Published in Mol Pain on January 21, 2010
Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron (2013) 1.95
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers. J Neurosci (2010) 1.66
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO J (2012) 1.15
The molecular and cellular basis of cold sensation. ACS Chem Neurosci (2012) 1.11
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain (2012) 1.11
Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol (2011) 1.06
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8. Nat Commun (2016) 0.95
Regulation of TRPM8 channel activity. Mol Cell Endocrinol (2011) 0.94
TRPA1 is essential for the vascular response to environmental cold exposure. Nat Commun (2014) 0.93
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One (2012) 0.92
Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons. Mol Pain (2010) 0.91
Methylglyoxal evokes pain by stimulating TRPA1. PLoS One (2013) 0.87
Species-specific temperature sensitivity of TRPA1. Temperature (Austin) (2015) 0.84
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice. Arthritis Rheumatol (2014) 0.83
Trafficking of ThermoTRP Channels. Membranes (Basel) (2014) 0.83
Are sensory TRP channels biological alarms for lipid peroxidation? Int J Mol Sci (2014) 0.83
Complex regulation of the TRPM8 cold receptor channel: role of arachidonic acid release following M3 muscarinic receptor stimulation. J Biol Chem (2011) 0.81
The effects of a co-application of menthol and capsaicin on nociceptive behaviors of the rat on the operant orofacial pain assessment device. PLoS One (2014) 0.79
An approach to identify microRNAs involved in neuropathic pain following a peripheral nerve injury. Front Neurosci (2014) 0.79
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. Pain (2014) 0.79
Enhancing effect of menthol on nicotine self-administration in rats. Psychopharmacology (Berl) (2016) 0.78
Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8. Mol Pain (2014) 0.78
Agonist-induced sensitisation of the irritant receptor ion channel TRPA1. J Physiol (2016) 0.78
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay. Temperature (Austin) (2016) 0.78
Down-regulation of TRPM8 in pulmonary arteries of pulmonary hypertensive rats. Cell Physiol Biochem (2013) 0.77
Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord. F1000Res (2014) 0.77
Streptozotocin Stimulates the Ion Channel TRPA1 Directly: INVOLVEMENT OF PEROXYNITRITE. J Biol Chem (2015) 0.77
Activation of Cold-Sensitive Channels TRPM8 and TRPA1 Inhibits the Proliferative Airway Smooth Muscle Cell Phenotype. Lung (2016) 0.76
Menthol smokers: metabolomic profiling and smoking behavior. Cancer Epidemiol Biomarkers Prev (2016) 0.75
Synergistic Effect of Ferulic Acid and Z-Ligustilide, Major Components of A. sinensis, on Regulating Cold-Sensing Protein TRPM8 and TPRA1 In Vitro. Evid Based Complement Alternat Med (2016) 0.75
An HSV-based library screen identifies PP1α as a negative TRPV1 regulator with analgesic activity in models of pain. Mol Ther Methods Clin Dev (2016) 0.75
Regulation of thermoTRPs by lipids. Temperature (Austin) (2016) 0.75
Nordihydroguaiaretic acid activates hTRPA1 and modulates behavioral responses to noxious cold in mice. Pharmacol Res Perspect (2014) 0.75
Cold Temperature Encoding by Cutaneous TRPA1 and TRPM8-Carrying Fibers in the Mouse. Front Mol Neurosci (2017) 0.75
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature (2004) 9.66
Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature (2002) 8.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron (2006) 8.57
The menthol receptor TRPM8 is the principal detector of environmental cold. Nature (2007) 6.16
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25
Attenuated cold sensitivity in TRPM8 null mice. Neuron (2007) 4.73
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci (2005) 4.00
Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing. J Neurosci (2005) 3.99
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
Specificity of cold thermotransduction is determined by differential ionic channel expression. Nat Neurosci (2002) 3.01
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci (2007) 2.78
Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. J Neurosci (2005) 2.59
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain (2004) 2.34
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron (2004) 2.19
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol (2006) 2.18
More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci (2006) 2.17
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci (2007) 2.00
Cold sensitivity of recombinant TRPA1 channels. Brain Res (2007) 1.88
How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain (2005) 1.84
TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol. Neuroreport (2005) 1.72
Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. J Neurosci (2009) 1.61
Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors. Brain (2004) 1.58
Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1. Cell Calcium (2006) 1.54
TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci (2008) 1.53
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol (2006) 1.48
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci (2004) 1.39
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch (2005) 1.30
TRPA1 and cold transduction: an unresolved issue? J Gen Physiol (2009) 1.30
Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. J Biol Chem (2006) 1.30
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Burning cold: involvement of TRPA1 in noxious cold sensation. J Gen Physiol (2009) 1.11
AG-3-5: a chemical producing sensations of cold. J Pharm Pharmacol (1983) 1.06
The effect of menthol on cold allodynia in patients with neuropathic pain. Pain Med (2008) 1.01
Psychophysical study of the effects of topical application of menthol in healthy volunteers. Pain (2006) 1.00
Representation of cold allodynia in the human brain--a functional MRI study. Neuroimage (2007) 0.98
Effect of menthol on two types of Ca currents in cultured sensory neurons of vertebrates. Pflugers Arch (1987) 0.97
A-type GABA receptor as a central target of TRPM8 agonist menthol. PLoS One (2008) 0.89
Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats. Eur J Pharmacol (2006) 0.86
Chemical stimulants of shaking behaviour. J Pharm Pharmacol (1976) 0.83
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci (2008) 3.30
Pain related behaviour in two models of osteoarthritis in the rat knee. Pain (2004) 2.24
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. Eur Urol (2007) 2.21
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci U S A (2007) 2.17
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci (2007) 2.00
siRNA relieves chronic neuropathic pain. Nucleic Acids Res (2004) 1.96
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem (2005) 1.88
Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J Neurosci (2002) 1.45
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol. Nat Commun (2011) 1.43
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci (2004) 1.39
Functional downregulation of P2X3 receptor subunit in rat sensory neurons reveals a significant role in chronic neuropathic and inflammatory pain. J Neurosci (2002) 1.33
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci (2004) 1.30
Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci (2003) 1.23
Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain (2007) 1.19
Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett (2005) 1.19
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1. J Biol Chem (2004) 1.13
A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis. Arthritis Rheum (2011) 1.12
Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc Res (2010) 1.10
Retracted Activation of capsaicin-sensitive primary sensory neurones induces anandamide production and release. J Neurochem (2003) 1.07
Therapeutic potential of cannabinoid receptor agonists as analgesic agents. Expert Opin Investig Drugs (2005) 0.98
TRPV1. Handb Exp Pharmacol (2014) 0.96
Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. J Neurosci (2002) 0.95
Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL/6 mice. Pain (2011) 0.95
TRP channel antagonists for pain--opportunities beyond TRPV1. Curr Opin Investig Drugs (2009) 0.93
TRPA1 has a key role in the somatic pro-nociceptive actions of hydrogen sulfide. PLoS One (2012) 0.92
4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther (2011) 0.91
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel. Pain (2013) 0.89
Methylglyoxal evokes pain by stimulating TRPA1. PLoS One (2013) 0.87
Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1. PLoS One (2013) 0.86
Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem (2006) 0.85
Selective internalization of sodium channels in rat dorsal root ganglion neurons infected with herpes simplex virus-1. J Cell Biol (2002) 0.85
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. J Clin Invest (2014) 0.85
Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration. J Neurochem (2010) 0.84
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice. Arthritis Rheumatol (2014) 0.83
Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol (2005) 0.83
7-tert-Butyl-6-(4-chloro-phenyl)-2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one, a classic polymodal inhibitor of transient receptor potential vanilloid type 1 with a reduced liability for hyperthermia, is analgesic and ameliorates visceral hypersensitivity. J Pharmacol Exp Ther (2012) 0.82
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists. J Med Chem (2014) 0.81
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain (2004) 0.79
Oxidation of plutonium dioxide. Nat Mater (2004) 0.78