PubRank

H G Floss

Author PubWeight™ 102.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol 1998 2.64
2 Production of 'hybrid' antibiotics by genetic engineering. Nature 1985 2.04
3 Enzymatic formation of beta-cyanoalanine from cyanide. Nature 1965 1.60
4 Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. J Bacteriol 1990 1.55
5 Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives. J Antibiot (Tokyo) 1985 1.41
6 Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proc Natl Acad Sci U S A 1999 1.32
7 3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics. J Biol Chem 1998 1.28
8 The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host. Chem Biol 1998 1.20
9 Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor. J Antibiot (Tokyo) 1987 1.18
10 Stereochemistry of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase reaction and the chorismate synthetase reaction. J Biol Chem 1972 1.18
11 Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase. J Biol Chem 1980 1.17
12 Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus. J Am Chem Soc 2001 1.16
13 Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. J Am Chem Soc 2001 1.14
14 Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. Proc Natl Acad Sci U S A 1999 1.13
15 Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry 1996 1.12
16 The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. J Biol Chem 1999 1.11
17 Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chem Biol 2000 1.11
18 Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase. Arch Biochem Biophys 1991 1.10
19 Physiological studies on ergot: Influence of 5-methyltryptophan on alkaloid biosynthesis and the incorporation of tryptophan analogs into protein. J Pharm Sci 1970 1.08
20 Nucleotide sequence and transcriptional analysis of the nosiheptide-resistance gene from Streptomyces actuosus. Gene 1990 1.04
21 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. J Biol Chem 2001 1.04
22 Physiological studies on ergot: further studies on the induction of alkaloid synthesis by tryptophan and its inhibition by phosphate. J Bacteriol 1972 1.03
23 Isolation of dimethylallylpyrophosphate: tryptophan dimethylallyl transferase from the rgot fungus (Claviceps spec.). Biochem Biophys Res Commun 1971 1.03
24 Biosynthesis of pyrrolnitrin. Incorporation of 13C, 15N double-labelled D- and L-tryptophan. J Basic Microbiol 1992 1.02
25 Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58. Arch Biochem Biophys 1976 1.01
26 An antifungal compound from Solanum nigrescens. J Ethnopharmacol 1994 1.01
27 Steric course of the chorismate synthetase reaction and the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase reaction. J Am Chem Soc 1969 1.00
28 Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA. Eur J Biochem 1994 0.99
29 Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety. Bioorg Med Chem 1996 0.99
30 Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. J Antibiot (Tokyo) 2000 0.98
31 Isolation and characterization of tryptophan transaminase and indolepyruvate C-methyltransferase. Enzymes involved in indolmycin biosynthesis in Streptomyces griseus. J Biol Chem 1975 0.97
32 The biosynthesis of the antibiotic pyrrolnitrin by Pseudomonas aureofaciens. J Antibiot (Tokyo) 1981 0.96
33 Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase. Arch Biochem Biophys 1990 0.95
34 Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate. Biochemistry 1977 0.94
35 Stereochemistry of the myo-inositol-1-phosphate synthase reaction. J Biol Chem 1980 0.93
