Published in Front Biosci on April 01, 2002
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol (2005) 1.61
PTEN, the Achilles' heel of myocardial ischaemia/reperfusion injury? Br J Pharmacol (2007) 1.39
Encapsulated Streptococcus suis inhibits activation of signaling pathways involved in phagocytosis. Infect Immun (2004) 1.20
Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells. Br J Pharmacol (2008) 1.11
Expression-based network biology identifies alteration in key regulatory pathways of type 2 diabetes and associated risk/complications. PLoS One (2009) 1.09
Hepatitis C virus infection and type 1 and type 2 diabetes mellitus. World J Diabetes (2014) 0.98
Increased insulin action in SKIP heterozygous knockout mice. Mol Cell Biol (2008) 0.91
Differentiation-dependent expression of Adhfe1 in adipogenesis. Arch Biochem Biophys (2007) 0.88
Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem J (2004) 0.87
Targeting the Pentose Phosphate Pathway in Syndrome X-related Cardiovascular Complications. Drug Dev Res (2010) 0.82
I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice. BMC Cardiovasc Disord (2014) 0.77
Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Gαi/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons. Mol Pain (2014) 0.75
Endothelial Cell Surface Expressed Chemotaxis and Apoptosis Regulator (ECSCR) Regulates Lipolysis in White Adipocytes via the PTEN/AKT Signaling Pathway. PLoS One (2015) 0.75
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75
Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 4.69
Glucagon and regulation of glucose metabolism. Am J Physiol Endocrinol Metab (2003) 2.92
Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology (2002) 2.72
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes (2006) 2.63
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 2.35
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med (2005) 2.12
Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes (2008) 2.03
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J Clin Invest (2005) 2.03
Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Diabetes (2006) 1.98
Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Mol Endocrinol (2003) 1.96
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators. J Clin Endocrinol Metab (2002) 1.67
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab (2006) 1.48
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc Natl Acad Sci U S A (2011) 1.43
Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci (2009) 1.39
Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists. Endocrinology (2002) 1.38
PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes (2008) 1.31
Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Diabetes (2008) 1.25
A novel glucagon receptor antagonist inhibits glucagon-mediated biological effects. Diabetes (2004) 1.16
Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARgamma agonists. Diabetes (2002) 1.16
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes. Eur J Pharmacol (2009) 1.13
FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents. Diabetes (2011) 1.10
Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med (2002) 1.09
Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist. PLoS One (2012) 0.98
A model selection approach for expression quantitative trait loci (eQTL) mapping. Genetics (2010) 0.98
Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists. Eur J Pharmacol (2004) 0.97
Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species. Endocrinology (2011) 0.96
Discovery of potent, orally active benzimidazole glucagon receptor antagonists. Bioorg Med Chem Lett (2008) 0.94
Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core. Bioorg Med Chem Lett (2010) 0.93
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Mol Endocrinol (2003) 0.92
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists. Bioorg Med Chem Lett (2005) 0.91
Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes. Endocrinology (2004) 0.91
A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat. Eur J Pharmacol (2010) 0.91
Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Eur J Pharmacol (2009) 0.90
Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity. Eur J Pharmacol (2009) 0.90
Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo. Biochem J (2004) 0.87
The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets. J Pharmacol Exp Ther (2012) 0.87
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator. Biochem J (2002) 0.86
Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization. Biochem J (2009) 0.86
Peroxisome proliferator-activated receptor (PPAR)-alpha agonism prevents the onset of type 2 diabetes in Zucker diabetic fatty rats: A comparison with PPAR gamma agonism. Endocrinology (2006) 0.86
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem (2008) 0.85
Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor. Bioorg Med Chem Lett (2005) 0.81
Direct observation (NMR) of the efficacy of glucagon receptor antagonists in murine liver expressing the human glucagon receptor. Bioorg Med Chem (2005) 0.81
Detection of glucagon-dependent GTPgammaS binding in high-throughput format. Anal Biochem (2002) 0.81
Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X. J Pharmacol Exp Ther (2005) 0.80
Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett (2006) 0.79
A miniaturized cell-based fluorescence resonance energy transfer assay for insulin-receptor activation. Anal Biochem (2006) 0.78
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett (2010) 0.76
Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes (2002) 0.76
A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis. PLoS One (2012) 0.75
Cloning and expression of canine glucagon receptor and its use to evaluate glucagon receptor antagonists in vitro and in vivo. Eur J Pharmacol (2006) 0.75