Published in Transgenic Res on February 01, 2002
Relevance of BAC transgene copy number in mice: transgene copy number variation across multiple transgenic lines and correlations with transgene integrity and expression. Mamm Genome (2007) 1.71
Use of real-time PCR for determining copy number and zygosity in transgenic plants. Plant Cell Rep (2004) 1.61
Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer. Cancer Immun (2007) 1.06
Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition. J Physiol (2014) 0.97
Development of a transgenic mouse model susceptible to human coronavirus 229E. Proc Natl Acad Sci U S A (2005) 0.94
Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev Biol (2012) 0.90
Discovery of transgene insertion sites by high throughput sequencing of mate pair libraries. BMC Genomics (2014) 0.90
Characterisation of Muta™Mouse λgt10-lacZ transgene: evidence for in vivo rearrangements. Mutagenesis (2010) 0.89
Hippocampal "cholinergic interneurons" visualized with the choline acetyltransferase promoter: anatomical distribution, intrinsic membrane properties, neurochemical characteristics, and capacity for cholinergic modulation. Front Synaptic Neurosci (2015) 0.89
ZyFISH: a simple, rapid and reliable zygosity assay for transgenic mice. PLoS One (2012) 0.86
Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner. Behav Genet (2014) 0.81
GEC-targeted HO-1 expression reduces proteinuria in glomerular immune injury. Am J Physiol Renal Physiol (2009) 0.80
The Convenience of Single Homology Arm Donor DNA and CRISPR/Cas9-Nickase for Targeted Insertion of Long DNA Fragment. Cell J (2016) 0.75
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo. PLoS One (2016) 0.75
Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLoS One (2016) 0.75
Knockout rats via embryo microinjection of zinc-finger nucleases. Science (2009) 12.33
Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol (2011) 8.45
Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy. Circulation (2005) 2.02
A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood (2007) 1.91
Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. Blood (2005) 1.86
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood (2007) 1.83
Characterization of immunoglobulin heavy chain knockout rats. Eur J Immunol (2010) 1.63
Safety and efficacy of regional intravenous (r.i.) versus intramuscular (i.m.) delivery of rAAV1 and rAAV8 to nonhuman primate skeletal muscle. Mol Ther (2008) 1.63
Generation of gene-specific mutated rats using zinc-finger nucleases. Methods Mol Biol (2010) 1.51
Lentiviral vectors that express UGT1A1 in liver and contain miR-142 target sequences normalize hyperbilirubinemia in Gunn rats. Gastroenterology (2010) 1.48
IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells. Eur J Immunol (2007) 1.46
Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Transplantation (2005) 1.41
A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles. Hum Gene Ther (2002) 1.37
Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. J Immunol (2006) 1.32
CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest (2007) 1.23
Zinc-finger nucleases: a powerful tool for genetic engineering of animals. Transgenic Res (2009) 1.22
Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J (2005) 1.21
Lack of immunotoxicity after regional intravenous (RI) delivery of rAAV to nonhuman primate skeletal muscle. Mol Ther (2009) 1.21
Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity. J Immunol (2009) 1.19
Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. Stem Cells Dev (2012) 1.11
Transgenic modifications of the rat genome. Transgenic Res (2005) 1.08
Macrophages expressing heme oxygenase-1 improve renal function in ischemia/reperfusion injury. Mol Ther (2010) 1.08
Mechanism and localization of CD8 regulatory T cells in a heart transplant model of tolerance. J Immunol (2010) 1.05
Gene transfer of heme oxygenase-1 and carbon monoxide delivery inhibit chronic rejection. Am J Transplant (2002) 1.04
Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. Am J Transplant (2005) 1.02
Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Mol Ther (2002) 1.01
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases. FASEB J (2012) 1.00
Mesenchymal stem cells induce a weak immune response in the rat striatum after allo or xenotransplantation. J Cell Mol Med (2009) 1.00
TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4+ CD25+ T cell. Int Immunol (2007) 0.99
Pronuclear DNA injection for the production of transgenic rats. Methods Mol Biol (2009) 0.95
Transgenic expression of CTLA4-Ig by fetal pig neurons for xenotransplantation. Transgenic Res (2005) 0.93
The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation. J Immunol (2009) 0.93
Anti-CD28 antibody-induced kidney allograft tolerance related to tryptophan degradation and TCR class II B7 regulatory cells. Am J Transplant (2005) 0.93
Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol (2007) 0.92
Suppression of experimental crescentic glomerulonephritis by interleukin-10 gene transfer. Kidney Int (2004) 0.92
Analysis by quantitative PCR of zygosity in genetically modified organisms. Methods Mol Biol (2010) 0.89
