Published in J Immunol on April 01, 2002
Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol (2007) 2.35
Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest (2003) 2.22
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol (2002) 2.16
Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells. Am J Respir Cell Mol Biol (2005) 1.83
Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood (2004) 1.80
Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? Br J Pharmacol (2008) 1.80
Targeting proteinase-activated receptors: therapeutic potential and challenges. Nat Rev Drug Discov (2012) 1.75
Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol (2005) 1.53
Role of pancreatic trypsin in chronic esophagitis induced by gastroduodenal reflux in rats. J Gastroenterol (2006) 1.47
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem (2009) 1.27
New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol (2009) 1.23
Mucosal sensitization to German cockroach involves protease-activated receptor-2. Respir Res (2010) 1.15
Retracted A role for proteinase-activated receptor-1 in inflammatory bowel diseases. J Clin Invest (2004) 1.15
Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2. Am J Physiol Lung Cell Mol Physiol (2011) 1.10
Optimization of allergen standardization. Yonsei Med J (2011) 1.09
Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact. Cell Commun Signal (2013) 1.06
Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med (2008) 1.06
Tissue factor, blood coagulation, and beyond: an overview. Int J Inflam (2011) 1.05
Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder. Am J Pathol (2003) 1.04
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol (2005) 1.03
Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol (2009) 1.00
Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway. J Biol Chem (2011) 1.00
G-protein-coupled receptors and melanoma. Pigment Cell Melanoma Res (2008) 0.97
Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol (2011) 0.96
The protease allergen Pen c 13 induces allergic airway inflammation and changes in epithelial barrier integrity and function in a murine model. J Biol Chem (2011) 0.95
Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation. Am J Respir Cell Mol Biol (2014) 0.95
Thrombin and TNF-alpha/IL-1beta synergistically induce fibroblast-mediated collagen gel degradation. Am J Respir Cell Mol Biol (2006) 0.94
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis. Biomed Res Int (2015) 0.91
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol (2007) 0.91
Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis. Clin Rheumatol (2007) 0.90
Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors. PLoS One (2013) 0.89
Induction of CXC chemokines in A549 airway epithelial cells by trypsin and staphylococcal proteases - a possible route for neutrophilic inflammation in chronic rhinosinusitis. Clin Exp Immunol (2006) 0.89
Airway epithelium interactions with aeroallergens: role of secreted cytokines and chemokines in innate immunity. Front Immunol (2015) 0.88
Gastrointestinal roles for proteinase-activated receptors in health and disease. Br J Pharmacol (2007) 0.88
Coagulation factor Xa modulates airway remodeling in a murine model of asthma. Am J Respir Crit Care Med (2006) 0.88
Initial support for the hypothesis that PAR2 is involved in the immune response to Nippostrongylus brasiliensis in mice. Parasitol Res (2007) 0.88
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. PLoS One (2013) 0.88
Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2. Int Arch Allergy Immunol (2012) 0.88
Correlation of protease-activated receptor-2 expression and synovitis in rheumatoid and osteoarthritis. Rheumatol Int (2011) 0.88
Polarized secretion of interleukin (IL)-6 and IL-8 by human airway epithelia 16HBE14o- cells in response to cationic polypeptide challenge. PLoS One (2010) 0.85
The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. J Physiol (2007) 0.84
Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation. J Matern Fetal Neonatal Med (2008) 0.84
House dust mite allergy: environment evaluation and disease prevention. Asia Pac Allergy (2014) 0.83
Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation. Mediators Inflamm (2014) 0.81
Induction of release and up-regulated gene expression of interleukin (IL)-8 in A549 cells by serine proteinases. BMC Cell Biol (2006) 0.81
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation. Genes (Basel) (2013) 0.81
Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation (2013) 0.80
Signaling mechanism of thrombin-induced gingival fibroblast-populated collagen gel contraction. Br J Pharmacol (2006) 0.80
Plasminogen activation/plasmin in rheumatoid arthritis: matrix degradation and more. Am J Pathol (2005) 0.80
Perilla frutescens leaf extract inhibits mite major allergen Der p 2-induced gene expression of pro-allergic and pro-inflammatory cytokines in human bronchial epithelial cell BEAS-2B. PLoS One (2013) 0.80
Store-Operated Ca2+ Release-Activated Ca2+ Channels Regulate PAR2-Activated Ca2+ Signaling and Cytokine Production in Airway Epithelial Cells. J Immunol (2015) 0.79
Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions. Int J Parasitol (2015) 0.79
Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells. Cytotechnology (2010) 0.79
Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z. J Matern Fetal Neonatal Med (2008) 0.78
PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. PLoS One (2012) 0.78
P2Y6 receptor-mediated proinflammatory signaling in human bronchial epithelia. PLoS One (2014) 0.78
Constitutive expression of functionally active protease-activated receptors 1 and 2 in human conjunctival epithelial cells. Mediators Inflamm (2006) 0.78
Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts. Physiol Rep (2015) 0.77
House dust mite potentiates capsaicin-evoked Ca2+ transients in mouse pulmonary sensory neurons via activation of protease-activated receptor-2. Exp Physiol (2011) 0.77
Role of Aspergillus fumigatus in Triggering Protease-Activated Receptor-2 in Airway Epithelial Cells and Skewing the Cells toward a T-helper 2 Bias. Am J Respir Cell Mol Biol (2016) 0.77
Anti-Inflammatory mechanisms of the proteinase-activated receptor 2-inhibiting peptide in human synovial cells. J Biomed Sci (2011) 0.76
In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin. PLoS One (2015) 0.76
Downregulation of protease activated receptor expression and cytokine production in P815 cells by RNA interference. BMC Cell Biol (2009) 0.76
New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review. Channels (Austin) (2015) 0.76
Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells. Sci Rep (2016) 0.76
Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury. J Mol Cell Cardiol (2015) 0.76
High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis (2016) 0.75
Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells. Respir Res (2016) 0.75
PAR2 Modulators Derived from GB88. ACS Med Chem Lett (2016) 0.75
Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses. Br J Pharmacol (2003) 0.75
Clinical and laboratory studies of the fate of intranasal allergen. PLoS One (2015) 0.75
Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation. PLoS One (2017) 0.75
Tight junctions in pulmonary epithelia during lung inflammation. Pflugers Arch (2016) 0.75
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med (2014) 4.95
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet (2011) 3.03
Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A (2010) 2.66
Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma. J Allergy Clin Immunol (2004) 2.33
Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma. Am J Respir Crit Care Med (2006) 1.84
Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am J Respir Crit Care Med (2009) 1.83
A sequence variant on 17q21 is associated with age at onset and severity of asthma. Eur J Hum Genet (2010) 1.74
Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: effects of nonviral and viral stimulation. Am J Respir Cell Mol Biol (2011) 1.70
Six minute walk distance in healthy subjects aged 55-75 years. Respir Med (2005) 1.64
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
alpha(v)beta(3) Integrin interacts with the transforming growth factor beta (TGFbeta) type II receptor to potentiate the proliferative effects of TGFbeta1 in living human lung fibroblasts. J Biol Chem (2004) 1.41
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol (2006) 1.40
Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation. Am J Pathol (2003) 1.31
Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs. Am J Respir Cell Mol Biol (2003) 1.27
Characterization of side population cells from human airway epithelium. Stem Cells (2008) 1.25
Structural changes in the airways in asthma: observations and consequences. Clin Sci (Lond) (2005) 1.24
The role of epithelial injury and repair in the origins of asthma. Curr Opin Allergy Clin Immunol (2007) 1.22
Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution. Am J Respir Cell Mol Biol (2011) 1.22
Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway. J Biol Chem (2008) 1.20
Deliberately provoking local inflammation drives tumors to become their own protective vaccine site. Int Immunol (2008) 1.19
Impaired expression of perforin and granulysin in CD8+ T cells at the site of infection in human chronic pulmonary tuberculosis. Infect Immun (2007) 1.18
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter. J Allergy Clin Immunol (2012) 1.17
Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. Am J Pathol (2009) 1.17
Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF. Am J Respir Cell Mol Biol (2007) 1.14
Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. Am J Respir Crit Care Med (2010) 1.14
Inhaled, dual release liposomal ciprofloxacin in non-cystic fibrosis bronchiectasis (ORBIT-2): a randomised, double-blind, placebo-controlled trial. Thorax (2013) 1.12
The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A. J Clin Invest (2011) 1.10
Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol (2008) 1.10
Mouse models of dominant ACTA1 disease recapitulate human disease and provide insight into therapies. Brain (2011) 1.08
Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production. J Bone Miner Res (2005) 1.07
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis. EMBO Mol Med (2012) 1.07
Deleterious role of TLR3 during hyperoxia-induced acute lung injury. Am J Respir Crit Care Med (2008) 1.05
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1. PLoS One (2012) 1.05
Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. PLoS One (2011) 1.05
