Published in Gene Expr on January 01, 2003
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One (2007) 2.08
Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia (2006) 1.91
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem (2008) 1.83
Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol (2009) 1.72
Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol (2007) 1.68
Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes (2011) 1.30
Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol (2010) 1.21
Dickkopf-3 is expressed in a subset of adult human pancreatic beta cells. Histochem Cell Biol (2007) 0.95
Lack of beta-catenin in early life induces abnormal glucose homeostasis in mice. Diabetologia (2009) 0.94
Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res (2009) 0.93
Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours. Nat Commun (2014) 0.86
Dkk1, -2, and -3 expression in mouse craniofacial development. J Mol Histol (2005) 0.84
Beta-catenin signalling in mesenchymal islet-derived precursor cells. Cell Prolif (2008) 0.80
Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus. Mol Brain (2016) 0.80
Thrombin promotes epithelial ovarian cancer cell invasion by inducing epithelial-mesenchymal transition. J Gynecol Oncol (2013) 0.77
SFRP2 Is Associated with Increased Adiposity and VEGF Expression. PLoS One (2016) 0.75
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell (2008) 8.57
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
WNT signaling pathway and stem cell signaling network. Clin Cancer Res (2007) 4.24
Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev (2003) 4.00
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell (2009) 3.63
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metab (2006) 3.28
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
Human FOX gene family (Review). Int J Oncol (2004) 2.63
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48
Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. J Clin Invest (2007) 2.46
Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02
Screening for insulitis in adult autoantibody-positive organ donors. Diabetes (2007) 2.02
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Notch signaling in gastrointestinal tract (review). Int J Oncol (2007) 1.96
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med (2008) 1.85
Specifying pancreatic endocrine cell fates. Mech Dev (2006) 1.84
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development (2013) 1.83
Cancer genetics and genomics of human FOX family genes. Cancer Lett (2012) 1.81
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol (2002) 1.79
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res (2010) 1.68
Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther (2006) 1.68
FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol (2003) 1.62
Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Dev Dyn (2002) 1.61
Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft. Proc Natl Acad Sci U S A (2006) 1.60
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes (2010) 1.55
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascades. Int J Mol Med (2009) 1.52
Identification and characterization of JMJD2 family genes in silico. Int J Oncol (2004) 1.52
Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int J Mol Med (2006) 1.49
Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3. Diabetes (2011) 1.47
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell (2013) 1.46
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro. Gastroenterology (2009) 1.42
Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther (2005) 1.40
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells. Int J Mol Med (2006) 1.34
FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review). Int J Mol Med (2009) 1.33
FGF signaling network in the gastrointestinal tract (review). Int J Oncol (2006) 1.32
The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development (2004) 1.30
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem (2007) 1.28
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients. Diabetes (2009) 1.27
STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Int J Mol Med (2007) 1.25
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation. Free Radic Biol Med (2006) 1.24
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol (2004) 1.23
Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. Int J Oncol (2009) 1.23
Artifactual insulin release from differentiated embryonic stem cells. Diabetes (2004) 1.22
Correlation between GABA release from rat islet beta-cells and their metabolic state. Am J Physiol Endocrinol Metab (2002) 1.21
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas. Gastroenterology (2011) 1.20
Stem cell marker prominin-1/AC133 is expressed in duct cells of the adult human pancreas. Pancreas (2008) 1.19
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells. Dev Biol (2009) 1.16
Identification and characterization of ASXL3 gene in silico. Int J Oncol (2004) 1.15
Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. Int J Oncol (2002) 1.15
Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol (2005) 1.14
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Dev Biol (2004) 1.14
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14
Comparative genomics on PROM1 gene encoding stem cell marker CD133. Int J Mol Med (2007) 1.13
Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico. Int J Oncol (2003) 1.12
Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol (2006) 1.12
Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. Int J Mol Med (2002) 1.11
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem (2002) 1.11
Bioinformatics for cancer management in the post-genome era. Technol Cancer Res Treat (2006) 1.11
Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med (2007) 1.10
Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas. BMC Dev Biol (2007) 1.08
Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. J Histochem Cytochem (2008) 1.08
Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn (2003) 1.07
Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Int J Oncol (2003) 1.07
Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med (2002) 1.06
Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Int J Oncol (2004) 1.05
Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB. Int J Oncol (2009) 1.05
Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. PLoS One (2009) 1.05
Beta cells within single human islets originate from multiple progenitors. PLoS One (2008) 1.05
Analysis of pancreatic endocrine development in GDF11-deficient mice. Dev Dyn (2006) 1.05
NUMB is a break of WNT-Notch signaling cycle. Int J Mol Med (2006) 1.03
Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle. Int J Mol Med (2003) 1.03
CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family. Int J Mol Med (2003) 1.03
Identification and characterization of human CXXC10 gene in silico. Int J Oncol (2004) 1.02
Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes (2006) 1.02
WNT antagonist, SFRP1, is Hedgehog signaling target. Int J Mol Med (2006) 1.02
Mind bomb 1 is required for pancreatic β-cell formation. Proc Natl Acad Sci U S A (2012) 1.02
Nestin is expressed in vascular endothelial cells in the adult human pancreas. J Histochem Cytochem (2003) 1.01