Immunoregulatory properties of heme oxygenase-1. Methods Mol Biol (2011) 0.89
Temporal analysis of cytokine gene expression during infiltration of porcine neuronal grafts implanted into the rat brain. J Neurosci Res (2002) 0.89
Characterization of human CD55 and CD59 transgenic pigs and kidney xenotransplantation in the pig-to-baboon combination. Transplantation (2004) 0.88
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region. J Immunol (2013) 0.88
Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion. J Reprod Immunol (2005) 0.88
β2-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells. J Immunol (2013) 0.88
Promises and obstacles for the blockade of CD40-CD40L interactions in allotransplantation. Transplantation (2008) 0.87
Cytotoxic immune response blunts long-term transgene expression after efficient retroviral-mediated hepatic gene transfer in rat. Mol Ther (2002) 0.87
CD8+ regulatory T cells in solid organ transplantation. Curr Opin Organ Transplant (2010) 0.87
Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells. Eur J Immunol (2013) 0.86
Effects of Human Alpha-Synuclein A53T-A30P Mutations on SVZ and Local Olfactory Bulb Cell Proliferation in a Transgenic Rat Model of Parkinson Disease. Parkinsons Dis (2011) 0.85
Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Transplantation (2005) 0.85
IL-34 is a Treg-specific cytokine and mediates transplant tolerance. J Clin Invest (2015) 0.84
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels. Mol Med (2002) 0.84
Expression of heme oxygenase-1 in neural stem/progenitor cells as a potential mechanism to evade host immune response. Stem Cells (2012) 0.84
The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection. J Immunol (2004) 0.84
Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig. Blood (2002) 0.83
Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer. Immunotherapy (2011) 0.83
Differential pattern recognition receptor expression but stereotyped responsiveness in rat spleen dendritic cell subsets. J Immunol (2006) 0.83
MHC-derived allopeptide activates TCR-biased CD8+ Tregs and suppresses organ rejection. J Clin Invest (2014) 0.83
Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig. Mol Ther (2007) 0.83
Induction of Fractalkine and CX3CR1 mediated by host CD8+ T cells in allograft tolerance induced by donor specific blood transfusion. Transplantation (2004) 0.83
CFTR inactivation by lentiviral vector-mediated RNA interference and CRISPR-Cas9 genome editing in human airway epithelial cells. Curr Gene Ther (2015) 0.82
T-cell receptor specificity of CD8(+) Tregs in allotransplantation. Immunotherapy (2011) 0.82
CTLA4Ig adenoviral gene transfer induces long-term islet rat allograft survival, without tolerance, after systemic but not local intragraft expression. Hum Gene Ther (2003) 0.82
Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival. Invest Ophthalmol Vis Sci (2007) 0.82
Allogeneic murine mesenchymal stem cells: migration to inflamed joints in vivo and amelioration of collagen induced arthritis when transduced to express CTLA4Ig. Stem Cells Dev (2013) 0.82
Accumulation of T cells with potent regulatory properties and restricted Vbeta7-TCR rearrangements in tolerated allografts. Transplantation (2005) 0.82
Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival in heart allografts in rats. Transplantation (2007) 0.81
Adenovirus-mediated CTLA4Ig or CD40Ig gene transfer delays pancreatic islet rejection in a rat-to-mouse xenotransplantation model after systemic but not local expression. Cell Transplant (2005) 0.81
Long term transgene expression by hepatocytes transduced with retroviral vectors requires induction of immune tolerance to the transgene. J Hepatol (2004) 0.81
Editorial: Heme oxygenase-1 and dendritic cells: what else? J Leukoc Biol (2010) 0.81
Human antibody expression in transgenic rats: comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regions. J Immunol Methods (2013) 0.80
The use of lentiviral vectors to obtain transgenic rats. Methods Mol Biol (2010) 0.80
Carbon monoxide exposure improves immune function in lupus-prone mice. Immunology (2013) 0.80
Phenotypic and functional characterization of CD8(+) T regulatory cells. Methods Mol Biol (2011) 0.80
Measuring immune responses to recombinant AAV gene transfer. Methods Mol Biol (2011) 0.80
Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes. Eur J Immunol (2012) 0.80
Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum. Cell Transplant (2013) 0.79
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus. Immunology (2012) 0.79
Trophic and immunoregulatory properties of neural precursor cells: benefit for intracerebral transplantation. Exp Neurol (2010) 0.79
Effector mechanisms of rejection. Cold Spring Harb Perspect Med (2013) 0.79
Immunobiological characterization of N -nitrosomethylurea-induced rat breast carcinomas: tumoral IL-10 expression as a possible immune escape mechanism. Breast Cancer Res Treat (2004) 0.78
The study of mitoxantrone as a potential immunosuppressor in transgenic pig renal xenotransplantation in baboons: comparison with cyclophosphamide. Xenotransplantation (2004) 0.78