Published in Nat Med on May 01, 2002
Oxidative stress and nitration in neurodegeneration: cause, effect, or association? J Clin Invest (2003) 2.60
Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med (2009) 1.94
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. PLoS One (2008) 1.61
Vitamin C: update on physiology and pharmacology. Br J Pharmacol (2009) 1.53
Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr (2011) 1.45
Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet (2013) 1.45
Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest (2010) 1.33
Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2. Hum Genet (2004) 1.27
Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem (2010) 1.24
Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Arch (2003) 1.20
Inflammation in the vascular bed: importance of vitamin C. Pharmacol Ther (2008) 1.11
Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A (2004) 1.10
New view at C. Nat Med (2002) 1.09
A deletion causing spontaneous fracture identified from a candidate region of mouse Chromosome 14. Mamm Genome (2005) 1.08
Development of ascorbate transporters in brain cortical capillary endothelial cells in culture. Brain Res (2008) 1.06
Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med (2009) 1.05
Vitamin C transport and its role in the central nervous system. Subcell Biochem (2012) 1.05
Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice. Pharmacol Biochem Behav (2009) 1.02
Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing. Nat Biotechnol (2014) 1.02
Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function. Annu Rev Nutr (2013) 1.02
Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2. Free Radic Biol Med (2010) 1.00
Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development. Brain Res (2010) 0.99
The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C. Br J Pharmacol (2011) 0.98
Biotelemetric monitoring of brain neurochemistry in conscious rats using microsensors and biosensors. Sensors (Basel) (2009) 0.98
Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antioxid Redox Signal (2013) 0.97
Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal (2013) 0.97
Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer (2008) 0.96
Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion. Biochem Biophys Res Commun (2011) 0.94
Regulation of vitamin C homeostasis during deficiency. Nutrients (2013) 0.93
A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport. Mol Cell Biol (2004) 0.92
Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility: A Link to Diabetes Via Glucose, Glucose Transporters, and Dehydroascorbic Acid. EBioMedicine (2015) 0.92
Vitamin C protects HL60 and U266 cells from arsenic toxicity. Blood (2005) 0.91
Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung. PLoS One (2012) 0.90
Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J Biol Chem (2012) 0.90
Vitamin C distribution and retention in the mouse brain. Brain Res (2010) 0.89
Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PLoS One (2012) 0.89
Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem (2013) 0.88
Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci (2010) 0.88
Antioxidant vitamins and their use in preventing cardiovascular disease. Molecules (2010) 0.87
Uterine glands: biological roles in conceptus implantation, uterine receptivity and decidualization. Int J Dev Biol (2014) 0.87
CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a. Biochem J (2011) 0.86
A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J Alzheimers Dis (2012) 0.86
Sodium-dependent vitamin C transporter 2 (SVCT2) expression and activity in brain capillary endothelial cells after transient ischemia in mice. PLoS One (2011) 0.86
Choroid plexus transport: gene deletion studies. Fluids Barriers CNS (2011) 0.85
Biological roles of uterine glands in pregnancy. Semin Reprod Med (2014) 0.85
Vitamin C promotes maturation of T-cells. Antioxid Redox Signal (2013) 0.84
Metabolism and Epigenetics. Annu Rev Cell Dev Biol (2015) 0.83
Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure. Am J Physiol Cell Physiol (2016) 0.83
Cellular phenotype-dependent and -independent effects of vitamin C on the renewal and gene expression of mouse embryonic fibroblasts. PLoS One (2012) 0.82
Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family. PLoS One (2012) 0.82
Endotoxin increases ascorbate recycling and concentration in mouse liver. J Nutr (2005) 0.82
Selective macrophage ascorbate deficiency suppresses early atherosclerosis. Free Radic Biol Med (2010) 0.82
Ascorbic acid and the brain: rationale for the use against cognitive decline. Nutrients (2014) 0.82
Macrophage differentiation increases expression of the ascorbate transporter (SVCT2). Free Radic Biol Med (2009) 0.82
Vitamin C: the known and the unknown and Goldilocks. Oral Dis (2016) 0.82
Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice. ACS Chem Neurosci (2015) 0.81
Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1. Am J Physiol Cell Physiol (2009) 0.81
Molecular determinants dictating cell surface expression of the human sodium-dependent vitamin C transporter-2 in human liver cells. Am J Physiol Gastrointest Liver Physiol (2009) 0.81
Intravenous ascorbate improves spatial memory in middle-aged APP/PSEN1 and wild type mice. Behav Brain Res (2014) 0.81
Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol (2010) 0.80
SVCT2 vitamin C transporter expression in progenitor cells of the postnatal neurogenic niche. Front Cell Neurosci (2013) 0.80
