperature resistance of higher plants is significantly enhanced by a nonspecific cyanobacterial desaturase. Nat Biotechnol (1996) 2.36

Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus. Jpn J Exp Med (1970) 2.35

Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol (1986) 2.33

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci U S A (1996) 2.31

Chilling Susceptibility of the Blue-green Alga Anacystis nidulans: I. EFFECT OF GROWTH TEMPERATURE. Plant Physiol (1981) 2.31

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Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated. J Cell Biol (1991) 2.29

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med (1994) 2.26

Orchiectomy for suspected microscopic tumor in patients with anti-Ma2-associated encephalitis. Neurology (2006) 2.25

Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. EMBO J (1988) 2.25

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A (1992) 2.23

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22

Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene (1995) 2.22

Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem (1998) 2.19

Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene (1986) 2.14

Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11

Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos (1996) 2.11

Molecular mechanism of active calcium transport by sarcoplasmic reticulum. Physiol Rev (1978) 2.11

Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor. J Physiol (2000) 2.11

Initial events of myelination involve Fyn tyrosine kinase signalling. Nature (1994) 2.08

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc Natl Acad Sci U S A (1990) 2.08

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other. Nucleic Acids Res (1988) 2.08

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Mech Dev (1994) 2.07

Isolation of a protein from the parasporal crystal of Bacillus thuringiensis var. Kurstaki toxic to the mosquito larva, Aedes taeniorhynchus. Biochem Biophys Res Commun (1981) 2.06

Oxidative stress inhibits the repair of photodamage to the photosynthetic machinery. EMBO J (2001) 2.06

Increase of solubility of foreign proteins in Escherichia coli by coproduction of the bacterial thioredoxin. J Biol Chem (1995) 2.05

Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology (2001) 2.05

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol (2000) 2.05

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. J Immunol (1992) 2.02

Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure. Circulation (2000) 2.01

Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell (2000) 2.01

Ionic and osmotic effects of NaCl-induced inactivation of photosystems I and II in Synechococcus sp. Plant Physiol (2000) 2.01

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. Oncogene (1988) 1.99

Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel. Nature (1987) 1.99

Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis. J Virol (2001) 1.98