Published in J Neurosci on March 01, 2002
An unexpected role for ion channels in brain tumor metastasis. Exp Biol Med (Maywood) (2008) 2.00
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
A neurocentric perspective on glioma invasion. Nat Rev Neurosci (2014) 1.61
A role for ion channels in glioma cell invasion. Neuron Glia Biol (2006) 1.57
Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch (2004) 1.53
Expression and function of calcium-activated potassium channels in human glioma cells. Glia (2006) 1.52
Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. J Neurosci Res (2004) 1.47
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol (2011) 1.37
BK channels are linked to inositol 1,4,5-triphosphate receptors via lipid rafts: a novel mechanism for coupling [Ca(2+)](i) to ion channel activation. J Biol Chem (2007) 1.37
Membrane potential and cancer progression. Front Physiol (2013) 1.35
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem (2010) 1.32
Mislocalization of Kir channels in malignant glia. Glia (2004) 1.29
Role of KCNMA1 gene in breast cancer invasion and metastasis to brain. BMC Cancer (2009) 1.26
A BK (Slo1) channel journey from molecule to physiology. Channels (Austin) (2013) 1.17
Calcium-activated potassium channels BK and IK1 are functionally expressed in human gliomas but do not regulate cell proliferation. PLoS One (2010) 1.16
Hydrodynamic cellular volume changes enable glioma cell invasion. J Neurosci (2011) 1.16
Targeting potassium channels in cancer. J Cell Biol (2014) 1.15
KCa3.1 channels are involved in the infiltrative behavior of glioblastoma in vivo. Cell Death Dis (2013) 1.10
BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells. J Membr Biol (2006) 1.10
Role of Kir4.1 channels in growth control of glia. Glia (2007) 1.09
Ionizing radiation, ion transports, and radioresistance of cancer cells. Front Physiol (2013) 1.09
Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death. Am J Physiol Cell Physiol (2012) 1.05
MaxiK channel and cell signalling. Pflugers Arch (2014) 1.02
Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons. Brain Res (2006) 1.01
The inhibition of KCa3.1 channels activity reduces cell motility in glioblastoma derived cancer stem cells. PLoS One (2012) 0.98
Control of alternative pre-mRNA splicing by Ca(++) signals. Biochim Biophys Acta (2008) 0.95
Cancer as a channelopathy: ion channels and pumps in tumor development and progression. Front Cell Neurosci (2015) 0.92
Molecular mechanisms of paraptosis induction: implications for a non-genetically modified tumor vaccine. PLoS One (2009) 0.91
Urine stimulation activates BK channels in mouse vomeronasal neurons. J Neurophysiol (2008) 0.90
Voltage-gated ion channels in cancer cell proliferation. Cancers (Basel) (2015) 0.89
Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model. Mol Cancer (2007) 0.89
Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy. J Immunol (2012) 0.88
Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease. Am J Transl Res (2014) 0.88
Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle. PLoS One (2012) 0.88
Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration. J Biomed Sci (2009) 0.87
Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol (2013) 0.87
Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma. J Signal Transduct (2012) 0.87
Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes. PLoS One (2011) 0.83
Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site. J Biol Chem (2014) 0.82
Modulation of glioma BK channels via erbB2. J Neurosci Res (2005) 0.81
Ion channels in glioblastoma. ISRN Neurol (2011) 0.81
Characterization of a functionally expressed stretch-activated BKca channel cloned from chick ventricular myocytes. J Membr Biol (2003) 0.81
Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth. Biol Open (2013) 0.81
Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels. Biomolecules (2015) 0.81
Role of ion channels in regulating Ca²⁺ homeostasis during the interplay between immune and cancer cells. Cell Death Dis (2015) 0.81
An oncologist׳s friend: How Xenopus contributes to cancer research. Dev Biol (2015) 0.81
Ion channel gene expression predicts survival in glioma patients. Sci Rep (2015) 0.78
Current transients associated with BK channels in human glioma cells. J Membr Biol (2003) 0.78
The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma. Front Cell Neurosci (2015) 0.77
Ion channel blockers and glioblastoma risk and outcome: a nested case-control and retrospective cohort studies. Pharmacoepidemiol Drug Saf (2016) 0.76
Progesterone and Src family inhibitor PP1 synergistically inhibit cell migration and invasion of human basal phenotype breast cancer cells. Biomed Res Int (2015) 0.76
Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy. PLoS One (2017) 0.75
Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors. Front Pharmacol (2013) 0.75
BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncol Rep (2014) 0.75
