Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy.

PubWeight™: 1.60‹?› | Rank: Top 4%

🔗 View Article (PMID 11920483)

Published in Cancer on February 15, 2002

Authors

Hanifa Bouzourene1, Fred T Bosman, Walter Seelentag, Maurice Matter, Philippe Coucke

Author Affiliations

1: Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Hanifa.Bouzourene@chuv.hospvd.ch

Associated clinical trials:

Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Treatment Combining Cetuximab With FOLFOX or FOLFIRI in RAS and B-RAF WT Tumors | NCT01858662

Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Bevacizumab With FOLFOX or FOLFIRI. (BEV-ONCO2012) | NCT01858649

Articles citing this

Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg (2004) 3.50

Positron emission tomography with [(18)F]-3'-deoxy-3'fluorothymidine (FLT) as a predictor of outcome in patients with locally advanced resectable rectal cancer: a pilot study. Mol Imaging Biol (2013) 2.05

Prognostic value of Dworak grade of regression (GR) in patients with rectal carcinoma treated with preoperative radiochemotherapy. Int J Colorectal Dis (2005) 1.17

Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer. Cancer Gene Ther (2014) 1.12

Phase II study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer. Br J Cancer (2008) 1.09

Radiation dose-response model for locally advanced rectal cancer after preoperative chemoradiation therapy. Int J Radiat Oncol Biol Phys (2012) 1.04

Partial pathologic response and nodal status as most significant prognostic factors for advanced rectal cancer treated with preoperative chemoradiotherapy. World J Surg (2012) 1.03

Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery. Radiat Oncol (2013) 1.02

Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy. Ann Surg (2007) 0.90

Pathological response grade of colorectal liver metastases treated with neoadjuvant chemotherapy. HPB (Oxford) (2010) 0.90

[Regression grading of colorectal carcinoma after preoperative radiochemotherapy. An inventory]. Pathologe (2003) 0.90

Preoperative radiation therapy for locally advanced rectal cancer: a comparison between two different time intervals to surgery. Int J Colorectal Dis (2006) 0.90

Long-term results of a randomized trial in locally advanced rectal cancer: no benefit from adding a brachytherapy boost. Int J Radiat Oncol Biol Phys (2014) 0.89

Survivin, p53, and Ki-67 as predictors of histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiotherapy. Int J Colorectal Dis (2007) 0.88

Proforma-based reporting in rectal cancer. Cancer Imaging (2010) 0.87

Bromodeoxyuridine labeling index as an indicator of early tumor response to preoperative radiotherapy in patients with rectal cancer. J Gastrointest Surg (2007) 0.85

Tumor kinase activity in locally advanced rectal cancer: angiogenic signaling and early systemic dissemination. Angiogenesis (2011) 0.85

Preoperative oxaliplatin, capecitabine, and external beam radiotherapy in patients with newly diagnosed, primary operable, cT₃NxM0, low rectal cancer: a phase II study. Strahlenther Onkol (2011) 0.85

MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer. Br J Radiol (2015) 0.83

Possible predictors of histopathological response to neoadjuvant chemoradiotherapy for rectal cancer. J Cancer Res Clin Oncol (2011) 0.83

Prognostic value of tumor shrinkage versus fragmentation following radiochemotherapy and surgery for rectal cancer. Virchows Arch (2015) 0.83

Prognostic value of tumour regression grading and depth of neoplastic infiltration within the perirectal fat after combined neoadjuvant chemo-radiotherapy and surgery for rectal cancer. J Clin Pathol (2006) 0.83

Preoperative rectal cancer staging with phased-array MR. Radiat Oncol (2012) 0.82

The role of COX-2 in rectal cancer treated with preoperative radiotherapy. Virchows Arch (2008) 0.82

Lymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery. Oncotarget (2016) 0.81

Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer. Clin Cancer Res (2016) 0.81

Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I-II study. Br J Cancer (2006) 0.81

A multi-centre pathologist survey on pathological processing and regression grading of colorectal cancer resection specimens treated by neoadjuvant chemoradiation. Virchows Arch (2012) 0.80

Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297. Int J Radiat Oncol Biol Phys (2008) 0.78

Usefulness of two independent histopathological classifications of tumor regression in patients with rectal cancer submitted to hyperfractionated pre-operative radiotherapy. World J Gastroenterol (2007) 0.78

Instrumental clinical restaging, pathological evaluation, and tumor regression grading: how to assess the response to neoadjuvant chemoradiotherapy for rectal cancer. Int J Colorectal Dis (2006) 0.77

The relationship of histological tumor regression grade (TRG) and two different time intervals to surgery following radiation therapy for locally advanced rectal cancer. Int J Colorectal Dis (2009) 0.77

Clinical impact of tumor regression grade after preoperative chemoradiation for locally advanced rectal cancer: subset analyses in lymph node negative patients. J Korean Soc Coloproctol (2011) 0.77

Phospho-ERK1/2 levels in cancer cell nuclei predict responsiveness to radiochemotherapy of rectal adenocarcinoma. Oncotarget (2015) 0.77

Low Mmp 9 and VEGF levels predict good oncologic outcome in mid and low rectal cancer patients with neoadjuvant chemoradiation. BMC Clin Pathol (2012) 0.77

Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer. Oncotarget (2016) 0.77

Pathologic Assessment of Rectal Carcinoma after Neoadjuvant Radio(chemo)therapy: Prognostic Implications. Biomed Res Int (2015) 0.76

A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer. Front Oncol (2013) 0.76

Neoadjuvant treatment of mid-to-lower rectal cancer with oxaliplatin plus 5-fluorouracil and leucovorin in combination with radiotherapy: a Korean single center phase II study. Int J Clin Oncol (2012) 0.76

YKL-40/c-Met expression in rectal cancer biopsies predicts tumor regression following neoadjuvant chemoradiotherapy: a multi-institutional study. PLoS One (2015) 0.76

The pathologist's role in rectal cancer patient assessments. Clin Colon Rectal Surg (2007) 0.75

Response to chemoradiotherapy and lymph node involvement in locally advanced rectal cancer. World J Gastrointest Surg (2015) 0.75

Prognosis Can Be Predicted More Accurately Using Pre- and Postchemoradiotherapy Carcinoembryonic Antigen Levels Compared to Only Prechemoradiotherapy Carcinoembryonic Antigen Level in Locally Advanced Rectal Cancer Patients Who Received Neoadjuvant Chemoradiotherapy. Medicine (Baltimore) (2016) 0.75

Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer. PLoS One (2012) 0.75

SNAI2 modulates colorectal cancer 5-fluorouracil sensitivity through miR145 repression. Mol Cancer Ther (2014) 0.75

Multiphoton microscopy for tumor regression grading after neoadjuvant treatment for colorectal carcinoma. World J Gastroenterol (2015) 0.75

Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening. BMC Cancer (2016) 0.75

In rectal cancer, the type of desmoplastic response after preoperative chemoradiotherapy is associated with prognosis. Virchows Arch (2015) 0.75

Do pathological variables have prognostic significance in rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and surgery? World J Gastroenterol (2017) 0.75

Association between the expression of microRNAs and the response of patients with locally advanced rectal cancer to preoperative chemoradiotherapy. Oncol Lett (2017) 0.75

Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer. Int J Colorectal Dis (2009) 0.75

Articles by these authors

Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem (2005) 3.43

Identification of a poor-prognosis BRAF-mutant-like population of patients with colon cancer. J Clin Oncol (2012) 2.66

Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging (2013) 2.35

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS One (2012) 1.77

Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity. Int J Cancer (2002) 1.64

Efficiency of recombinant human TNF in human cancer therapy. Cancer Immun (2006) 1.58

Effect of timing of surgery on survival after preoperative hyperfractionated accelerated radiotherapy (HART) for locally advanced rectal cancer (LARC): is it a matter of days? Acta Oncol (2006) 1.43

A cost-effective algorithm for hereditary nonpolyposis colorectal cancer detection. Am J Clin Pathol (2006) 1.40

