The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

PubWeight™: 1.66‹?› | Rank: Top 3%

🔗 View Article (PMID 17336088)

Published in Mol Cell Neurosci on January 25, 2007

Authors

David R Riddell1, Hua Zhou, Thomas A Comery, Evguenia Kouranova, C Frederick Lo, Helen K Warwick, Robert H Ring, Yolanda Kirksey, Suzan Aschmies, Jane Xu, Katie Kubek, Warren D Hirst, Catherine Gonzales, Yi Chen, Erin Murphy, Sarah Leonard, Dmytro Vasylyev, Aram Oganesian, Robert L Martone, Menelas N Pangalos, Peter H Reinhart, J Steve Jacobsen

Author Affiliations

1: Discovery Neuroscience, Wyeth Research, CN8000, Princeton, NJ 08543, USA. riddeld@wyeh.com

Articles citing this

ApoE promotes the proteolytic degradation of Abeta. Neuron (2008) 4.75

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol (2013) 4.16

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci (2009) 3.97

Alzheimer's disease as homeostatic responses to age-related myelin breakdown. Neurobiol Aging (2009) 2.14

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med (2015) 1.88

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J Neurosci (2012) 1.71

ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice. J Biol Chem (2010) 1.64

Apolipoprotein E: from lipid transport to neurobiology. Prog Lipid Res (2010) 1.63

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. J Neurosci (2010) 1.48

Nuclear receptors as therapeutic targets for Alzheimer's disease. Expert Opin Ther Targets (2011) 1.46

ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron (2014) 1.33

A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta (2010) 1.28

Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem (2011) 1.23

The vascular contribution to Alzheimer's disease. Clin Sci (Lond) (2010) 1.21

Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (2013) 1.21

Memory deficits in APP23/Abca1+/- mice correlate with the level of Aβ oligomers. ASN Neuro (2009) 1.17

The role of ATP-binding cassette transporter A1 in Alzheimer's disease and neurodegeneration. Biochim Biophys Acta (2010) 1.17

Expression profiling in APP23 mouse brain: inhibition of Abeta amyloidosis and inflammation in response to LXR agonist treatment. Mol Neurodegener (2007) 1.13

Spines, plasticity, and cognition in Alzheimer's model mice. Neural Plast (2011) 1.06

The effects of cholesterol on learning and memory. Neurosci Biobehav Rev (2010) 1.05

NR4A nuclear receptors support memory enhancement by histone deacetylase inhibitors. J Clin Invest (2012) 1.04

eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice. Stroke (2009) 1.03

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease. Front Aging Neurosci (2014) 1.01

Neurosteroids as regenerative agents in the brain: therapeutic implications. Nat Rev Endocrinol (2013) 0.99

ATP-binding cassette transporter A1: from metabolism to neurodegeneration. Neurobiol Dis (2014) 0.98

Evidence for impaired amyloid β clearance in Alzheimer's disease. Alzheimers Res Ther (2013) 0.97

Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice. J Cereb Blood Flow Metab (2009) 0.97

Allopregnanolone promotes regeneration and reduces β-amyloid burden in a preclinical model of Alzheimer's disease. PLoS One (2011) 0.95

Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators. J Neurochem (2010) 0.94

Role of ABC transporters in the pathogenesis of Alzheimer's disease. ACS Chem Neurosci (2012) 0.90

Frontiers in therapeutic development of allopregnanolone for Alzheimer's disease and other neurological disorders. Front Cell Neurosci (2014) 0.90

SUMO and Alzheimer's disease. Neuromolecular Med (2013) 0.89

Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines. Biochem Pharmacol (2014) 0.89

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts. PLoS One (2014) 0.88

Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease. Alzheimers Res Ther (2012) 0.86

The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One (2013) 0.86

Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol (2010) 0.85

Nuclear receptors in neurodegenerative diseases. Neurobiol Dis (2014) 0.85

Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci (2014) 0.85

HDL and cognition in neurodegenerative disorders. Neurobiol Dis (2014) 0.84

Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist. J Alzheimers Dis (2014) 0.84

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein. Mol Neurodegener (2008) 0.84

Neuroregenerative mechanisms of allopregnanolone in Alzheimer's disease. Front Endocrinol (Lausanne) (2012) 0.84

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease. Neurobiol Aging (2014) 0.84

Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem (2009) 0.83

ABC Transporters and the Alzheimer's Disease Enigma. Front Psychiatry (2012) 0.83

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Mol Neurodegener (2015) 0.82

Hippocampal neurogenesis: Learning to remember. Prog Neurobiol (2016) 0.82

Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis? Mol Neurodegener (2010) 0.81

Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials. Biomed Res Int (2014) 0.81

Intracellular cholesterol homeostasis and amyloid precursor protein processing. Biochim Biophys Acta (2010) 0.81

Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats. F1000Res (2016) 0.81

Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats. Mol Neurodegener (2010) 0.80

Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage. J Neuroinflammation (2016) 0.79

Viable mouse gene ablations that robustly alter brain Aβ levels are rare. BMC Neurosci (2010) 0.79

Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice. J Biol Chem (2015) 0.79

Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment. Brain Res (2014) 0.78

Liver X receptors and cholesterol metabolism: role in ventral midbrain development and neurodegeneration. F1000Prime Rep (2015) 0.78

Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression. PLoS One (2013) 0.77

