Published in J Pharmacol Exp Ther on May 01, 2002
Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nat Med (2006) 4.74
A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell (2010) 2.37
Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature (2008) 2.30
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance. Proc Natl Acad Sci U S A (2007) 2.27
The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis. Plant Cell (2004) 2.20
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J (2007) 2.00
Blockade of TNF-α rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci U S A (2011) 1.95
The DP-E2F-like gene DEL1 controls the endocycle in Arabidopsis thaliana. Curr Biol (2005) 1.61
The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients. Drug Saf (2004) 1.57
Cyclooxygenase-2--10 years later. J Pharmacol Exp Ther (2002) 1.44
Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. Tissue Eng (2006) 1.40
TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis. Nucleic Acids Res (2012) 1.39
Novel plant-specific cyclin-dependent kinase inhibitors induced by biotic and abiotic stresses. J Biol Chem (2007) 1.32
In vivo magnetic resonance imaging of dendritic cell migration into the draining lymph nodes of mice. Eur J Immunol (2006) 1.31
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype. J Clin Invest (2005) 1.30
Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography. Biomed Chromatogr (2003) 1.29
Survey of adverse drug reactions on a pediatric ward: a strategy for early and detailed detection. Pediatrics (2002) 1.23
Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck. Biochemistry (2002) 1.17
Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins. Plant Cell (2011) 1.17
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies. Clin Pharmacokinet (2007) 1.14
Identification of adverse drug reactions in geriatric inpatients using a computerised drug database. Drugs Aging (2003) 1.12
A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur J Pharmacol (2002) 1.10
Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles. Clin Chem (2002) 1.10
Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism. J Lipid Res (2007) 1.10
Caffeine accelerates absorption and enhances the analgesic effect of acetaminophen. J Clin Pharmacol (2007) 1.07
Calmodulin association with connexin32-derived peptides suggests trans-domain interaction in chemical gating of gap junction channels. J Biol Chem (2008) 1.06
Analgesic strategies beyond the inhibition of cyclooxygenases. Trends Pharmacol Sci (2006) 1.05
Lack of awareness of community-acquired adverse drug reactions upon hospital admission : dimensions and consequences of a dilemma. Drug Saf (2003) 1.03
Gene expression changes in blood after phlebotomy: implications for gene expression profiling. Blood (2002) 1.02
Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc. Plant Physiol (2011) 1.02
A model for the activation of plasma membrane calcium pump isoform 4b by calmodulin. Biochemistry (2003) 1.01
Overproduction of a rice aldo-keto reductase increases oxidative and heat stress tolerance by malondialdehyde and methylglyoxal detoxification. Plant Mol Biol (2011) 1.00
Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. Eur J Pharmacol (2008) 0.99
Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport (2010) 0.96
Drug utilisation on a preterm and neonatal intensive care unit in Germany: a prospective, cohort-based analysis. Eur J Clin Pharmacol (2009) 0.96
Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions. Mol Immunol (2009) 0.95
Imaging of hyperalgesia in rats by functional MRI. Eur J Pain (2006) 0.95
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB J (2007) 0.94
15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. Biochem Biophys Res Commun (2003) 0.94
Stabilization of gene expression profiles in blood after phlebotomy. Clin Chem (2002) 0.94
Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator. J Am Chem Soc (2011) 0.94
Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients? Eur J Clin Pharmacol (2006) 0.94
Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J Cancer Res Clin Oncol (2009) 0.93
Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor. J Biol Chem (2006) 0.93
Evaluation of NT-proBNP and high sensitivity C-reactive protein for predicting cardiovascular risk in patients with arthritis taking longterm nonsteroidal antiinflammatory drugs. J Rheumatol (2011) 0.93
Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations. Ann Rheum Dis (2011) 0.93
Human retinal progenitor cell transplantation preserves vision. J Biol Chem (2014) 0.92
Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct. Biochemistry (2009) 0.92