36 Purification and characterization of TDP-D-glucose 4,6-dehydratase from anthracycline-producing streptomycetes. J Gen Microbiol 1992 0.92
37 Stereochemistry and mechanism of reactions catalyzed by tryptophan synthetase and its beta2 subunit. J Biol Chem 1978 0.92
38 The biosynthesis of acarbose and validamycin. Chem Rec 2001 0.92
39 Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin. Mol Gen Genet 1995 0.91
40 Stereochemistry of methyl transfer catalyzed by tRNA (m5U54)-methyltransferase--evidence for a single displacement mechanism. Nucleic Acids Res 1991 0.91
41 Chiral methyl groups. Adv Enzymol Relat Areas Mol Biol 1979 0.91
42 Stereochemistry of the dTDP-glucose oxidoreductase reaction. J Biol Chem 1977 0.90
43 Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase. Biochemistry 1999 0.90
44 Biosynthesis of ergot alkaloids. Studies on the mechanism of the conversion of chanoclavin-I into tetracyclic ergolines. J Am Chem Soc 1974 0.89
45 Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage. Biochemistry 1988 0.89
46 Tryptophan metabolism, protein and alkaloid synthesis in saprophytic cultures of the ergot fungus (Claviceps sp.). Lloydia 1969 0.89
47 Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. Eur J Biochem 1999 0.88
48 Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D. J Antibiot (Tokyo) 1989 0.88
49 Demonstration of a C-methylating enzyme in cell free extracts of indolmycin-producing Streptomyces griseus. Biochem Biophys Res Commun 1970 0.87
50 Further studies on the biosynthesis of chlorothricin. J Antibiot (Tokyo) 1986 0.87
51 Physiological study of ergot: induction of alkaloid synthesis by tryptophan at the enzymatic level. J Bacteriol 1976 0.86
52 Thin-layer chromatographic separation of some indolic methyl esters including indoleisopropionic acid methyl ester. Anal Biochem 1968 0.86
53 Reexamination of the 1H and 13C NMR spectral assignments of thiostrepton. J Antibiot (Tokyo) 1989 0.85
54 Biosynthesis of ergot alkaloids. Evidence for two isomerizations in the isoprenoid moiety during the formation of tetracyclic ergolines. J Am Chem Soc 1968 0.85
55 [On the biosynthesis of 2,3-dihydroxybenzoic acid in submersion cultures of Claviceps paspali Stevens et Hall]. Z Naturforsch B 1965 0.85
56 Origin of the oxygen atoms in the conversion of anthranilic acid to 2,3-dihydroxybenzoic acid by Claviceps paspali. Arch Biochem Biophys 1969 0.84
57 Carbon-13 magnetic resonance spectroscopy coumarins. Carbon-13-proton long-range couplings. J Org Chem 1977 0.84
58 Biosynthesis of riboflavin. Incorporation of 13C-labeled precursors into the xylene ring. J Biol Chem 1983 0.84
59 Biosynthesis of indoleisopropionic acid by Claviceps. Biological C-methylation involving an intact methyl group. Arch Biochem Biophys 1969 0.84
60 1H and 13C NMR assignments of the thiopeptide antibiotic nosiheptide. J Antibiot (Tokyo) 1989 0.84
61 Stereochemistry and mechanism of the GDP-mannose dehydratase reaction. Carbohydr Res 1990 0.83
62 Stereochemistry of the beta-cyanoalanine synthetase and S-alkylcysteine lyase reactions. Arch Biochem Biophys 1978 0.83
63 The biosynthesis of indolmycin. J Am Chem Soc 1971 0.83
64 Biosynthesis of riboflavin. Enzymatic formation of 6,7-dimethyl-8-ribityllumazine from pentose phosphates. J Biol Chem 1986 0.83
65 Biosynthesis of the antibiotic 2,5-dihydrophenylalanine by Streptomyces arenae. Biochemistry 1978 0.83
66 Biosynthesis of ergot alkaloids. Synthesis of 6-methyl-8-acetoxymethylene-9-ergolene and its incorporation into ergotoxine by Claviceps. J Org Chem 1973 0.83
