Published in Am J Physiol Endocrinol Metab on April 01, 2002
GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A (2011) 1.69
Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. Diabetes (2008) 1.33
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells. J Gen Physiol (2004) 1.31
GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule. J Gen Physiol (2004) 1.11
Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric acid shunt. J Biol Chem (2008) 1.10
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes. Diabetologia (2012) 1.10
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells. J Gen Physiol (2007) 1.10
Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine. J Biol Chem (2012) 1.00
Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue. Biochem J (2004) 0.88
GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 β-cells. PLoS One (2011) 0.88
Segregation of two glutaminase isoforms in islets of Langerhans. Biochem J (2004) 0.86
GABAergic system in the endocrine pancreas: a new target for diabetes treatment. Diabetes Metab Syndr Obes (2015) 0.83
Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content. Interface Focus (2010) 0.81
Micellar electrokinetic chromatography method for measuring amino acid secretions from islets of Langerhans. Electrophoresis (2015) 0.76
Extraction, purification and anti-fatigue activity of γ-aminobutyric acid from mulberry (Morus alba L.) leaves. Sci Rep (2016) 0.75
Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets. PLoS One (2016) 0.75
Hyperglycemia associated dissociative fugue (organic dissociative disorder) in an elderly. J Family Med Prim Care (2015) 0.75
Gamma-aminobutyric acid secreted from islet beta-cells modulates exocrine secretion in rat pancreas. World J Gastroenterol (2006) 0.75
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 10.16
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet (2008) 5.49
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science (2008) 4.38
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res (2010) 4.25
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet (2008) 3.94
Chromosome instability is common in human cleavage-stage embryos. Nat Med (2009) 3.85
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci (2006) 3.82
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab (2006) 3.28
Characterization of proposed human B-1 cells reveals pre-plasmablast phenotype. Blood (2013) 3.07
Role of PFKFB3-driven glycolysis in vessel sprouting. Cell (2013) 3.04
miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes (2008) 2.23
Using ribosomal protein genes as reference: a tale of caution. PLoS One (2008) 2.06
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
Screening for insulitis in adult autoantibody-positive organ donors. Diabetes (2007) 2.02
Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes (2005) 1.81
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors. Diabetes (2004) 1.68
Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res (2010) 1.67
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. Am J Hum Genet (2007) 1.62
Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. Proc Natl Acad Sci U S A (2006) 1.60
Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes (2010) 1.55
Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A (2008) 1.52
A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation. Gastroenterology (2011) 1.44
Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS One (2011) 1.38
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood (2009) 1.37
Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells. Diabetes (2002) 1.27
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients. Diabetes (2009) 1.27
Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem (2005) 1.24
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med (2006) 1.24
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol (2004) 1.23
Why expression of some genes is disallowed in beta-cells. Biochem Soc Trans (2008) 1.22
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology (2011) 1.20
Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations. Diabetes (2006) 1.19
Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas (2008) 1.19
Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes (2002) 1.17
Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. PLoS One (2009) 1.16
Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. J Biol Chem (2007) 1.16
The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation. J Immunol (2010) 1.12
Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids. Hepatology (2004) 1.12
Reciprocal changes of Foxp3 expression in blood and intestinal mucosa in IBD patients responding to infliximab. Inflamm Bowel Dis (2010) 1.10
Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment. Am J Gastroenterol (2011) 1.10
PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res (2002) 1.10
The beta cell population in type 1 diabetes. Novartis Found Symp (2008) 1.08
Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr (2003) 1.05
IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms. Blood (2010) 1.04
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proc Natl Acad Sci U S A (2008) 1.03
Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Gastroenterology (2003) 1.03
In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression. Hum Reprod (2009) 1.03
Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease. Inflamm Bowel Dis (2010) 1.02
Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Histochem Cytochem (2003) 1.01
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype. PLoS One (2011) 1.01
Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology (2004) 1.00
Protein markers for insulin-producing beta cells with higher glucose sensitivity. PLoS One (2010) 0.99
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming. PLoS One (2012) 0.97
Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis (2011) 0.96
Anti-alpha-enolase antibodies in patients with inflammatory Bowel disease. Clin Chem (2008) 0.95
Essential role of chicken ovalbumin upstream promoter-transcription factor II in insulin secretion and insulin sensitivity revealed by conditional gene knockout. Diabetes (2005) 0.95
Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity. Diabetes (2006) 0.95
Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase. Am J Physiol Endocrinol Metab (2006) 0.95
Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor. Diabetes (2008) 0.94
A view on beta cell transplantation in diabetes. Ann N Y Acad Sci (2002) 0.94
Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice. PLoS One (2012) 0.94
Feasibility, safety, and efficacy of percutaneous transhepatic injection of beta-cell grafts. J Vasc Interv Radiol (2005) 0.93
Plasma-equivalent glucose at the point-of-care: evaluation of Roche Accu-Chek Inform and Abbott Precision PCx glucose meters. Clin Chim Acta (2007) 0.93
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PLoS One (2009) 0.93
A glucose sensor role for glucokinase in anterior pituitary cells. Diabetes (2006) 0.93
Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One (2013) 0.93
Transcription of genes encoding synaptic vesicle proteins in human neural stem cells: chromatin accessibility, histone methylation pattern, and the essential role of rest. J Biol Chem (2008) 0.92
Glucose, regulator of survival and phenotype of pancreatic beta cells. Vitam Horm (2009) 0.91
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab (2007) 0.91
Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity. FEBS J (2007) 0.91
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochem Pharmacol (2008) 0.90
Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells. J Physiol (2004) 0.89
Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects. PLoS One (2012) 0.89
Human pancreatic duct cells exert tissue factor-dependent procoagulant activity: relevance to islet transplantation. Diabetes (2004) 0.89
Growth without growth hormone receptor: estradiol is a major growth hormone-independent regulator of hepatic IGF-I synthesis. J Bone Miner Res (2005) 0.88
Comparative evaluation of simple indices of graft function after islet transplantation. Transplantation (2011) 0.88
Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness. Biochem Pharmacol (2004) 0.88
Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function. Diabetes (2013) 0.87
Species and epitope specificity of two 65 kDa glutamate decarboxylase time-resolved fluorometric immunoassays. J Immunol Methods (2006) 0.86
Detection of novel 3' untranslated region extensions with 3' expression microarrays. BMC Genomics (2010) 0.86
Interaction of glibenclamide and metformin at the level of translation in pancreatic β cells. J Endocrinol (2010) 0.86
Growth and functional maturation of beta-cells in implants of endocrine cells purified from prenatal porcine pancreas. Diabetes (2005) 0.86