Interaction of the transcription start site core region and transcription factor YY1 determine ascorbate transporter SVCT2 exon 1a promoter activity. PLoS One (2012) 0.80
High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice. Cell Death Dis (2014) 0.79
Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases. Adv Nutr (2016) 0.79
Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease. Epilepsy Res (2014) 0.79
Ascorbic Acid and gene expression: another example of regulation of gene expression by small molecules? Curr Genomics (2010) 0.78
Prenatal vitamin C deficiency results in differential levels of oxidative stress during late gestation in foetal guinea pig brains. Redox Biol (2014) 0.78
Regulation of the human ascorbate transporter SVCT2 exon 1b gene by zinc-finger transcription factors. Free Radic Biol Med (2011) 0.78
Expression, purification and low-resolution structure of human vitamin C transporter SVCT1 (SLC23A1). PLoS One (2013) 0.78
The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain. Mol Brain (2014) 0.77
Vitamin C Transporters, Recycling and the Bystander Effect in the Nervous System: SVCT2 versus Gluts. J Stem Cell Res Ther (2014) 0.77
Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid. Brain Res (2013) 0.77
Ascorbic acid is a dose-dependent inhibitor of adipocyte differentiation, probably by reducing cAMP pool. Front Cell Dev Biol (2014) 0.77
Base-resolution profiling of active DNA demethylation using MAB-seq and caMAB-seq. Nat Protoc (2016) 0.76
Maternal vitamin C deficiency during pregnancy results in transient fetal and placental growth retardation in guinea pigs. Eur J Nutr (2014) 0.76
Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders. Int J Mol Sci (2015) 0.76
Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women. PLoS One (2013) 0.76
Noninvasive quantification of human brain antioxidant concentrations after an intravenous bolus of vitamin C. NMR Biomed (2010) 0.76
Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice. Nutr Neurosci (2012) 0.76
Current limitations of murine models in oncology for ascorbate research. Front Oncol (2014) 0.76
Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics. Stem Cells Int (2017) 0.75
The human sodium-dependent ascorbic acid transporters SLC23A1 and SLC23A2 do not mediate ascorbic acid release in the proximal renal epithelial cell. Physiol Rep (2013) 0.75
Does vitamin C deficiency affect cognitive development and function? Nutrients (2014) 0.75
Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study. BMJ Open (2015) 0.75
Chronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression. Nutrients (2014) 0.75
Molecular mechanism(s) involved in differential-expression of Vitamin C transporters along the intestinal tract. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
Transendothelial Transport and Its Role in Therapeutics. Int Sch Res Notices (2014) 0.75
Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal. J Neurosci Res (2015) 0.75
Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? Nutrients (2017) 0.75
Vitamin C acts as a hepatoprotectant in carbofuran treated rat liver slices in vitro. Toxicol Rep (2017) 0.75
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate. Free Radic Biol Med (2017) 0.75
Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo. EBioMedicine (2017) 0.75
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med (2013) 22.73
Beyond prejudice: are negative evaluations the problem and is getting us to like one another more the solution? Behav Brain Sci (2012) 18.61
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
NT5E mutations and arterial calcifications. N Engl J Med (2011) 8.71
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
Research ethics recommendations for whole-genome research: consensus statement. PLoS Biol (2008) 5.24
ClinGen--the Clinical Genome Resource. N Engl J Med (2015) 4.45
Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst (2002) 4.33
Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med (2004) 4.30
Effect of a decision aid on knowledge and treatment decision making for breast cancer surgery: a randomized trial. JAMA (2004) 4.18
Exploring concordance and discordance for return of incidental findings from clinical sequencing. Genet Med (2012) 4.04
Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci (2002) 4.01
An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature (2003) 3.90
Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem (2004) 3.87
Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA (2012) 3.85
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol (2005) 3.59
Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr (2003) 3.34
Complete genome sequence of Kytococcus sedentarius type strain (541). Stand Genomic Sci (2009) 3.30
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30
Microtubule assembly dynamics at the nanoscale. Curr Biol (2007) 3.02
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
Ice-shelf collapse from subsurface warming as a trigger for Heinrich events. Proc Natl Acad Sci U S A (2011) 2.83
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome (2002) 2.79
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci U S A (2007) 2.71
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity (2011) 2.69
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet (2003) 2.67
Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab (2011) 2.65
Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes (2010) 2.63
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma. Nat Genet (2009) 2.58
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. Mol Cell (2003) 2.55
