Published in Nature on March 21, 1985
Molecular model of the action potential sodium channel. Proc Natl Acad Sci U S A (1986) 4.61
Ion-channel entrances influence permeation. Net charge, size, shape, and binding considerations. Biophys J (1986) 3.19
Hypothesis about the function of membrane-buried proline residues in transport proteins. Proc Natl Acad Sci U S A (1986) 2.90
The effect of capping and polyadenylation on the stability, movement and translation of synthetic messenger RNAs in Xenopus oocytes. Nucleic Acids Res (1985) 2.28
Monovalent and divalent cation permeation in acetylcholine receptor channels. Ion transport related to structure. J Gen Physiol (1987) 2.20
A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron (1990) 2.10
Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys J (1991) 1.86
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol (2008) 1.49
Mouse-Torpedo hybrid acetylcholine receptors: functional homology does not equal sequence homology. Proc Natl Acad Sci U S A (1985) 1.46
Negatively charged amino acid residues in the nicotinic receptor delta subunit that contribute to the binding of acetylcholine. Proc Natl Acad Sci U S A (1993) 1.42
Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating. J Clin Invest (2003) 1.36
Channel protein engineering: synthetic 22-mer peptide from the primary structure of the voltage-sensitive sodium channel forms ionic channels in lipid bilayers. Proc Natl Acad Sci U S A (1988) 1.35
Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly. J Cell Biol (1990) 1.34
The role of the asparagine-linked oligosaccharides of the alpha subunit in the secretion and assembly of human chorionic gonadotrophin. J Cell Biol (1988) 1.33
A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors. Proc Natl Acad Sci U S A (1996) 1.20
Tris+/Na+ permeability ratios of nicotinic acetylcholine receptors are reduced by mutations near the intracellular end of the M2 region. J Gen Physiol (1992) 1.20
Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation. Biophys J (1994) 1.17
N-linked glycosylation sites determine HERG channel surface membrane expression. J Physiol (1999) 1.16
Threonine in the selectivity filter of the acetylcholine receptor channel. Biophys J (1992) 1.13
Relationships of agonist properties to the single channel kinetics of nicotinic acetylcholine receptors. Biophys J (1988) 1.12
Mutations in the M4 domain of Torpedo californica acetylcholine receptor dramatically alter ion channel function. Biophys J (1994) 1.12
An acetylcholine receptor precursor alpha subunit that binds alpha-bungarotoxin but not d-tubocurare. Proc Natl Acad Sci U S A (1986) 1.09
Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras. Br J Pharmacol (2007) 1.06
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiol Rev (2012) 1.06
Region of peptide 125-147 of acetylcholine receptor alpha subunit is exposed at neuromuscular junction and induces experimental autoimmune myasthenia gravis, T-cell immunity, and modulating autoantibodies. Proc Natl Acad Sci U S A (1985) 1.04
Site-specific, photochemical proteolysis applied to ion channels in vivo. Proc Natl Acad Sci U S A (1997) 1.02
How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. Proc Natl Acad Sci U S A (1992) 1.02
Creating an α7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses. J Biol Chem (2011) 0.95
The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library. Proc Natl Acad Sci U S A (1997) 0.94
Structural information from functional measurements: single-channel studies on gramicidin analogues. Biophys J (1986) 0.92
alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations. J Cell Biol (1999) 0.92
Snake acetylcholine receptor: cloning of the domain containing the four extracellular cysteines of the alpha subunit. Proc Natl Acad Sci U S A (1989) 0.91
NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit. Biochim Biophys Acta (2010) 0.90
Assembly of Torpedo acetylcholine receptors in Xenopus oocytes. J Cell Biol (1991) 0.88
Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membrane-spanning regions in the alpha and delta subunits. J Cell Biol (1992) 0.87
Tunicamycin increases desensitization of acetylcholine receptors in cultured mouse muscle cells. Proc Natl Acad Sci U S A (1991) 0.86
Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit. EMBO J (1990) 0.86
Profile of the alpha-bungarotoxin-binding regions on the extracellular part of the alpha-chain of Torpedo californica acetylcholine receptor. Biochem J (1987) 0.86
Aberrant development of neuromuscular junctions in glycosylation-defective Large(myd) mice. Neuromuscul Disord (2009) 0.85
Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit. J Biol Chem (2011) 0.84
Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline subsite. Proc Natl Acad Sci U S A (1995) 0.83
Kinetics of the functional loss of different muscarinic receptor isoforms in Xenopus oocytes. Biochem J (1992) 0.79
Control of Torpedo acetylcholine receptor biosynthesis in Xenopus oocytes. Proc Natl Acad Sci U S A (1988) 0.77
Nobel Lecture. Elementary steps in synaptic transmission revealed by currents through single ion channels. EMBO J (1992) 0.76
Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors. PLoS One (2016) 0.76
Expression of functional pituitary somatostatin receptors in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 0.75
Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist. Sci Rep (2017) 0.75
Mouse-Torpedo chimeric alpha-subunit used to probe channel-gating determinants on the nicotinic acetylcholine receptor primary sequence. Cell Mol Neurobiol (1997) 0.75
The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature (1997) 33.47
Hybridization of synthetic oligodeoxyribonucleotides to phi chi 174 DNA: the effect of single base pair mismatch. Nucleic Acids Res (1979) 14.12
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem (1996) 10.70
The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucleic Acids Res (1981) 9.56
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02
Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
Differences in diagnostic criteria for gastric carcinoma between Japanese and western pathologists. Lancet (1997) 7.59
Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. Proc Natl Acad Sci U S A (1981) 7.24
Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1. N Engl J Med (1996) 7.09
Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature (1987) 6.66
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med (1994) 6.59
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature (2000) 6.49
