PubRank

Gabriel Núñez

Author PubWeight™ 210.05‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol 2006 10.55
2 Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006 9.77
3 Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 2007 6.75
4 Intracellular NOD-like receptors in host defense and disease. Immunity 2007 6.48
5 RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002 5.95
6 Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006 5.92
7 Sensing and reacting to microbes through the inflammasomes. Nat Immunol 2012 5.24
8 Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem 2006 5.11
9 The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 2008 4.72
10 Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol 2013 4.34
11 Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem 2007 4.27
12 Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol 2007 4.19
13 Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 2012 4.17
14 K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 2013 3.96
15 RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 2007 3.43
16 Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 2009 3.32
17 Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol 2010 3.25
18 Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol 2011 3.05
19 Control of pathogens and pathobionts by the gut microbiota. Nat Immunol 2013 2.84
20 Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J 2004 2.81
21 DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012 2.81
22 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 2007 2.72
23 Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002 2.71
24 Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol 2008 2.65
25 Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics 2008 2.64
26 The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 2008 2.53
27 The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 2011 2.47
28 A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. J Immunol 2009 2.29
29 Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 2004 2.26
30 Intracellular NOD-like receptors in innate immunity, infection and disease. Cell Microbiol 2007 2.25
31 Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol 2006 2.21
32 Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J Immunol 2008 2.13
33 Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J Exp Med 2012 2.03
34 A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol 2011 1.98
35 NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol 2012 1.97
36 Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med 2006 1.95
37 PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe 2009 1.89
38 The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J Immunol 2007 1.89
39 Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. Cell Host Microbe 2013 1.89
40 Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest 2011 1.88
41 Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol 2007 1.87
42 Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe 2011 1.86
43 The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res 2008 1.78
44 Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. J Immunol 2006 1.73
45 Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun 2003 1.71
46 ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 2003 1.70
47 Inflammasomes as microbial sensors. Eur J Immunol 2010 1.70
48 Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol 2011 1.63
49 Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol 2007 1.60
50 Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol 2009 1.60
51 Staphylococcus δ-toxin induces allergic skin disease by activating mast cells. Nature 2013 1.56
52 Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol 2010 1.43
53 TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. J Immunol 2012 1.42
54 Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner. J Leukoc Biol 2009 1.40
55 Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. J Mol Biol 2006 1.36
56 Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med 2009 1.36
57 TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem 2007 1.30
58 Inflammasomes in intestinal inflammation and cancer. Gastroenterology 2011 1.28
59 TLR3 increases disease morbidity and mortality from vaccinia infection. J Immunol 2008 1.26
60 Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol 2009 1.26
61 Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect Immun 2009 1.25
62 Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J Immunol 2012 1.24
63 NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol 2010 1.24
64 The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol 2008 1.23
65 Interleukin-10 ablation promotes tumor development, growth, and metastasis. Cancer Res 2011 1.22
66 The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol 2013 1.21
67 Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol 2009 1.19
68 MyD88: a critical adaptor protein in innate immunity signal transduction. J Immunol 2013 1.16
69 P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue. Circ Res 2010 1.14
70 Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. Gastroenterology 2013 1.06
71 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J Biol Chem 2013 1.05
72 Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol 2010 1.04
73 The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Eur J Immunol 2013 1.02
74 Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog 2008 1.02
75 Immunology. Orchestrating inflammasomes. Science 2012 1.01
76 Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res 2013 1.00
77 A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways. Sci Signal 2013 0.99
78 Level of endothelial cell apoptosis required for a significant decrease in microvessel density. Exp Cell Res 2007 0.98
79 Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun 2009 0.97
80 Role of the gut microbiota in the development and function of lymphoid cells. J Immunol 2013 0.95
81 Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity 2012 0.95
82 Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages. J Immunol 2008 0.94
83 Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B. J Immunol 2012 0.92
84 MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J 2006 0.91
85 Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol 2011 0.91
86 Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. J Biol Chem 2002 0.89
87 Nod2 and Rip2 contribute to innate immune responses in mouse neutrophils. Immunology 2014 0.87
88 Gut Immunity: a NOD to the commensals. Curr Biol 2009 0.87
89 Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester. J Biol Chem 2002 0.86
90 RICK promotes inflammation and lethality after gram-negative bacterial infection in mice stimulated with lipopolysaccharide. Infect Immun 2009 0.84
91 Binding of arachidonic acid and two flavonoid inhibitors to human 12- and 15-lipoxygenases: a steered molecular dynamics study. J Mol Model 2009 0.84
92 Functional expression of the intracellular pattern recognition receptor NOD1 in human keratinocytes. J Invest Dermatol 2009 0.83
93 A role for Nod-like receptors in autophagy induced by Shigella infection. Autophagy 2007 0.83
94 Multiple effects of dendritic cell depletion on murine norovirus infection. J Gen Virol 2013 0.82
95 A complex microworld in the gut: Harnessing pathogen-commensal relations. Nat Med 2012 0.79
96 4-Methylthioamphetamine increases dopamine in the rat striatum and has rewarding effects in vivo. Basic Clin Pharmacol Toxicol 2012 0.77
97 A new twist on the PYRIN Mediterranean coast. Immunity 2011 0.77
98 Corrigendum: Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nat Med 2016 0.75
99 Understanding the microbiota in the midst of Renaissance architecture and olive groves. Nat Immunol 2013 0.75
100 Inhibition of B-cell death does not restore T-cell-dependent immune responses in CD40-deficient mice. Immunology 2003 0.75
101 A New Twist in the Regulation of Legionella Replication through ASC and Caspase-1. Front Microbiol 2011 0.75
102 A putative role for human BFK in DNA damage-induced apoptosis. Biotechnol J 2009 0.75