Hormonal modulators of glial ABCA1 and apoE levels. J Lipid Res (2013) 0.77

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease. Future Med Chem (2015) 0.77

Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. PLoS One (2014) 0.77

Development of Cerebral Microbleeds in the APP23-Transgenic Mouse Model of Cerebral Amyloid Angiopathy-A 9.4 Tesla MRI Study. Front Aging Neurosci (2016) 0.75

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice. PLoS One (2017) 0.75

Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS One (2017) 0.75

APOE genotype and stress response - a mini review. Lipids Health Dis (2016) 0.75

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes. PLoS One (2016) 0.75

Therapeutic potential of nuclear receptor agonists in Alzheimer's disease. J Lipid Res (2017) 0.75

Cholesterol as a modifying agent of the neurovascular unit structure and function under physiological and pathological conditions. Metab Brain Dis (2017) 0.75

Articles by these authors

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med (2005) 28.73

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity (2005) 14.95

Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 14.60

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest (2006) 11.89

TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol (2007) 11.14

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol (2009) 6.74

ApoE promotes the proteolytic degradation of Abeta. Neuron (2008) 4.75

IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med (2007) 3.69

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61

Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet (2005) 3.45

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med (2006) 3.38

From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal. Nature (2009) 3.18

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol (2012) 3.09

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci (2010) 2.78

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med (2012) 2.70

IL-10 elicits IFNγ-dependent tumor immune surveillance. Cancer Cell (2011) 2.57

Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. Am J Hum Genet (2013) 2.47

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol (2009) 2.39

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron (2007) 2.38

Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int (2008) 2.37

Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays. FEBS J (2009) 2.14

Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin Cancer Res (2010) 2.07

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. J Neurosci (2005) 2.05

mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res (2002) 1.98

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chem Biol (2012) 1.96

Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer. Eur J Radiol (2006) 1.95

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci (2008) 1.92

Functional characterization of Narc 1, a novel proteinase related to proteinase K. Arch Biochem Biophys (2003) 1.88

Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab (2013) 1.88

Mendel: the Swiss army knife of genetic analysis programs. Bioinformatics (2013) 1.85

'Social evils' and harm reduction: the evolving policy environment for human immunodeficiency virus prevention among injection drug users in China and Vietnam. Addiction (2007) 1.85

The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci (2008) 1.83

ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther (2008) 1.81

Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol (2010) 1.81

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease. Cell Metab (2011) 1.81

Changes of functional connectivity of the motor network in the resting state in Parkinson's disease. Neurosci Lett (2009) 1.78

Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry (2014) 1.78

A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide. J Bone Miner Res (2005) 1.78

PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle: defective regulation in heart failure. J Cell Biol (2003) 1.78

MRI of the basement membrane using charged nanoparticles as contrast agents. Magn Reson Med (2008) 1.77

Chiral separation of tamsulosin isomers by HPLC using cellulose tris (3,5-dimethhylphenylcarbamate) as a chiral stationary phase. J Pharm Biomed Anal (2004) 1.75

Effects of a one-month treatment with PTH(1-34) on bone formation on cancellous, endocortical, and periosteal surfaces of the human ilium. J Bone Miner Res (2007) 1.75

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci U S A (2005) 1.73

Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator. Am J Physiol Renal Physiol (2007) 1.72

Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. J Physiol (2003) 1.71

Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. Cancer Biol Ther (2006) 1.70

Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat Neurosci (2006) 1.70

Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer (2011) 1.69

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nat Neurosci (2010) 1.67

Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients. Cochrane Database Syst Rev (2015) 1.67

Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. Cancer Prev Res (Phila) (2013) 1.66

Characterizing the grape transcriptome. Analysis of expressed sequence tags from multiple Vitis species and development of a compendium of gene expression during berry development. Plant Physiol (2005) 1.65

A DNAzyme that walks processively and autonomously along a one-dimensional track. Angew Chem Int Ed Engl (2005) 1.65

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. J Neurosci (2004) 1.64

Down-regulation of BLIMP1α by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas. Blood (2011) 1.64

The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity (2010) 1.64

Prognostic significance of serum gamma-glutamyl transferase in patients with intermediate hepatocellular carcinoma treated with transcatheter arterial chemoembolization. Eur J Gastroenterol Hepatol (2011) 1.63

Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: new experimental paradigms. Eur Urol (2006) 1.63

Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2008) 1.59

Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.56

Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China. J Antimicrob Chemother (2010) 1.56

Cloning and characterization of glioma BK, a novel BK channel isoform highly expressed in human glioma cells. J Neurosci (2002) 1.56

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. Nature (2009) 1.54

Reducing HIV infection among new injecting drug users in the China-Vietnam Cross Border Project. AIDS (2007) 1.53

Whole-rat conditional gene knockout via genome editing. Nat Methods (2013) 1.53

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci (2003) 1.52

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease. J Clin Invest (2006) 1.52

Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1. Kidney Int (2011) 1.52

MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer. Carcinogenesis (2011) 1.51

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther (2009) 1.51

Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. J Am Chem Soc (2012) 1.50

Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. Blood (2008) 1.50

Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites. J Neurosci (2007) 1.49

Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. Am J Pathol (2009) 1.47

Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res (2008) 1.46

Impact of warming blood transfusion and infusion toward cerebral oxygen metabolism and cognitive recovery in the perioperative period of elderly knee replacement. J Orthop Surg Res (2014) 1.45

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease. Neuroimage (2010) 1.44