67 Structural determination of alginic acid and the effects of calcium binding as determined by high-field n.m.r. Carbohydr Res 1992 0.83
68 Conversion of Elymoclavine to Paspalic Acid by a Particulate Fraction from an Ergotamine-Producing Strain of Claviceps sp. Planta Med 1983 0.82
69 Conformation-reactivity relationship for pyridoxal Schiff's bases. Rates of racemization and alpha-hydrogen exchange of the pyridoxal Schiff's bases of amino acids. Biochemistry 1978 0.82
70 Some characteristics of tryptophan uptake in Claviceps species. J Bacteriol 1973 0.81
71 Transcriptional organization and regulation of the nosiheptide resistance gene in Streptomyces actuosus. J Ind Microbiol 1991 0.81
72 Biosynthesis of riboflavin. Enzymatic formation of the xylene moiety from [14C]ribulose 5-phosphate. Biochem Biophys Res Commun 1984 0.81
73 Biosynthesis of riboflavin in Bacillus subtilis: origin of the four-carbon moiety. J Bacteriol 1985 0.81
74 Synthesis of methionine carrying a chiral methyl group and its use in determining the steric course of the enzymatic C-methylation of indolepyruvate during indolmycin biosynthesis. J Am Chem Soc 1977 0.81
75 Studies on the biosynthesis of the alpha-glucosidase inhibitor acarbose: valienamine, a m-C7N unit not derived from the shikimate pathway. J Antibiot (Tokyo) 1987 0.81
76 Ergolines as potential prolactin and mammary tumor inhibitors. Lloydia 1977 0.81
77 S-adenoxylmethionine:indolepyruvate 3-methyltransferase. Methods Enzymol 1975 0.81
78 On the biosynthesis of cantharidin. J Pharm Sci 1969 0.81
79 Purification and properties of anthranilate synthetase from the ergot fungus, Claviceps spec., strain SD 58. Lloydia 1977 0.80
80 Biosynthesis of ansatrienin by Streptomyces collinus: cell-free transformations of cyclohexene- and cyclohexadienecarboxylic acids. J Antibiot (Tokyo) 1992 0.80
81 Stereospecificity of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase reaction. Biochem Biophys Res Commun 1969 0.80
82 Thiopeptides. Biotechnology 1995 0.80
83 Biosynthesis of the ansamycin antibiotic ansatrienin (mycotrienin) by Streptomyces collinus. J Nat Prod 1987 0.80
84 Nuclear magnetic resonance and biosynthetic studies of neoantimycin and structure elucidation of isoneoantimycin, a minor metabolite related to neoantimycin. J Nat Prod 1998 0.79
85 Stereochemistry of sodium borohydride reduction of tryptophan synthase of Escherichia coli and its amino acid Schiff's bases. J Biol Chem 1982 0.79
86 Stereochemistry of the in vitro and in vivo methylation of DNA by (R)- and (S)-N-[2H1,3H]methyl-N-nitrosourea and (R)- and (S)-N-nitroso-N-[2H1,3H]methyl-N-methylamine. Chem Res Toxicol 1997 0.79
87 Three new omega-cycloheptyl fatty acids from Alicyclobacillus cycloheptanicus and their biosynthetic interrelationships. J Nat Prod 1995 0.79
88 [Biosynthesis of ergot alkaloids. On the origin of side chains in d-lysergic acid methylcarbinolamide]. Z Naturforsch B 1968 0.79
89 Some stereochemical features of aspartate beta-decarboxylase. J Biol Chem 1982 0.79
90 The thiostrepton-resistance-encoding gene in Streptomyces laurentii is located within a cluster of ribosomal protein operons. Gene 1995 0.79
91 Isolation and absolute configuration of indolmycenic acid, an intermediate in the biosynthesis of indolmycin by Streptomyces griseus. Tetrahedron Lett 1970 0.79
92 Biosynthesis of phenylalanine, tyrosine, 3-(3-carbocyphenyl) alanine and 3-(3-carbocy-4-hydroxyphenyl) alanine in higher plants. Examples of the transformation possibilities for chorismic acid. Biochim Biophys Acta 1975 0.79