Measurement of sub-membrane [Ca2+] in adult myofibers and cytosolic [Ca2+] in myotubes from normal and mdx mice using the Ca2+ indicator FFP-18. Cell Calcium (2006) 1.04
Dissociated flexor digitorum brevis myofiber culture system--a more mature muscle culture system. Cell Motil Cytoskeleton (2007) 1.04
DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children. PLoS One (2012) 1.04
Human lung parenchyma but not proximal bronchi produces fibroblasts with enhanced TGF-beta signaling and alpha-SMA expression. Am J Respir Cell Mol Biol (2010) 1.01
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One (2012) 0.99
Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin. J Cell Biol (2009) 0.99
Dual organism transcriptomics of airway epithelial cells interacting with conidia of Aspergillus fumigatus. PLoS One (2011) 0.98
Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2006) 0.98
ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet (2006) 0.97
Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22. Eur Cytokine Netw (2004) 0.97
Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response. J Leukoc Biol (2003) 0.96
Physiological concentrations of transforming growth factor beta1 selectively inhibit human dendritic cell function. Int Immunopharmacol (2007) 0.96
Role of protease-activated receptors in airway function: a target for therapeutic intervention? Pharmacol Ther (2002) 0.96
Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts. Br J Pharmacol (2002) 0.96
Granzyme K activates protease-activated receptor-1. PLoS One (2011) 0.96
BMP-7 does not protect against bleomycin-induced lung or skin fibrosis. PLoS One (2008) 0.95
Targeting interleukin-13 with tralokinumab attenuates lung fibrosis and epithelial damage in a humanized SCID idiopathic pulmonary fibrosis model. Am J Respir Cell Mol Biol (2014) 0.94
Transforming growth factor beta induces vascular endothelial growth factor elaboration from pleural mesothelial cells in vivo and in vitro. Am J Respir Crit Care Med (2002) 0.94
STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF. Am J Pathol (2012) 0.94
Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2. Immunol Cell Biol (2004) 0.94
Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration. J Leukoc Biol (2007) 0.92
Altered expression and in vivo lung function of protease-activated receptors during influenza A virus infection in mice. Am J Physiol Lung Cell Mol Physiol (2003) 0.92
Mesothelial cell differentiation into osteoblast- and adipocyte-like cells. J Cell Mol Med (2011) 0.92
Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils: role in kinin generation in rheumatoid arthritis. Rheumatology (Oxford) (2009) 0.92
Allergic and asthmatic reactions to alcoholic drinks. Addict Biol (2003) 0.90
Remote ischemic preconditioning stimulus decreases the expression of kinin receptors in human neutrophils. J Surg Res (2009) 0.89
Fibrin sealant promotes migration and proliferation of human articular chondrocytes: possible involvement of thrombin and protease-activated receptors. Int J Mol Med (2006) 0.89
Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus. BMC Genomics (2010) 0.89
Oxidative stress and lipid-derived inflammatory mediators during acute exacerbations of cystic fibrosis. Respirology (2007) 0.89
EDL and soleus muscles of the C57BL6J/dy2j laminin-alpha 2-deficient dystrophic mouse are not vulnerable to eccentric contractions. Exp Physiol (2004) 0.88
Dendritic cell influx differs between the subglottic and glottic mucosae during acute laryngotracheitis induced by a broad spectrum of stimuli. Ann Otol Rhinol Laryngol (2002) 0.88
The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis--a randomised controlled trial. Respir Res (2014) 0.87
Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects. Am J Respir Crit Care Med (2004) 0.87
Transcription factor p63 regulates key genes and wound repair in human airway epithelial basal cells. Am J Respir Cell Mol Biol (2013) 0.87
Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2015) 0.87
Human airway epithelial cell innate immunity: relevance to asthma. Curr Opin Immunol (2012) 0.87
Pro-inflammatory effects of Burkholderia cepacia on cystic fibrosis respiratory epithelium. FEMS Immunol Med Microbiol (2003) 0.87
Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma. Biol Chem (2007) 0.87
Lipopolysaccharide-induced weakness in the preterm diaphragm is associated with mitochondrial electron transport chain dysfunction and oxidative stress. PLoS One (2013) 0.86
The role of the Na(+)/Ca(2+) exchanger (NCX) in neurons following ischaemia. J Clin Neurosci (2007) 0.86
STAT3: a central mediator of pulmonary fibrosis? Proc Am Thorac Soc (2012) 0.85
A confocal microscopic study of solitary pulmonary neuroendocrine cells in human airway epithelium. Respir Res (2005) 0.85
Peptidase allergen Der p 1 initiates apoptosis of epithelial cells independently of tight junction proteolysis. Mol Membr Biol (2003) 0.85
Observational studies on the effect of dietary antioxidants on asthma: a meta-analysis. Respirology (2008) 0.85
Modeling asthma in mice: what have we learned about the airway epithelium? Am J Respir Cell Mol Biol (2010) 0.85
The airway epithelium in asthma: developmental issues that scar the airways for life? Pulm Pharmacol Ther (2012) 0.84
Potential role of stem cells in management of COPD. Int J Chron Obstruct Pulmon Dis (2010) 0.84
Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes. Med Mycol (2013) 0.84