A role for ion channels in perivascular glioma invasion. Eur Biophys J (2016) 0.75
Cloning and distribution of Ca2+-activated K+ channels in lobster Panulirus interruptus. Neuroscience (2010) 0.75
Reconciling the discrepancies on the involvement of large-conductance Ca(2+)-activated K channels in glioblastoma cell migration. Front Cell Neurosci (2015) 0.75
Changes in tumor-antigen expression profile as human small-cell lung cancers progress. Cancer Biol Med (2015) 0.75
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29
Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J Biol Chem (2002) 2.21
Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci (2005) 2.17
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. FEBS J (2009) 2.14
Autocrine glutamate signaling promotes glioma cell invasion. Cancer Res (2007) 2.03
Glutamate release by primary brain tumors induces epileptic activity. Nat Med (2011) 2.00
Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci (2008) 1.92
Chlorotoxin, a scorpion-derived peptide, specifically binds to gliomas and tumors of neuroectodermal origin. Glia (2002) 1.85
FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method. BMC Biotechnol (2011) 1.72
Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. J Physiol (2003) 1.71
The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci (2007) 1.66
Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation. J Neurochem (2008) 1.66
Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. J Neurosci (2004) 1.64
A role for ion channels in glioma cell invasion. Neuron Glia Biol (2006) 1.57
Expression and function of calcium-activated potassium channels in human glioma cells. Glia (2006) 1.52
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther (2009) 1.51
Functional rundown of gamma-aminobutyric acid(A) receptors in human hypothalamic hamartomas. Ann Neurol (2011) 1.48
Glutamate and the biology of gliomas. Glia (2010) 1.48
Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. J Neurosci Res (2004) 1.47
Mechanism of action of benzodiazepines on GABAA receptors. Br J Pharmacol (2006) 1.40
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration. Am J Physiol Cell Physiol (2011) 1.37
BK channels are linked to inositol 1,4,5-triphosphate receptors via lipid rafts: a novel mechanism for coupling [Ca(2+)](i) to ion channel activation. J Biol Chem (2007) 1.37
Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia (2007) 1.34
A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci (2009) 1.33
Cytoplasmic volume condensation is an integral part of mitosis. Cell Cycle (2007) 1.33
Anion channels in astrocytes: biophysics, pharmacology, and function. Glia (2006) 1.32
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol Chem (2010) 1.32
Inhibition of the Sodium-Potassium-Chloride Cotransporter Isoform-1 reduces glioma invasion. Cancer Res (2010) 1.30
ClC3 is a critical regulator of the cell cycle in normal and malignant glial cells. J Neurosci (2008) 1.30
Bradykinin promotes the chemotactic invasion of primary brain tumors. J Neurosci (2011) 1.28
Chloride accumulation drives volume dynamics underlying cell proliferation and migration. J Neurophysiol (2008) 1.28
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A (2007) 1.23
BK channels in human glioma cells have enhanced calcium sensitivity. Glia (2002) 1.21
Hydrodynamic cellular volume changes enable glioma cell invasion. J Neurosci (2011) 1.16
Cytoplasmic condensation is both necessary and sufficient to induce apoptotic cell death. J Cell Sci (2008) 1.14
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A (2008) 1.12
Role of Kir4.1 channels in growth control of glia. Glia (2007) 1.09
TRPV1b, a functional human vanilloid receptor splice variant. Mol Pharmacol (2005) 1.09
Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. J Biol Chem (2004) 1.08
GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsia (2007) 1.08
Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB. J Neurochem (2009) 1.07
Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death. Am J Physiol Cell Physiol (2012) 1.05
Spinal cord injury causes a wide-spread, persistent loss of Kir4.1 and glutamate transporter 1: benefit of 17 beta-oestradiol treatment. Brain (2010) 1.05
Contribution of chloride channels to volume regulation of cortical astrocytes. Am J Physiol Cell Physiol (2003) 1.04
Transient receptor potential canonical channels are essential for chemotactic migration of human malignant gliomas. J Cell Physiol (2011) 1.03
Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3. J Neurosci (2013) 1.03
Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease. Neurobiol Dis (2010) 1.01
The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtype. J Pharmacol Exp Ther (2013) 1.01
Identification of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR) α6 subunits that influence effects of wild-type or mutant β3 subunits on function of α6β2*- or α6β4*-nAChR. J Biol Chem (2011) 1.01
Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. J Biol Chem (2003) 0.99
Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas. Glia (2010) 0.99
Hypoxia increases the dependence of glioma cells on glutathione. J Biol Chem (2010) 0.97
Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors. Mol Pharmacol (2008) 0.96
Agonist- and antagonist-induced conformational changes of loop F and their contributions to the rho1 GABA receptor function. J Physiol (2008) 0.96
Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif. PLoS One (2010) 0.96
Extracellular glutamine is a critical modulator for regulatory volume increase in human glioma cells. Brain Res (2007) 0.94
Cl- and K+ channels and their role in primary brain tumour biology. Philos Trans R Soc Lond B Biol Sci (2014) 0.94
Biophysical and pharmacological characterization of hypotonically activated chloride currents in cortical astrocytes. Glia (2004) 0.93
Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. Mol Biol Cell (2002) 0.93
Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia (2005) 0.93
With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume. Am J Physiol Cell Physiol (2011) 0.92
Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Am J Physiol Cell Physiol (2011) 0.92
Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses. J Biol Chem (2006) 0.92
Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 Subunits and/or variants modulate function of α6*-nAChR. J Biol Chem (2011) 0.91
Glutamate transporters in the biology of malignant gliomas. Cell Mol Life Sci (2013) 0.90
Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci (2013) 0.90
Growth hormone alters epidermal growth factor receptor binding affinity via activation of extracellular signal-regulated kinases in 3T3-F442A cells. Endocrinology (2004) 0.90
GABA(A) receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas. Exp Neurol (2008) 0.89
Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ. J Neurophysiol (2003) 0.89
A proinvasive role for the Ca(2+) -activated K(+) channel KCa3.1 in malignant glioma. Glia (2014) 0.89
Electrophysiological properties and subunit composition of GABAA receptors in patients with gelastic seizures and hypothalamic hamartoma. J Neurophysiol (2007) 0.88
Protein kinase A inhibits intermediate conductance Ca2+-activated K+ channels expressed in Xenopus oocytes. Pflugers Arch (2004) 0.88
Involvement of tumor acidification in brain cancer pathophysiology. Front Physiol (2013) 0.87
Human glioma cells induce hyperexcitability in cortical networks. Epilepsia (2012) 0.87
Unique biology of gliomas: challenges and opportunities. Trends Neurosci (2012) 0.87
Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. Biochim Biophys Acta (2011) 0.87
K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport. Respir Res (2010) 0.87
Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway. PLoS One (2011) 0.87
Modulation of recombinant, α2*, α3* or α4*-nicotinic acetylcholine receptor (nAChR) function by nAChR β3 subunits. J Neurochem (2012) 0.85
Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem (2011) 0.85
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia (2014) 0.85
Calcium entry via TRPC1 channels activates chloride currents in human glioma cells. Cell Calcium (2012) 0.85
Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo. BMC Cancer (2011) 0.84
Biophysical properties of human medulloblastoma cells. J Membr Biol (2010) 0.84
Chemotaxis of MDCK-F cells toward fibroblast growth factor-2 depends on transient receptor potential canonical channel 1. Pflugers Arch (2010) 0.84
Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2. J Neurochem (2009) 0.83
MAPK induces AQP1 expression in astrocytes following injury. Glia (2010) 0.83
Erythropoietin-induced neuroprotection requires cystine glutamate exchanger activity. Brain Res (2010) 0.83
Modulation of glial glutamate transport through cell interactions with the extracellular matrix. Int J Dev Neurosci (2002) 0.82
Hypoxic preconditioning involves system Xc- regulation in mouse neural stem cells. Stem Cell Res (2011) 0.81
Sulfasalazine for brain cancer fits. Expert Opin Investig Drugs (2012) 0.80
Ablation of the locus coeruleus increases oxidative stress in tg-2576 transgenic but not wild-type mice. Int J Alzheimers Dis (2010) 0.79
Characterization of a novel splice variant of δ ENaC subunit in human lungs. Am J Physiol Lung Cell Mol Physiol (2012) 0.79
Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release. J Pharmacol Exp Ther (2007) 0.79
Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR). Int J Mol Sci (2012) 0.78
Identification of novel splice variants and exons of human endothelial cell-specific chemotaxic regulator (ECSCR) by bioinformatics analysis. Comput Biol Chem (2012) 0.78
Glutamate and tumor-associated epilepsy. Oncotarget (2011) 0.78
Social odor recognition: a novel behavioral model for cognitive dysfunction in Parkinson's disease. Neurodegener Dis (2010) 0.78
Pyridinyl aminohydantoins as small molecule BACE1 inhibitors. Bioorg Med Chem Lett (2010) 0.77