Published in J Biol Chem on April 12, 2002
Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol (2010) 2.68
Toll-like receptor 9: a new target of ischemic preconditioning in the brain. J Cereb Blood Flow Metab (2008) 1.79
Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol (2010) 1.58
Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol (2004) 1.53
Roles of specific amino acids in the N terminus of Pseudomonas aeruginosa flagellin and of flagellin glycosylation in the innate immune response. Infect Immun (2005) 1.38
Differential effects of CpG-DNA in Toll-like receptor-2/-4/-9 tolerance and cross-tolerance. Immunology (2005) 1.34
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol (2012) 1.31
Flagellin suppresses the inflammatory response and enhances bacterial clearance in a murine model of Pseudomonas aeruginosa keratitis. Infect Immun (2007) 1.27
Mammalian Toll-like receptors: to immunity and beyond. Clin Exp Immunol (2005) 1.23
Contribution of Burkholderia cenocepacia flagella to infectivity and inflammation. Infect Immun (2004) 1.22
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin. J Immunol (2009) 1.20
Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun (2011) 1.20
Modulation of corneal epithelial innate immune response to pseudomonas infection by flagellin pretreatment. Invest Ophthalmol Vis Sci (2007) 1.17
Airway epithelial cell tolerance to Pseudomonas aeruginosa. Respir Res (2005) 1.05
Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection. Infect Immun (2003) 1.05
Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. BMC Immunol (2008) 0.97
Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell Mol Immunol (2011) 0.95
Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88. J Immunol (2011) 0.93
Antigen receptor signals rescue B cells from TLR tolerance. J Immunol (2009) 0.93
Host and bacterial factors affecting induction of immune responses to flagellin expressed by attenuated Salmonella vaccine strains. Infect Immun (2004) 0.89
Protection against multiple influenza A virus strains induced by candidate recombinant vaccine based on heterologous M2e peptides linked to flagellin. PLoS One (2015) 0.89
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Sci Rep (2015) 0.89
CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases. J Biol Chem (2008) 0.88
Persistently active microbial molecules prolong innate immune tolerance in vivo. PLoS Pathog (2013) 0.88
Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res (2005) 0.86
Differential expression of toll-like receptor 3 and 5 in ileal pouch mucosa of ulcerative colitis patients. Int J Colorectal Dis (2006) 0.83
Downregulation of the DNA-binding activity of nuclear factor-kappaB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance. Infect Immun (2004) 0.82
Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. Respir Res (2005) 0.82
Salmonella enterica serovar Typhimurium vaccine strains expressing a nontoxic Shiga-like toxin 2 derivative induce partial protective immunity to the toxin expressed by enterohemorrhagic Escherichia coli. Clin Vaccine Immunol (2010) 0.82
Microbial cell components induced tolerance to flagellin-stimulated inflammation through Toll-like receptor pathways in intestinal epithelial cells. Cytokine (2012) 0.78
Dietary interactions with the bacterial sensing machinery in the intestine: the plant polyphenol case. Front Genet (2014) 0.77
Novel Immunomodulatory Flagellin-Like Protein FlaC in Campylobacter jejuni and Other Campylobacterales. mSphere (2015) 0.76
Advanced glycation endproducts induce self- and cross-tolerance in monocytes. Inflamm Res (2017) 0.75
Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. J Pharmacol Exp Ther (2005) 2.13
Depolarization of mitochondria in endothelial cells promotes cerebral artery vasodilation by activation of nitric oxide synthase. Arterioscler Thromb Vasc Biol (2013) 1.57
Heart mitochondria contain functional ATP-dependent K+ channels. J Mol Cell Cardiol (2003) 1.27
Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. Diabetes (2004) 1.26
Impaired insulin-induced vasodilation in small coronary arteries of Zucker obese rats is mediated by reactive oxygen species. Am J Physiol Heart Circ Physiol (2005) 1.26
Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol (2006) 1.19
Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS. Free Radic Biol Med (2003) 1.16
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons. J Neurochem (2003) 1.10
Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species. Stroke (2004) 1.09
Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats. J Cereb Blood Flow Metab (2007) 1.08
Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production. Am J Physiol Heart Circ Physiol (2005) 1.06
ROS-independent preconditioning in neurons via activation of mitoK(ATP) channels by BMS-191095. J Cereb Blood Flow Metab (2008) 1.05
Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol (2008) 1.05
Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain. Brain Res (2003) 1.02
Putative cyclooxygenase-3 expression in rat brain cells. J Cereb Blood Flow Metab (2003) 1.02
The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning. Neuroreport (2004) 0.98
Delayed neuronal preconditioning by NS1619 is independent of calcium activated potassium channels. J Neurochem (2007) 0.97
Acetaminophen-sensitive prostaglandin production in rat cerebral endothelial cells. Am J Physiol Regul Integr Comp Physiol (2004) 0.93
Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. Life Sci (2006) 0.92
Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats. J Cereb Blood Flow Metab (2012) 0.90
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. Am J Physiol Cell Physiol (2008) 0.90
Effects of LPS stimulation on the expression of prostaglandin carriers in the cells of the blood-brain and blood-cerebrospinal fluid barriers. J Appl Physiol (1985) (2005) 0.90
Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons. J Neurochem (2006) 0.87
Neuronal preconditioning with the antianginal drug, bepridil. J Neurochem (2007) 0.87
Lack of mitochondrial nitric oxide production in the mouse brain. J Neurochem (2004) 0.85
The role of nitric oxide in the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Brain Res (2005) 0.82
Impaired endothelin-induced vasoconstriction in coronary arteries of Zucker obese rats is associated with uncoupling of [Ca2+]i signaling. Am J Physiol Regul Integr Comp Physiol (2005) 0.82
Neuroprotective effect of adenoviral catalase gene transfer in cortical neuronal cultures. Brain Res (2009) 0.82
Immediate neuronal preconditioning by NS1619. Brain Res (2009) 0.80
An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. PLoS One (2013) 0.80
Rosuvastatin induces delayed preconditioning against L-glutamate excitotoxicity in cultured cortical neurons. Neurochem Int (2009) 0.77
Vasoconstrictor mechanisms in the cerebral circulation are unaffected by insulin resistance. Am J Physiol Regul Integr Comp Physiol (2004) 0.77
N-methyl-D-aspartate induces cortical hyperemia through cortical spreading depression-dependent and -independent mechanisms in rats. Microcirculation (2009) 0.76
Impaired vascular responses of insulin-resistant rats after mild subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol (2011) 0.76
Insulin resistance does not impair contractile responses of cerebral arteries. Life Sci (2005) 0.75