Clinical outcome following combination of cutting balloon angioplasty and coronary beta-radiation for in-stent restenosis: a report from the RENO registry. J Invasive Cardiol (2003) 1.39

Repeated intracoronary beta radiation for recurrent in-stent restenosis. Catheter Cardiovasc Interv (2002) 1.38

p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus. Gastroenterology (2002) 1.38

Expression of NDRG1, a differentiation-related gene, in human tissues. Histochem Cell Biol (2002) 1.32

Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr (2013) 1.31

A let-7 microRNA SNP in the KRAS 3'UTR is prognostic in early-stage colorectal cancer. Clin Cancer Res (2011) 1.28

CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res (2005) 1.27

Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice? Virchows Arch (2007) 1.15

Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation. J Pathol (2006) 1.12

Immunohistochemical localization of hTERT protein in human tissues. Histochem Cell Biol (2004) 1.09

A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations. PLoS One (2012) 1.08

BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells. Nucleic Acids Res (2010) 1.04

Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer. BMC Cancer (2013) 1.02

Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma. Int J Cancer (2010) 1.01

Impact of genomic methylation on radiation sensitivity of colorectal carcinoma. Int J Radiat Oncol Biol Phys (2010) 0.99

Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells. Int J Cancer (2011) 0.99

Monoallelic methylation of the APC promoter is altered in normal gastric mucosa associated with neoplastic lesions. Cancer Res (2004) 0.93

Beta-catenin expression and its association with prognostic factors in adenocarcinoma developed in Barrett esophagus. Am J Clin Pathol (2002) 0.93

Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo. Oncoimmunology (2012) 0.92

An agarose matrix facilitates sectioning of tissue microarray blocks. J Histochem Cytochem (2006) 0.91

Kayexalate Intake (in Sorbitol) and Jejunal Diverticulitis, a Causative Role or an Innocent Bystander? Case Rep Gastroenterol (2007) 0.91

Radiotherapy staffing in the European countries: final results from the ESTRO-HERO survey. Radiother Oncol (2014) 0.90

Implication of the exon region in the regulation of the human telomerase reverse transcriptase gene promoter. Biochem Biophys Res Commun (2003) 0.89

Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study. Virchows Arch (2015) 0.88

The cytoskeleton and disease. J Pathol (2004) 0.88

PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells. J Pathol (2010) 0.87

Monoamine oxidase A down-regulation contributes to high metanephrine concentration in pheochromocytoma. J Clin Endocrinol Metab (2012) 0.87

Lymphocoele: a rare and little known complication of anterior lumbar surgery. Eur Spine J (2009) 0.85

Background staining of visualization systems in immunohistochemistry: comparison of the Avidin-Biotin Complex system and the EnVision+ system. Appl Immunohistochem Mol Morphol (2007) 0.85

The use of virtual slides in the EUROPALS examination. Diagn Pathol (2011) 0.84

Isolated limb perfusion with tumor necrosis factor and melphalan for non-resectable soft tissue sarcomas: long-term results on efficacy and limb salvage in a selected group of patients. J Surg Oncol (2008) 0.84

Sentinel lymph node biopsy in nonmelanoma skin cancer patients. J Skin Cancer (2013) 0.84

Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients. Int J Cancer (2008) 0.84

Decreased local control following radiation therapy alone in early-stage glottic carcinoma with anterior commissure extension. Strahlenther Onkol (2004) 0.83

Predictive factors in locally advanced rectal cancer treated with preoperative hyperfractionated and accelerated radiotherapy. Hum Pathol (2003) 0.83

Hepatic sinusoidal obstruction syndrome (SOS) reduces the effect of oxaliplatin in colorectal liver metastases. Histopathology (2012) 0.82

The role of COX-2 in rectal cancer treated with preoperative radiotherapy. Virchows Arch (2008) 0.82

A dosimetric selectivity intercomparison of HDR brachytherapy, IMRT and helical tomotherapy in prostate cancer radiotherapy. Strahlenther Onkol (2009) 0.81

Malakoplakia and colonic adenoma: a rare association. Ann Diagn Pathol (2004) 0.80

