Inflammasomes as microbial sensors.

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

Sensing and reacting to microbes through the inflammasomes. Nat Immunol (2012) 5.24

How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol (2010) 2.11

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol (2012) 1.97

Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity. Nat Immunol (2013) 1.51

TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48

Critical role for NLRP3 in necrotic death triggered by Mycobacterium tuberculosis. Cell Microbiol (2011) 1.44

TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. J Immunol (2012) 1.42

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J Immunol (2012) 1.24

Sterile inflammatory responses mediated by the NLRP3 inflammasome. Eur J Immunol (2010) 1.14

The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm (2013) 1.11

The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis? Curr Opin Rheumatol (2014) 1.08

Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam (2011) 1.05

Stress responses from the endoplasmic reticulum in cancer. Front Oncol (2015) 1.03

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes. Clin Exp Immunol (2012) 1.01

Genetic dissection of the Canq1 locus governing variation in extent of the collateral circulation. PLoS One (2012) 0.99

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun (2015) 0.99

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity (2012) 0.95

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin. PLoS One (2010) 0.91

Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities. Expert Rev Anti Infect Ther (2011) 0.90

Mechanisms of Borrelia burgdorferi internalization and intracellular innate immune signaling. Front Cell Infect Microbiol (2014) 0.86

Nedd8 regulates inflammasome-dependent caspase-1 activation. Mol Cell Biol (2014) 0.84

Modulation of inflammasome activity by Porphyromonas gingivalis in periodontitis and associated systemic diseases. J Oral Microbiol (2016) 0.83

Role of inflammasomes in salmonella infection. Front Microbiol (2011) 0.82

General anesthetics inhibit LPS-induced IL-1β expression in glial cells. PLoS One (2013) 0.81

Inflammasomes in the Pathophysiology of Kidney Diseases. Kidney Dis (Basel) (2015) 0.80

A Role for the Inflammasome in Spontaneous Labor at Term. Am J Reprod Immunol (2016) 0.80

Immunosuppressive property within the Streptococcus pneumoniae cell wall that inhibits generation of T follicular helper, germinal center, and plasma cell response to a coimmunized heterologous protein. Infect Immun (2013) 0.79

Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization. Biomolecules (2015) 0.77

Targeting the inflammasome in rheumatic diseases. Transl Res (2015) 0.77

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages. Cytokine (2015) 0.76

HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome. Biol Reprod (2016) 0.76

Unified Modeling of Familial Mediterranean Fever and Cryopyrin Associated Periodic Syndromes. Comput Math Methods Med (2015) 0.76

NLRP3 mediates NF-κB activation and cytokine induction in microbially induced and sterile inflammation. PLoS One (2015) 0.75

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med (2017) 0.75

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol (2009) 7.80

Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity (2007) 6.75

Intracellular NOD-like receptors in host defense and disease. Immunity (2007) 6.48

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem (2006) 5.92

Sensing and reacting to microbes through the inflammasomes. Nat Immunol (2012) 5.24

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol (2008) 4.72

Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol (2013) 4.34

Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem (2007) 4.27

Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol (2007) 4.19

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science (2012) 4.17

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity (2013) 3.96

RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol (2007) 3.43

Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol (2009) 3.32

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25

Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol (2011) 3.05

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest (2005) 2.91

Control of pathogens and pathobionts by the gut microbiota. Nat Immunol (2013) 2.84

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J (2004) 2.81

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72

Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology (2002) 2.71

Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol (2008) 2.65

Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics (2008) 2.64

The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity (2008) 2.53

The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity (2011) 2.47

NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol (2008) 2.45

A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome. J Immunol (2009) 2.29

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem (2004) 2.26

Intracellular NOD-like receptors in innate immunity, infection and disease. Cell Microbiol (2007) 2.25

Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol (2006) 2.21

Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J Immunol (2008) 2.13

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J Exp Med (2012) 2.03

Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe (2010) 2.03

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J Immunol (2011) 1.98

NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nat Immunol (2012) 1.97

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95

PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe (2009) 1.89

The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J Immunol (2007) 1.89

Induction of bone loss by pathobiont-mediated Nod1 signaling in the oral cavity. Cell Host Microbe (2013) 1.89

Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut. J Clin Invest (2011) 1.88

Caspase-1 inflammasomes in infection and inflammation. J Leukoc Biol (2007) 1.87

Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe (2011) 1.86

The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res (2008) 1.78

Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense. J Immunol (2006) 1.73

Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun (2003) 1.71

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun (2003) 1.70

T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nat Immunol (2009) 1.67

Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol (2011) 1.63

Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60

Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol (2009) 1.60

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity. J Exp Med (2012) 1.57

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells. Nature (2013) 1.56

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol (2010) 1.43

TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo. J Immunol (2012) 1.42

Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner. J Leukoc Biol (2009) 1.40

Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. J Mol Biol (2006) 1.36

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med (2009) 1.36

TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30

Inflammasomes in intestinal inflammation and cancer. Gastroenterology (2011) 1.28

TLR3 increases disease morbidity and mortality from vaccinia infection. J Immunol (2008) 1.26

Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol (2009) 1.26

Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect Immun (2009) 1.25

Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop. J Immunol (2012) 1.24

NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell Microbiol (2010) 1.24

The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol (2008) 1.23

Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling. J Biol Chem (2013) 1.22

Interleukin-10 ablation promotes tumor development, growth, and metastasis. Cancer Res (2011) 1.22

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol (2013) 1.21

Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19

MyD88: a critical adaptor protein in innate immunity signal transduction. J Immunol (2013) 1.16

P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue. Circ Res (2010) 1.14

Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2. Gastroenterology (2013) 1.06

3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J Biol Chem (2013) 1.05

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome. Eur J Immunol (2010) 1.04

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Eur J Immunol (2013) 1.02

Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog (2008) 1.02

Immunology. Orchestrating inflammasomes. Science (2012) 1.01

Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury. Cancer Res (2013) 1.00

A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways. Sci Signal (2013) 0.99

Level of endothelial cell apoptosis required for a significant decrease in microvessel density. Exp Cell Res (2007) 0.98

Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun (2009) 0.97

Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol (2007) 0.96

Complement C5a potentiates uric acid crystal-induced IL-1β production. Eur J Immunol (2014) 0.96

Role of the gut microbiota in the development and function of lymphoid cells. J Immunol (2013) 0.95

Critical role for mast cells in interleukin-1β-driven skin inflammation associated with an activating mutation in the nlrp3 protein. Immunity (2012) 0.95

Cross-tolerization between Nod1 and Nod2 signaling results in reduced refractoriness to bacterial infection in Nod2-deficient macrophages. J Immunol (2008) 0.94

Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B. J Immunol (2012) 0.92

Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol (2011) 0.91

MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J (2006) 0.91

Caspy, a zebrafish caspase, activated by ASC oligomerization is required for pharyngeal arch development. J Biol Chem (2002) 0.89