Chemical synthesis of genes for human insulin. Proc Natl Acad Sci U S A (1978) 6.09
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature (1989) 6.07
SLAM (CDw150) is a cellular receptor for measles virus. Nature (2000) 6.07
A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol Microbiol (1996) 6.07
High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe. Nucleic Acids Res (1990) 5.00
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature (1986) 4.97
Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside. Ann Neurol (2001) 4.96
Heterogeneity of the principal sigma factor in Escherichia coli: the rpoS gene product, sigma 38, is a second principal sigma factor of RNA polymerase in stationary-phase Escherichia coli. Proc Natl Acad Sci U S A (1993) 4.92
The role of exon sequences in splice site selection. Genes Dev (1993) 4.86
Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci U S A (1979) 4.72
Structural homology of Torpedo californica acetylcholine receptor subunits. Nature (1983) 4.70
Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J (2009) 4.63
Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature (1989) 4.55
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature (1992) 4.43
Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nat Genet (1994) 4.36
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect Immun (1995) 4.28
Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. J Biol Chem (2001) 4.22
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
Efficient correction of a mutation by use of chemically synthesized DNA. Proc Natl Acad Sci U S A (1978) 4.13
In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob Agents Chemother (1987) 3.84
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders. Ann Rheum Dis (2008) 3.77
C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J Cell Biol (1998) 3.72
Primary structure of alpha-subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature (1982) 3.69
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. Brain (2007) 3.64
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell (1990) 3.56
Rho1p, a yeast protein at the interface between cell polarization and morphogenesis. Science (1996) 3.42
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res (1996) 3.37
Report on 640 victims of the Tokyo subway sarin attack. Ann Emerg Med (1996) 3.34
Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet (1997) 3.34
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol (1997) 3.33
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology (1996) 3.30
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med (2001) 3.23
The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers. J Cell Sci (1991) 3.20
Depletion of CD4(+) T cells causes reactivation of murine persistent tuberculosis despite continued expression of interferon gamma and nitric oxide synthase 2. J Exp Med (2000) 3.20
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep (2001) 3.19
Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature (1982) 3.09
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
Modified formalin test: characteristic biphasic pain response. Pain (1989) 3.00
Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study. Kidney Int (2006) 3.00
Malignant peripheral nerve sheath tumor: analysis of treatment outcome. Int J Radiat Oncol Biol Phys (1998) 2.99
Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF. J Immunol (1980) 2.95
Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J (1994) 2.94
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94
Columns for visual features of objects in monkey inferotemporal cortex. Nature (1992) 2.93
A class-wide phylogenetic assessment of Dothideomycetes. Stud Mycol (2009) 2.91
Neuronal selectivities to complex object features in the ventral visual pathway of the macaque cerebral cortex. J Neurophysiol (1994) 2.87
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.87
A new NEDD8-ligating system for cullin-4A. Genes Dev (1998) 2.82
Bni1p and Bnr1p: downstream targets of the Rho family small G-proteins which interact with profilin and regulate actin cytoskeleton in Saccharomyces cerevisiae. EMBO J (1997) 2.80
Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin. Nature (1982) 2.79
A consensus linkage map of the chicken genome. Genome Res (2000) 2.79
Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Nature (1983) 2.78
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J (1996) 2.76
Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. J Cell Biol (1994) 2.74
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature (1996) 2.70
Covalent modification of all members of human cullin family proteins by NEDD8. Oncogene (1999) 2.67
Selective reduction of T cells bearing invariant V alpha 24J alpha Q antigen receptor in patients with systemic sclerosis. J Exp Med (1995) 2.63
Portal vein anomaly associated with deviation of the ligamentum teres to the right and malposition of the gallbladder. Radiology (1998) 2.62
Impact of graft size mismatching on graft prognosis in liver transplantation from living donors. Transplantation (1999) 2.61
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res (1994) 2.61
Rapid focus reduction neutralization test of influenza A and B viruses in microtiter system. J Clin Microbiol (1990) 2.60
Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteins. Mol Gen Genet (1973) 2.59
Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science (1991) 2.56
Primary structures of beta- and delta-subunit precursors of Torpedo californica acetylcholine receptor deduced from cDNA sequences. Nature (1983) 2.55
Microsatellite instability in acute myelocytic leukaemia developed from A-bomb survivors. Int J Radiat Biol (2001) 2.54
Cloning and nucleotide sequence of phoP, the regulatory gene for alkaline phosphatase and phosphodiesterase in Bacillus subtilis. J Bacteriol (1987) 2.52
Rho as a regulator of the cytoskeleton. Trends Biochem Sci (1995) 2.52
Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke (2001) 2.51
Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med (1999) 2.51
Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J Cell Biol (2001) 2.51
Molecular analysis of the Escherichia coli hns gene encoding a DNA-binding protein, which preferentially recognizes curved DNA sequences. Mol Gen Genet (1991) 2.50
A spin-valve-like magnetoresistance of an antiferromagnet-based tunnel junction. Nat Mater (2011) 2.47
High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J Virol (1998) 2.47