Published in Arthritis Rheum on April 01, 2002
Aggrecanases and cartilage matrix degradation. Arthritis Res Ther (2003) 1.97
Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta (2011) 1.73
Targeting subchondral bone for treating osteoarthritis: what is the evidence? Best Pract Res Clin Rheumatol (2010) 1.33
Cathepsin K inhibitors for osteoporosis and potential off-target effects. Expert Opin Investig Drugs (2009) 1.26
Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharm Res (2008) 1.11
Development of macromolecular prodrug for rheumatoid arthritis. Adv Drug Deliv Rev (2012) 1.07
Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage. Am J Pathol (2008) 1.00
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Res Ther (2005) 0.93
Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage. Arthritis Res Ther (2012) 0.93
Cartilage aggrecan can undergo self-adhesion. Biophys J (2008) 0.92
Oxygen and pH-sensitivity of human osteoarthritic chondrocytes in 3-D alginate bead culture system. Osteoarthritis Cartilage (2013) 0.92
Human articular chondrocytes express multiple gap junction proteins: differential expression of connexins in normal and osteoarthritic cartilage. Am J Pathol (2013) 0.88
Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis. Ann Rheum Dis (2004) 0.87
Beyond oncology--application of HPMA copolymers in non-cancerous diseases. Adv Drug Deliv Rev (2009) 0.86
Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand. Arthritis Res Ther (2011) 0.84
Detecting cathepsin activity in human osteoarthritis via activity-based probes. Arthritis Res Ther (2015) 0.83
Drugs in development: bisphosphonates and metalloproteinase inhibitors. Arthritis Res Ther (2002) 0.83
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am J Pathol (2005) 0.83
Activity and potential role of licofelone in the management of osteoarthritis. Clin Interv Aging (2007) 0.82
Factors influencing the crystallization of monosodium urate: a systematic literature review. BMC Musculoskelet Disord (2015) 0.81
Chopping off the chondrocyte proteome. Biomarkers (2014) 0.78
Resveratrol and N-acetylcysteine influence redox balance in equine articular chondrocytes under acidic and very low oxygen conditions. Free Radic Biol Med (2015) 0.77
Metabolism of cartilage proteoglycans in health and disease. Biomed Res Int (2014) 0.76
Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis. Arthritis Res Ther (2015) 0.75
Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am (2002) 5.95
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet (2002) 4.06
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. EMBO J (2002) 3.99
A simplified laminin nomenclature. Matrix Biol (2005) 3.81
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol (2009) 3.12
Overview of image-guided radiation therapy. Med Dosim (2006) 3.07
Three-dimensional tissue culture based on magnetic cell levitation. Nat Nanotechnol (2010) 2.11
DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J Exp Med (2003) 2.04
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99
Laminin isoforms in tumor invasion, angiogenesis and metastasis. Semin Cancer Biol (2002) 1.83
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev (2008) 1.81
Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res (2006) 1.80
Two year randomized controlled trial of etidronate in rheumatoid arthritis: changes in serum aminoterminal telopeptides correlate with radiographic progression of disease. J Rheumatol (2003) 1.77
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Inhibition of beta-catenin signaling causes defects in postnatal cartilage development. J Cell Sci (2008) 1.67
Use of polymerase chain reaction to diagnose tuberculous arthritis from joint tissues and synovial fluid. Arch Pathol Lab Med (2004) 1.63
Operative and nonoperative treatments of medial collateral ligament rupture with early anterior cruciate ligament reconstruction: a prospective randomized study. Am J Sports Med (2006) 1.62
Increased expression and processing of ADAM 12 (meltrin-alpha) in osteolysis associated with aseptic loosening of total hip replacement implants. J Rheumatol (2005) 1.46
Inflammatory immune cell responses and Toll-like receptor expression in synovial tissues in rheumatoid arthritis patients treated with biologics or DMARDs. Clin Rheumatol (2013) 1.42
Transcription factors zeb1, twist and snai1 in breast carcinoma. BMC Cancer (2011) 1.35
Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol (2003) 1.29
Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J Histochem Cytochem (2006) 1.25
Compositional differences between infant and adult human corneal basement membranes. Invest Ophthalmol Vis Sci (2007) 1.25
Macrophages-Key cells in the response to wear debris from joint replacements. J Biomed Mater Res A (2013) 1.18
Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy. Biochem Biophys Res Commun (2013) 1.18