Evaluating the pharmacological mechanism of Chinese medicine Si-Wu-Tang through multi-level data integration. PLoS One (2013) 0.92
Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. Br J Pharmacol (2002) 0.92
Mechanism of the T286A-mutant alphaCaMKII interactions with Ca2+/calmodulin and ATP. Biochemistry (2004) 0.91
Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs. J Virol (2006) 0.91
Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis. BMC Med Genomics (2013) 0.91
Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. FASEB J (2005) 0.91
Time-dependent autoinactivation of phospho-Thr286-alphaCa2+/calmodulin-dependent protein kinase II. J Biol Chem (2009) 0.91
Ca2+/calmodulin-dependent activation and inactivation mechanisms of alphaCaMKII and phospho-Thr286-alphaCaMKII. Biochemistry (2004) 0.90
HDAM: a resource of human disease associated mutations from next generation sequencing studies. BMC Med Genomics (2013) 0.89
Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clin Pharmacol Ther (2003) 0.88
Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography. Biomed Chromatogr (2003) 0.88
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells. J Pharmacol Exp Ther (2005) 0.88
Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol (2008) 0.88
Kinetics and functional characterization of the glycine receptor alpha2 and alpha3 subunit. Neurosci Lett (2007) 0.87
Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisal. Nat Clin Pract Rheumatol (2007) 0.87
Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor. Eur J Neurosci (2003) 0.87
Intrinsic versus extrinsic vascularization in tissue engineering. Adv Exp Med Biol (2006) 0.87
Ca2+-dependent and -independent mechanisms of calmodulin nuclear translocation. J Cell Sci (2004) 0.87
Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells. Mol Pharmacol (2004) 0.87
More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib. Arthritis Rheum (2006) 0.87
Paracetamol and cyclooxygenase inhibition: is there a cause for concern? Ann Rheum Dis (2011) 0.86
Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways. Hepatol Res (2011) 0.86
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. Biochem Biophys Res Commun (2005) 0.86
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia. Respir Res (2005) 0.86
Lobe-specific functions of Ca2+·calmodulin in alphaCa2+·calmodulin-dependent protein kinase II activation. J Biol Chem (2011) 0.86
Pain and osteoarthritis: new drugs and mechanisms. Curr Opin Rheumatol (2004) 0.86
Guidelines for blood smear preparation and staining procedure for setting up an external quality assessment scheme for blood smear interpretation. Part I: Control material. Clin Chem Lab Med (2004) 0.86
Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF. Eur J Pharmacol (2006) 0.85
Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling. Neurochem Int (2010) 0.85
Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences. Virology (2002) 0.85
E-pharmacovigilance: development and implementation of a computable knowledge base to identify adverse drug reactions. Br J Clin Pharmacol (2013) 0.85
Consumption of analgesics before a marathon and the incidence of cardiovascular, gastrointestinal and renal problems: a cohort study. BMJ Open (2013) 0.85
Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival. J Immunol (2005) 0.84
Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac. Clin Pharmacol Ther (2003) 0.84
Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. Eur J Pharmacol (2010) 0.84
R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. Biochem Biophys Res Commun (2004) 0.84
MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis. PLoS One (2010) 0.83
Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs. Biochem Pharmacol (2006) 0.83
Altered inactivation pathway of factor Va by activated protein C in the presence of heparin. Eur J Biochem (2004) 0.83
Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology. Trends Pharmacol Sci (2008) 0.83
Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry. Biomed Chromatogr (2002) 0.83
Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography. Biomed Chromatogr (2006) 0.82
Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa. J Pharmacol Exp Ther (2009) 0.82
The adaptor Grb7 is a novel calmodulin-binding protein: functional implications of the interaction of calmodulin with Grb7. Oncogene (2005) 0.82
Bioavailability of diclofenac potassium at low doses. Br J Clin Pharmacol (2005) 0.81
Persistent unsealed internal limiting membrane after Nd:YAG laser treatment for valsalva retinopathy. BMC Ophthalmol (2013) 0.81
Modulation of TNF and GM-CSF release from dispersed human nasal polyp cells and human whole blood by inhibitors of different PDE isoenzymes and glucocorticoids. Pulm Pharmacol Ther (2002) 0.81