Preoperative hyper-fractionated accelerated radiotherapy (HART) in locally advanced rectal cancer (LARC) immediately followed by surgery. A prospective phase II trial. Radiother Oncol (2006) 0.80

Diagnosis and workup of 522 consecutive patients with neuroendocrine neoplasms in Switzerland. Swiss Med Wkly (2014) 0.79

Is it possible to improve radiotherapy team members' communication skills? A randomized study assessing the efficacy of a 38-h communication skills training program. Radiother Oncol (2013) 0.78

Preoperative hyperfractionated accelerated radiotherapy (HART) and concomitant CPT-11 in locally advanced rectal carcinoma: a phase I study. Int J Radiat Oncol Biol Phys (2003) 0.78

Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods. Melanoma Res (2003) 0.78

Risk-adjusted rates for potentially avoidable reoperations were computed from routine hospital data. J Clin Epidemiol (2006) 0.77

Respiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation. Pathol Oncol Res (2015) 0.77

An unusual case of metastatic melanoma sensitive to chemotherapy and immunotherapy, with late immune escape in the brain. Cancer Immun (2008) 0.77

Efficacy and safety of universal valganciclovir prophylaxis combined with a tacrolimus/mycophenolate-based regimen in kidney transplantation. Swiss Med Wkly (2007) 0.77

Role of metallothioneins in irradiated human rectal carcinoma. Cancer (2002) 0.77

Measurement of the whole body clearance of infused glycerol as a test of liver function after major hepatectomy. Clin Physiol Funct Imaging (2002) 0.77

Radiation-associated synovial sarcoma: clinicopathologic and molecular analysis of two cases. Mod Pathol (2002) 0.77

[Molecular pathology of colon cancer]. Pol J Pathol (2014) 0.77

Large proximal serrated polyps: natural history and colorectal cancer risk in a retrospective series. J Clin Gastroenterol (2013) 0.76

Nodal staging in colorectal cancer: should distant lymph nodes be recovered in surgical specimens? Hum Pathol (2009) 0.75

Soft tissue sarcomas: introduction to the Virchows Archiv review issue. Virchows Arch (2010) 0.75

Small-bowel perforation: a consequence of feeding jejunostomy. Can J Surg (2005) 0.75

Diffuse nesidioblastosis with hypoglycemia mimicking an insulinoma: a case report. J Med Case Rep (2012) 0.75

Recurrent laryngeal nerve injury after thyroid and parathyroid surgery: Incidence and postoperative evolution assessment. Medicine (Baltimore) (2017) 0.75

[Tumors of the musculoskeletal system: from the "lumps" to multidisciplinary care]. Rev Med Suisse (2013) 0.75

Evolving trends in the costs associated with hospital use of immunosuppressive drugs. Transplantation (2013) 0.75

Virchows Archiv: quo vadis? Virchows Arch (2012) 0.75

[Update in thyroid and parathyroid surgery: the role for minimally invasive surgery]. Rev Med Suisse (2011) 0.75

Screening for malnutrition in lung cancer patients undergoing radiotherapy. Support Care Cancer (2014) 0.75

The debate on sentinel node biopsy in melanoma: any clue? Melanoma Res (2012) 0.75

[Change in pathology]. Rev Med Suisse (2005) 0.75

Application of molecular genetics to the diagnosis of lymphoid-rich effusions: study of 95 cases with concomitant immunophenotyping. Diagn Cytopathol (2002) 0.75

Accuracy of sentinel lymph node dissection for melanoma staging in the presence of a collision tumour with a lymphoproliferative disease. Melanoma Res (2014) 0.75

How far did we get? Virchows Arch (2013) 0.75

[Pathology near the patient]. Rev Med Suisse (2007) 0.75

Feasibility and efficacy of accelerated weekly concomitant boost postoperative radiation therapy combined with concomitant chemotherapy in patients with locally advanced head and neck cancer. Ann Surg Oncol (2009) 0.75

[Primary hyperaldosteronism with adrenal adenoma or hyperplasia: surgical case or not?]. Rev Med Suisse (2013) 0.75