Published in Nature on November 27, 1975
Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med (2009) 1.41
Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A (2002) 1.39
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Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. J Clin Invest (2001) 1.29
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PGE2 decreases reactivity of human platelets by activating EP2 and EP4. Thromb Res (2010) 0.82
Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thromb Res (2015) 0.75
Selective inhibition of platelet responses to bisenoic prostaglandins [proceedings]. Br J Pharmacol (1977) 0.75
Extracellular ATP: effects, sources and fate. Biochem J (1986) 8.45
Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature (1994) 4.78
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
A simple fluorimetric microassay for adenine compounds in platelets and plasma and its application to studies on the platelet release reaction. Biochem J (1974) 2.73
Localisation and stimulation of prostacyclin production in vascular cells. Nature (1978) 2.45
Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature (1979) 2.42
Uptake and metabolism of adenosine by pig aortic endothelial and smooth-muscle cells in culture. Biochem J (1978) 2.32
The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol (1993) 2.13
Stimulation of prostaglandin production through purinoceptors on cultured porcine endothelial cells. Biochem J (1983) 2.05
Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture. Biochem J (1980) 1.95
Endothelium-dependent relaxation of the pig aorta: relationship to stimulation of 86Rb efflux from isolated endothelial cells. Br J Pharmacol (1983) 1.94
Stereoselectivity of ectonucleotidases on vascular endothelial cells. Biochem J (1983) 1.89
Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res (2000) 1.83
Differential effects of hydrogen peroxide on indices of endothelial cell function. J Exp Med (1984) 1.72
Granulocyte migration through endothelium in culture. J Cell Sci (1979) 1.66
A model of the smooth pursuit eye movement system. Biol Cybern (1986) 1.66
Specificity of P2-purinoceptor that mediates endothelium-dependent relaxation of the pig aorta. Eur J Pharmacol (1985) 1.60
Effects of isolation and culture on prostaglandin synthesis by porcine aortic endothelial and smooth muscle cells. J Cell Physiol (1982) 1.55
Specific binding sites for 5-hydroxytryptamine on rat blood platelets. Biochem J (1975) 1.51
Characteristics of the P2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells. Eur J Pharmacol (1987) 1.48
Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. FEBS Lett (1985) 1.44
Stimulation of endothelial prostacyclin production plays no role in endothelium-dependent relaxation of the pig aorta. Br J Pharmacol (1983) 1.43
Thromboxane-induced phosphatidate formation in human platelets. Relationship to receptor occupancy and to changes in cytosolic free calcium. Biochem J (1984) 1.39
Evidence for an early inflammatory response in the central nervous system of mice with scrapie. Neuroscience (1996) 1.38
Stimulation of platelets by bis-enoic prostaglandins [proceedings]. Br J Pharmacol (1976) 1.31
Nucleotide metabolism by endothelium. Annu Rev Physiol (1985) 1.30
Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae. J Clin Invest (1992) 1.27
Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides. Bioorg Med Chem Lett (2000) 1.25
The impact of occupational injury on injured worker and family: outcomes of upper extremity cumulative trauma disorders in Maryland workers. Am J Ind Med (2000) 1.23
Granulocyte adhesion to endothelium in culture. J Cell Sci (1979) 1.22
Discrimination between platelet prostaglandin receptors with a specific antagonist of bisenoic prostaglandins. Thromb Res (1977) 1.21
Uptake of 5-hydroxytryptamine by rat blood platelets and its inhibition by adenosine 5'-diphosphate. Br J Pharmacol (1976) 1.16
Differential calcium dependence of contractile responses and 86Rb efflux from the rabbit aorta induced by vasoactive stimuli. J Cell Physiol (1983) 1.16
Regulation of lymphatic contractility by arachidonate metabolites. Nature (1981) 1.15
Letter: Rapid, sensitive microassay for platelet 5HT. Thromb Diath Haemorrh (1974) 1.14
Prostaglandin receptors on human platelets. Structure-activity relationships of stimulatory prostaglandins. Biochem J (1978) 1.14
Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology (1996) 1.12
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. Biochem J (1983) 1.10
Endothelial functional responses and increased vascular permeability induced by polycations. Lab Invest (1988) 1.10
2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist. J Med Chem (1996) 1.08
The measurement of platelet aggregation in small blood samples. Atherosclerosis (1972) 1.07