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation (2006) 2.55
Helping patients make informed choices: a randomized trial of a decision aid for adjuvant chemotherapy in lymph node-negative breast cancer. J Natl Cancer Inst (2003) 2.51
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A (2008) 2.50
Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein. J Biol Chem (2001) 2.49
Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int (2009) 2.46
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. Am J Pathol (2005) 2.45
Phylogeography of the fungal pathogen Histoplasma capsulatum. Mol Ecol (2003) 2.44
Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Clin Cancer Res (2005) 2.43
Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet (2002) 2.39
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.28
The Kitty Genovese murder and the social psychology of helping: the parable of the 38 witnesses. Am Psychol (2007) 2.23
Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice. J Clin Invest (2012) 2.18
Randomized trial of high-dose chemotherapy with autologous peripheral-blood stem-cell support compared with standard-dose chemotherapy in women with metastatic breast cancer: NCIC MA.16. J Clin Oncol (2007) 2.15
Oxalic acid excretion after intravenous ascorbic acid administration. Metabolism (2009) 2.14
Retro-orbital injections in mice. Lab Anim (NY) (2011) 2.09
Randomized trial comparing two fractionation schedules for patients with localized prostate cancer. J Clin Oncol (2005) 2.06
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest (2007) 2.04
Regional FMRP deficits and large repeat expansions into the full mutation range in a new Fragile X premutation mouse model. Gene (2007) 2.01
Cryptococcal yeast cells invade the central nervous system via transcellular penetration of the blood-brain barrier. Infect Immun (2004) 1.99
Warfarin dose assessment every 4 weeks versus every 12 weeks in patients with stable international normalized ratios: a randomized trial. Ann Intern Med (2011) 1.98
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. J Biol Chem (2011) 1.96
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis (2006) 1.96
Complete genome sequence of Meiothermus ruber type strain (21). Stand Genomic Sci (2010) 1.96
Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol (2002) 1.94
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. Mov Disord (2006) 1.93
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One (2010) 1.92
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Sci Transl Med (2014) 1.91
Clinical practice guidelines for the care and treatment of breast cancer: follow-up after treatment for breast cancer (summary of the 2005 update). CMAJ (2005) 1.89
New American Cancer Society process for creating trustworthy cancer screening guidelines. JAMA (2011) 1.88
Drosophila male germline stem cells do not asymmetrically segregate chromosome strands. J Cell Sci (2011) 1.83
Complete genome sequence of Pedobacter heparinus type strain (HIM 762-3). Stand Genomic Sci (2009) 1.82
Dent Disease with mutations in OCRL1. Am J Hum Genet (2004) 1.81
Parkinson patient fibroblasts show increased alpha-synuclein expression. Exp Neurol (2008) 1.79
Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med (2009) 1.77
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol (2009) 1.76
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol (2005) 1.71
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One (2009) 1.71
Recommendations for control of pathogens and infectious diseases in fish research facilities. Comp Biochem Physiol C Toxicol Pharmacol (2008) 1.66
Differentiation of human pulmonary type II cells in vitro by glucocorticoid plus cAMP. Am J Physiol Lung Cell Mol Physiol (2002) 1.66
Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol (2005) 1.66
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat Biotechnol (2003) 1.64
Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development (2003) 1.64
Human adrenal glands secrete vitamin C in response to adrenocorticotrophic hormone. Am J Clin Nutr (2007) 1.60
Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity (2012) 1.59
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res (2010) 1.57
Randomized trial comparing iridium implant plus external-beam radiation therapy with external-beam radiation therapy alone in node-negative locally advanced cancer of the prostate. J Clin Oncol (2005) 1.54
Coverage with evidence development: the Ontario experience. Int J Technol Assess Health Care (2011) 1.53
Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J (2006) 1.53
Draft genome sequence of Frankia sp. strain CN3, an atypical, noninfective (Nod-) ineffective (Fix-) isolate from Coriaria nepalensis. Genome Announc (2013) 1.51
Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer. CMAJ (2004) 1.51
Using administrative databases to measure waiting times for patients undergoing major cancer surgery in Ontario, 1993-2000. Can J Surg (2005) 1.49
The deficiency of PIP2 5-phosphatase in Lowe syndrome affects actin polymerization. Am J Hum Genet (2002) 1.47
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. Mol Cell Proteomics (2008) 1.46
Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy. CMAJ (2004) 1.46
Central venous catheter care for the patient with cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol (2013) 1.46
The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis. Genome Res (2003) 1.44
Lymphatic function is required prenatally for lung inflation at birth. J Exp Med (2014) 1.44
Intravenously administered vitamin C as cancer therapy: three cases. CMAJ (2006) 1.43