93 Influence of ergot alkaloids on pituitary prolactin and prolactin-dependent processes. J Pharm Sci 1973 0.78
94 Biosynthesis of the macrolide antibiotic chlorothricin. Biochemistry 1981 0.78
95 Stereochemical course of the transmethylation catalyzed by histamine N-methyltransferase. Arch Biochem Biophys 1984 0.78
96 Biosynthesis of the macrolide antibiotic chlorothricin: basic building blocks. Biochemistry 1978 0.78
97 Ergot alkaloids. Ergolines and related compounds as inhibitors of prolactin release. J Med Chem 1974 0.77
98 Synthesis of 4-amino 3,4-dideoxy-D-arabino-heptulosonic acid 7-phosphate, the biosynthetic precursor of C7N units in ansamycin antibiotics. Carbohydr Res 1994 0.77
99 Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus. J Bacteriol 1992 0.77
100 Stereochemistry and mechanism of reactions catalyzed by tryptophanase Escherichia coli. J Biol Chem 1978 0.77
101 Urdamycins, new angucycline antibiotics from Streptomyces fradiae. III. The structures of urdamycins C and D. J Antibiot (Tokyo) 1988 0.77
102 Biosynthesis of the shikimate-derived starter unit of the immunosuppressant ascomycin: stereochemistry of the 1,4-conjugate elimination. J Antibiot (Tokyo) 1997 0.77
103 Stereochemical course of biotin-independent malonate decarboxylase catalysis. Arch Biochem Biophys 1999 0.77
104 Further studies on the biosynthesis of pyrrolnitrin from tryptophan by Pseudomonas. Biochem Biophys Res Commun 1971 0.77
105 Nuclear magnetic resonance spectral analysis of the ergot alkaloids. J Org Chem 1974 0.76
106 Stereochemistry and mechanism of reactions catalyzed by tyrosine phenol-lyase from Escherichia intermedia. Z Naturforsch C 1987 0.76
107 Biosynthesis of the boron-containing antibiotic aplasmomycin. Nuclear magnetic resonance analysis of aplasmomycin and desboroaplasmomycin. J Antibiot (Tokyo) 1980 0.76
108 Biosynthesis of ergot alkaloids: formation of 4-dimethylallyltryptophan by the ergot fungus. Arch Biochem Biophys 1968 0.76
109 Ergot alkaloids. Synthesis of 6-methyl-8-ergolenes as inhibitors of prolactin release. J Med Chem 1975 0.76
110 Clavicipitic acid, a new 4-substituted indolic amino acid obtained from submerged cultures of the ergot fungus. Tetrahedron Lett 1969 0.76
111 New type II manumycins produced by Streptomyces nodosus ssp. asukaensis and their biosynthesis. J Antibiot (Tokyo) 2001 0.76
112 Identification of four genes from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22 involved in the biosynthesis of L-rhodinose. J Antibiot (Tokyo) 2001 0.75
113 Biosynthesis of peptide-type ergot alkaloids. Ergotamine. Lloydia 1971 0.75
114 On the biosynthesis of peptide ergot alkaloids. Experientia 1974 0.75
115 Ergot alkaloids. Synthesis of 6-alkyl-8-ergolenes and 6-methyl-8-aminoergolines as potential prolactin inhibitors. J Med Chem 1977 0.75
116 Biosynthesis of ketomycin. J Antibiot (Tokyo) 1984 0.75
117 Studies on the biosynthesis of antibiotics. J Nat Prod 1987 0.75
118 Synthesis of [6"-3H]-, (6"-2H)- and (2-2H)-maltotriose. Carbohydr Res 1996 0.75
119 Application of long-range spin-spin couplings in biosynthetic studies. J Org Chem 1976 0.75
120 [Biosynthesis of ergot alkaloids. Some new results on an old problem (Review)]. Prikl Biokhim Mikrobiol 1993 0.75
121 [Biosynthesis of ergot alkaloids. Biogenetic relationships between clavine and lysergic acid derivatives]. Z Naturforsch B 1966 0.75
122 Model studies of pyridoxal Schiff's bases. Coplanarity and intramolecular hydrogen bonding. J Med Chem 1977 0.75