Novel treatment for joint inflammation. Nature (1978) 1.07
The role of platelet membrane potential in the initiation of platelet aggregation. Thromb Haemost (1982) 1.07
Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett (2000) 1.06
Effects of sulphinpyrazone and aspirin on prostaglandin I2 (prostacyclin) synthesis by endothelial cells. Br J Pharmacol (1978) 1.06
The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets. Neuropharmacology (2000) 1.04
Interaction of leukocytes with vascular cells in culture. J Cell Sci (1978) 1.04
Is prostacyclin a physiologically important circulating anti-platelet agent? Nature (1980) 1.03
Proceedings: Inhibition of collagen-induced platelet aggregation by aspirin. Br J Pharmacol (1974) 1.00
Spontaneous and agonist-induced 86Rb efflux from rabbit aortic smooth muscle cells in culture: a comparison with fresh tissue. J Cell Physiol (1983) 0.99
Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents. J Clin Invest (1984) 0.99
Endotoxin-induced platelet aggregation and secretion. I. Morphological changes and pharmacological effects. J Cell Sci (1977) 0.98
Purinoceptors in the rat heart. Br J Pharmacol (1987) 0.98
Simple, sensitive fluorimetric assay for malondialdehyde production by blood platelets. Thromb Res (1977) 0.98
P2 purinoceptors in the blood vessel wall. Biochem Pharmacol (1989) 0.96
Effects of synthetic prostaglandin analogues on platelet aggregation and secretion [proceedings]. Br J Pharmacol (1977) 0.96
Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. FEBS Lett (1985) 0.96
The morphological and biochemical characterization of a line of rat promegakaryoblasts. Blood (1981) 0.96
Binding of radiolabelled collagen to blood platelets. J Cell Sci (1974) 0.96
Platelet-aggregating activity of type I and type III collagens from human aorta and chicken skin. Biochem J (1976) 0.95
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. J Med Chem (2000) 0.94
Effects of arachidonic acid and its cyclo-oxygenase and lipoxygenase products on lymphatic vessel contractility in vitro. Prostaglandins (1983) 0.94
Platelet aggregaton by basement membrane-associated collagens. Thromb Res (1980) 0.93
Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leukocyte adherence. Inflammation (1992) 0.93
Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease. Vision Res (1997) 0.92
5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors. Mol Pharmacol (1991) 0.92
Transport of 5-hydroxytryptamine by endothelial cells [proceedings]. Biochem Soc Trans (1977) 0.92
Plasma von Willebrand factor in connective tissue disease. Ann Rheum Dis (1987) 0.91
Desensitization of agonist-stimulated prostacyclin release in human umbilical vein endothelial cells. Eur J Pharmacol (1988) 0.90
A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res (1995) 0.90
Prostacyclin generation by cultured endothelial cells in haemolytic uraemic syndrome. Lancet (1980) 0.90
ADP plays a key role in thrombogenesis in rats. Thromb Haemost (1988) 0.90
Genetic engineering of carbohydrate biosynthetic pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells. Proc Natl Acad Sci U S A (1996) 0.89
Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets. Biochem J (1986) 0.89
Kinetics of adenine nucleotide catabolism in coronary circulation of rats. Am J Physiol (1989) 0.89
Potentiation of adrenaline-induced platelet aggregation by angiotensin II. Thromb Haemost (1985) 0.89
Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides. Bioorg Med Chem Lett (1999) 0.89
Melanocortin mediated inhibition of feeding behavior in rats. Neuropeptides (1998) 0.88
A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J Clin Invest (1998) 0.88
Endothelial adenine uptake as an assay for cell- or complement-mediated cytotoxicity. Immunology (1977) 0.87
Trimethoquinol is a potent prostaglandin endoperoxide antagonist [proceedings]. Br J Pharmacol (1978) 0.86
Radioimmunoassay of 6-oxoprostaglandin F1 alpha and prostaglandin E2 produced by pig aortic endothelium in culture [proceedings]. Biochem Soc Trans (1979) 0.85
Proceedings: Inhibition of 5-hydroxy-(3H)-tryptamine binding to rat blood platelets by 5-HT antagonists and uptake inhibitors. Br J Pharmacol (1975) 0.85
Comparison of the effects of prostaglandin analogues on rabbit platelets, rabbit isolated vascular tissues and rabbit skin microvasculature [proceedings]. Br J Pharmacol (1978) 0.85
Stimulation of endothelial cells by protease activity in commercial preparations of xanthine oxidase. Thromb Res (1984) 0.85
Endotoxin-induced platelet aggregation and secretion. II. Changes in plasma membrane proteins. J Cell Sci (1977) 0.84
Lack of effect of pertussis toxin on TNF-alpha-induced formation of reactive oxygen intermediates by human neutrophils. Biochem Biophys Res Commun (1989) 0.84
Production of leptin in Escherichia coli: a comparison of methods. Protein Expr Purif (1998) 0.84