Bioabsorbable miniplating versus metallic fixation for metacarpal fractures. Clin Orthop Relat Res (2003) 1.17
Snail1 protein in the stroma as a new putative prognosis marker for colon tumours. PLoS One (2009) 1.16
Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium. J Rheumatol (2002) 1.16
Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J Biol Chem (2010) 1.16
Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis. Angiogenesis (2006) 1.15
Total hip replacement in patients eighty years of age and older. J Bone Joint Surg Am (2008) 1.12
CT arthrography of the wrist using a novel, mobile, dedicated extremity cone-beam CT (CBCT). Skeletal Radiol (2012) 1.11
The microenvironment around total hip replacement prostheses. Clin Orthop Relat Res (2005) 1.07
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro. Mol Cancer Ther (2003) 1.06
Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo. J Biol Chem (2002) 1.05
Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia. J Cell Mol Med (2009) 1.03
Basement membrane proteins in multiple sclerosis-associated inflammatory cuffs: potential role in influx and transport of leukocytes. J Neuropathol Exp Neurol (2005) 1.03
Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support. J Cell Mol Med (2008) 1.03
Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants. J Rheumatol (2009) 1.02
OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med (Berl) (2009) 1.02
Expression of Snail is associated with myofibroblast phenotype development in oral squamous cell carcinoma. Histochem Cell Biol (2009) 1.00
Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms. Mol Cell Endocrinol (2012) 1.00
Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1. Cancer Med (2013) 1.00
Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction. Exp Cell Res (2008) 1.00
Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling. J Bone Miner Res (2010) 1.00
Human osteoblasts produce cathepsin K. Bone (2005) 1.00
Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome. J Rheumatol (2005) 0.99
Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles. J Orthop Res (2011) 0.99
Bone stress injuries of the lower extremity: a review. Acta Orthop Scand (2002) 0.98
Distribution of laminins in the developing human eye. Invest Ophthalmol Vis Sci (2006) 0.98
Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis. J Rheumatol (2011) 0.97
Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas. Cell Tissue Res (2007) 0.95
Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma. Hum Pathol (2010) 0.94
Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression. BMC Cancer (2009) 0.94
Localization of laminin alpha4-chain in developing and adult human tissues. J Histochem Cytochem (2002) 0.94
Occurrence and types of associated injuries in patients with fractures of the facial bones. J Oral Maxillofac Surg (2010) 0.94
Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells. Histochem Cell Biol (2008) 0.94
Biocompatibility of total joint replacements: A review. J Biomed Mater Res A (2009) 0.93
Basement membrane collagen type IV expression by human mesenchymal stem cells during adipogenic differentiation. J Cell Mol Med (2012) 0.93
Hyaluronate inhibits the interleukin-1beta-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. Tohoku J Exp Med (2004) 0.93
Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. Cancer Sci (2014) 0.93
Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture. Stem Cell Res (2011) 0.92
Toll-like receptors in the interface membrane around loosening total hip replacement implants. J Biomed Mater Res A (2007) 0.92
Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. J Hypertens (2008) 0.92
Titanium particles modulate expression of Toll-like receptor proteins. J Biomed Mater Res A (2010) 0.91
Disease-associated increased HIF-1, alphavbeta3 integrin, and Flt-1 do not suffice to compensate the damage-inducing loss of blood vessels in inflammatory myopathies. Rheumatol Int (2003) 0.90
Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol (2008) 0.90
Innervation of the joint and role of neuropeptides. Ann N Y Acad Sci (2006) 0.90
The response of macrophages to titanium particles is determined by macrophage polarization. Acta Biomater (2013) 0.89
Interferon-gamma induces C/EBP beta expression and activity through MEK/ERK and p38 in T84 colon epithelial cells. Am J Physiol Cell Physiol (2002) 0.89
Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J Rheumatol (2005) 0.89
Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: a novel in vivo rat model. Spine (Phila Pa 1976) (2006) 0.88
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. J Orthop Res (2009) 0.88
Increased expression of a novel osteoclast-stimulating factor, ADAM8, in interface tissue around loosened hip prostheses. J Rheumatol (2003) 0.88
Upregulation of matrix metalloproteinase (MMP)-1 and its activator MMP-3 of human osteoblast by uniaxial cyclic stimulation. J Biomed Mater Res B Appl Biomater (2007) 0.88