Published in J Neurosci on April 01, 2002
The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) (2005) 1.27
Arthritis and pain. Future targets to control osteoarthritis pain. Arthritis Res Ther (2007) 1.17
Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats. J Physiol (2011) 1.05
Alcoholic neuropathy: possible mechanisms and future treatment possibilities. Br J Clin Pharmacol (2012) 1.00
Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem (2009) 0.96
Simulated whiplash modulates expression of the glutamatergic system in the spinal cord suggesting spinal plasticity is associated with painful dynamic cervical facet loading. J Neurotrauma (2010) 0.92
Differential regulation of glutamate receptors in trigeminal ganglia following masseter inflammation. Neurosci Lett (2007) 0.89
Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord. Pain (2012) 0.89
Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. Mol Pain (2012) 0.88
Glutamate receptor phosphorylation and trafficking in pain plasticity in spinal cord dorsal horn. Eur J Neurosci (2010) 0.87
Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity. Brain Res (2012) 0.86
Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II). Med Sci Monit (2014) 0.85
Metabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways. Front Neurosci (2011) 0.85
Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol (2006) 0.83
Spinal nerve ligation decreases γ-aminobutyric acidB receptors on specific populations of immunohistochemically identified neurons in L5 dorsal root ganglion of the rat. J Comp Neurol (2012) 0.80
Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity. Br J Pharmacol (2014) 0.78
Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats. Korean J Physiol Pharmacol (2008) 0.78
Metabotropic glutamate and cannabinoid receptor crosstalk in periaqueductal grey pain processing. Curr Neuropharmacol (2006) 0.77
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia. J Neural Transm (Vienna) (2010) 0.76
Nerve demyelination increases metabotropic glutamate receptor subtype 5 expression in peripheral painful mononeuropathy. Int J Mol Sci (2015) 0.76
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci (2008) 3.30
Pain related behaviour in two models of osteoarthritis in the rat knee. Pain (2004) 2.24
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol (2007) 2.21
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A (2007) 2.17
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci (2007) 2.00
siRNA relieves chronic neuropathic pain. Nucleic Acids Res (2004) 1.96
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. J Clin Invest (2015) 1.74
Role of spinal microglia in rat models of peripheral nerve injury and inflammation. Eur J Pain (2006) 1.70
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66
Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives. Curr Opin Pharmacol (2002) 1.58
Rapid co-release of interleukin 1beta and caspase 1 in spinal cord inflammation. J Neurochem (2006) 1.45
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol. Nat Commun (2011) 1.43
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci (2004) 1.39
A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A (2005) 1.35
Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci (2002) 1.33
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci (2004) 1.30
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity. Mol Pain (2010) 1.25
Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci (2003) 1.23
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain (2007) 1.19
Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett (2005) 1.19
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression. J Clin Invest (2012) 1.14
A predictive model of hospitalisation and death from chronic obstructive pulmonary disease. Respir Med (2009) 1.13
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1. J Biol Chem (2004) 1.13
A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. Arthritis Rheum (2011) 1.12
Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc Res (2010) 1.10
Restored plasticity in a mouse model of neurofibromatosis type 1 via inhibition of hyperactive ERK and CREB. Eur J Neurosci (2007) 1.10
Activation of Ras is necessary and sufficient for upregulation of vanilloid receptor type 1 in sensory neurons by neurotrophic factors. Mol Cell Neurosci (2003) 1.08
Retracted Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. J Neurochem (2003) 1.07
Cloning and functional characterization of the guinea pig vanilloid receptor 1. Neuropharmacology (2002) 1.03
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem (2007) 1.01
Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat. Pain (2005) 1.00
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol (2005) 0.99
Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs (2005) 0.98
Use of indicators to evaluate the quality of community-acquired pneumonia management. Clin Infect Dis (2001) 0.98
Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain. Pain (2002) 0.95
Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice. Pain (2011) 0.95
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice. J Pharmacol Exp Ther (2010) 0.93
[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. Bioorg Med Chem Lett (2002) 0.93
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One (2012) 0.92
Adult Rat Dorsal Root Ganglion Neurons Extend Neurites on Predegenerated But Not on Normal Peripheral Nerves In Vitro. Eur J Neurosci (1992) 0.91
4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther (2011) 0.91
Methylglyoxal evokes pain by stimulating TRPA1. PLoS One (2013) 0.87
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. PLoS One (2013) 0.86
Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). Eur J Pharmacol (2002) 0.86
Effect of statins on total cholesterol concentrations, cardiovascular morbidity, and all-cause mortality in chronic obstructive pulmonary disease: a population-based cohort study. Clin Ther (2012) 0.85
Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease. PLoS Curr (2010) 0.85
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1. J Cell Biol (2002) 0.85
Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem (2006) 0.85
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. J Clin Invest (2014) 0.85
Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain. J Med Chem (2008) 0.85
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors. Mol Neurodegener (2010) 0.85
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice. Arthritis Rheumatol (2014) 0.83
Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol (2005) 0.83
7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther (2012) 0.82
Altered apoptotic responses in neurons lacking RhoB GTPase. Eur J Neurosci (2011) 0.79
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain (2004) 0.79
Atg4b-dependent autophagic flux alleviates Huntington's disease progression. PLoS One (2013) 0.77
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines. Bioorg Med Chem (2007) 0.76
Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice. Pain (2017) 0.75
Health System Chief Nurse Executive: Is a DNP the Degree of Choice? J Nurs Adm (2015) 0.75