Published in J Immunol on April 15, 2002
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med (2003) 3.24
Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol Cell Biol (2008) 1.87
Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology (2004) 1.17
Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol (2009) 1.16
Protein kinase C and toll-like receptor signaling. Enzyme Res (2011) 1.14
IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes. J Biol Chem (2009) 1.10
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response. Int J Clin Exp Med (2009) 1.09
The immunomodulating neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) suppresses LPS-stimulated TLR4 with IRAK-M in macrophages. J Neuroimmunol (2005) 1.04
Molecular pathways: pathogenesis and clinical implications of microbiome alteration in esophagitis and Barrett esophagus. Clin Cancer Res (2012) 1.02
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. BMC Immunol (2008) 0.97
The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. Mol Immunol (2008) 0.92
Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the suppression of TRAF6 polyubiquitination [corrected]. PLoS One (2012) 0.83
IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance. J Leukoc Biol (2013) 0.82
Protein kinase C and acute respiratory distress syndrome. Shock (2013) 0.82
Cross-talk between neural and immune receptors provides a potential mechanism of homeostatic regulation in the gut mucosa. Mucosal Immunol (2014) 0.81
Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration. Mol Immunol (2009) 0.80
Proteome of monocyte priming by lipopolysaccharide, including changes in interleukin-1beta and leukocyte elastase inhibitor. Proteome Sci (2008) 0.79
Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14(+) Monocytes. J Immunol (2017) 0.77
Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1. PLoS One (2016) 0.76
Microbiome and potential targets for chemoprevention of esophageal adenocarcinoma. Semin Oncol (2015) 0.75
Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study. Cancer Res (2004) 1.91
Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter. J Immunol (2005) 1.80
IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. J Biol Chem (2004) 1.65
Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. J Natl Cancer Inst (2005) 1.55
Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One (2007) 1.46
Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab (2010) 1.45
Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. J Leukoc Biol (2009) 1.43
Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol (2002) 1.39
Macrophages and fibroblasts during inflammation, tissue damage and organ injury. Front Biosci (Landmark Ed) (2009) 1.25
Characterization of Tollip protein upon Lipopolysaccharide challenge. Mol Immunol (2004) 1.23
Molecular mechanisms and pathological consequences of endotoxin tolerance and priming. Arch Immunol Ther Exp (Warsz) (2011) 1.20
Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide. J Immunol (2012) 1.19
A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput Biol (2011) 1.18
Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. Mol Immunol (2006) 1.17
Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol (2009) 1.16
Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein δ. J Immunol (2011) 1.15
Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2006) 1.10
IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes. J Biol Chem (2009) 1.10
MAP kinase phosphatase-1, a critical negative regulator of the innate immune response. Int J Clin Exp Med (2009) 1.09
Regulations and roles of the interleukin-1 receptor associated kinases (IRAKs) in innate and adaptive immunity. Immunol Res (2006) 1.09
Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cell Mol Immunol (2010) 1.08
Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Mol Immunol (2007) 1.07
The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation. Cytokine (2008) 1.07
Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci (2005) 1.06
Molecular mechanism responsible for the priming of macrophage activation. J Biol Chem (2012) 1.05
Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling. Cell Signal (2007) 1.05
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring) (2011) 1.03
Molecular mechanism underlying the suppression of lipid oxidation during endotoxemia. Mol Immunol (2009) 1.00
Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells. PLoS Comput Biol (2012) 1.00
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Mol Cell Biol (2009) 1.00
A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells. BMC Syst Biol (2012) 0.97
Interleukin-1 receptor-associated kinase M (IRAK-M) promotes human rhinovirus infection in lung epithelial cells via the autophagic pathway. Virology (2013) 0.95
The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study. Exp Mol Pathol (2007) 0.95
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Arterioscler Thromb Vasc Biol (2012) 0.95
Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation. AIDS Res Hum Retroviruses (2007) 0.94
Hydrogen isotopic compositions of n-alkanes from terrestrial plants correlate with their ecological life forms. Oecologia (2006) 0.93
The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT. Mol Immunol (2008) 0.92
The interleukin-1 receptor-associated kinase M selectively inhibits the alternative, instead of the classical NFkappaB pathway. J Innate Immun (2009) 0.92
Molecular mechanism underlying the inflammatory complication of leptin in macrophages. Mol Immunol (2010) 0.92
Genomic DNA extraction from cells by electroporation on an integrated microfluidic platform. Anal Chem (2012) 0.90
Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation (2010) 0.89
Histone modification analysis by chromatin immunoprecipitation from a low number of cells on a microfluidic platform. Lab Chip (2011) 0.89
Mathematical modeling for the pathogenesis of Alzheimer's disease. PLoS One (2010) 0.88
RelB: an outlier in leukocyte biology. J Leukoc Biol (2013) 0.88
Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes. J Endotoxin Res (2003) 0.86
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Mol Cancer (2006) 0.86
Causes and consequences of low grade endotoxemia and inflammatory diseases. Front Biosci (Schol Ed) (2013) 0.84
Change in mononuclear leukocyte responsiveness in midpregnancy and subsequent preterm birth. Obstet Gynecol (2013) 0.84
The C2 domain of Tollip, a Toll-like receptor signalling regulator, exhibits broad preference for phosphoinositides. Biochem J (2011) 0.82
Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression. Kidney Int (2003) 0.81
Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration. Mol Immunol (2009) 0.80
Intervention of Toll-like receptor-mediated human innate immunity and inflammation by synthetic compounds and naturally occurring products. Curr Med Chem (2006) 0.80
Molecular mechanism underlying persistent induction of LCN2 by lipopolysaccharide in kidney fibroblasts. PLoS One (2012) 0.79
Differential induction of apoptosis by LPS and taxol in monocytic cells. Mol Immunol (2004) 0.79
Backbone (1)H, (15)N, and (13)C resonance assignments and secondary structure of the Tollip CUE domain. Mol Cells (2010) 0.78
Potent suppression of arginase 1 expression in murine macrophages by low dose endotoxin. Am J Clin Exp Immunol (2013) 0.78
Reduced oxidative tissue damage during endotoxemia in IRAK-1 deficient mice. Mol Immunol (2012) 0.77
Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease. J Inflamm Res (2010) 0.76