123 Shikimic acid and quinic acid are not mutagenic in the Ames assay. Lloydia 1979 0.75
124 Identity of the antitumor antibiotic litmomycin with granaticin A. J Antibiot (Tokyo) 1975 0.75
125 [Recent advances in the chemistry and biosynthesis of ergot alkaloids]. Cesk Farm 1976 0.75
126 [Isolation of elymoclavin-O-beta-D-fructoside from cultures of ergot]. Z Naturforsch B 1967 0.75
127 Instrumental methods in biosynthetic studies. Lloydia 1972 0.75
128 Biosynthesis of chloramphenicol in Streptomyces species 3022a. Isotope incorporation experiments with (G-14C) chorismic, (G-14C) prephenic, and (G-14C, 6-3H) shikimic acids. Can J Microbiol 1974 0.75
129 Isolation of two minor components of the boromycin fermentation: N-acetylboromycin and N-formylboromycin. J Antibiot (Tokyo) 1985 0.75
130 Microdegradation procedure for radioactive peptide ergot alkaloids. J Pharm Sci 1971 0.75
131 Stereochemistry and mechanism of reactions catalyzed by indolyl-3-alkane alpha-hydroxylase. J Biol Chem 1979 0.75
132 Further studies on the biosynthesis of granaticin. Z Naturforsch C 1986 0.75
133 Stereochemistry of the kynureninase reaction. J Biol Chem 1985 0.75
134 Biosynthesis of ergot alkaloids. Ergometrine. Lloydia 1971 0.75
135 Steric course of the rhodium-catalyzed decarbonylation of chiral 4-methyl-[1-3H,2-2H1]pentanal. Z Naturforsch C 1987 0.75
136 Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents. J Med Chem 1980 0.75
137 Carbon-13 magnetic resonance spectroscopy of drugs. Sulfonamides. J Med Chem 1975 0.75
138 Steric course of the N-methylation in the biosynthesis of ergot alkaloids by Claviceps purpurea. J Basic Microbiol 1991 0.75
139 Stereochemistry of enzyjme reactions at prochiral centers. Naturwissenschaften 1970 0.75
140 Biosynthetic studies on the origin of the cyclohexanecarboxylic acid moiety of ansatrienin A and omega-cyclohexyl fatty acids. J Nat Prod 1994 0.75
141 Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents. J Med Chem 1979 0.75
142 Biosynthesis of peptide-type ergot alkaloids. Ergocornine and ergocryptine. Lloydia 1971 0.75
143 Mechanism of the anthranilate synthetase reaction. Evidence against an intramolecular hydrogen transfer. Biochim Biophys Acta 1970 0.75
144 Stereochemistry of the formation of cysteine by O-acetylserine sulfhydrase. J Biol Chem 1976 0.75
145 Molecular cloning of the nosiheptide resistance gene from Streptomyces actuosus ATCC 25421. Biochem Biophys Res Commun 1988 0.75
146 Biosynthesis of ergot alkaloids. Origin of the oxygens of chanoclavine-I and elymoclavine. J Pharm Sci 1967 0.75
147 Nidation inhibition by simple ergoline derivatives. J Pharm Sci 1975 0.75
148 Stereochemical course of the methylation of the polygalacturonic acid carboxyl groups of pectin. Arch Biochem Biophys 1981 0.75
149 Ergot alkaloids. Isolation of N-demethylchanoclavine-II from Claviceps strain SD 58 and the role of demethylchanoclavines in ergoline biosynthesis. Lloydia 1973 0.75
150 Stereochemistry of the tryptophan synthetase reaction. J Am Chem Soc 1974 0.75
151 Conformational analysis of pyridoxal Schiff's bases. Nuclear magnetic resonance studies of the conformations about the C4-C4', Calpha-Cbeta, and N-Calpha bonds of the pyridoxal Schiff's bases of amino acids. Biochemistry 1978 0.75
152 Biosynthesis of ergot alkaloids. Incorporation of (5R)- and (5S)-mevalonate-5-T into chanoclavines and tetracyclic ergolines. Lloydia 1972 0.75
153 Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae. J Basic Microbiol 1991 0.75